LOCUS       NM_014650               4637 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 432 (ZNF432), transcript variant
            1, mRNA.
ACCESSION   NM_014650 XM_375637
VERSION     NM_014650.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4637)
  AUTHORS   O'Sullivan,J., Kothari,C., Caron,M.C., Gagne,J.P., Jin,Z.,
            Nonfoux,L., Beneyton,A., Coulombe,Y., Thomas,M., Atalay,N.,
            Meng,X.W., Milano,L., Jean,D., Boisvert,F.M., Kaufmann,S.H.,
            Hendzel,M.J., Masson,J.Y. and Poirier,G.G.
  TITLE     ZNF432 stimulates PARylation and inhibits DNA resection to balance
            PARPi sensitivity and resistance
  JOURNAL   Nucleic Acids Res 51 (20), 11056-11079 (2023)
   PUBMED   37823600
  REMARK    GeneRIF: ZNF432 stimulates PARylation and inhibits DNA resection to
            balance PARPi sensitivity and resistance.
REFERENCE   2  (bases 1 to 4637)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4637)
  AUTHORS   Wu,A.C., Himes,B.E., Lasky-Su,J., Litonjua,A., Peters,S.P.,
            Lima,J., Kubo,M., Tamari,M., Nakamura,Y., Qiu,W., Weiss,S.T. and
            Tantisira,K.
  TITLE     Inhaled corticosteroid treatment modulates ZNF432 gene variant's
            effect on bronchodilator response in asthmatics
  JOURNAL   J Allergy Clin Immunol 133 (3), 723-8 (2014)
   PUBMED   24280104
  REMARK    GeneRIF: Inhaled corticosteroids appear to modulate the association
            of bronchodilator response with variant(s) in the ZNF432 gene among
            adults and children with asthma.
REFERENCE   4  (bases 1 to 4637)
  AUTHORS   Zhan,X. and Desiderio,D.M.
  TITLE     Nitroproteins from a human pituitary adenoma tissue discovered with
            a nitrotyrosine affinity column and tandem mass spectrometry
  JOURNAL   Anal Biochem 354 (2), 279-289 (2006)
   PUBMED   16777052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB079612.1, BC002858.2, AC011468.8 and AB018341.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014650.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.149012.1,
                                           SRR1803612.275284.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221315.10/ ENSP00000221315.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DB079612.1         287-304
            19-2591             BC002858.2         1-2573
            2592-4180           AC011468.8         47524-49112         c
            4181-4636           AB018341.1         4062-4517
            4637-4637           AC011468.8         47067-47067         c
FEATURES             Location/Qualifiers
     source          1..4637
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..4637
                     /gene="ZNF432"
                     /note="zinc finger protein 432"
                     /db_xref="GeneID:9668"
                     /db_xref="HGNC:HGNC:20810"
                     /db_xref="MIM:620554"
     exon            1..144
                     /gene="ZNF432"
                     /inference="alignment:Splign:2.1.0"
     exon            145..351
                     /gene="ZNF432"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..2295
                     /gene="ZNF432"
                     /codon_start=1
                     /product="zinc finger protein 432"
                     /protein_id="NP_055465.1"
                     /db_xref="CCDS:CCDS12848.1"
                     /db_xref="GeneID:9668"
                     /db_xref="HGNC:HGNC:20810"
                     /db_xref="MIM:620554"
                     /translation="MINAQELLTLEDVTVEFTWEEWQLLGPFQKDLYRDVMLEIYSNL
                     LSMGYQVSKPDALSKLERGEEPWTMEDERHSRICPENNEVDDHLQDHLENQRMLKSVE
                     QYHEHNAFGNTASQTKSLCLFRENHDTFELYIKTLKSNLSLVNQNKSCEINNSTKFSG
                     DGKSFLHGNYEELYSAAKFSVSTKANSTKSQVSKHQRTHEIEKNHVCSECGKAFVKKS
                     QLTDHERVHTGEKPYGCTLCAKVFSRKSRLNEHQRIHKREKSFICSECGKVFTMKSRL
                     IEHQRTHTGEKPYICNECGKGFPGKRNLIVHQRNHTGEKSYICSECGKGFTGKSMLII
                     HQRTHTGEKPYICSECGKGFTTKHYVIIHQRNHTGEKPYICNECGKGFTMKSRMIEHQ
                     RTHTGEKPYICSECGKGFPRKSNLIVHQRNHTVEKSYLCSECGKGFTVKSMLIIHQRT
                     HTGEKPYTCSECGKGFPLKSRLIVHQRTHTGEKPYRCSECGKGFIVNSGLMLHQRTHT
                     GEKPYICNECGKGFAFKSNLVVHQRTHTGEKPFMCSECGKGFTMKRYLIVHQQIHTEE
                     KSCICSECGRGFAKETELALHKQVHTGEKPYGCNECGKGFTMKSRLIVHQRTHTGEKP
                     FVCSECRKAFSSKRNLIVHQRTHNGNKP"
     exon            352..478
                     /gene="ZNF432"
                     /inference="alignment:Splign:2.1.0"
     exon            479..574
                     /gene="ZNF432"
                     /inference="alignment:Splign:2.1.0"
     exon            575..4637
                     /gene="ZNF432"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4606..4611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF432"
                     /note="hexamer: AATAAA"
     polyA_site      4637
                     /gene="ZNF432"
                     /note="major polyA site"
ORIGIN      
        1 gcattccgct ctccatggaa acgcggctga ccgtctctgg aggtttagag ggggagggag
       61 ttgggcgagg ggcccagaag tggaagaagt ttagggaagt aagttcagct tttaagaggt
      121 cgcggcgatt ccaaggagag tcagtccaca ggtcctggct accctgggaa gagacaagaa
      181 gtaaatgaag aaagaggaag attccaggac ctagatatga tttctgtgga cacccttcac
      241 tggtgactga agtttctaaa tagaaattta aggcagatcc agaggagaca aagacagagt
      301 atcccaggtg ctggccattt cccacaacag aagaaaatga tcaatgccca ggaattgctg
      361 acactggagg atgttactgt ggagttcacc tgggaggagt ggcagctcct gggccctttt
      421 cagaaggatt tgtaccggga tgtgatgttg gagatctaca gcaacctgct atcaatgggt
      481 tatcaagtca gcaaaccaga tgcactctcc aagttggaac gaggagaaga accatggaca
      541 atggaagatg aaaggcacag tcgaatctgt ccagaaaaca acgaagttga tgatcatctg
      601 caggatcact tggaaaatca aaggatgctg aagagtgtgg aacaatacca tgaacataat
      661 gcatttggaa atactgcctc tcaaaccaaa agcctttgtc ttttcaggga aaatcatgat
      721 acatttgagt tatatataaa aactttgaaa tcaaatttaa gtttagtcaa ccagaacaaa
      781 agctgtgaaa ttaacaactc tactaaattt agtggagatg ggaaatcatt tcttcatggt
      841 aactatgaag aactttattc tgcagctaaa ttctctgtaa gtacaaaagc caatagcact
      901 aaatcccaag tcagtaagca tcagagaact catgaaatag aaaaaaacca cgtatgcagt
      961 gaatgtggga aagcgtttgt caagaagtct cagctcactg atcatgagag agttcataca
     1021 ggagaaaaac cttatggatg tactttgtgt gcaaaagtgt tctccagaaa gtccaggcta
     1081 aatgaacatc aaagaattca taaaagagag aaatctttta tatgcagtga atgtggaaaa
     1141 gtcttcacta tgaagagccg tctgattgaa catcagcgaa ctcatactgg agagaaaccc
     1201 tacatatgca atgaatgtgg aaaaggcttc ccaggcaagc gtaatctcat tgtacatcag
     1261 cgaaatcata ctggagagaa atcctatata tgtagtgaat gtggaaaagg cttcactggg
     1321 aagagcatgc ttattataca tcagcgaact catacaggag agaagcccta catctgtagt
     1381 gaatgtggga aaggcttcac cacaaaacac tatgtcatca tacatcaacg aaatcataca
     1441 ggagagaaac catatatatg caatgaatgt gggaaaggct tcaccatgaa gagccgtatg
     1501 atcgaacatc aacgaactca tacaggagag aaaccctaca tatgcagtga atgtggaaaa
     1561 ggctttccca ggaagagtaa tcttattgta catcagagaa atcatacagt agagaagtca
     1621 tatctatgta gtgaatgtgg aaaaggtttt actgtgaaaa gcatgctcat catacatcag
     1681 cgaactcata caggagagaa gccctacaca tgcagtgaat gtgggaaagg cttccccttg
     1741 aagagtcggc tgattgtaca tcagcgaact catactggag agaaacctta caggtgcagt
     1801 gaatgtggga aaggtttcat tgtgaatagc ggactgatgt tacatcagcg aactcatact
     1861 ggagagaaac cgtacatatg caatgaatgt ggaaaaggtt ttgcctttaa gagcaatctt
     1921 gttgtacacc agcgaactca tactggagag aaacccttta tgtgcagtga atgtggaaaa
     1981 ggcttcacca tgaaacgcta tctcattgta catcagcaaa ttcatacaga agagaaatct
     2041 tgtatatgta gtgaatgtgg aagaggcttt gccaaggaaa cagagcttgc tttacataag
     2101 caagttcata ctggagaaaa accttatgga tgtaatgaat gtggtaaagg cttcactatg
     2161 aagagccgtc taattgttca tcaacgaact catacaggag agaaaccctt tgtatgcagt
     2221 gaatgtagaa aagccttctc ctcaaagaga aatctcattg tacatcagcg aactcataat
     2281 ggaaacaaac cctgacaatg cagtggacat gttcatgcct ttgggaagaa aatctgcctt
     2341 gtacaacatc agagatttca cagtatagat tttctacatg tgtactgagt atgaaaaatc
     2401 atatttcaaa atccagtgtt attcactagg atgaatgcta tcaatgtcag aaaggcttca
     2461 acatgaattc aggctctgaa ttctttgatg taccaatgta tagaaaatta ctcatctgag
     2521 agagagtctg tggattgggg gtaacctttc atttgtcaac cttcattaaa actatgacaa
     2581 cgtccacatg acaaatgtgt aaggtacata gtccttttgc agagaatctg aactgattac
     2641 atacaaacaa attcatgcag agagaaaacc acgttagtaa tgtgaactga ttaaacagca
     2701 gtgtgctcct agcatacatg catataggca gtgtagagca gcctgttgct agattttcac
     2761 ccttggaaga caatgcaatt tccaggagcg aattttaatg aatgcagaga atgcactagt
     2821 gccttcggtg attaattacc tcatatttta tgtcacaata aacatgtagg aaataaactt
     2881 gatacatcca atgcagaaaa gtcttgaaaa ttttctaagt aactatgtct tgaaaagtat
     2941 ttactgagat aaatcttaca aaggagtagg ctaggaaagc cttctatggg aagaaagacc
     3001 ctatctcttc agtgatcata atagatcatc aatgaactta cacatactag cagcattatc
     3061 atgggaaagc ctttgcccag aaataaaacc ttaacagttg gcagatatat ttcatactgg
     3121 agaacaagtt tcagatggca gtgaatacac gaggatttca gtgatacatg ctgcctcatc
     3181 atcattactt catacagaaa taaaacttat atgaagagta actttaaaaa ggatcaggaa
     3241 attcatgaag taaaaaagtc tcatgaaaat gatacataat gccgggcatg gtggcttgca
     3301 cctgtaatcc cagcactttg ggaggccaag gtgggtggat cacttgaggt cgggagttcg
     3361 agaccagcct gaccaacatg gtgaagcccc cctctctact aaaaatacaa aattagccga
     3421 gcatggtggc tcacgcttgt aatcccagct actctggagg ctaagctgga gaatcacttg
     3481 aacctgggag gcagaggttt cagtgagcca agattgcgcc attgcattcc agcctgggca
     3541 acaagagcga aactctgcct caaaaaaaaa aaaaaaaaac catatttgag gactgtcaca
     3601 aatctaaact catgatacac ttgatatcta ttctgtgaca gcataccttg catcatatta
     3661 tcaatgattc cataattgta aagcgggctg ttcttatcac tgattaaatt ttaatcctat
     3721 atataacaca ggtgttttct gtgccaatct ggtgttattt attagttctt acatattata
     3781 ggccccaaat ttattttttt caatttactg ataaatgtaa ttcagtatat ttggatgtgt
     3841 ttatccaagt tactaggtac cattatgtag tttacaaaaa tgccttaaat gttatttttc
     3901 taaaatttgt tttgaaataa ttctagattc acaagagatt acaaaatata caaaagtttc
     3961 ctgagtattc tttgcttagc atcatcaatg ttatcttaca taaccataat aataaaaacc
     4021 acggagttct gctcttgttg cccaggttgg agtgtaatag cacgatcttg gctcactgca
     4081 accccgcctc ccaggttcaa gagattttcc tgcctcagcc tcctaagtag ctgggattac
     4141 aggcacccac gaccacgctc gactaatttt tgtattttta gtagagacgg ggtttcactg
     4201 tgttggccag gctggccttg aactctcgac cccgggcggt ccacccgcct cagcctccca
     4261 aagtgctggg attacaggca tgagccacca cgcctggcct cctcttgcta cctctttata
     4321 ctcacactgt cctcccaata tgacccatgg tagccactga tcccattacc ctaattttgt
     4381 tatttcaaga atgctattaa aatggaatcg taaggtacgc aagctttgag atagggcttt
     4441 gttcactcag caaattaccc ttaagatcta tccaagttgt taggtgtcta aatagtttta
     4501 atttttgtta ctgagttagt attcttttaa atggatgcac cagggtttgt gtatccattc
     4561 actgttgatg gacatttggg ttgtttccag tgttttgctg ttataaataa agatgctgtg
     4621 actatttgtg tacccga
//
