LOCUS       NM_001077195            4465 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 436 (ZNF436), transcript variant
            1, mRNA.
ACCESSION   NM_001077195
VERSION     NM_001077195.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4465)
  AUTHORS   Wang,H., Wang,X. and Xu,L.
  TITLE     Chromosome 1p36 candidate gene ZNF436 predicts the prognosis of
            neuroblastoma: a bioinformatic analysis
  JOURNAL   Ital J Pediatr 49 (1), 145 (2023)
   PUBMED   37904225
  REMARK    GeneRIF: Chromosome 1p36 candidate gene ZNF436 predicts the
            prognosis of neuroblastoma: a bioinformatic analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4465)
  AUTHORS   Zhang,L., Chang,S., Zhao,Y., Cao,G. and Zhang,D.
  TITLE     MicroRNA-4317 suppresses the progression of hepatocellular
            carcinoma by targeting ZNF436-mediated PI3K/AKT signaling pathway
  JOURNAL   Tissue Cell 74, 101696 (2022)
   PUBMED   34861581
  REMARK    GeneRIF: MicroRNA-4317 suppresses the progression of hepatocellular
            carcinoma by targeting ZNF436-mediated PI3K/AKT signaling pathway.
REFERENCE   3  (bases 1 to 4465)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4465)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4465)
  AUTHORS   Shang,Y., Li,Y., Zhang,Y. and Wang,J.
  TITLE     ZNF436 promotes tumor cell proliferation through transcriptional
            activation of BCL10 in glioma
  JOURNAL   Biochem Biophys Res Commun 515 (4), 572-578 (2019)
   PUBMED   31178130
  REMARK    GeneRIF: ZNF436 has a role in promoting tumor cell proliferation
            through transcriptional activation of BCL10 in glioma
REFERENCE   6  (bases 1 to 4465)
  AUTHORS   Weimann,M., Grossmann,A., Woodsmith,J., Ozkan,Z., Birth,P.,
            Meierhofer,D., Benlasfer,N., Valovka,T., Timmermann,B.,
            Wanker,E.E., Sauer,S. and Stelzl,U.
  TITLE     A Y2H-seq approach defines the human protein methyltransferase
            interactome
  JOURNAL   Nat Methods 10 (4), 339-342 (2013)
   PUBMED   23455924
REFERENCE   7  (bases 1 to 4465)
  AUTHORS   Li,Y., Du,X., Li,F., Deng,Y., Yang,Z., Wang,Y., Pen,Z., Wang,Z.,
            Yuan,W., Zhu,C. and Wu,X.
  TITLE     A novel zinc-finger protein ZNF436 suppresses transcriptional
            activities of AP-1 and SRE
  JOURNAL   Mol Biol Rep 33 (4), 287-294 (2006)
   PUBMED   17089209
  REMARK    GeneRIF: ZNF436 is a member of the zinc finger transcription factor
            family and may act as a negative regulator in gene transcription
            mediated by the MAPK signaling pathways.
REFERENCE   8  (bases 1 to 4465)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
REFERENCE   9  (bases 1 to 4465)
  AUTHORS   Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
  TITLE     Characterization and mapping of human genes encoding zinc finger
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
   PUBMED   1946370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL109936.11 and AB051497.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001077195.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.264439.1,
                                           SRR1660805.71455.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398, SAMEA2467147
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314011.9/ ENSP00000313582.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-394               AL109936.11        131958-132351       c
            395-1472            AB051497.1         1-1078
            1473-4465           AL109936.11        121963-124955       c
FEATURES             Location/Qualifiers
     source          1..4465
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..4465
                     /gene="ZNF436"
                     /gene_synonym="Zfp46; ZNF"
                     /note="zinc finger protein 436"
                     /db_xref="GeneID:80818"
                     /db_xref="HGNC:HGNC:20814"
                     /db_xref="MIM:611703"
     exon            1..471
                     /gene="ZNF436"
                     /gene_synonym="Zfp46; ZNF"
                     /inference="alignment:Splign:2.1.0"
     exon            472..564
                     /gene="ZNF436"
                     /gene_synonym="Zfp46; ZNF"
                     /inference="alignment:Splign:2.1.0"
     CDS             532..1944
                     /gene="ZNF436"
                     /gene_synonym="Zfp46; ZNF"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DNA-binding protein"
                     /codon_start=1
                     /product="zinc finger protein 436 isoform 1"
                     /protein_id="NP_001070663.1"
                     /db_xref="CCDS:CCDS233.1"
                     /db_xref="GeneID:80818"
                     /db_xref="HGNC:HGNC:20814"
                     /db_xref="MIM:611703"
                     /translation="MAATLLMAGSQAPVTFEDMAMYLTREEWRPLDAAQRDLYRDVMQ
                     ENYGNVVSLDFEIRSENEVNPKQEISEDVQFGTTSERPAENAEENPESEEGFESGDRS
                     ERQWGDLTAEEWVSYPLQPVTDLLVHKEVHTGIRYHICSHCGKAFSQISDLNRHQKTH
                     TGDRPYKCYECGKGFSRSSHLIQHQRTHTGERPYDCNECGKSFGRSSHLIQHQTIHTG
                     EKPHKCNECGKSFCRLSHLIQHQRTHSGEKPYECEECGKSFSRSSHLAQHQRTHTGEK
                     PYECNECGRGFSERSDLIKHYRVHTGERPYKCDECGKNFSQNSDLVRHRRAHTGEKPY
                     HCNECGENFSRISHLVQHQRTHTGEKPYECNACGKSFSRSSHLITHQKIHTGEKPYEC
                     NECWRSFGERSDLIKHQRTHTGEKPYECVQCGKGFTQSSNLITHQRVHTGEKPYECTE
                     CEKSFSRSSALIKHKRVHTD"
     exon            565..691
                     /gene="ZNF436"
                     /gene_synonym="Zfp46; ZNF"
                     /inference="alignment:Splign:2.1.0"
     exon            692..4465
                     /gene="ZNF436"
                     /gene_synonym="Zfp46; ZNF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3915..3920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF436"
                     /gene_synonym="Zfp46; ZNF"
                     /note="hexamer: AATAAA"
     polyA_site      3938
                     /gene="ZNF436"
                     /gene_synonym="Zfp46; ZNF"
                     /note="major polyA site"
     regulatory      4441..4446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF436"
                     /gene_synonym="Zfp46; ZNF"
                     /note="hexamer: ATTAAA"
     polyA_site      4465
                     /gene="ZNF436"
                     /gene_synonym="Zfp46; ZNF"
                     /note="major polyA site"
ORIGIN      
        1 cttccctctc caaggctaca gcgagctggg agctcttccc cacgcagaat gcctgctttc
       61 cccagtgctc gacttccatt gtctaattcc ctcatcctgg ctggggaaag ggagagctgc
      121 gagtcctccc gttccgagga actccagctg aatgcagctt agttgctggt ggtttctcgg
      181 ccagcctctg tggtctcagg gatctgccta tgagcctgtg gtttctgagc tgcctgcgag
      241 tctgaggcct cgggaatctg agtctttagg atcagcctac gatatctggg cttcgcctgc
      301 aagtctacga attcgagatc tacctgcggg tctgagacct ccgggacctg cccgtgctct
      361 ctagaatctt cctgaacgcc aggtctgaga gaacgctgcg gctctggaac ccgttcgcgg
      421 tctctcaggt tttggagacg acgatctagt ggatcttttg cgggacagga gcgctgtctg
      481 ctagctgctt ttcctgctct ctctccctgg aggcgaaccc ttgtgctcga gatggcagcc
      541 accctgctca tggctgggtc ccaggcacct gtgacgtttg aagatatggc catgtatctc
      601 acccgggaag aatggagacc tctggacgct gcacagaggg acctttaccg ggatgttatg
      661 caggagaatt atggaaatgt tgtctcacta gattttgaga tcaggagtga gaacgaggta
      721 aatcccaagc aagagattag tgaagatgta caatttggga ctacatctga aagacctgct
      781 gagaatgctg aggaaaatcc tgaaagtgaa gagggctttg aaagcggaga taggtcagaa
      841 agacaatggg gagatttaac agcagaagag tgggtaagct atcctctcca accagtcact
      901 gatctacttg tccacaaaga agtccacaca ggcatccgct atcatatatg ttctcattgt
      961 ggaaaggcct tcagtcagat ctcagacctt aatcgacatc agaagaccca cactggagac
     1021 agaccctata aatgttatga atgtggaaaa ggcttcagtc gcagctcaca ccttattcag
     1081 catcaaagaa cacatactgg ggagaggcct tatgactgta acgagtgtgg gaaaagtttt
     1141 ggaagaagtt ctcacctgat tcagcatcag acaatccaca ctggagagaa gcctcacaaa
     1201 tgtaatgagt gtggaaaaag tttctgccgt ctctctcacc taatccaaca ccaaaggacc
     1261 cacagtggtg agaaacccta tgagtgtgag gagtgtggga aaagcttcag ccggagctct
     1321 cacctagctc agcaccagag gacccacacg ggtgagaaac cttatgaatg taacgaatgt
     1381 ggccgaggct tcagtgagag atctgatctc atcaaacact atcgagtcca cacaggggag
     1441 aggccctaca agtgtgatga gtgtgggaag aatttcagtc agaactccga ccttgtgcgt
     1501 catcgcagag cccacacggg agagaagcca taccactgta acgaatgtgg ggaaaatttc
     1561 agccgcatct cacacttggt tcagcaccag agaactcaca ctggagagaa gccatatgaa
     1621 tgcaatgctt gtgggaaaag cttcagccgg agctctcatc tcatcacaca ccagaaaatt
     1681 cacactggag agaagcctta tgagtgtaat gagtgttggc gaagctttgg tgaaaggtca
     1741 gatctaatta aacatcagag aacccacaca ggggagaagc cctacgagtg tgtgcagtgt
     1801 gggaaaggtt tcacccagag ctccaacctc atcacacatc aaagagttca cacgggagag
     1861 aaaccttatg aatgtaccga atgtgagaag agtttcagca ggagctcagc tcttattaaa
     1921 cataagagag ttcatacgga ctaagctgta attatgatgg ctgagaaatg attcatttga
     1981 agatacaatt ttatttgata tcaatgaacg ccctcaagac tgagctgctt ttatcatact
     2041 ctcctagttg tgggccacga tttaaaccat cagagatgac aagccatttg aaattctgac
     2101 cctcagcttt gggaatgtta tctcctccaa aatggtgatt tttattcact caatgggtta
     2161 cttcattaaa agcagcccca caagtaactg gaaatctgaa gaccagggga caaatgctgg
     2221 tgaatgctta ggcctggaaa tggagtaaat ctttcaatgt tattttctcc catccttggc
     2281 ccaaggaact atgctaagtg aaacgtggga ctgtaatagg gtggtaatgg ctgctttgga
     2341 aaaaggcaac tagagactct gcctaaattg ccacacctat tcacacacca tagtagttgg
     2401 gcacacacat cttcccttcc aaagggcttt ttccttgagt tgctcatgca tttgtatctt
     2461 ttccatcttc ctgagggcaa gattttgcac gatgaaggca atgattgtaa cttttctcct
     2521 tctcattgtt tctaattagc tcctttaaag cttgcatctt tgtgaaggct aactgaagat
     2581 acggttggaa aggaaaaatg agacacaggt ttggggacca aggacccatc aatgatggtg
     2641 actttagcag aagatgccca cagttattac tgccattaat cagatttatg aattttcttt
     2701 ggggatcact atagggaata ttgtatagaa aatatcttca agaaaagata ggaccatcag
     2761 tgacagttaa gtgtaaggag caagtggaat tgagtccttc agggaaggaa ccacagagtc
     2821 ccttcccaag gaatgtaggt cgtttctgtg ttctttccct tctaatcttt aagatcaact
     2881 cttcctatcc tgctaactct aagatttgat aagggccaca tcccagtgtt tatcttagct
     2941 tgcatcaggg catgtgtatg tacagtaatg tgtattcctg tggtttttct aatagaaact
     3001 gaatttacag agacttagca tgttcttggg tgatgtgagt catgtgacag aagtacagac
     3061 ataactccaa tgtgagaaat gtcctttttt cattatggaa aataatttaa acactagtgc
     3121 tttagtgtgc actctcctgt aaggtctgtc tttgtacaga gctaagcact tgtttgtatg
     3181 tgtttgtcaa ttgtggaaga taatgaccag acaaataggt cgattgtcct attctcagaa
     3241 tgaattatct tctatggtaa tgaagaactc tttggcttag tcagaaggaa ttaacgaacc
     3301 tcggtaggaa tgtatttcca tcctcccacc ctacagatat aagaggttaa aataacagtt
     3361 cgcccaattt aagcccagta gtgtcagttt tcctaatctc agtccaggta ggaattaaga
     3421 aatatctcaa gtgttgatgc tatccaagca tgttggggtg gaagggaatt ggtgcccaga
     3481 aaatgggact ggagtgagga atatcttttc ttttgagagt acccccagtt tatttctact
     3541 gtgctttatt gctactgttc tttattgtga atgttgtaac attttaaaaa tgttttgcca
     3601 tagcttttta ggacttggtg ttaaaggagc cagtggtctc tctgggtggg tactataatg
     3661 agttattgtg acccacagct gtgtgggacc acatcacttg ttaataacac aacctttaaa
     3721 gtaacccatc ttccaggggg gttccttcat gttgccactc ctttttaagg acaaactcag
     3781 gcaaggagca tgtttttttg ttatttacaa aatctagcag actgtgggta tccatatttt
     3841 aattgtcggg tgacacatgt tcttggtaac taaactcaaa tatgtctttt ctcatatatg
     3901 ttgctgatgg ttttaataaa tgtcaaagtt ctcctgttgc ttctgtgagc cactatgggt
     3961 atcagcttgg gagtggccat agatgaccgc atttccatga cctaactgta tttcaccccc
     4021 ttttccttcc ctactgttct tgccccaccc caaccagttc ctgctgctgc ttttggcttc
     4081 ttggaggtga agggcttaaa acaaggcttc taagcaccca gctatctcca tacatgaaca
     4141 atctagctgg gaaacttaag ggacaagggc cacaccagct gtctcctctt tctgccaatt
     4201 gttgcccgtt tgctgtgttg aactttgtat agaactcatg catcagactc ccttcactaa
     4261 tgctttttgc atgccttctg ctcccaagtc cctggctgcc tctgcacatc ccgtgaacac
     4321 tttgtgcctg ttttctatgg ttgtggagaa ttaatgaaca aatcaatatg tagaacagtt
     4381 ttccttatgg tattggtcac agttatccta gtgtttgtat tattctaaca atattctata
     4441 attaaaaata taatttttaa agtca
//
