LOCUS       NM_001369454           18157 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 445 (ZNF445), transcript variant
            2, mRNA.
ACCESSION   NM_001369454
VERSION     NM_001369454.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 18157)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 18157)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 18157)
  AUTHORS   Takahashi,N., Coluccio,A., Thorball,C.W., Planet,E., Shi,H.,
            Offner,S., Turelli,P., Imbeault,M., Ferguson-Smith,A.C. and
            Trono,D.
  TITLE     ZNF445 is a primary regulator of genomic imprinting
  JOURNAL   Genes Dev 33 (1-2), 49-54 (2019)
   PUBMED   30602440
REFERENCE   4  (bases 1 to 18157)
  AUTHORS   Luo,K., Yuan,J., Shan,Y., Li,J., Xu,M., Cui,Y., Tang,W., Wan,B.,
            Zhang,N., Wu,Y. and Yu,L.
  TITLE     Activation of transcriptional activities of AP1 and SRE by a novel
            zinc finger protein ZNF445
  JOURNAL   Gene 367, 89-100 (2006)
   PUBMED   16368201
REFERENCE   5  (bases 1 to 18157)
  AUTHORS   Calabro,V., Pengue,G., Bartoli,P.C., Pagliuca,A., Featherstone,T.
            and Lania,L.
  TITLE     Positional cloning of cDNAs from the human chromosome 3p21-22
            region identifies a clustered organization of zinc-finger genes
  JOURNAL   Hum Genet 95 (1), 18-21 (1995)
   PUBMED   7814019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY295873.2 and AC134943.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.213933.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AY295873.2         1-80
            81-884              AY295873.2         202-1005
            885-8948            AY295873.2         1042-9105
            8949-18157          AC134943.2         33734-42942
FEATURES             Location/Qualifiers
     source          1..18157
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..18157
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /note="zinc finger protein 445"
                     /db_xref="GeneID:353274"
                     /db_xref="HGNC:HGNC:21018"
                     /db_xref="MIM:619508"
     exon            1..80
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /inference="alignment:Splign:2.1.0"
     exon            81..656
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..3287
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein 168; zinc finger protein with KRAB and SCAN
                     domains 15"
                     /codon_start=1
                     /product="zinc finger protein 445 isoform 2"
                     /protein_id="NP_001356383.1"
                     /db_xref="GeneID:353274"
                     /db_xref="HGNC:HGNC:21018"
                     /db_xref="MIM:619508"
                     /translation="MPPGRWHAAYPAQAQSSRERGRLQTVKKEEEDESYTPVQAARPQ
                     TLNRPGQELFRQLFRQLRYHESSGPLETLSRLRELCRWWLRPDVLSKAQILELLVLEQ
                     FLSILPGELRVWVQLHNPESGEEAVALLEELQRDLDGTSWRDPGPAQSPDVHWMGTGA
                     LRSAQIWSLASPLRSSSALGDHLEPPYEIEARDFLAGQSDTPAAQMPALFPREGCPGD
                     QETMTFKDVEVTFSQDEWGWLDSAQRNLYRDVMLENYRNMASLVGPFTKPALISWLEA
                     REPWGLNMQAAQPKGNPVAAPTGDDLQSKTNKFILNQEPLEEAETLAVSSGCPATSVS
                     EGIGLRESFQQKSRQKDQCENPIQVRVKKEETNFSHRTGKDSEVSGSNSLDLKHVTYL
                     RVSGRKESLKHGCGKHFRMSSHHYDYKKYGKGLRHMIGGFSLHQRIHSGLKGNKKDVC
                     GKDFSLSSHHQRGQSLHTVGVSFKCSDCGRTFSHSSHLAYHQRLHTQEKAFKCRVCGK
                     AFRWSSNCARHEKIHTGVKPYKCDLCEKAFRRLSAYRLHRETHAKKKFLELNQYRAAL
                     TYSSGFDHHLGDQSGEKLFDCSQCRKSFHCKSYVLEHQRIHTQEKPYKCTKCRKTFRW
                     RSNFTRHMRLHEEEKFYKQDECREGFRQSPDCSQPQGAPAVEKTFLCQQCGKTFTRKK
                     TLVDHQRIHTGEKPYQCSDCGKDFAYRSAFIVHKKKHAMKRKPEGGPSFSQDTVFQVP
                     QSSHSKEEPYKCSQCGKAFRNHSFLLIHQRVHTGEKPYKCRECGKAFRWSSNLYRHQR
                     IHSLQKQYDCHESEKTPNVEPKILTGEKRFWCQECGKTFTRKRTLLDHKGIHSGEKRY
                     KCNLCGKSYDRNYRLVNHQRIHSTERPFKCQWCGKEFIGRHTLSSHQRKHTRAAQAER
                     SPPARSSSQDTKLRLQKLKPSEEMPLEDCKEACSQSSRLTGLQDISIGKKCHKCSICG
                     KTFNKSSQLISHKRFHTRERPFKCSKCGKTFRWSSNLARHMKNHIRD"
     exon            657..825
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /inference="alignment:Splign:2.1.0"
     exon            826..884
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1011
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1122
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..18157
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8199..8204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /note="hexamer: AGTAAA"
     polyA_site      8221
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /note="major polyA site"
     regulatory      10072..10077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /note="hexamer: AGTAAA"
     polyA_site      10092
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
     regulatory      12359..12364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /note="hexamer: AATAAA"
     polyA_site      12381
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
     regulatory      18121..18126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /note="hexamer: AATAAA"
     polyA_site      18157
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
ORIGIN      
        1 ggagccgccg ggaggtaggc gcgggacggg cggctgcggt ggcggcgggt ggaccgattg
       61 tcgctcggcg gcgggagtcg aaatgctggt aatttcagtc acttgctgat gacttctgat
      121 gtcccagcaa atgttggcat tgttgactgc tgagaagata cttctgagga cccacgtcta
      181 aggtggactt ggttcgcact cttctggtta gtccctgaac aggagtgatg cctccaggca
      241 ggtggcatgc tgcctatcca gctcaggccc agtcttcgag ggagcgaggg cggcttcaga
      301 cagtaaagaa ggaagaagag gatgaaagct atactccagt gcaggctgcc aggccacaga
      361 ctctcaaccg ccctggccag gagctgttcc gccagctctt cagacagctt cgctaccatg
      421 agtcttcagg gcccctagaa actctgagcc ggctccggga actctgtcgc tggtggctga
      481 ggcctgacgt tctctccaag gcacagatcc tagagctgct ggtgctggaa cagttcctga
      541 gcatcctgcc tggggagctc cgggtttggg tgcagcttca taaccctgag agtggcgagg
      601 aggctgtggc cttgctggag gagctgcaga gggaccttga tgggacatcc tggagggacc
      661 cgggccctgc ccagagccca gatgtgcatt ggatgggtac aggagccctg cgatctgcac
      721 agatatggtc ccttgcttca cctctcagga gcagctctgc tctgggggac cacctggagc
      781 ctccctatga aatagaagca cgtgacttcc tggctgggca atccgatact cctgctgccc
      841 agatgcctgc ccttttcccg agagaggggt gcccgggaga ccaggagacc atgactttca
      901 aggatgtgga ggtgaccttc tcccaggacg agtgggggtg gctggactct gctcagagga
      961 acctgtacag ggatgtgatg ctggagaatt ataggaacat ggcttccctg gtgggaccat
     1021 tcaccaaacc tgctctgatc tcctggttgg aagcaaggga gccatggggc ctgaacatgc
     1081 aggcagctca gcctaagggg aatccagttg ctgctcctac aggagatgac ctccagagta
     1141 aaacaaacaa attcatctta aatcaggaac ctttggaaga agcagaaacc ttagctgtgt
     1201 catcaggatg tcctgcgaca agtgtttctg agggaattgg gctcagagaa tcttttcaac
     1261 agaagagcag gcagaaggat caatgtgaaa atcccataca agtaagagtt aagaaagaag
     1321 agaccaattt cagtcacagg acaggaaaag actctgaagt atcaggaagt aatagtcttg
     1381 acttaaaaca tgttacatat ttgagagttt ctggaagaaa ggaatccctt aaacatggct
     1441 gtggcaaaca cttcagaatg agttcacacc actatgacta caagaaatat gggaaggggc
     1501 tcagacacat gattgggggc ttcagcctac atcagagaat tcatagtgga ctgaaaggga
     1561 acaaaaagga cgtgtgtgga aaagacttca gccttagctc tcatcaccaa cgtgggcaga
     1621 gtcttcacac agtgggagtg tcatttaagt gcagtgactg tggaaggact ttcagtcata
     1681 gctcccatct tgcgtatcat cagagacttc acactcaaga gaaagcattt aaatgtaggg
     1741 tgtgtgggaa agccttccgg tggagttcca actgtgcgcg gcatgagaaa attcacactg
     1801 gagtgaagcc ttataaatgc gatttatgtg agaaagcttt ccgacgcctg tcagcctacc
     1861 gtctgcaccg agaaacccat gctaagaaga aatttcttga attgaatcag tatagggcag
     1921 ctctcaccta cagctcaggg tttgatcatc atttgggaga ccaaagtggg gagaaactct
     1981 ttgactgcag ccagtgcagg aaatccttcc actgtaagtc atatgttctt gaacatcaaa
     2041 ggattcacac ccaggagaag ccctataaat gtaccaaatg taggaaaacc tttagatgga
     2101 gatcaaactt tactcgtcat atgaggttgc atgaggagga aaaattctac aaacaagatg
     2161 aatgtcgtga aggcttcagg caatctcctg actgcagtca gccccagggt gctcccgctg
     2221 tggagaaaac atttctgtgt cagcagtgtg ggaaaacttt tactagaaag aaaactctcg
     2281 ttgaccacca gagaattcac acaggtgaga aaccttacca gtgtagcgat tgtgggaagg
     2341 actttgccta taggtcagcc tttattgttc ataagaagaa gcatgccatg aaaagaaaac
     2401 ctgagggcgg gccatctttt agtcaggaca cagtgttcca ggttcctcag agcagtcact
     2461 ccaaagagga gccctacaaa tgcagccagt gtggcaaggc cttccgcaat cactcattcc
     2521 tcctcatcca tcagagagtt cacactggag agaagccata taagtgcagg gagtgtggga
     2581 aagccttcag atggagttcc aatctctacc gacatcagag gattcactct cttcaaaaac
     2641 agtatgattg ccatgaaagt gaaaagactc caaatgtgga gccaaaaatc ctcactggtg
     2701 agaaacgttt ttggtgtcaa gaatgtggga aaacctttac acgtaaaaga acccttttag
     2761 atcataaggg aatacacagt ggagagaagc gctataaatg taatctatgt gggaaatctt
     2821 atgatagaaa ctatcgcctt gttaaccatc agaggatcca ctctacagag agacctttca
     2881 aatgtcagtg gtgtgggaaa gagttcattg ggagacatac cctttccagt caccagagga
     2941 aacacaccag agcagcacag gctgaacgta gcccgcctgc acggtcttcc tctcaggaca
     3001 caaagttgag attacagaag ctaaaaccaa gtgaagagat gcccctcgaa gactgcaaag
     3061 aagcttgcag ccagagctcc aggctcactg gactccagga cataagcatt gggaaaaagt
     3121 gccacaaatg cagcatatgt gggaaaactt ttaacaagag ttcacaactc attagccaca
     3181 agagatttca tactcgagag aggcccttca aatgcagcaa gtgtggaaag accttcaggt
     3241 ggtcttcgaa cctggctcgg catatgaaaa accatattag agattagcct gggacctgac
     3301 agtgacagtg ggggtgggtt ctcagtcccc tgctagagaa cccttaatta taggcattgt
     3361 ggagtaactt tgataaaggg cccagccctt tctgttttgg aagctagtga cagaatccca
     3421 aggatttgaa agctcgggga gtccccagcc tgcctgctag gatgtgacgc tggggaagtg
     3481 cagcaccatg tcctttggag cccttctgga gactccggcc cctaggagtg gcctctgcac
     3541 catagcctgc ggctccccta ttcaggtctc cttccacaac tctgaagaga gagaccactg
     3601 ccctttgtgg ttggacagaa tatctgtggc atcatgggct atggctgctg gaaaggggcc
     3661 agtgggatcc tagatttgtc ttcaagtttg gcctgtggcc atgcctattc tgttgacttt
     3721 aaaagcagca gcatcaagaa ctcctagcct tcccaaatgc cccctgggga gttctggctg
     3781 gggcttcagc cttcctggct ggcttttgga tatctgctag ggggttagag tggtctcagc
     3841 ggcaggtgga ggagagcagg atgctgggct caagcgcttg gcgtgtggat ctctaccagt
     3901 accctgttgc catccccatc ccacaggcct gcataggcag cagcggtcca tctgtttaac
     3961 agaaatgtgc tgagcactcc catacaccag gcgctggtgt gtttgccaga gacccagcag
     4021 ggaccagaac agatgaaaat cctgccatct tggatcttta cagatgacaa acaaatggga
     4081 tacgcagtat tctggatggt gatgtgtgta gtggacaaag tgaatcagag aagagcagag
     4141 ggagtgctgg attgggagat cagtcgtgat tttagatagt ctggtcaggg agggcctcaa
     4201 ctgagaaggt gaaatgtgag caaagacgtg aaggaagcca gggaggtagc aggtagctct
     4261 ctagggagag ttgcaggcag aggagattgg gtcttgactg gtgtcctcag gaaggaagcc
     4321 cctgggatgg agtgcaggga gccagctgga agggaaggag aggggccagg gaggccacag
     4381 gcccggccat atgagcatca tgggtcatta cgggggcttg agctggctca gagggaggca
     4441 gggagctttt ggacaatttt gagttgagga gtgatgtggt ttgaatctga attatatttt
     4501 ataagggtta accacagatc caaggactca gtaaaagggt gaaaggcttc tcatgcagtt
     4561 agccttgctg ccagttccca taaatcagac tcctccccac tccgtttctg aattttctat
     4621 aggatcctcg gcctcagcag atataaacgc ttaccattgt tgtgttcatg tctctagccc
     4681 ctgcacactg caggcccctc tcagcttcac atacccctct ccatgtatga gatctggtgc
     4741 tagcaatcag attcaacccg aaggaacaag tgcatgtgcc tgctgctctc aggagaaaag
     4801 gcagcctgtt ctgggaggag ctccctcact ggcccaccca cttgtgttga agcaaaaagc
     4861 aagaatcaat tacttaaagg caaaggagtg atattgctaa agcatgtgag taatcattgc
     4921 ttctgattat tgaagaggtc agattatgaa tgaaaggata aaatgtttta atagtagagc
     4981 agtgtcctga ctataggggc ccgttcatgg agctggtcat ttcttgaaat gagaagaaac
     5041 caacctggaa gatgtctttt tcagtagagt atggaataat cttacctgct ctggattgcc
     5101 atgagcaggt gaaaatgaag gctctgatat tgtgtggtgg tgtcacagga tggtgggggc
     5161 ggggcagaag tctcctgttg gtgttctgat gcctgttcag ctttgtcctc aggaaggttt
     5221 ggtcatcttg gttctgccat cctcttgcct tcctacggca gcagctgttc atggcactga
     5281 agatgtccct tcactgtccc aaaactggca ctagaagtgg ctgggcaggg gggccagagt
     5341 cataggaagg gtcttggagt catcagatct gggttccagg catggtgtgc cttttcttgg
     5401 caggattgat cttgagcaag tcaatgaacc tctgcatcaa tttccttatg tgtgaagtta
     5461 gagtgcttgg ctgtgctacc tgattcctga gattggtgaa agagggcttg gtttaccaag
     5521 gctctccatc aggtggttga cctctaggac cagggccctc tcagaggtgc agcttccatg
     5581 tcagttggtg ttgtaaccat ggaaaagtcc ctttccaatc aaacttttag cacccctttc
     5641 cccccatctc tgctcccttt gccacaggat accttgtaaa gttcctgccc cagtataggg
     5701 atatttttac tgtctttttt attttttgag acagggttgc ccagggtgga gtgcagtggc
     5761 aggatcacag cttactgcag ccttgacctc ccaggctcag gtcccatctg agcctcccga
     5821 gtagctgggg ctacaggtgt gtgccaccct gccagctaat tttttatatt tttttgtaga
     5881 gacaaaactt ttattttttt ttcccatgtt gctcatgctg gtctcaaact cctgggctca
     5941 agcaatccac ccacctctgc ctcccaaagt gctgggatta caggcgtgag ccactgtgcc
     6001 tgacctgtca tttttataga atgaaatgtg cttatttcta aacattctaa tcaaatttta
     6061 aaatgtgcaa agaatgaagt gaaaaactga attttttttt ttttttgata cggagtctca
     6121 ctctgttacc caggctagag tgcagtggcg cgatctccgc tcactgcaag ctctgcctcc
     6181 tgggctcaca ccattctcct gcctcagcct cctcagtagc tgggactaca agtgcctgcc
     6241 accacgcctg ggttattttt tatattttta gtagagacgg ggtttcactg tgttagccag
     6301 gatggtctcg atctccagga tggtctcgat ctccaggatg gtctcgatct cctgacgtcg
     6361 tgatccaccc gcctcggcct cccaaaatgc tgggattaca ggtgtgagcc actgtgcccg
     6421 gccaaaagaa cagaaattat tttatcctga agtaagctgt ttatatttgg gattatactg
     6481 aacctatttg tccaataacc tgagttttca aataatttta gttctataag tactataatt
     6541 atataaatat taatgaattc agattagctg aaaggaaaaa aagtagaagc ctgactactt
     6601 ggtgctaact actaaagatt ttggcagaat caatgttgga tttggctttc ctgtcccttc
     6661 cccatgccag ccccccagag tgttctgcct tgtgctgcct cccttcacct ggagtgccac
     6721 acccctctct ctgccagttc agctcttcat tcttcaaggc ctgaccttgt ctgacccttg
     6781 tgcctctaaa cccgtggccc cacctctctt ggttcctatg tcaggtgatg tttgtgtttt
     6841 tggttatgcc catctccata gccagaccaa gcactctgga agccagggtt gggtgcttat
     6901 ttatctgttt gccatgcaga aaatatcttg cacaaaatta cctctgttaa ggaatctgaa
     6961 gctgaattta gtttggctga gtcagggttg ggtttttttt aaggggctgt ggggtgaaat
     7021 gttgactgga agccacccac aaacacacac ctgctggtta ggaacccggc tgtgggtggt
     7081 tctgagctgt ttggcttcag ttgacagttt ctgattgccc tgagcaccag gtctcatctt
     7141 gcatctcatc ctggcctgga gaacattcag tttccttcca acccttccca cctttccccc
     7201 actcccttgg aggaactgaa gttggggttg aggagagcca gatggctgga gtgggtattt
     7261 gaaggtcttt ctgtcacctg ttcagtgtgg tctgccccac ccctgctgac caagactgac
     7321 tgaaatgtaa aataatacag accatctcac actcagaaag ctggcacatt tttgaaagcc
     7381 caagtgtggg taagtgcgtg gaacaacgat aattcacact gctttatgag tagaaattgt
     7441 gagaaatatt gtgccaggca atttgcaaaa tcttggaagg ttgtgtgcac ttaaccaccc
     7501 agcaactact cctggatgca tcctagagaa gtgccatgtg aacagagaat gattttaaga
     7561 cttcactgaa gtattgttta ggtagcaaga ttgggaaaag cctgcatttc atcagcagaa
     7621 gaatggataa ataaatgggt tgtttttggt ccttggaaag tgaatatgaa agagttacgt
     7681 ctcaacacag atagatgaaa aattatgctg agaaagttgg tgaagctaca tacaaggtac
     7741 ccttagtgta aagttaagca tactgtgtac ctgtgggcac gttacttcaa cttgtttttc
     7801 actttttctg taaaatggga tagtagtggc aatctcacag ggtgattgtg ggtggggggg
     7861 tggtcaatga agtaatgcat gtaaaatgct tagaatagtg tctagcatgt aagccttgtg
     7921 gacatataga aagtgttatt gttttgcaca gtaatctatt ttctgtggat tcaaataata
     7981 tgaaatgagt ataaaatcat gtattggaac gatgtgtgca agtcaccatt ctgccttcct
     8041 aaggcaggag acctgatgga tttggggagg gtacatgggg ccttcagttg tgttttcttt
     8101 gtttttttct aaaaattgat gcagaggcat cacaatgtta agatttttac agggtagtgt
     8161 ggtgggtact ttttaactgt ttgcttaaag tgtttcaaag taaaaatatt tcttaagcat
     8221 agtctctgac atcttatgac tttatagaaa tccctgccag gtacatgatg ttacttagag
     8281 tgagccacct aatctttcaa ggcttccatt tcctcacctg caaaaattgg gagtgtcaga
     8341 ggcgtttgaa ccagagtgac tccatcttga atagggaact gggtaaaata aggctgagac
     8401 ctactgggct gcattcccag gaggttaggc attccaagtc atgggatgag ataggaggtc
     8461 agcacaagat acagtcataa agaccttgcc aataaaacag catgtggtaa agaagccggt
     8521 caaaaccaag atggcaatga aagtgacctc tggttgtcct cactgctgta attatactgt
     8581 aattataatg cattagcatg ctaacagaca ctcccaccag tgccatgaca gtttacaaac
     8641 gccatggcag gcctggcacg atggctcatg cctgtaatcc cagcactttg ggaggccaag
     8701 gcgggcggat tatgaggtca ggagattgag accagcctgg ccaacatggt gaaaccctgt
     8761 ctctactaaa aaatacaaaa attagctggg catggtggca cgtgcctgta atcccagcta
     8821 cttgagaggc tgaggcagga gaatctctag atcccgggag ttggaggttg cagtgagcca
     8881 agatggtgcc actgcactcc agcctgggtg acagagcaag actctgtctc aaaaaaaaaa
     8941 aaaaaaaatg ccatggcaac atcaggaagt aacactatat ggtctaaaaa ggagaggaac
     9001 cctcagttct ggtaattgct cacacctttc ccgggaaact tatgaataat ctaccccttg
     9061 tttagcatat aatcaataaa taaccataaa aataggcaac cagcagccct tggggctact
     9121 cttcctatgg agtagccatt ctgtatttct ttactttctt aatattaact actttcactt
     9181 tgtggactcg cccgaattct tttcttgagc aaggtccaag aactctctct tggggactgg
     9241 atcacgaccg ctttctggta acaggagcaa tacaaatggc tattagtaaa cgaacgctta
     9301 agtaactcta gtacatctat gatgaaatac caggccacag tttttttaaa aatgaggatg
     9361 ttctctatat actgacgcac agtcaccaag acatgcactt tataggaaat tataagctcc
     9421 tccttgccta aatctcctta attttgctta ataaataaca agtgaagcca gaagctgtaa
     9481 actcataatt ttaatgaaga aatgggatcc agaagatgga gatgtttttc attctacttt
     9541 attagatgag gaaaaggaga gtaaatactt gtatgccagc taccacacct tttaaagtta
     9601 atgttaaccc tgctaagaac agcaaggaga ttttatatca gccaggtttt agttgccaga
     9661 aaccacacca gttattttag caaagacctt ataaagaagt gtactatatt taagtagcta
     9721 aaaaggcaag aagaaaatgc caaggtgtct tggaggtagc aactgctaag cagctgccac
     9781 cccaggactg ggggagctag aatagagtct ccccatgttt gacgtttgtc tgctaatagc
     9841 attcaagctc tccccctcag tttgcctgga tctggacaag ctgataagaa agcccagcca
     9901 cttcctcttt gcgtcagagg ggaagttcaa actgtgcaaa ccctgactgt caaatgcact
     9961 gagctctcat aaccacaaca aaaaccagag ccacttgttc gtcctttcac tgaagcccaa
    10021 cagactggcg tgggtgcccg ctttgctttc cctagaaggc ctcatgtgag tagtaaactt
    10081 tttcataacc tcttggtgtc tgcagtgtca tcagtttcaa catccgaacc agttttgagt
    10141 gatggtagtt tattgatccc acctcatgtg gagcaaagtg caaagcagga acaaagagac
    10201 gtggctagaa ttgttgaaag gtgggagatt ggaagaggga ccttgtggag ctgaactcag
    10261 acctatggtg gaggagtgga ctgctgggct gacatagtgt ctgtgctcag ggaggggccc
    10321 tgtggccttt ggatctgtgc ttctgtggag aggtcccagc tactaatgct ggggcaggga
    10381 gcagaaggga gggtcacaat gagactttga gtgttagtta accacctttt gcctgaagaa
    10441 catgtaatgg ccttccctga ggtatatgtc ttccaaaagt ccgctgacgt tgctcatgac
    10501 ctatggtcac cactgctttt tgcgttttgc tttttttttt tttttttttt tgagacaagg
    10561 tctcaccctg tcacccaggc tggagtgcag tggcacgatc tcagctcact gcaacctcca
    10621 ctttcccagg ctcaagcgat tctccagcct cagcctcctg actagctggg actacaagcg
    10681 tgcaccacca cacccagcta atttttgtat ttttgtagag acaaggtttg gccatgttgc
    10741 ccaagctggt cttgaactcc tgacctcaag tgacccacct gcctcagctt gccaaagtgc
    10801 tgggattaca ggtgtgagcc accatgcctg gagtccttgt tttttttttt tttatacttt
    10861 tagggtacat gtgcacaatg tgcaggttag ttacatatgt atacatgtgc catgctggtg
    10921 cgctgcaccc actaactcat catctagcat taggtatatc tcccaatgct atccctcccc
    10981 ccctcccccc accccacaac agtccccaga gtgtgatgtt ccccttcctg tgtccatgtt
    11041 ttctcattgt tcaattccca cctatgagtg agaatatgcg gtgtttggtt ttttgttctt
    11101 gcgatagttt actgagaatg attatttcca ccttcatcca tgtccctaca aaggacatga
    11161 actcatcatt ttttatggct gcatagtatt ccatggtgta tgtgtgccac attttcttaa
    11221 tccagtctat cattgcctgg agtcctttta aaaaaattat ttttttggcc aggcacggtg
    11281 gctcacacct gtaatcccag cactttggga ggctgaggcg ggcagatcac gaggtcaaga
    11341 gatcgagacc atgctggcta acgcggtgaa accccgtctc tagtaaaaat acaaaaaatt
    11401 aaccgggcgt ggcagcgggc gcctgtagtc ccagctactc gggaggctga ggcgggcaga
    11461 tcacgagatc aggagattga gaccagccag cctggccaat atggtgaaac cccatctcta
    11521 ttaaaaatac aaaaattagc cgggtgtggt ggtgtgtgcc tgtaatccta gctactgggg
    11581 aggctgaggc aggagaatca cttgaaccca ggaggtggaa gttgcagtga gccgagatcg
    11641 cacaactgca ctccagcctg ggcgacagag tgaaactttg tctcaattaa aaaaaaaaaa
    11701 aagtgaagtg caaaatgtga ctgaggagat acagtactct ccaaattgca taattttgcc
    11761 aatttttata gaaacctggg gaatctgtag agatagcgtc agaagcattg gaacgagagc
    11821 aactccatgt tgaatagggg ctgggtaaaa gtgtcagagg tatttgaacc agagcgactc
    11881 cattttgagt gagggctggg aaaatgaggc tgagacttac tggcctgcat tctcagaaag
    11941 ttaggcattc ctaccctcta ggattgaatt gggacccctt tcctgtaaca tatttctggt
    12001 gaccacagaa gggactatag tgcagaaacg ttgacccaac ggctaccttt gcgtaagtgt
    12061 tggggtcctg taacatattt ctggcaaacc acagaaagga tgatactgaa gaaatccccc
    12121 caaccccaaa gaaatagact gcagcactga ttggacgact ttgggtaagt gatggggtac
    12181 ccgagtaaca aatgggattg ggttagaggc ccaacttagg ggagttggag tttctcctaa
    12241 gacagagtga gttagaggcc cctcttaata aaaggcaagg acacttgact gacctcaggt
    12301 tagaggttac tccatcctac tctatggagt agctgtcctt tcaccacttt actttcttaa
    12361 taaacttgtt tttgctttgc actgcggact tgccctgaat cctttcttgc acgagatcca
    12421 agaactctct taagagtctg gatcgggacc cctttcctgt aacaaaatga ggctgagacc
    12481 tactgggctg cattcccaga cggttaaggc attctaagtc acgggatgag ataggagatt
    12541 ggcacaagat ccaggccaca aagaccttgc tgataaagca ggttgcagta aagaagccag
    12601 ctaaaaccca ccaaaaccaa gacggtgatg agaatgacct ctggtcatcc tcactgctac
    12661 cctcccacca gtgccatgac agtttacagt tgccatggca acatcaggaa gttaccctat
    12721 atggcctgga gaggggaggc atgaataatc caccccttgt ttagcatatc atcaagaaac
    12781 cataaaatag acaaccagca gccctcgggg ctgctctgtc tatggagtag ccattctttt
    12841 attcctttac ttaataaact tgctttctct ttacggactc gccctgaatt ctttcttgtg
    12901 cgagatccaa gaaccctctc ttggggtctg gattgggaac cttttgcggt aacaagggtg
    12961 caggatcatc gtggaaggaa tataaagtca gatcaagctg aattattcga tatgggataa
    13021 ttaagcagag atttgtggtt cattgtttta acttgagaag ctgagaatgg ctgtcttcat
    13081 ttgctttgag ttgttgagat atggactcac tgtaatccca gcttgggagg ctgaggtggg
    13141 aggattgctt gaggccagga gtttgagact ggcttgggca atatagtgag aactcatctc
    13201 caaaagaaaa aaaaaacacg aatgcaaaca taacctgcac tgaatgagtt gaaatgcgag
    13261 aacttcgttg gtatactgta gaggaagata tgtaaatgct taaggagata aaaatgcttg
    13321 agtatttatc atgtaaatac ctgctcaccc acccagggag ggtccagagg acacttcatt
    13381 atgagaaata aattcatgta gagagtgcca gatattctat acaggccaca ttacagtggg
    13441 aaatgctccc tgaagtgcag tggggctgat ggaatcctga ggaggcaggg accatatggt
    13501 aacacttagt caccaaaaac acaattggtg tggtgactgc catggacagt gcagccaaag
    13561 caggatcctg aatggtctga cccacagaga tctgtgatgt ctgcctgctg atcatagtgt
    13621 cctgagaact gaaatggatg ggctgcctac taaagtttta cttgatccga gtaagtagga
    13681 aagctccaga tctggtgaat aaagtctgac ctaaattacc aacacagagt tacaatcact
    13741 cagtcaattc caagtcttga tctagttcac aaacccacag cttcttgaat aaaggatagg
    13801 ccaggtccct ttgaagtagg accctgctgc actgacaata atttatactt tttatcttcc
    13861 taggcctccc caaaggcacc caaggccatt tatcagagtg attgtgcatt gggaagggca
    13921 aataattaga cttttctggg ataaccagcc tctagttctg aactagcagt aattacagga
    13981 gactcaaaat gccaccatgg ttcctcagag taagagtgta tggaggtcag gtgatcaatg
    14041 ggctttttgg ctcagattca tctcacagta gatctagtag attcctgaac ccatcctatg
    14101 gttatttccc tggttctaga atgcgtaatt agaatagaca tagtcaacaa tgggcagaat
    14161 cccacactag ttccctgatc catacagtaa aagtaattct ggtagaaaag gccaagtaga
    14221 agccactaga gctgcctcat tcacaaaaat attaaagcaa actaatacca cattcctgga
    14281 gagattgttg agattagtgc caccatcaaa gacgggaaca catctccact tagctcacct
    14341 actcagcctg tgcagaagac agatggatct tggagaatga caattggatt aattgtaaac
    14401 ttaattaact agtgattcca agtgcaggtg ctgtttccac atgtggtttc agtgctgagc
    14461 aaacgatacg tctgacaact ggtttgcagt tgttactgag ccaggcccag gtttgttctg
    14521 ttctcacaca gtaaatcaat cactgtgaca tgggttttgc aaaagagaga agaattattc
    14581 acaaggctgt ccagtgagga gatgggagaa tggctctcaa attcacctcc ccaaagatga
    14641 ggcttagaga gatttatagg ttagagaagt agggtggtct gaggcatggg gaaaggtgat
    14701 tggcagtggg gaaaaatgca gtcataattg gggttcatat gacatatgtg cagaaaatgg
    14761 tggcgttaac atgatctgag ggtggagttt ttggccctct gatgtcaaaa ggccacctct
    14821 tgggcatgtg tacaggccca gttgaagggt tggcagtctc aactggtttg aactggacag
    14881 gatctgcccc aagttcctga aaaataagtg gttgttatgg tgacttataa atgttatcta
    14941 taaggtagca cgtaaaagtt gagttacagt gttcaatagc atagccttca gctatcgtgg
    15001 ccttcagctt catgggggaa aaaataacaa agagcaagca accaaaagca agcggggcag
    15061 gcgaagtgtg gcacacccga tccgattatc cccttggctg cccagttacc catctggtga
    15121 atgtttctct atacctgtga gtaaagacca tcaggaacag tttgctttca gctagataca
    15181 ccttcaccac cctatctcaa ggctgcctca actctgccgc ccagctcatg atctagttcc
    15241 caggtccttt gagaaccttt tcaccctcag gacgacacac tggtccatta tattgatgac
    15301 attatagtca ctggacctgg tgtacaggga gtagcaactg ctccagacat gttggaagac
    15361 acataatatg actcagtgta ggaaataaac ccacaacatg gctaagggca aataatgttt
    15421 ccaaaacttc tttctctctt ttttttttct tttttgagac agagtctcac tctgtagctc
    15481 gagctggagt ggaggcaatc ttggctcact gcaacctgca cctcctgggt acaagtgaag
    15541 ctgcttcctc agcctgttgg gactacaggt gtgcgccacc acgcccggct aatttttttt
    15601 tttttttttt tggtaaaggc agggtttcac catgttagcc agcttggtct tgaactcttg
    15661 acctcaagtg atctgcccac ctcagcctcc caaagtgctg ggattacaga agtgagccac
    15721 caagccaggc cctttttctc tctctttcca atagttacat tctatatgtt taaaagggac
    15781 acgagacaat tttgtatgtg attttctgaa tcacataatt ccacatttaa cattttgggg
    15841 aaatgccaaa ctgttttcca aaggggctgc ctgggagtct cagctctagt tctcagtcct
    15901 cagcagccat tcctttcctc agtggggcgt cagtgctgcc ttccaaagtc cagggctgcc
    15961 ttgagacctg atcaggaccg gctattttgc caggtgcagt gcatgatgtt caagaccatt
    16021 cagaatttca agaccctgac agcagagcaa gatagcaggc ggaggccatt ctaagtgtgg
    16081 ggccccgcag ggctgcccag gctgcctgcc tgtgaagcca gtcctgcctg atggagatgc
    16141 ttttgccatg gcgtgaggga aagtgagctg atggttctcc actttcccac tctctctctg
    16201 caggtccggc tcctctaagg gcagaagcca gaacttggtc cctgaacctt ctccagtctc
    16261 cctccctggg catttctctc ataaccccat cagacccccc agtaatggcc tgacgtgggt
    16321 tctggaaata gaacatgggt tcttagaatg gctctctgag acttcattga gttgtctgtc
    16381 ctatttcttt cctcaacaaa atgtccacat cctcaatctc ctgtctcagc aggaaagatg
    16441 aaaagaacag tgaggcttag gccaggcacg gtggctcaca cctgtaatcc caacactttg
    16501 ggaggctgag gtgggcagat cacctgagaa cgggagttcg agaccagtct gaactccctg
    16561 tctctactaa aaatacaaaa gtagccaggc gtggtagcgg gcacctgtaa atcccagcta
    16621 ctggggaggc tgagacagga gaatcgtttg aacctgggag gcggacgttg tggtgagccg
    16681 agatagtgcc actgcactcc agcctggaca acagagcggg aaaaaaaaaa aaaaagaacg
    16741 atgaccctta gcatcccagg aagctttggg tggtgagaga tggagagtat ctccttcctg
    16801 tggtacttca gtttcccgtc tccttgttag gatgttgcaa agctggcctg ctgaggtctt
    16861 ctgtgatctc ctgtgcttcc tacacttcca cctgaaaatg aacctactgc agggatgaat
    16921 ccatgagcag aattttaatg aaaaggaagc agacacaaag gaatccatgg gttgtaactc
    16981 caccgactta aaatgaaaaa cacaggcaac aaagaacagg cacgatgctg cttcgccagc
    17041 tggttccttg ttgggttctg ccattcaggg atgtaagagg gaagctggga tgttggagga
    17101 ctggagtgtg agggtaaatt ttaggtgtca acttggctga gccacaaggt ccccaggtat
    17161 ttgatcaaac attatgctgg gtgtttctgt gaggttgctt tggatgagat taacgtttaa
    17221 atttgtggac tttgaggaaa gcagattgcc ctctatctgt gggtgggctt catccaatca
    17281 cctgaagacc tgaggagaac ataaagtctg gctgccccag actctctctc aggcaagaga
    17341 gaattcttcc gcagactgcc ttcagagttc atgcacacca tctactaatc ctgctccaca
    17401 gcaggtgcca ctgggctctc actggaatat gtattctcct ggttctccag cctgctcatc
    17461 caccctgaag atttgggact tgccagcctc cttaattcta taagccaatt ccttatcata
    17521 aattcataaa tccctctctc tctatctcca tccacacaca cacacacaca cacacacaca
    17581 cacacacaga cacacacaca caaatgagtg tagatgtgtt ccaataaaac ttcatttaga
    17641 gacattgaaa tttaaatttc aagggctggg catggtggct caacgcctgt aatctcagca
    17701 ctttgggagg ctgaggcagg tggatcactt gaggtcagga gttcgagacc agcctggcca
    17761 acatggtgaa accccgtctc tactaaaaat acaaaacatg tagccacgtg cagtggctca
    17821 tgcctgtaat cccagctggg aggctaagat gggagaatag cttgaacaca ggaggcagag
    17881 gttgctgtga gctgaaatgg tgcccagaag acagagcgac cctgtctcaa aaaaataaaa
    17941 aataaaaaat aaatttcata taatcttcag atatattcat tcatttacat attgtctgtg
    18001 gttgttttca ccctttaggt cagaagtagc cgacaacctt tacacagtat ttaccactgt
    18061 tatagacatc tttaaatatg gtttactttt gcctgttttt gtactttata gaaatgaagt
    18121 aataaagtat tgtctgtctt gcattttttg ctcaaaa
//
