LOCUS       NM_001143768            3098 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 438 (ZNF438), transcript variant
            4, mRNA.
ACCESSION   NM_001143768
VERSION     NM_001143768.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3098)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3098)
  AUTHORS   He,M., Xu,M., Zhang,B., Liang,J., Chen,P., Lee,J.Y., Johnson,T.A.,
            Li,H., Yang,X., Dai,J., Liang,L., Gui,L., Qi,Q., Huang,J., Li,Y.,
            Adair,L.S., Aung,T., Cai,Q., Cheng,C.Y., Cho,M.C., Cho,Y.S.,
            Chu,M., Cui,B., Gao,Y.T., Go,M.J., Gu,D., Gu,W., Guo,H., Hao,Y.,
            Hong,J., Hu,Z., Hu,Y., Huang,J., Hwang,J.Y., Ikram,M.K., Jin,G.,
            Kang,D.H., Khor,C.C., Kim,B.J., Kim,H.T., Kubo,M., Lee,J., Lee,J.,
            Lee,N.R., Li,R., Li,J., Liu,J., Longe,J., Lu,W., Lu,X., Miao,X.,
            Okada,Y., Ong,R.T., Qiu,G., Seielstad,M., Sim,X., Song,H.,
            Takeuchi,F., Tanaka,T., Taylor,P.R., Wang,L., Wang,W., Wang,Y.,
            Wu,C., Wu,Y., Xiang,Y.B., Yamamoto,K., Yang,H., Liao,M., Yokota,M.,
            Young,T., Zhang,X., Kato,N., Wang,Q.K., Zheng,W., Hu,F.B., Lin,D.,
            Shen,H., Teo,Y.Y., Mo,Z., Wong,T.Y., Lin,X., Mohlke,K.L., Ning,G.,
            Tsunoda,T., Han,B.G., Shu,X.O., Tai,E.S., Wu,T. and Qi,L.
  TITLE     Meta-analysis of genome-wide association studies of adult height in
            East Asians identifies 17 novel loci
  JOURNAL   Hum Mol Genet 24 (6), 1791-1800 (2015)
   PUBMED   25429064
REFERENCE   3  (bases 1 to 3098)
  AUTHORS   Mitchell,L.E., Agopian,A.J., Bhalla,A., Glessner,J.T., Kim,C.E.,
            Swartz,M.D., Hakonarson,H. and Goldmuntz,E.
  TITLE     Genome-wide association study of maternal and inherited effects on
            left-sided cardiac malformations
  JOURNAL   Hum Mol Genet 24 (1), 265-273 (2015)
   PUBMED   25138779
REFERENCE   4  (bases 1 to 3098)
  AUTHORS   Okada,Y., Wu,D., Trynka,G., Raj,T., Terao,C., Ikari,K., Kochi,Y.,
            Ohmura,K., Suzuki,A., Yoshida,S., Graham,R.R., Manoharan,A.,
            Ortmann,W., Bhangale,T., Denny,J.C., Carroll,R.J., Eyler,A.E.,
            Greenberg,J.D., Kremer,J.M., Pappas,D.A., Jiang,L., Yin,J., Ye,L.,
            Su,D.F., Yang,J., Xie,G., Keystone,E., Westra,H.J., Esko,T.,
            Metspalu,A., Zhou,X., Gupta,N., Mirel,D., Stahl,E.A., Diogo,D.,
            Cui,J., Liao,K., Guo,M.H., Myouzen,K., Kawaguchi,T., Coenen,M.J.,
            van Riel,P.L., van de Laar,M.A., Guchelaar,H.J., Huizinga,T.W.,
            Dieude,P., Mariette,X., Bridges,S.L. Jr., Zhernakova,A., Toes,R.E.,
            Tak,P.P., Miceli-Richard,C., Bang,S.Y., Lee,H.S., Martin,J.,
            Gonzalez-Gay,M.A., Rodriguez-Rodriguez,L., Rantapaa-Dahlqvist,S.,
            Arlestig,L., Choi,H.K., Kamatani,Y., Galan,P., Lathrop,M., Eyre,S.,
            Bowes,J., Barton,A., de Vries,N., Moreland,L.W., Criswell,L.A.,
            Karlson,E.W., Taniguchi,A., Yamada,R., Kubo,M., Liu,J.S., Bae,S.C.,
            Worthington,J., Padyukov,L., Klareskog,L., Gregersen,P.K.,
            Raychaudhuri,S., Stranger,B.E., De Jager,P.L., Franke,L.,
            Visscher,P.M., Brown,M.A., Yamanaka,H., Mimori,T., Takahashi,A.,
            Xu,H., Behrens,T.W., Siminovitch,K.A., Momohara,S., Matsuda,F.,
            Yamamoto,K. and Plenge,R.M.
  CONSRTM   RACI consortium; GARNET consortium
  TITLE     Genetics of rheumatoid arthritis contributes to biology and drug
            discovery
  JOURNAL   Nature 506 (7488), 376-381 (2014)
   PUBMED   24390342
REFERENCE   5  (bases 1 to 3098)
  AUTHORS   Zhong,Z., Wan,B., Qiu,Y., Ni,J., Tang,W., Chen,X., Yang,Y.,
            Shen,S., Wang,Y., Bai,M., Lang,Q. and Yu,L.
  TITLE     Identification of a novel human zinc finger gene, ZNF438, with
            transcription inhibition activity
  JOURNAL   J Biochem Mol Biol 40 (4), 517-524 (2007)
   PUBMED   17669267
  REMARK    GeneRIF: The transcriptional activity of ZNF438 was studied by
            transfecting recombinant pM-ZNF438 into mammalian cells. The
            subsequent analysis based on the duel luciferase assay system
            showed that ZNF438 was a transcriptional repressor.
REFERENCE   6  (bases 1 to 3098)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3098)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA479799.1, AF428258.1, AI703004.1 and AL359532.26.
            
            On Aug 13, 2020 this sequence version replaced NM_001143768.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR,
            compared to variant 1. Variants 1-4 encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.3019193.1,
                                           SRR18074969.2855782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000436087.7/ ENSP00000406934.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-546               DA479799.1         15-560
            547-3021            AF428258.1         595-3069
            3022-3096           AI703004.1         10-84               c
            3097-3098           AL359532.26        77036-77037         c
FEATURES             Location/Qualifiers
     source          1..3098
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.23"
     gene            1..3098
                     /gene="ZNF438"
                     /gene_synonym="bA330O11.1"
                     /note="zinc finger protein 438"
                     /db_xref="GeneID:220929"
                     /db_xref="HGNC:HGNC:21029"
                     /db_xref="MIM:620749"
     exon            1..33
                     /gene="ZNF438"
                     /gene_synonym="bA330O11.1"
                     /inference="alignment:Splign:2.1.0"
     exon            34..91
                     /gene="ZNF438"
                     /gene_synonym="bA330O11.1"
                     /inference="alignment:Splign:2.1.0"
     exon            92..168
                     /gene="ZNF438"
                     /gene_synonym="bA330O11.1"
                     /inference="alignment:Splign:2.1.0"
     exon            169..251
                     /gene="ZNF438"
                     /gene_synonym="bA330O11.1"
                     /inference="alignment:Splign:2.1.0"
     exon            252..319
                     /gene="ZNF438"
                     /gene_synonym="bA330O11.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..2769
                     /gene="ZNF438"
                     /gene_synonym="bA330O11.1"
                     /note="isoform a is encoded by transcript variant 4"
                     /codon_start=1
                     /product="zinc finger protein 438 isoform a"
                     /protein_id="NP_001137240.1"
                     /db_xref="CCDS:CCDS7168.1"
                     /db_xref="GeneID:220929"
                     /db_xref="HGNC:HGNC:21029"
                     /db_xref="MIM:620749"
                     /translation="MQNSVSVPPKDEGESNIPSGTIQSRKGLQNKSQFRTIAPKIVPK
                     VLTSRMLPCHSPSRSDQVNLGPSINSKLLGMSTQNYALMQVAGQEGTFSLVALPHVAS
                     AQPIQKPRMSLPENLKLPIPRYQPPRNSKASRKKPILIFPKSGCSKAPAQTQMCPQMS
                     PSPPHHPELLYKPSPFEEVPSLEQAPASISTAALTNGSDHGDLRPPVTNTHGSLNPPA
                     TPASSTPEEPAKQDLTALSGKAHFVSKITSSKPSAVASEKFKEQVDLAKTMTNLSPTI
                     LGNAVQLISSVPKGKLPIPPYSRMKTMEVYKIKSDANIAGFSLPGPKADCDKIPSTTE
                     GFNAATKVASRLPVPQVSQQSACESAFCPPTKLDLNHKTKLNSGAAKRKGRKRKVPDE
                     ILAFQGKRRKYIINKCRDGKERVKNDPQEFRDQKLGTLKKYRSIMPKPIMVIPTLASL
                     ASPTTLQSQMLGGLGQDVLLNNSLTPKYLGCKQDNSSSPKPSSVFRNGFSGIKKPWHR
                     CHVCNHHFQFKQHLRDHMNTHTNRRPYSCRICRKSYVRPGSLSTHMKLHHGENRLKKL
                     MCCEFCAKVFGHIRVYFGHLKEVHRVVISTEPAPSELQPGDIPKNRDMSVRGMEGSLE
                     RENKSNLEEDFLLNQADEVKLQIKCGRCQITAQSFAEIKFHLLDVHGEEIEGRLQEGT
                     FPGSKGTQEELVQHASPDWKRHPERGKPEKVHSSSEESHACPRLKRQLHLHQNGVEML
                     MENEGPQSGTNKPRETCQGPECPGLHTFLLWSHSGFNCLLCAEMLGRKEDLLHHWKHQ
                     HNCEDPSKLWAILNTVSNQGVIELSSEAEK"
     exon            320..2156
                     /gene="ZNF438"
                     /gene_synonym="bA330O11.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..3098
                     /gene="ZNF438"
                     /gene_synonym="bA330O11.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2926..2931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF438"
                     /gene_synonym="bA330O11.1"
                     /note="hexamer: AATAAA"
     regulatory      2931..2936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF438"
                     /gene_synonym="bA330O11.1"
                     /note="hexamer: AATATA"
     polyA_site      2951
                     /gene="ZNF438"
                     /gene_synonym="bA330O11.1"
                     /note="major polyA site"
     polyA_site      2960
                     /gene="ZNF438"
                     /gene_synonym="bA330O11.1"
     regulatory      3077..3082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF438"
                     /gene_synonym="bA330O11.1"
                     /note="hexamer: AATACA"
     polyA_site      3098
                     /gene="ZNF438"
                     /gene_synonym="bA330O11.1"
ORIGIN      
        1 accccgctgt gacgcgcacg ctgtaggaaa actaattaat taaaaggatt tacggtatat
       61 cttatgactc tacaggagcc ttgggatata gataaaaatg aatgccattt cccatccagt
      121 actgaagtgt taaagttaga agacatttgc taagtcaaat cacttcaggt atgttgaaga
      181 aagtacgcac atcttatctt ctgaacattt tgatggaatt aaccacaaac ttcatgcaag
      241 aacagtaaaa ggaaagatac tattcaagtc cagtacatca taatgcagaa ttctgtatca
      301 gtaccaccaa aagatgaagg tgaatcaaac atcccttctg gaacaataca gagtaggaaa
      361 ggtttgcaga ataagagtca gtttaggacc attgcaccaa aaattgtgcc caaagtccta
      421 acgtccagaa tgctgccatg tcattcacca tcacgctctg atcaggtgaa tctgggaccc
      481 tccatcaact ccaagctgct ggggatgtcc acccagaact atgccctgat gcaggttgct
      541 ggccaggagg ggacattttc tcttgttgct ctgccacatg ttgcctcagc tcagccaatt
      601 cagaaaccca gaatgtccct acctgaaaac ctgaaacttc ctattcctag atatcaaccc
      661 cctagaaata gcaaagcatc aagaaagaaa cccatcctga tctttcctaa gagtggctgt
      721 agcaaagctc ctgcccaaac ccaaatgtgt cctcagatgt ccccttcccc acctcaccac
      781 cctgaactcc tgtacaaacc cagtccattt gaggaagtac catcactaga gcaagcccca
      841 gccagcatta gcacagctgc gctgaccaat ggaagtgacc atggggactt gagaccacca
      901 gtgaccaaca cccatggcag tctgaaccct cctgctaccc cagcatcatc cacaccagag
      961 gagcctgcca agcaggacct cacagctctt tcagggaaag cacactttgt aagcaagata
     1021 acatctagta aaccttctgc tgttgccagt gaaaaattta aagaacaagt tgatcttgca
     1081 aaaaccatga ccaatttatc accaaccatt cttggcaatg cagttcagtt gatctcttca
     1141 gtccccaaag ggaaactgcc aatcccaccc tactcaagaa tgaagacaat ggaggtttac
     1201 aaaatcaaat cagatgctaa cattgcaggt ttttctttac caggacctaa ggccgactgt
     1261 gataagatac cctccaccac agaaggcttt aatgcagcca ccaaggtggc aagcaggcta
     1321 cctgttccac aagtgtcaca gcagagtgcc tgtgaaagtg ccttttgtcc acccaccaaa
     1381 cttgatctta accacaaaac aaaactgaac agtggagcag caaagagaaa aggaagaaaa
     1441 cggaaggtac cagatgaaat tttggcattt cagggaaaaa ggaggaaata tatcattaat
     1501 aagtgtagag atggtaaaga aagagtaaaa aatgatcccc aagaattcag agaccaaaag
     1561 ctggggaccc tgaaaaaata ccgtagcatt atgcccaaac ctatcatggt catacccact
     1621 ttggcctccc tggcttctcc aactacacta cagtcccaga tgcttggggg cctaggacag
     1681 gatgttttgt taaataattc actcactcct aaatatcttg gctgtaagca agacaacagc
     1741 tcttccccta agcccagctc cgtgttcaga aatggattct ctggcattaa gaagccttgg
     1801 cacagatgtc acgtctgcaa ccaccacttc cagttcaaac agcaccttcg agaccacatg
     1861 aatacacaca ccaacagacg cccttacagt tgtcggattt gtcgcaagtc ctatgtacgt
     1921 cctggcagcc tgagcacaca catgaaactt catcatggtg agaaccgtct gaagaaactc
     1981 atgtgttgtg agttttgtgc aaaagtgttt ggccacatcc gagtctattt tggccatctg
     2041 aaagaagtgc atagggttgt gatcagcact gagcctgcgc ccagtgaact gcagccagga
     2101 gacataccaa agaacagaga catgagtgtg cgaggcatgg agggatcatt ggagagggaa
     2161 aacaagtcca acctggaaga agacttcctt ctaaaccagg cagacgaagt caaattacaa
     2221 atcaaatgtg gtcgttgtca gattactgct cagtcttttg cggaaataaa atttcattta
     2281 cttgatgttc atggagagga aattgagggc aggctacaag aagggacctt cccaggaagc
     2341 aaggggactc aggaagagtt ggtgcagcac gctagccccg actggaaaag gcatcctgag
     2401 agagggaagc cggagaaggt tcattcctcc tccgaggaat cacatgcatg tccaagactg
     2461 aaaaggcagc tccaccttca tcagaatggc gtggaaatgc tcatggaaaa tgaaggaccc
     2521 cagtcaggaa ccaacaagcc aagggaaacc tgccagggcc ctgagtgtcc tggcctccac
     2581 acgtttctct tgtggtccca ttcaggcttt aactgcctgc tttgtgcaga gatgctggga
     2641 cggaaagagg acctcctcca ccactggaag caccagcata actgtgagga cccttccaaa
     2701 ctgtgggcta ttttaaatac ggtctccaac cagggagtga tcgaactttc cagtgaagct
     2761 gagaaatgag accccaaggc agcctggggt taaggagaga gctctgccgc caccttcctt
     2821 cagagcttcg tgctttatgg tggtgcttag tcacaaagat caaacaacag gattggtgtg
     2881 agtgaacaga aatgattttt gtacatggtt ttattttctt aacgaaataa aatataagct
     2941 ctcgaagcat atttttctaa ctatatgcag tcttatttta aaatacgtac tgattcttaa
     3001 tatcttagac tttcagaata aataaaaaga tcaaaatttg aagattgaaa tttagcagaa
     3061 tataggctgt tcttcaaata cagctctcag tgaaaaca
//
