LOCUS       NM_001348719            2574 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 439 (ZNF439), transcript variant
            2, mRNA.
ACCESSION   NM_001348719
VERSION     NM_001348719.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2574)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2574)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2574)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008543.9 and AC020951.7.
            
            On Jul 13, 2020 this sequence version replaced NM_001348719.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1601135.1,
                                           SRR14038196.1852076.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682736.1/ ENSP00000506930.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC008543.9         225241-225445
            206-332             AC020951.7         32018-32144
            333-393             AC020951.7         32350-32410
            394-2574            AC020951.7         33119-35299
FEATURES             Location/Qualifiers
     source          1..2574
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2574
                     /gene="ZNF439"
                     /note="zinc finger protein 439"
                     /db_xref="GeneID:90594"
                     /db_xref="HGNC:HGNC:20873"
     exon            1..205
                     /gene="ZNF439"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1657
                     /gene="ZNF439"
                     /note="isoform b is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 439 isoform b"
                     /protein_id="NP_001335648.1"
                     /db_xref="CCDS:CCDS92520.1"
                     /db_xref="GeneID:90594"
                     /db_xref="HGNC:HGNC:20873"
                     /translation="MPCFTHRSCREDPGTSESREMDPVAFKDVAVNFTQEEWALLDIS
                     QKNLYREVMLETFWNLTSIGKKWKDQNIEYEYQNPRRNFRSVTEEKVNEIKEDSHCGE
                     TFTPVPDDRLNFQKKKASPEVKSCDSFVCEVGLGNSSSNMNIRGDTGHKACECQEYGP
                     KPWKSQQPKKAFRYHPSLRTQERDHTGKKPYACKECGKNIIYHSSIQRHMVVHSGDGP
                     YKCKFCGKAFHCLSLYLIHERTHTGEKPYECKQCGKSFSYSATHRIHERTHIGEKPYE
                     CQECGKAFHSPRSCHRHERSHMGEKAYQCKECGKAFMCPRYVRRHERTHSRKKLYECK
                     QCGKALSSLTSFQTHIRMHSGERPYECKTCGKGFYSAKSFQRHEKTHSGEKPYKCKQC
                     GKAFTRSGSFRYHERTHTGEKPYECKQCGKAFRSAPNLQLHGRTHTGEKPYQCKECGK
                     AFRSASQLRIHRRIHTGEKPYECKKCGKAFRYVQNFRFHERTQTHKNALWRKTL"
     exon            206..332
                     /gene="ZNF439"
                     /inference="alignment:Splign:2.1.0"
     exon            333..393
                     /gene="ZNF439"
                     /inference="alignment:Splign:2.1.0"
     exon            394..2574
                     /gene="ZNF439"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2540..2545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF439"
                     /note="hexamer: AATAAA"
     polyA_site      2574
                     /gene="ZNF439"
                     /note="major polyA site"
ORIGIN      
        1 actgtgcatc caggcacgga ggatgttgca ttcctgccgt cacctttgtc gctgcgaggg
       61 cggcggttgg gatctggcct ttccagcccc gagagggacc tagtgcctct acccagattt
      121 ctgtcgctct gtcacctgcg ctatgccctg ctttactcac aggagctgta gagaggaccc
      181 cggtacatct gaaagccggg aaatggaccc agtggctttt aaggatgtgg ctgtgaactt
      241 cacccaggag gagtgggctt tgctggatat ttcccagaag aatctctaca gggaagtgat
      301 gctggaaact ttctggaacc tgacctctat aggaaaaaag tggaaagacc agaacattga
      361 atatgagtac caaaacccca ggagaaactt caggagtgtc acagaagaga aagtcaatga
      421 aattaaagaa gacagtcatt gtggagaaac ttttacccca gttccagatg acaggctgaa
      481 cttccagaag aagaaagctt ctcctgaagt aaaatcatgt gacagctttg tgtgtgaagt
      541 tggcctaggt aactcatctt ctaatatgaa catcagaggt gacactggac acaaggcatg
      601 tgaatgtcag gaatatggac caaagccatg gaagagtcaa caacctaaaa aagccttcag
      661 atatcacccc tccttgagaa cacaagaaag ggatcacact ggaaagaaac cctatgcttg
      721 taaagaatgt ggaaaaaaca ttatttacca ttcaagcatt caaagacaca tggtagtgca
      781 cagtggggat ggaccttata aatgtaagtt ttgtgggaaa gcattccatt gtctcagttt
      841 atatcttatc catgaaagaa ctcacactgg agagaaaccg tatgaatgta aacaatgtgg
      901 taaatctttt agttattctg ctacccatcg aatacatgaa agaactcaca ttggagaaaa
      961 gccttatgaa tgtcaggaat gtgggaaagc attccatagt cccagatcct gtcacagaca
     1021 tgaaaggagt cacatgggag agaaggctta tcaatgtaag gaatgtggaa aagcattcat
     1081 gtgtccccgt tatgttcgta gacatgaaag gacccactct aggaaaaaac tttatgaatg
     1141 taagcagtgt gggaaagcat tatcctctct tacaagtttt caaacacaca taagaatgca
     1201 ctctggagaa agaccttatg aatgtaagac atgtgggaaa ggcttttatt ctgccaagtc
     1261 atttcaaaga catgaaaaaa ctcacagtgg agagaaaccg tataaatgca agcaatgtgg
     1321 taaagccttc actcgttccg gttcctttcg atatcatgaa aggactcaca ctggagagaa
     1381 accctatgag tgtaagcaat gtgggaaagc cttcagatct gccccaaatc ttcaattgca
     1441 tggtaggact cacactggag agaaaccgta tcaatgtaag gaatgtggga aagctttcag
     1501 atctgcctca caacttcgaa tccatcgtag gattcacact ggagagaaac cctatgaatg
     1561 taagaaatgt gggaaagcct tcagatatgt ccagaacttt cgatttcatg aaaggacaca
     1621 aacacataag aatgcactct ggagaaagac cttataaata taagatatat gggaaacact
     1681 tttattctgc caagttattt caaacacatg aaaaaattca cactggagag aaaccctata
     1741 aatgcaagca atgtggtaaa gccttaattg ttccagttcc tttcgatatc taaaaggact
     1801 cacagtggag aaaaactcta tgagtgtaag caatgtggga aagtcttcag atctgtcaag
     1861 aacctttcaa tttatgaaag gacacacact ggagagaaac cctatgaatg taagaaatgt
     1921 ggaaaagcgt tccataattt ctcttctttt caaatacatg aaagttgcac agaggagagg
     1981 cgccctaaga atgtaagcat tgtgggaaag cattcatatc tgccaagatc gtttgaatac
     2041 atgcaaaaca cacactggag agaaacctat gaatgtaagg aatgcaaaca agcattcaat
     2101 tatttttctt ccttgcatat acatgaaagg actcatacga gagagaatcc gtatgaatgt
     2161 aaggattgtg ggaaagcatt cagcttgctt aattgctttc atagacatgt aaagacacac
     2221 cagaaggaaa ccctatgaat gtaagcaatg tggcaaaagc tttcacttct tccagttctt
     2281 ttcaatatca tgaaaggact cacactgggg agaaaccgta tcaatgtaag caatgtggga
     2341 aagccgtcag atcagcctca agacttcaaa tgcatggaag cactcacact tggcagaaac
     2401 tctatgaatg taagcagtat gggaaagcct tcagatcggc taggattctt tgaatacaaa
     2461 taatgaatgt aaacaattaa ctgtttataa taactgtata ctaacaaatg ttattctttt
     2521 taaataatta agaagctata ataaaatatc cattggtgtc atgtattaga tcaa
//
