LOCUS       NM_016264               2636 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens zinc finger protein 44 (ZNF44), transcript variant 2,
            mRNA.
ACCESSION   NM_016264 XM_375575
VERSION     NM_016264.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2636)
  AUTHORS   Sun,L., Li,X., Tu,L., Stucky,A., Huang,C., Chen,X., Cai,J. and
            Li,S.C.
  TITLE     RNA-Sequencing Combined With Genome-Wide Allele-Specific Expression
            Patterning Identifies ZNF44 Variants as a Potential New Driver Gene
            for Pediatric Neuroblastoma
  JOURNAL   Cancer Control 30, 10732748231175017 (2023)
   PUBMED   37161925
  REMARK    GeneRIF: RNA-Sequencing Combined With Genome-Wide Allele-Specific
            Expression Patterning Identifies ZNF44 Variants as a Potential New
            Driver Gene for Pediatric Neuroblastoma.
REFERENCE   2  (bases 1 to 2636)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   3  (bases 1 to 2636)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
REFERENCE   4  (bases 1 to 2636)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
REFERENCE   5  (bases 1 to 2636)
  AUTHORS   Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
  TITLE     Characterization and mapping of human genes encoding zinc finger
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
   PUBMED   1946370
REFERENCE   6  (bases 1 to 2636)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC001868.1, DA815414.1, AC012618.7 and AA525756.1.
            
            On Jun 2, 2019 this sequence version replaced NM_016264.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. The resulting
            isoform (2) lacks an internal segment near the N-terminus, compared
            to isoform 1.
            
            Sequence Note: This sequence is assembled by in silico methods with
            additional support of similarity to paralogous human proteins
            contained in BC052597.1 and AK024418.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.750462.1,
                                           SRR1803616.278809.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355684.6/ ENSP00000347910.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                BC001868.1         17-97
            82-653              DA815414.1         1-572
            654-2583            AC012618.7         87920-89849         c
            2584-2636           AA525756.1         203-255
FEATURES             Location/Qualifiers
     source          1..2636
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2636
                     /gene="ZNF44"
                     /gene_synonym="GIOT-2; KOX7; ZNF; ZNF504; ZNF55; ZNF58"
                     /note="zinc finger protein 44"
                     /db_xref="GeneID:51710"
                     /db_xref="HGNC:HGNC:13110"
                     /db_xref="MIM:194542"
     exon            1..192
                     /gene="ZNF44"
                     /gene_synonym="GIOT-2; KOX7; ZNF; ZNF504; ZNF55; ZNF58"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..2037
                     /gene="ZNF44"
                     /gene_synonym="GIOT-2; KOX7; ZNF; ZNF504; ZNF55; ZNF58"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein 58; zinc finger protein 55; gonadotropin
                     inducible transcription repressor-2; zinc finger protein
                     ZnFP12; zinc finger protein KOX7; gonadotropin-inducible
                     ovary transcription repressor 2"
                     /codon_start=1
                     /product="zinc finger protein 44 isoform 2"
                     /protein_id="NP_057348.3"
                     /db_xref="CCDS:CCDS45988.1"
                     /db_xref="GeneID:51710"
                     /db_xref="HGNC:HGNC:13110"
                     /db_xref="MIM:194542"
                     /translation="MDSVAFEDVAVNFTHEEWALLGPSQKNLYRDVMRETIRNLNCIG
                     MKWENQNIDDQHQNLRRNPRCDVVERFGKSKDGSQCGETLSQIRNSIVNKNTPARVDA
                     CGSSVNGEVIMGHSSLNCYIRVDTGHKHRECHEYAEKSYTHKQCGKGLSYRHSFQTCE
                     RPHTGKKPYDCKECGKTFSSPGNLRRHMVVKGGDGPYKCELCGKAFFWPSLLRMHERT
                     HTGEKPYECKQCSKAFPVYSSYLRHEKIHTGEKPYECKQCSKAFPDYSSYLRHERTHT
                     GEKPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGKAFCHLGSFQRHMIMHSGD
                     GPHKCKICGKGFDFPGSARIHEGTHTLEKPYECKQCGKLLSHRSSFRRHMMAHTGDGP
                     HKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQCGKAFRTSSSLRKHETTHTGEQPYK
                     CKCGKAFSDLFSFQSHETTHSEEEPYECKECGKAFSSFKYFCRHERTHSEEKSYECQI
                     CGKAFSRFSYLKTHERTHTAEKPYECKQCRKAFFWPSFLLRHERTHTGERPYECKHCG
                     KAFSRSSFCREHERTHTGEKPYECKECGKAFSSLSSFNRHKRTHWKDIL"
     exon            193..319
                     /gene="ZNF44"
                     /gene_synonym="GIOT-2; KOX7; ZNF; ZNF504; ZNF55; ZNF58"
                     /inference="alignment:Splign:2.1.0"
     exon            320..380
                     /gene="ZNF44"
                     /gene_synonym="GIOT-2; KOX7; ZNF; ZNF504; ZNF55; ZNF58"
                     /inference="alignment:Splign:2.1.0"
     exon            381..2636
                     /gene="ZNF44"
                     /gene_synonym="GIOT-2; KOX7; ZNF; ZNF504; ZNF55; ZNF58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2611..2616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF44"
                     /gene_synonym="GIOT-2; KOX7; ZNF; ZNF504; ZNF55; ZNF58"
                     /note="hexamer: ATTAAA"
     polyA_site      2636
                     /gene="ZNF44"
                     /gene_synonym="GIOT-2; KOX7; ZNF; ZNF504; ZNF55; ZNF58"
                     /note="major polyA site"
ORIGIN      
        1 gtcaatcagg cgcgaggcag agaggagggt gtgacgttcc aggagctagt ggcctcttca
       61 ccctggtgac ctctgttccg tattctgtca ctgagagacg ccctgggaca tctgtggtgg
      121 cttttgtcgc gctgggacct accctgacta cgggagttgg gaggacccgg gacaccgcac
      181 agccgggaaa tggactcagt ggcctttgag gatgtggctg tgaacttcac ccatgaggag
      241 tgggctttgc tgggtccatc acagaagaat ctctacagag atgtgatgcg agaaaccatt
      301 aggaacctga actgtatagg aatgaaatgg gaaaaccaga acattgatga tcagcaccaa
      361 aatctcagga gaaatccaag gtgtgatgtg gtagagagat ttggtaaaag taaagatggt
      421 agtcagtgtg gagaaacctt aagccagatt cgaaatagta ttgtaaacaa gaacactccc
      481 gccagagtag atgcatgtgg aagcagtgtg aatggagaag tcataatggg tcattcatcc
      541 ctgaattgct acatcagagt tgatactgga cacaaacacc gggagtgtca tgaatatgca
      601 gagaagtcat atacacataa gcagtgtggg aaaggcttaa gttatcgcca ctcctttcaa
      661 acatgtgaaa ggcctcacac tggaaagaaa ccctatgatt gtaaggaatg tggaaaaacc
      721 ttcagttctc ctggaaacct tcgaagacat atggtagtaa aaggtggaga tggaccttat
      781 aaatgtgaat tgtgtgggaa agcctttttt tggcccagtt tattacgtat gcatgaaaga
      841 actcacactg gagagaaacc atatgaatgt aagcagtgtt ctaaagcctt ccctgtttac
      901 agttcctatc taagacatga aaaaatacac actggggaga aaccgtatga atgtaagcag
      961 tgttctaaag ccttccctga ttacagttca tatctaagac atgaaagaac tcacactgga
     1021 gagaaaccct acaaatgtaa acaatgtggg aaagccttca gtgtttccgg ttcccttcga
     1081 gtacatgaaa gaattcacac tggagagaaa ccctatacat gtaaacagtg tgggaaagcg
     1141 ttttgtcatc ttggaagctt tcaaagacac atgataatgc acagtggaga tggacctcat
     1201 aaatgtaaga tatgtgggaa aggctttgat tttcctggtt cagcacgaat tcatgaagga
     1261 actcacactc tagagaaacc ctatgaatgt aagcaatgtg ggaaattgtt atctcatcgc
     1321 tcaagctttc gaagacacat gatggcacac actggagatg gccctcataa atgcacagta
     1381 tgtgggaaag cctttgattc tcctagtgta tttcaaagac atgaaaggac tcacactgga
     1441 gagaaaccct atgaatgcaa gcaatgtggg aaagccttcc gtacttccag ttcccttcga
     1501 aaacatgaaa caacacacac tggagagcaa ccctataaat gtaaatgtgg aaaagctttt
     1561 agtgatttat tttcctttca aagtcatgaa acaacacaca gtgaagagga gccttatgaa
     1621 tgtaaggagt gtgggaaagc atttagttct tttaaatact tttgtcgcca tgaaaggact
     1681 cacagtgaag aaaaatctta tgagtgtcaa atttgtggca aagccttcag tcgtttcagt
     1741 tacttaaaaa ctcatgaaag gactcacacg gcagagaagc catatgaatg taagcaatgc
     1801 aggaaagcat tcttttggcc ctctttcctt ctaagacatg aaaggactca cactggagaa
     1861 agaccctatg aatgtaaaca ctgtggtaaa gccttcagtc gttccagttt ctgtcgagaa
     1921 catgaaagaa ctcacactgg agagaagccc tatgaatgta aggaatgtgg gaaagccttc
     1981 agttctctca gttcctttaa tagacataaa aggacacact ggaaggatat tctataagtg
     2041 tatggaatgt gggaaagcat tcattggttt tatcacattc agatacttga aagaaataaa
     2101 tcctgtgaat gtaaacgtgg taaagcctta agaagtttcc aggctgggcg cagcggctca
     2161 cacctgtaat cccagcactt tgagaggccg aggagggcag atcacgaggc caggagatcg
     2221 agaccagcct ggctaacatg ggaaaccctg tctctactaa aaatacggaa aaaaaaaaaa
     2281 atagccaggc atagttgctc acacctgtag tcctagctac tcaggaggct gaggcaggag
     2341 aatcccttga acccgggagg tggaggttgc agtgagccga gattgcacta ctgcactcca
     2401 gcttgggtgc tagagcgaga ctccatctca aaaaaaaaaa aaaaagtttc catttctttc
     2461 aaatagagtt gctgcctgct atatgcaaga agattggttc cagtacaccc tgagtatacc
     2521 taaatccaca gatgccagct cttttataaa atggaatatt cgcatgtacc tacccacatt
     2581 ctcctgtata ctctataaat gtctagatta attaaaatat ctcatgcatt gtaaaa
//
