LOCUS       NM_030824               6274 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 442 (ZNF442), transcript variant
            1, mRNA.
ACCESSION   NM_030824
VERSION     NM_030824.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6274)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 6274)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   3  (bases 1 to 6274)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008758.7, DA151257.1 and AK024418.1.
            
            On Nov 22, 2018 this sequence version replaced NM_030824.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024418.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2467143
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242804.9/ ENSP00000242804.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC008758.7         73195-73216         c
            23-151              DA151257.1         1-129
            152-1499            AK024418.1         102-1449
            1500-2847           AC008758.7         56904-58251         c
            2848-6274           AC008758.7         53477-56903         c
FEATURES             Location/Qualifiers
     source          1..6274
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..6274
                     /gene="ZNF442"
                     /note="zinc finger protein 442"
                     /db_xref="GeneID:79973"
                     /db_xref="HGNC:HGNC:20877"
     exon            1..151
                     /gene="ZNF442"
                     /inference="alignment:Splign:2.1.0"
     exon            152..593
                     /gene="ZNF442"
                     /inference="alignment:Splign:2.1.0"
     exon            594..711
                     /gene="ZNF442"
                     /inference="alignment:Splign:2.1.0"
     CDS             634..2517
                     /gene="ZNF442"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 442 isoform 1"
                     /protein_id="NP_110451.1"
                     /db_xref="CCDS:CCDS12271.1"
                     /db_xref="GeneID:79973"
                     /db_xref="HGNC:HGNC:20877"
                     /translation="MIVFGGEDRSDLFLPDSQTNEERKQYDSVAFEDVAVNFTQEEWA
                     LLGPSQKSLYRDVMWETIRNLDCIGMKWEDTNIEDQHRNPRRSLRCHIIERFSESRQP
                     DSTVNEKPPGVDPCKSSVCGEIMGCSFLNCYITFDAGHKPDECQEYGEKPHTHKQCGT
                     AFNYHHSFQTQERPHTGKKRYDCKECGKTFSSSGNLRRHIIVQRGGGPYICKLCGKAF
                     FWPSLFRMHERTHTGEKPYECKQCCKAFPIYSSYLRHERTHTGEKPYECKHCSKAFPD
                     YSSYVRHERTHTGEKPYKCKRCGRAFSVSSSLRIHERTHTGEKPYECKQCGKAFHHLG
                     SFQRHMIRHTGDGPHKCKICGKGFDCPSSLQSHERTHTGEKPYECKQCGKALSHHSSF
                     RSHMIMHTGDGPHKCKVCGKAFIYPSVFQGHERTHTGEKPYECKECGKAFRISSSLRR
                     HETTHTGEKPYKCKCGKAFIDFYSFQNHETTHTGEKPYECKECGKAFSCFTYLSQHRR
                     THMAEKPYECKTCKKAFSHFGNLKVHERIHTGEKPYECKECRKAFSWLTCLLRHERIH
                     TGKKSYECQQCGKAFTRSRFLRGHEKTHTGEKMHECKECGKALSSLSSLHRHKRTHWR
                     DTL"
     exon            712..838
                     /gene="ZNF442"
                     /inference="alignment:Splign:2.1.0"
     exon            839..899
                     /gene="ZNF442"
                     /inference="alignment:Splign:2.1.0"
     exon            900..6274
                     /gene="ZNF442"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2820..2825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF442"
                     /note="hexamer: AATAAA"
     polyA_site      2843
                     /gene="ZNF442"
                     /note="major polyA site"
     regulatory      5460..5465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF442"
                     /note="hexamer: AATAAA"
     polyA_site      5487
                     /gene="ZNF442"
     regulatory      6248..6253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF442"
                     /note="hexamer: AATAAA"
     polyA_site      6274
                     /gene="ZNF442"
ORIGIN      
        1 ggagctttct acacccctct gagctcccgc tcctggctct gtagctgaga gaagccctgg
       61 caggtcagtg gcaggcactg tcacgctgag tcctatgctg gcagcgggga accttgggga
      121 gaacacggga caccgcggaa gccgggaaat gattgtgcgg ctgtaaccgg cacaggttcg
      181 cggtccgagt cactgcaccg agactccaag gcctgcagca gaaacagttt aataggggga
      241 gaggagagaa gaccccagtt ccgcctccat gagaggtttg gggatggggg tgtttagggg
      301 tctggacagg ggcggctgaa gtgtggggtc gctggttggt ggggaagtga caggcgaatc
      361 ctgggacggg aggtgaagaa accgcattct cctgctgagt gggttccctc gtggggtttt
      421 caccctgctt ggcgccagcc tttccgttgg aattcaagat ctgagaaaga acttgggcaa
      481 ctcgagcagc tctccgagat cttatcccca ggcacaatgc agaagccggc ggtcagtgtc
      541 ttctgtgacc tgactctcag gaaggcggcc cccgcgaggc agtggggctc aggtttccat
      601 tccttgggga cacacggctg gtcagccagt tgaatgattg tatttggggg agaagacaga
      661 agtgatctct tccttcctga ctctcagact aatgaagaga gaaaacaata tgattcagta
      721 gcctttgagg atgtggcggt gaacttcacc caggaagagt gggctttgct gggtccatca
      781 cagaagagtc tgtacagaga tgtgatgtgg gaaaccatta ggaacctgga ctgtatagga
      841 atgaaatggg aagacacaaa cattgaagat cagcacagaa atcccaggag gagcctaaga
      901 tgtcatatca tagagagatt tagtgaaagt cgccagccag atagtactgt gaatgaaaaa
      961 cctcctggag tagatccatg taaaagcagt gtgtgtggag aaatcatggg ttgttcattc
     1021 cttaattgct atatcacatt tgatgctgga cacaaaccag atgagtgtca ggaatatgga
     1081 gagaagccac atacacataa acaatgtggg acagccttca attatcacca ctcctttcaa
     1141 acacaggaaa gacctcacac tggaaagaaa cgctatgatt gtaaggaatg tgggaaaacc
     1201 ttcagttctt cgggaaacct tcgaagacac ataatagtac aacgtggagg tggaccttat
     1261 atatgtaagt tgtgtgggaa agcctttttt tggcctagtt tatttcgtat gcatgaaaga
     1321 actcacactg gagagaaacc gtatgaatgt aagcagtgtt gtaaagcctt ccctatttac
     1381 agttcctatc taagacatga aagaacacac actggggaga aaccatatga atgcaagcac
     1441 tgttccaaag ccttccctga ttacagttcc tatgtaagac atgaaagaac tcacactgga
     1501 gaaaaaccct ataaatgtaa acgatgtgga agagccttca gtgtttccag ttcccttcga
     1561 atacatgaaa gaactcacac tggagagaaa ccctatgaat gcaagcaatg cgggaaagca
     1621 tttcatcatc tgggaagctt tcaaagacac atgataaggc acactggaga tggacctcat
     1681 aaatgtaaga tatgtgggaa aggctttgat tgtcctagtt cactgcaaag tcatgaaaga
     1741 actcacactg gagagaaacc ctatgaatgc aagcagtgtg ggaaagcgtt atctcatcac
     1801 tcaagctttc gaagtcatat gataatgcac actggagatg gacctcacaa atgcaaggta
     1861 tgtgggaaag ccttcattta tcccagtgta tttcaaggac atgaaaggac tcatactggt
     1921 gagaaaccct atgaatgtaa agaatgtggt aaagccttcc gtatttctag ttcccttcga
     1981 agacatgaaa caactcacac tggagagaaa ccctataaat gtaaatgtgg gaaagccttt
     2041 attgatttct attcctttca aaatcatgaa acaactcaca ctggagagaa gccatatgag
     2101 tgtaaggaat gtgggaaagc attcagttgt ttcacatacc tttctcaaca tagaaggact
     2161 cacatggctg aaaaacctta tgaatgtaaa acatgtaaga aagccttcag tcattttggt
     2221 aacttaaaag tccatgaaag gattcacact ggagagaagc catatgaatg taaggaatgc
     2281 aggaaagcat tctcttggct cacttgcctt ctgcgacatg aaagaattca cactggaaag
     2341 aaatcttatg aatgtcaaca atgtggtaaa gccttcactc gttctcgttt ccttcgagga
     2401 catgaaaaaa ctcacactgg agagaagatg catgaatgta aggaatgtgg gaaggcactg
     2461 agttctctca gttccttgca tagacataaa aggactcact ggagagatac tctataaatg
     2521 tggaaaagca ttcattaatt ttatttcatt tcagaaacgt gaaagaaatc acataggaga
     2581 taagcctcat gaatgcaaac acatggtaaa gccttaagat gtttcttttg aatatggtta
     2641 tcccctaacc atatgcaggg gattggttcc agacccccta agcataccta aatccacaga
     2701 tgctgtgttc cttttataaa aggacatttg catgtaacct atccacatcc tcctgcatcc
     2761 cataaatcat gcctagatta cttaattttt caccaaccca aagcttttgt aaaagtaaaa
     2821 ataaaaagta ggttactaaa atacctcatg tgttgtaaaa gctatgtaaa cagtcatttt
     2881 attgtatttt ttttagagaa tcgtgatatg aaaataatcc tgtgctgttg agaacagacc
     2941 caaccatcac aggcctgcct acatagtaca tgtcacctag aatgttacag tttctttttt
     3001 tctttttttt ttttttaaga cagagtttca ctcttattgc ccaggctgga gggcaatggc
     3061 acaatctcag ctcactgcat cctctgcctc ccgggttcaa gcaattctcc tgtcttagcc
     3121 tcctgagtag ctgggattac agatgcatgc caccacaccc agctaatttt tttttttttt
     3181 tttttttttt tgtattttta gtagagacgg ggtttcatca tattggtcag gctggtctcg
     3241 aactcctgac ctcagatgat ctgcctgcct tggtctccca aagtgctggg attacaggca
     3301 tgagcctgta atctacagtt tctttttttt caacaatcat agattgcttt tatttaatga
     3361 cctggaatcg tgtgttaaca cttatgaaaa tcctgatcct tcttgcttga taacccaagg
     3421 atgatgatga tgatcatgat catgatgatg ctgattacag tatggtgcct aatatgattc
     3481 actgaggtga ctagatgggt ggcactgtag ataaacagtg agacatcagg ctcacttgaa
     3541 tcttgacagg atgtcaggat gatcatctgt gttggatgaa ccaggttctg attgcagatg
     3601 ctgagtttgg aagagactaa ataatactaa tgtcagaatc tgttcagcat gagggctgaa
     3661 gatgtgtaca cactgaagga tctgtcttca tatttgcaga tatttagtta gaaacattgt
     3721 tgtaggaagc tggttctttt tctttaaata tccttgcagt gtttgttggc atgttatccc
     3781 ttgggtgaca cagaggtttt gttccattga aggatcttac ttgaggatgg caatctttat
     3841 tttattttta tttttattta tttatttatc atttgagact gagtttcgtt cttattgccc
     3901 agtctggagt gcagtggcgc gatctcgact cactgcaacc tccacctccc agattcaagc
     3961 gattctcctg cctcagcctc cagagtagct gggattacag gcactcgcca ccatgcctgg
     4021 ctaattttta tttttagtag agatggggtt tcaccatgtt ggtcaggctg gtctcgaact
     4081 cctgacctca ggtgatccac ctgcctcggc ctcccaaagt gctgagatta caggcatgag
     4141 ccaccgtgcc ctgcgaggat tgtaatcttt aatacttttc accttgcaga ggctgtagat
     4201 gccccaaaaa ctgctgcaca tgtttcaagt gtcacatctt tgatattacc tcttctaagt
     4261 cttctgcatc atcattatca tcattatctg cagagaattt cagtatatct tcgagttcct
     4321 tgttagtatt tatgctctct tatttgtgtt gggatagaaa gattaaggaa aggagagatg
     4381 agaaggtggc tcaacagttg agacagtttt attgggagta aacctgagaa gggcttccag
     4441 cggcagggtc aggtgcaaac ttctcttaca gcctgaggct tttttaaagg gcccagtgga
     4501 gaagtgtgct ttgaaacaaa attctgttag ggaggggttg gggaagtcct ggctgttctg
     4561 ttacagttag ggccgttatt ctctgttgaa gttatgggcg gggctgacat tttcagtttt
     4621 ggccaggtgg ccaaatagaa acttaaagct taggatggtg gagtgttata aagatggcgg
     4681 tgctcttgtc ctgtcaatgt gttcctcaat aaagtcttca agcatgtcat agattgtttt
     4741 ccccaccaac ctcccttgca gcatttgaga tattcctgat acttcatcaa tagtggagaa
     4801 gctcctgaaa tcattgactt cctcactcca taatggtttc caacacccaa tgaagtagta
     4861 ggaggaaaac atgggtttct tctcctggaa gcctccagaa gaaggtattt caatatgggg
     4921 agagtggtca gctgtgtcac aggtcactga gaatttgaat aagacaagga aaaagggttg
     4981 actgtagatt ttggcaagta tttggtcact gggggccttg ataagagctg tttcattgaa
     5041 gtattcatga gaataacttg tagtgaaata tatctcaaat agacctccac gatgttgcct
     5101 agagggcagt gttacccttt gaactaccaa cattaaccac tggaactgct catctggaag
     5161 cctcttacag tgctggtaca aactagaata cacaaaggaa gggatcattt tatacgtgtt
     5221 actgtgctac ttgctctatc tacttagtgt tccatacatg taattaccta ttccatccta
     5281 tcccaaagta ctgaaaatct ccattctact ttctctgtct gtgaatttga ctattcatag
     5341 agagagagat atgtggaagt atgcatgtgt ccttccatgt ctggcttatt tcacttagaa
     5401 cgttttcaag gtttatccat gtggtagcat gtatcaggaa ctcattgttt ttgtgtctga
     5461 ataaatttcc actgtatggt taaagcatac tttgtttatc catttttatg ttgataaaca
     5521 tgggttgttt ccacagtaat aatttgactg ctatcaataa ggctgctgtg gatgtggtat
     5581 gtctatgtct gtgtgagtcc ctgctttcaa ttcttttgga tatatgtatc cctaggagtg
     5641 taattgctgg ttcacagaat aattggtgta aacctttttc aggaacaggt atattgcttt
     5701 acaaagtggc tacaatgttt tacattctct ccagcaatgc ataagggttt ctattttcca
     5761 cattgtcaca tatactggtt gtcgtatttt tttcataata gccaattaat ggttctgtac
     5821 tgctttttca ttgtggtttt gatttgcatt tccctaatga ccaataataa tgcacattgg
     5881 tttttgtttt tgttggttgt ttatatattt tttgaaccag tttgttttaa aatcctttgc
     5941 tcattaaaat tgagtcattt gtgttttgtt gttgagttat aggaattctt atttaaaatt
     6001 tttagttttt aatatttaga aaatttcttt cttttttcag ctcccaagtg cttggaagag
     6061 agttgtagga attctttata cactgtgggt attaagccct tatttgatat gtgatatgca
     6121 gatgtgttct ccctttctgt aggttttctt ttcatcttga gattgtcctt tggtgcgcaa
     6181 aagtttttaa tttcgatgta gtccagttta tcttttattg gttgtctgtg ccttaaatgt
     6241 cgtatccaat aaatcactgc caaatttaac aaaa
//
