LOCUS       NM_005815               2573 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 443 (ZNF443), mRNA.
ACCESSION   NM_005815
VERSION     NM_005815.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2573)
  AUTHORS   Lee,S.M., Li,M.L., Tse,Y.C., Leung,S.C., Lee,M.M., Tsui,S.K.,
            Fung,K.P., Lee,C.Y. and Waye,M.M.
  TITLE     Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells
            growth by inducing apoptosis in a p53 independent pathway
  JOURNAL   Life Sci 71 (19), 2267-2277 (2002)
   PUBMED   12215374
  REMARK    GeneRIF: The gene expression of ZK1 was down-regulated during early
            apoptosis of human hepatoma cells exposed to Paeoniae Radix extract
            in vitro.
REFERENCE   2  (bases 1 to 2573)
  AUTHORS   Katoh,O., Oguri,T., Takahashi,T., Takai,S., Fujiwara,Y. and
            Watanabe,H.
  TITLE     ZK1, a novel Kruppel-type zinc finger gene, is induced following
            exposure to ionizing radiation and enhances apoptotic cell death on
            hematopoietic cells
  JOURNAL   Biochem Biophys Res Commun 249 (3), 595-600 (1998)
   PUBMED   9731181
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008758.7.
            
            On Nov 23, 2018 this sequence version replaced NM_005815.4.
            
            Summary: Zinc finger proteins (ZNFs) bind DNA and, through this
            binding, regulate gene transcription. Most ZNFs contain conserved
            C2H2 motifs and are classified as Kruppel-type zinc fingers. For a
            general description of these proteins, see ZNF91 (MIM
            603971).[supplied by OMIM, Jul 2002].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032753.1, AB011414.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301547.10/ ENSP00000301547.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AC008758.7         148445-148554       c
            111-237             AC008758.7         140604-140730       c
            238-298             AC008758.7         139910-139970       c
            299-2573            AC008758.7         137239-139513       c
FEATURES             Location/Qualifiers
     source          1..2573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2573
                     /gene="ZNF443"
                     /gene_synonym="ZK1"
                     /note="zinc finger protein 443"
                     /db_xref="GeneID:10224"
                     /db_xref="HGNC:HGNC:20878"
                     /db_xref="MIM:606697"
     exon            1..110
                     /gene="ZNF443"
                     /gene_synonym="ZK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..2123
                     /gene="ZNF443"
                     /gene_synonym="ZK1"
                     /note="Kruppel-type zinc finger (C2H2); krueppel-type zinc
                     finger protein ZK1"
                     /codon_start=1
                     /product="zinc finger protein 443"
                     /protein_id="NP_005806.3"
                     /db_xref="CCDS:CCDS32918.1"
                     /db_xref="GeneID:10224"
                     /db_xref="HGNC:HGNC:20878"
                     /db_xref="MIM:606697"
                     /translation="MASVALEDVAVNFTREEWALLGPCQKNLYKDVMQETIRNLDCVV
                     MKWKDQNIEDQYRYPRKNLRCRMLERFVESKDGTQCGETSSQIQDSIVTKNTLPGVGP
                     CESSMRGEKVMGHSSLNCYIRVGAGHKPHEYHECGEKPDTHKQRGKAFSYHNSFQTHE
                     RLHTGKKPYDCKECGKSFSSLGNLQRHMAVQRGDGPYKCKLCGKAFFWPSLLHMHERT
                     HTGEKPYECKQCSKAFSFYSSYLRHERTHTGEKPYECKQCSKAFPFYSSYLRHERTHT
                     GEKPYKCKQCSKAFPDSSSCLIHERTHTGEKPYTCKQCGKAFSVSGSLQRHETTHSAE
                     KPYACQQCGKAFHHLGSFQRHMIRHTGNGPHKCKICGKGFDCPSSLQSHERTHTGEKP
                     YECKQCGKALSHRSSFRSHMIMHTGDGPHKCKVCGKAFVYPSVFQRHERTHTAEKPYK
                     CKQCGKAYRISSSLRRHETTHTGEKPYKCKLGKACIDFCSFQNHKTTHTGEKPYECKE
                     CGKAFSRFRYLSRHKRTHTGEKPYECKTCRKAFGHYDNLKVHERIHSGEKPYECKECG
                     KAFSWLTCFLRHERIHMREKSYECPQCGKAFTHSRFLQGHEKTHTGENPYECKECGKA
                     FASLSSLHRHKKTHWKKTHTGENPYECKECGKAFASLSSLHRHKKTH"
     exon            111..237
                     /gene="ZNF443"
                     /gene_synonym="ZK1"
                     /inference="alignment:Splign:2.1.0"
     exon            238..298
                     /gene="ZNF443"
                     /gene_synonym="ZK1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..2573
                     /gene="ZNF443"
                     /gene_synonym="ZK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2547..2552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF443"
                     /gene_synonym="ZK1"
                     /note="hexamer: ATTAAA"
     polyA_site      2573
                     /gene="ZNF443"
                     /gene_synonym="ZK1"
                     /note="major polyA site"
ORIGIN      
        1 gtagctgaga gacgacctgg aagttctgag gcagcctttg tctggctgga acacgcattg
       61 gcagcgggag ctgtcggtag gacctgggac accgcggaag tcgggaaatg gcctcagtgg
      121 ctttagagga tgtggctgtg aacttcaccc gagaagagtg ggctttgctg ggtccttgtc
      181 agaagaatct ctacaaagat gtgatgcagg aaaccatcag gaacctggat tgtgtagtaa
      241 tgaaatggaa agaccagaac attgaagatc aatatagata tcccaggaaa aatctaagat
      301 gtcgtatgtt agagagattt gttgaaagta aagatggaac tcaatgtgga gaaacatcta
      361 gccagattca agatagtatt gtgaccaaga acactcttcc tggagtaggt ccttgtgaaa
      421 gcagtatgag aggagaaaaa gtcatgggtc attcatccct taattgttac atcagagttg
      481 gtgctgggca caaaccacat gagtatcatg aatgtggaga gaagccagat acgcataaac
      541 aacgtgggaa agccttcagt taccacaact catttcaaac acatgagagg cttcacactg
      601 gaaagaaacc atatgattgt aaagaatgtg ggaagtcctt cagttctttg ggaaaccttc
      661 aaagacacat ggcagtgcag cgtggagatg gaccttataa atgtaagttg tgtgggaaag
      721 cgtttttttg gcccagttta ttacatatgc atgaaagaac gcacactgga gagaaaccat
      781 atgaatgtaa gcagtgttct aaagcctttt ctttttacag ttcctatcta agacatgaaa
      841 gaacacatac tggggagaaa ccgtatgaat gtaaacagtg ttctaaagcc tttccttttt
      901 acagttccta tctaagacat gaaagaacac atactgggga gaaaccatat aaatgtaagc
      961 agtgttctaa agccttccct gattccagtt cttgtctaat acatgaaaga actcacactg
     1021 gagagaaacc ctatacatgt aaacaatgtg ggaaagcctt cagtgtttcc ggttcccttc
     1081 aaagacatga aaccactcac agtgcagaga aaccctatgc atgtcagcaa tgtgggaaag
     1141 cgtttcatca tctgggaagc tttcaaagac acatgataag gcacactgga aatggacctc
     1201 ataaatgtaa gatatgtggg aaaggctttg attgtcctag ttcactgcaa agtcatgaaa
     1261 gaactcacac tggagagaaa ccctatgaat gcaagcagtg tgggaaagca ttatctcatc
     1321 gctcaagctt tcgaagtcat atgataatgc acactggaga tggacctcat aaatgcaagg
     1381 tatgtgggaa agcctttgtt tatcccagtg tatttcaaag acatgaaagg actcacactg
     1441 cagagaaacc ctataaatgt aaacaatgtg gcaaagccta ccgtatttcc agttcccttc
     1501 gaaggcatga aacaactcat actggagaga aaccctataa atgcaaactt gggaaagcct
     1561 gtattgattt ctgttccttt caaaatcaca aaacaactca cactggagag aagccatatg
     1621 agtgtaagga atgtgggaaa gcattcagtc gtttcagata cctttctcga cataaaagga
     1681 ctcacacagg agagaaacct tatgagtgta aaacatgtag gaaagccttc ggtcattatg
     1741 ataacttaaa ggtacatgaa agaattcact ctggagagaa gccgtatgaa tgtaaggaat
     1801 gtgggaaagc attctcttgg ctcacttgct ttctacgaca tgaaagaatt cacatgagag
     1861 agaaatccta tgaatgtcca caatgtggta aagccttcac tcattcccgt tttcttcaag
     1921 gacatgaaaa aactcatact ggagagaacc cgtatgaatg taaggaatgt gggaaagcat
     1981 ttgcttctct cagttccttg catagacata aaaagactca ctggaaaaaa actcacactg
     2041 gagagaaccc atatgaatgt aaggaatgtg ggaaagcatt tgcttctctc agttccttgc
     2101 atagacataa aaagactcac tagcattctc tctaaatgta tggaatgtgg gaaagcattt
     2161 attaatttta tttcatttca gatacttgta cgaaacacat tggagataga ccctgtgaat
     2221 gtaagcactt ggtaaagcct taagtagttt cagtttcttt ccagtacagt catcccttga
     2281 tacctgctgg gtattggttc cagcactccg tgagccatgt ccagtccctt ttataaaatg
     2341 acatgtttgt atgtaactta cccacatcct cttgtatagt ctcaattatg tctagattac
     2401 ttaaaatacc tcatgcatta taaaagctat gcaaatagtt gttctattgt attgtttagg
     2461 gaatcatgat aaggaaaaga gtctatgtat tttcagtata gatgcagtaa ttgtgagcct
     2521 atcaacatag tgtagtcagc cagaacatta aagtttcttt gtttcaactc tca
//
