LOCUS       NM_018337               1943 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 444 (ZNF444), transcript variant
            1, mRNA.
ACCESSION   NM_018337
VERSION     NM_018337.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1943)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1943)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1943)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1943)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   5  (bases 1 to 1943)
  AUTHORS   Brandal,P., Panagopoulos,I., Bjerkehagen,B. and Heim,S.
  TITLE     t(19;22)(q13;q12) Translocation leading to the novel fusion gene
            EWSR1-ZNF444 in soft tissue myoepithelial carcinoma
  JOURNAL   Genes Chromosomes Cancer 48 (12), 1051-1056 (2009)
   PUBMED   19760602
  REMARK    GeneRIF: t(19;22)(q13;q12) Translocation leading to the novel
            fusion gene EWSR1-ZNF444 is associated with soft tissue
            myoepithelial carcinoma.
REFERENCE   6  (bases 1 to 1943)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 1943)
  AUTHORS   Adachi,H. and Tsujimoto,M.
  TITLE     Characterization of the human gene encoding the scavenger receptor
            expressed by endothelial cell and its regulation by a novel
            transcription factor, endothelial zinc finger protein-2
  JOURNAL   J Biol Chem 277 (27), 24014-24021 (2002)
   PUBMED   11978792
  REMARK    GeneRIF: regulates the human gene encoding the scavenger receptor
            expressed by endothelial cells
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI823582.1 and AL834130.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018337.3.
            
            Summary: This gene encodes a zinc finger protein which activates
            transcription of a scavenger receptor gene involved in the
            degradation of acetylated low density lipoprotein (Ac-LDL) (PMID:
            11978792). This gene is located in a cluster of zinc finger genes
            on chromosome 19 at q13.4. A pseudogene of this gene is located on
            chromosome 15. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Dec
            2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL834130.1, SRR3476690.46629.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337080.8/ ENSP00000338860.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               BI823582.1         108-224
            118-1943            AL834130.1         219-2044
FEATURES             Location/Qualifiers
     source          1..1943
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..1943
                     /gene="ZNF444"
                     /gene_synonym="EZF-2; EZF2; ZSCAN17"
                     /note="zinc finger protein 444"
                     /db_xref="GeneID:55311"
                     /db_xref="HGNC:HGNC:16052"
                     /db_xref="MIM:607874"
     exon            1..71
                     /gene="ZNF444"
                     /gene_synonym="EZF-2; EZF2; ZSCAN17"
                     /inference="alignment:Splign:2.1.0"
     exon            72..245
                     /gene="ZNF444"
                     /gene_synonym="EZF-2; EZF2; ZSCAN17"
                     /inference="alignment:Splign:2.1.0"
     exon            246..564
                     /gene="ZNF444"
                     /gene_synonym="EZF-2; EZF2; ZSCAN17"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1251
                     /gene="ZNF444"
                     /gene_synonym="EZF-2; EZF2; ZSCAN17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     endothelial zinc finger protein 2; zinc finger and SCAN
                     domain-containing protein 17"
                     /codon_start=1
                     /product="zinc finger protein 444 isoform 1"
                     /protein_id="NP_060807.2"
                     /db_xref="CCDS:CCDS12939.1"
                     /db_xref="GeneID:55311"
                     /db_xref="HGNC:HGNC:16052"
                     /db_xref="MIM:607874"
                     /translation="MEVAVPVKQEAEGLALDSPWHRFRRFHLGDAPGPREALGLLRAL
                     CRDWLRPEVHTKEQMLELLVLEQFLSALPADTQAWVCSRQPQSGEEAVALLEELWGPA
                     ASPDGSSATRVPQDVTQGPGATGGKEDSGMIPLAGTAPGAEGPAPGDSQAVRPYKQEP
                     SSPPLAPGLPAFLAAPGTTSCPECGKTSLKPAHLLRHRQSHSGEKPHACPECGKAFRR
                     KEHLRRHRDTHPGSPGSPGPALRPLPAREKPHACCECGKTFYWREHLVRHRKTHSGAR
                     PFACWECGKGFGRREHVLRHQRIHGRAAASAQGAVAPGPDGGGPFPPWPLG"
     exon            565..673
                     /gene="ZNF444"
                     /gene_synonym="EZF-2; EZF2; ZSCAN17"
                     /inference="alignment:Splign:2.1.0"
     exon            674..1943
                     /gene="ZNF444"
                     /gene_synonym="EZF-2; EZF2; ZSCAN17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1917..1922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF444"
                     /gene_synonym="EZF-2; EZF2; ZSCAN17"
                     /note="hexamer: AATAAA"
     polyA_site      1943
                     /gene="ZNF444"
                     /gene_synonym="EZF-2; EZF2; ZSCAN17"
                     /note="major polyA site"
ORIGIN      
        1 agtcccggcg agctttgtgc gcatgtgcgg ggaggtgagg gggcttgggg ggcctcgcct
       61 gagagagtga ggacaggctg cgggaggagc tgcaggactg aggtacagag gccaggggcc
      121 cagggcagga cccagcctgg acttgactcc ctgggatccc aggaagggca caccctttcc
      181 tcaccacccg agtgagcgct gccccctcac agagacctct ttgccccctg ggccaggcag
      241 agcaggcgct gcggtccggg aggccccatg gaggtggcgg tgcccgtgaa gcaggaggcc
      301 gagggcctgg cgctggactc cccgtggcac cgcttccgcc gcttccacct gggcgacgcg
      361 ccgggcccgc gggaggcgct ggggctgctc cgcgccctgt gccgggactg gctgcggccc
      421 gaggtgcaca ccaaggagca gatgttggag ctgctggtgc tggaacagtt cctgagcgcg
      481 ctgcccgccg acacgcaggc ctgggtgtgc agccggcagc cgcagagcgg ggaggaggcg
      541 gtggccctgc tggaggagct ctgggggcca gcagcctccc ccgatgggtc gtcagcaacg
      601 agggtgcctc aggatgtgac gcagggccct ggggccacag gtggaaagga ggacagtggg
      661 atgattccct tagcaggcac cgcccctggg gctgaggggc cggcgcctgg ggactcccag
      721 gctgtgcgcc cctacaagca ggagcccagc agccccccgc tggcgcctgg cctgcccgcc
      781 ttcctagcgg ccccgggcac cacgtcctgc cccgagtgcg gcaaaacgtc cctgaaacca
      841 gctcacctgc tgcgccaccg gcagagccac tcgggcgaga agccgcacgc ctgccctgag
      901 tgcgggaagg cctttcggcg caaggagcac ctgcggcgcc accgcgacac gcaccccggc
      961 agccccggca gccccgggcc cgcgctgcgc cctctgcccg cccgtgagaa gccccacgcg
     1021 tgctgcgagt gtggcaagac cttctactgg cgcgagcacc tggtgcgcca ccgcaagacg
     1081 cactcgggag cgcggccctt tgcctgctgg gagtgtggca agggcttcgg gcgccgcgag
     1141 cacgtgctgc gccaccagcg catccacggc cgggcagcgg ccagcgcgca gggggcggta
     1201 gctccgggcc cggatggtgg aggccccttc ccgccctggc ccttgggtta gccgcctccc
     1261 ggccagcgcc atctcccgcc cttggtgctg cccccgggcg gtacctgctc tctcccagcg
     1321 ccacttggcc tcttcctctc ctccttccct cccatcgtcc tcctccacct gcgcctccct
     1381 tgtctgaact tcccaacgcc ttcctattcc tttccaactc cttttccccc aaatttcact
     1441 ttccttctca ggtctcacct cagccccccc cttctccctg atttctcggc ctctctctct
     1501 gtgtgaaggg gcctctccct aatgtctcct ccttcccccc tcttctctct cctgcggccc
     1561 agcctccctc tccctcctcc attcctctct ccctgccctt ttcctgcctg aagagcagag
     1621 gtgaggacct gggacccctg aggggcaggc caggaggagc tcgggcgcag gccaggcccc
     1681 cttggtgaag cagaggctga aggaaagggg tctgggtctt gtccctagga attctcctcc
     1741 ctcaggagat tgggggttgg gggaggcagc gggtgatggc tctgaagctg aacccagggc
     1801 ctggctgtgg tcttcttggt cttgctgccc cctgtgaccc aaaggcatgg gatggacaga
     1861 gatgcctgcc cccgtgaagc tggttgggga gggcagttca ccagcatcca tagagtaata
     1921 aagtcactgt gtgtagaccc gga
//
