LOCUS       NM_152357               4215 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 440 (ZNF440), mRNA.
ACCESSION   NM_152357 XM_001126500 XM_001131146
VERSION     NM_152357.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4215)
  AUTHORS   Nakamura,A., Rampersaud,Y.R., Sundararajan,K., Nakamura,S., Wu,B.,
            Matip,E., Haroon,N., Krawetz,R.J., Rossomacha,E., Gandhi,R.,
            Kotlyar,M., Rockel,J.S., Jurisica,I. and Kapoor,M.
  TITLE     Zinc finger protein-440 promotes cartilage degenerative mechanisms
            in human facet and knee osteoarthritis chondrocytes
  JOURNAL   Osteoarthritis Cartilage 29 (3), 372-379 (2021)
   PUBMED   33347923
  REMARK    GeneRIF: Zinc finger protein-440 promotes cartilage degenerative
            mechanisms in human facet and knee osteoarthritis chondrocytes.
REFERENCE   2  (bases 1 to 4215)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4215)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4215)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4215)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008543.9.
            
            On May 17, 2019 this sequence version replaced NM_152357.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.264851.1,
                                           SRR1803613.181134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304060.10/ ENSP00000305373.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC008543.9         190788-190806
            20-178              AC008543.9         190807-190965
            179-305             AC008543.9         206798-206924
            306-366             AC008543.9         207132-207192
            367-4200            AC008543.9         207883-211716
            4201-4215           AC008543.9         211717-211731
FEATURES             Location/Qualifiers
     source          1..4215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..4215
                     /gene="ZNF440"
                     /note="zinc finger protein 440"
                     /db_xref="GeneID:126070"
                     /db_xref="HGNC:HGNC:20874"
     exon            1..178
                     /gene="ZNF440"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1963
                     /gene="ZNF440"
                     /codon_start=1
                     /product="zinc finger protein 440"
                     /protein_id="NP_689570.2"
                     /db_xref="CCDS:CCDS42503.1"
                     /db_xref="GeneID:126070"
                     /db_xref="HGNC:HGNC:20874"
                     /translation="MDPVAFKDVAVNFTQEEWALLDISQRKLYREVMLETFRNLTSLG
                     KRWKDQNIEYEHQNPRRNFRSLIEEKVNEIKDDSHCGETFTPVPDDRLNFQEKKASPE
                     VKSCESFVCGEVGLGNSSFNMNIRGDIGHKAYEYQEYGPKPCKCQQPKKAFRYRPSFR
                     TQERDHTGEKPNACKVCGKTFISHSSVRRHMVMHSGDGPYKCKFCGKAFHCLRLYLIH
                     ERIHTGEKPCECKQCGKSFSYSATHRIHKRTHTGEKPYEYQECGKAFHSPRSYRRHER
                     IHMGEKAYQCKECGKAFTCPRYVRIHERTHSRKNLYECKQCGKALSSLTSFQTHVRLH
                     SGERPYECKICGKDFCSVNSFQRHEKIHSGEKPYKCKQCGKAFPHSSSLRYHERTHTG
                     EKPYECKQCGKAFRSASHLRVHGRTHTGEKPYECKECGKAFRYVNNLQSHERTQTHIR
                     IHSGERRYKCKICGKGFYCPKSFQRHEKTHTGEKLYECKQRSVVPSVVPVPFDIMKGL
                     TLERSPINASNVGKPSELCQSFECMVGLTLKRNPMSVSNDGKPSDLPHTFEYVVGHTM
                     ERSPMHVRNVGNPSDLPRTFEFMKGHKHT"
     exon            179..305
                     /gene="ZNF440"
                     /inference="alignment:Splign:2.1.0"
     exon            306..366
                     /gene="ZNF440"
                     /inference="alignment:Splign:2.1.0"
     exon            367..4215
                     /gene="ZNF440"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3041..3046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF440"
                     /note="hexamer: GATAAA"
     polyA_site      3072
                     /gene="ZNF440"
                     /note="major polyA site"
     regulatory      3673..3678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF440"
                     /note="hexamer: AATATA"
     polyA_site      3691
                     /gene="ZNF440"
ORIGIN      
        1 gccctccgtc cattccttta gtgctgcgcc gacagcggtc aggatctcgg ctttcttgct
       61 tcgagaggga ctaggtgcct ccaccagagc ttctgtcgct ctgtaacctg cactgtgacc
      121 tacactagtc gcgggagcca cgcagaggac gccggaacac cctggaagcc gagaaatgga
      181 cccagtggct tttaaggatg tggctgtgaa cttcacccag gaggagtggg ctttgctgga
      241 tatttcccag aggaaactct acagggaagt gatgctggaa actttcagga acctgacctc
      301 tttaggaaaa aggtggaaag accagaacat tgaatatgag caccaaaacc ccaggagaaa
      361 cttcaggagt ctcatagaag aaaaagtcaa tgaaattaaa gatgacagtc attgtggaga
      421 aacttttacc ccagttccag atgacagact gaacttccag gagaagaaag cttctcctga
      481 agtaaaatca tgtgaaagct ttgtgtgtgg agaagttggc ctaggtaact catcttttaa
      541 tatgaacatc agaggtgaca ttggacacaa ggcatatgag tatcaggaat atggaccaaa
      601 gccatgtaag tgtcaacaac ctaaaaaagc cttcagatac cgcccctcct ttagaacaca
      661 agaaagggat cacactggag agaaacccaa tgcttgtaaa gtatgtggaa aaacctttat
      721 ttcccattca agtgttcgaa gacacatggt aatgcacagt ggggatggac cttataaatg
      781 taagttttgt gggaaagcat tccattgtct cagattatat cttatccatg aaagaattca
      841 cactggagag aaaccatgtg aatgtaaaca gtgtggtaaa tcctttagtt attctgctac
      901 ccatcgaata cataaaagaa ctcacactgg agaaaagcct tatgaatatc aggagtgtgg
      961 gaaagcattt catagtccca gatcctatcg tagacatgaa aggattcaca tgggagaaaa
     1021 ggcttatcaa tgtaaggaat gtggaaaagc attcacgtgt ccccgttatg ttcgtataca
     1081 tgaaaggacc cactctagga aaaatctcta tgaatgtaag cagtgtggga aagcattatc
     1141 ctctcttaca agttttcaaa cacacgtaag attgcactct ggagaaagac cttatgaatg
     1201 taagatatgt ggaaaagact tttgttctgt gaattcattt caaagacatg aaaaaattca
     1261 cagtggagag aaaccctata aatgtaagca gtgtggtaaa gccttccctc attccagttc
     1321 ccttcgatat catgaaagga ctcacactgg agagaaaccc tatgagtgta agcaatgtgg
     1381 gaaagccttc agatctgcct cacaccttcg agtgcatggt aggactcaca ctggagagaa
     1441 accgtatgaa tgtaaggaat gtgggaaagc cttcagatat gtgaataacc ttcaaagtca
     1501 tgaaaggaca caaacacaca taagaataca ctctggagaa agacgttata aatgtaagat
     1561 atgtgggaaa ggcttttatt gtcccaaatc atttcaaaga catgaaaaaa ctcacactgg
     1621 agagaaactc tatgaatgca agcaacgttc agtagttcct tcagtagttc cagttccttt
     1681 tgatatcatg aaaggactca cactggagag aagccctata aatgcgagca atgtgggaaa
     1741 gccttcagag ctgtgtcaat cctttgaatg catggtagga ctcaccctga agagaaaccc
     1801 tatgagtgtg agcaatgacg gaaagccttc agatctgccc cacacctttg aatacgtggt
     1861 aggacacaca atggagagaa gccctatgca tgtaaggaat gtgggaaacc cttcggatct
     1921 gcccagaacc ttcgaattca tgaaaggaca caaacacaca taatgcactc tgtagagaga
     1981 ccttataaat gtaagatatg tgggaggggc ttttattctg ccaagtcatt tcaaatacat
     2041 gaaaaatctt acactggaga gaaaccctat gagtgtaagc aatgtgggaa agcctttgtt
     2101 tccttcactt cctttcgata tcatgaaagg actcacactg gagagaaccc ctatgagtgt
     2161 aagcaatttg ggaaagcctt cagatctgtc aaaaatcttc gatttcataa aaggacacac
     2221 actggagaga aaccctgtga atgtaagaaa tgtagaaaag cattccataa tttctcttct
     2281 ttgcaaatac atgaaaggat gcacagagga gagaagctct gtgaatgtaa gcattgtggg
     2341 aaagcattca tatctgccaa gatcctttga atacatgcaa gaacacacaa tggagagaaa
     2401 ccctatgaat gtaaagaatg cagaaaagca ttcagcttgc ctacttcctt tcatagacat
     2461 gaaaagactc acactggaag gaaacactat gaatgcaagc aatgtggcaa agctttcact
     2521 tcttccagtt cttttcaata tcatgaaaga acacactagg gagaaaccct atcaatgtaa
     2581 gcaatgtgca aaagccttta tttcttccac ttcttttcaa tatcatgaaa ggactcacat
     2641 gggagagaaa ccctatgagt gtatgccaag tgggaaagcc ttcatttctt ctagttccct
     2701 tcaatatcat gaaaggactc acactggaga gaagccctat gaatataagc aatgtgggaa
     2761 agccttcaga tcagcctcgc accttcaaat gcatggaagg actcacactg gagaaaaacc
     2821 ctatgaatgt aagcagtatg ggaaagcgtt cagacctgac aagattcttt gaatacagat
     2881 aatgaatgta aacaattaac tgtttataat aactgtatac taacaaatga tattcttttt
     2941 aaataagaag ctataatatc ccattggtgt catgtattag atcagcctta tactgttaaa
     3001 ttgttattat ttggacattg tgagtcagta taaccatgtg gataaaatgc cagacatctt
     3061 tttattcgaa aattttactt ttcatgcttc tgtacttaca tttttatctc aaccttaatt
     3121 tttctttctt tttttttttc ccccagaaag aatctcactc tgtcacccag gctggagtgc
     3181 agtggcatga tctcaggtca ctgcaacctc tgcctccagg gttcaagcaa ttctcctgcc
     3241 tcagtctcct gagtagctgg gactacaggc atgcgccacc atgccaggct aattttttgt
     3301 attttttagt agagacgggg tttcaccata ttggctaggc tggtctcaaa ctccagacct
     3361 catgatttac ccacctcggc ctcccaaaat gctgggatta cagacatgaa ccatcatgcc
     3421 cagctgcaac cctaattttt cattcagtca taataccaat agttatctca tgcacctctg
     3481 agtgccttct tccccaaaac cagcagtgcc atacctgctg tcagcaaggg tgtaatatac
     3541 catagtgata aatatgacca aaagccataa atgactgtga gatgtatgag aattacaagt
     3601 cacattagta agaagagaaa aattttggtc atgtttatga tttgaaatac gttttcctct
     3661 atcacattta aaaatatagt tacaaaatgc ccttgttttt gtcctgattc atcatggtca
     3721 ctgaggagca tcgtctcata tgcctggtat gtgacacgtg tctctccaac aataaaagac
     3781 ttggccttgg ctgggcatgg tggctcacgc ctgtaatccc agcactttgg gaggccgagg
     3841 tcaggagtta gagaccattc tgaccaatat gatcaaaccc cgtctctact aaaaatacaa
     3901 aagttagcag ggcgtggtgg catgctcctg taatcctagc tattcaggag gctgacatag
     3961 gagaattgct tgaatatagg aagcagaggt tgcagtgagc cgaggttgca ccattgtact
     4021 ccagcctggg caacaagagt gaaactctgt cttaaaaaac acaaaaaaag acttggcctt
     4081 agggccgagt gcggtggctc acgcctataa tcccagcact ttgggaggcc gaggcgggcg
     4141 gatcactagg tcaggaaatg gagaccatcc tggccaacac agtgaaaccc agtctctact
     4201 aaaaaataca aaaaa
//
