LOCUS       NM_133473              13894 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 431 (ZNF431), transcript variant
            2, mRNA.
ACCESSION   NM_133473
VERSION     NM_133473.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13894)
  AUTHORS   Camargo,M., Rivera,D., Moreno,L., Lidral,A.C., Harper,U., Jones,M.,
            Solomon,B.D., Roessler,E., Velez,J.I., Martinez,A.F.,
            Chandrasekharappa,S.C. and Arcos-Burgos,M.
  TITLE     GWAS reveals new recessive loci associated with non-syndromic
            facial clefting
  JOURNAL   Eur J Med Genet 55 (10), 510-514 (2012)
   PUBMED   22750566
REFERENCE   2  (bases 1 to 13894)
  AUTHORS   He,Z., Cai,J., Lim,J.W., Kroll,K. and Ma,L.
  TITLE     A novel KRAB domain-containing zinc finger transcription factor
            ZNF431 directly represses Patched1 transcription
  JOURNAL   J Biol Chem 286 (9), 7279-7289 (2011)
   PUBMED   21177534
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY034806.1, BC040506.1 and
            AC010620.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_133473.3.
            
            Summary: This gene encodes a member of the Krueppel C2H2-type
            zinc-finger family of proteins. The encoded protein may negatively
            regulate transcription of target genes, including the hedgehog
            signaling pathway receptor patched 1, by interacting with histone
            deacetylases. Mutations in this gene may be associated with
            non-syndromic facial clefting in human patients. [provided by
            RefSeq, Jul 2016].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK293072.1, SRR1660807.113366.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311048.11/ ENSP00000308578.6
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                HY034806.1         31-75
            46-463              BC040506.1         1-418
            464-3588            AC010620.4         80826-83950
            3589-3843           BC040506.1         3546-3800
            3844-13894          AC010620.4         84206-94256
FEATURES             Location/Qualifiers
     source          1..13894
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..13894
                     /gene="ZNF431"
                     /gene_synonym="ZFP932"
                     /note="zinc finger protein 431"
                     /db_xref="GeneID:170959"
                     /db_xref="HGNC:HGNC:20809"
                     /db_xref="MIM:619505"
     exon            1..147
                     /gene="ZNF431"
                     /gene_synonym="ZFP932"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1875
                     /gene="ZNF431"
                     /gene_synonym="ZFP932"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 431 isoform 2"
                     /protein_id="NP_597730.2"
                     /db_xref="CCDS:CCDS32979.1"
                     /db_xref="GeneID:170959"
                     /db_xref="HGNC:HGNC:20809"
                     /db_xref="MIM:619505"
                     /translation="MDDLKYGVYPLKEASGCPGAERNLLVYSYFEKETLTFRDVAIEF
                     SLEEWECLNPAQQNLYMNVMLENYKNLVFLGVAVSKQDPVTCLEQEKEPWNMKRHEMV
                     DEPPAMCSYFTKDLWPEQDIKDSFQQVILRRYGKCEHENLQLRKGSASVDEYKVHKEG
                     YNELNQCLTTTQSKIFPCDKYVKVFHKFLNANRHKTRHTGKKPFKCKKCGKSFCMLLH
                     LSQHKRIHIRENSYQCEECGKAFKWFSTLTRHKRIHTGEKPFKCEECGKAFKQSSTLT
                     THKIIHTGEKPYRCEECGKAFNRSSHLTTHKIIHTGEKPYKCEECGKAFNQSSTLSTH
                     KFIHAGEKPYKCEECDKAFNRFSYLTKHKIIHTGEKSYKCEECGKGFNWSSTLTKHKR
                     IHTGEKPYKCEVCGKAFNESSNLTTHKMIHTGEKPYKCEECGKAFNRSPQLTAHKIIH
                     TGEKPYKCEECGKAFSQSSILTTHKRIHTGEKPYKCEECGKAFNRSSNLTKHKIIHTG
                     EKSYKCEECGKAFNQSSTLTKHRKIHTRQKPYNCEECDNTFNQSSNLIKQNNSYWRET
                     LQMSRMWESL"
     exon            148..240
                     /gene="ZNF431"
                     /gene_synonym="ZFP932"
                     /inference="alignment:Splign:2.1.0"
     exon            241..367
                     /gene="ZNF431"
                     /gene_synonym="ZFP932"
                     /inference="alignment:Splign:2.1.0"
     exon            368..463
                     /gene="ZNF431"
                     /gene_synonym="ZFP932"
                     /inference="alignment:Splign:2.1.0"
     exon            464..13894
                     /gene="ZNF431"
                     /gene_synonym="ZFP932"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8044..8049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF431"
                     /gene_synonym="ZFP932"
                     /note="hexamer: AATAAA"
     polyA_site      8072
                     /gene="ZNF431"
                     /gene_synonym="ZFP932"
                     /note="major polyA site"
     regulatory      9997..10002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF431"
                     /gene_synonym="ZFP932"
                     /note="hexamer: AATAAA"
     polyA_site      10023
                     /gene="ZNF431"
                     /gene_synonym="ZFP932"
                     /note="major polyA site"
     regulatory      13874..13879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF431"
                     /gene_synonym="ZFP932"
                     /note="hexamer: TATAAA"
     polyA_site      13894
                     /gene="ZNF431"
                     /gene_synonym="ZFP932"
                     /note="major polyA site"
ORIGIN      
        1 gtctctcgcc gcagcctgag ctccaggtct ccccttcgct gctctgtgtc ctctgctcct
       61 agaggcccaa catctgtggc cctgtgacct gcaggtattg ggagacccac agctaagaca
      121 ccgggacccc ctgaaagcct agaaatggac gacttgaaat atggagtgta tcctctcaag
      181 gaagcaagtg gatgccctgg ggctgagagg aatcttctag tttactctta ttttgaaaag
      241 gagacattga catttaggga tgtggccata gaattctctc tggaggagtg ggaatgcctg
      301 aaccctgctc agcagaattt atatatgaat gtgatgttag aaaactacaa aaacctggtc
      361 ttcttgggtg ttgctgtctc taagcaagac ccagtcacct gtctggagca agaaaaagag
      421 ccctggaata tgaagagaca tgagatggtg gatgaacccc cagctatgtg ttcttatttt
      481 accaaagacc tttggccaga gcaagacata aaagattctt ttcaacaagt aatactgaga
      541 agatatggca aatgtgaaca tgagaattta cagttaagaa aaggctccgc aagtgtagat
      601 gagtataagg tgcacaaaga aggttataat gagctaaacc agtgtttgac aactacccag
      661 agcaaaatat ttccatgtga taaatatgtg aaagtctttc ataaattttt aaatgcaaat
      721 agacataaga caagacatac tggaaagaaa cctttcaaat gtaaaaaatg tggcaaatca
      781 ttttgcatgc ttttacacct aagtcaacat aaaagaattc atattagaga gaattcttac
      841 caatgtgaag aatgtggcaa agcttttaaa tggttctcaa cccttactag acacaagaga
      901 attcatactg gagagaaacc cttcaaatgt gaagaatgtg gcaaagcttt taagcagtcc
      961 tcaaccctta ctacacataa gataattcat actggggaga aaccatatag atgtgaagaa
     1021 tgtggcaaag ccttcaaccg gtcctcacac cttactacac ataagataat tcatactgga
     1081 gagaagccct acaaatgtga agaatgtggc aaagctttta accagtcttc aacccttagt
     1141 acacataagt tcattcatgc tggagagaaa ccctacaaat gtgaggaatg tgacaaagct
     1201 tttaatcgat tctcatacct tactaaacat aagataattc atactggaga aaaatcttac
     1261 aaatgtgaag aatgtggcaa aggctttaat tggtcctcaa cccttactaa acataaaaga
     1321 attcatactg gagagaaacc ctacaaatgt gaagtgtgtg gcaaagcctt taatgagtcc
     1381 tcaaacctta ctacacataa gatgattcat actggagaga aaccctacaa atgtgaagaa
     1441 tgtggcaaag cttttaaccg gtccccacaa cttactgcac ataagataat tcatactgga
     1501 gagaaacctt acaaatgtga agaatgtggc aaagctttta gccagtcatc aatccttact
     1561 acacataaga gaattcacac tggagagaaa ccctacaaat gtgaagaatg tggcaaagct
     1621 tttaaccgat cctcaaatct tactaaacat aagataattc atacaggaga gaaatcttac
     1681 aaatgtgaag aatgtggtaa agcctttaac caatcctcaa ctcttactaa acataggaaa
     1741 attcatacta gacagaaacc ctacaactgt gaagaatgtg acaatacatt taaccagtcc
     1801 tcaaacctta ttaaacaaaa taattcatac tggagagaaa ctctacaaat gtcaagaatg
     1861 tgggaaagcc tttaagcagt cctcaactct tactaagcat taaatattgg ccgggtgcgg
     1921 tggcttatgc aaaatggctc ccagcatttt gggaggctga ggtgggtgga tcacaaggtc
     1981 aagagatcga gaccatcctg gccaacatgg tgaaaccctg tctctactaa aaatacaaaa
     2041 attatctggg tgtggtggca cgtgcctgta ttcccatcta ctcgggaggc ttaggcagga
     2101 taatcacttg aacctgggag gtggaagttg cagtgagcca agattgtacc actgcactcc
     2161 agtttggcaa cagagtgaga ctccgtctca aaaaaaattt atactgtaca aaaaccccac
     2221 aagtgtgaaa aacatggcaa agcctttaag aagccctcaa ttcttaacag acataagata
     2281 atttatactg gagagaaact ctacaaatca gaaagatgtg actacttttg acaacgcctc
     2341 aaacttttct aaccataaaa gtaattatac tggtgagaaa tcctagaaat ctgaagagtg
     2401 agataaagcc tttaaatggt tgtcacactt cattgtaggt aagataattc atactggaga
     2461 aaacgcctac atgtgtgaac aatatggcaa aacttaatgc tcacacttta ttgctaggaa
     2521 agcatttata cttgagataa attatacaaa tataaagact gtgaaaaagc catcattatc
     2581 tgctcacatt ttactcaaca cagagagttc ctgcttaata aaagcattat aagtgcaatt
     2641 actgtcaaaa gatctttcag aaaatataag cttttttagt gaagagtatt tattttgaag
     2701 ttgaacatca caaatataaa aagggttgta gtgcctttac ttgtatcaca gatctttttg
     2761 tagacatttt cttctagagg aaaactctga agcagttgat caaactttgt tcaacatcag
     2821 ggaatttata ttgaaaaatt gtgcaaatat aataaatttg gaaaaacaat ttttcaaaaa
     2881 ctacagctta gaaatcaaca gttatactag aatatatttt ttccagatgc agtaaaagta
     2941 aaatatttaa tccataatta agtctatgca aatatcagag aatttatggt agaaatatat
     3001 aaggtactga cacttcagat atactaaatc agagtgctaa gtatagaaaa tctgaaacta
     3061 aagttggtag aaaagttatt tgtatagaac tttaagagga tcagaaggtt ttttgcagag
     3121 ttataattac attcaaagta tactttattt cttgaaaaat attacagatt ttttgaaaat
     3181 tgaataatgt catcattcaa ctctgaaatt atttcctgtt gtttcttcat tcctattgga
     3241 ttcacatgtg aaagcatggg gttaattgtt gctacatcaa agagagagat tcttttgttt
     3301 gtttgttcgt ttgttttttg agactgagtt tcactctttc gcccaggctg gagtgcattg
     3361 gcatgatctc agctcactac aacctctgcc ttctggtttc aagcaactct tctgcctcag
     3421 catcccaagt agctgggata acaggtgcca gccaccatgc ccagctaatt tgtgtatttc
     3481 tagtagagat ggggtttcac catattggcc aagctggtct tgaactcctg acctcatgtg
     3541 atccgcccgc ctcagcctcc caaagtgctg ggattacagg cttgagccac cacgcccagc
     3601 ctgtagcata ttttaatagg agaatacaat atataatagt agcagggtta agtaaggcat
     3661 ccatcatctg tagcatttct cctttgtttt acaaacaatc caattctaca ctttaaaaaa
     3721 aaatttttaa atgtacaatt aaatttttat ttaccacagt gttattttta tcgtcataat
     3781 aaaaattata tacgagtata aatgaaattc atttctaaat tcttaataaa tattttctca
     3841 tgccaggtgt ggtggctcac gtctgtaatc ccagcacttt gacaggctga gcgagggagt
     3901 ggatcttgag gtcagcagtt cgagaccagc atggccaata tggagaaatc ccgtctctac
     3961 taaaaataca aaaattagcc aggcgtggtg gcatgtgcct gtaatcccag ctactcagga
     4021 ggctgaggca ggagaatcgc ttgaacctgg gaggtggagg ttgcaatgag ccaagatcac
     4081 cccactgcac tccagcctgg gcaacagagc gagactccat ctcaaaaagt aaaatatatt
     4141 ttcaaatttt ctatatattt ttctttgaac atgtggcctg tctgcctgca aacatataca
     4201 gacttttagt tttgattcat atagagttaa atacatgtta gtctaaagac aaatcttagg
     4261 tgtaagaaaa ttatggagtt aagtatgtgt gtgtgagtat gagtttgtac atattttcag
     4321 aaggaaagaa tgatacggga acaaaaatca ttttaatatg gtgactacta taaaactaaa
     4381 aacctaaaaa atgctgaaag caaatgtata ctttttggtt tgtattgaat ttattactgt
     4441 acagtctatg acttagagtt ctgaatcttc ccaagcaaat tctctgtata tacttgcctg
     4501 gtactcatgc tagacccata ctttttttgt ttcttacatt ttttttgttt tatattttat
     4561 gaagtattca ttatgtgagc tggtctgcga ttataagaat ttttatgaaa tttagtgcac
     4621 acaaaataat ctttagatgt aattccaaaa gtagtgtatt aagttacatt ttatttagtt
     4681 agagcactcc attttgttct tttaagagga gaacaatata taggttttct ttagtgattt
     4741 gttcctttca ctttttataa ttgacataag catatttatt gagtcaattt gttcagctaa
     4801 gtactaggga ggcttcatta gtcatgagga tgtttttata tataaatgta gcaaacatat
     4861 attacagttt tcactgtgta atagattatc cataataatt cataaatatt cctgctgaag
     4921 ttagtttgta acttcaagtc aaagatgaaa aatatcaatg gtgaagattg attgttcata
     4981 tagagaggac attttttttc cagactgtaa aactgaatct tgttgaattt aaagagaaat
     5041 tctggcagag gcagatgaat cacctgaggt caggagtttg agaccagcct gatgaatatg
     5101 gtgaaaccca gtctctacta aaactacaaa aatagccagg catggtggtg ggtgcctgta
     5161 atcccactcg ggaggctgag tcaggagaat tgcttgaacc cggaggtgaa gattggagta
     5221 agccaagatt gtgccgttgc actacagcct gggcgacaga gcgagactcc atataaaaaa
     5281 aaaaaaaaaa aaaaaagagc tgggcgtggt ggctcacgcc tgtaatccca gcactttggg
     5341 aggccaaggt gggcgaatca cttgaggtcg ggagtttgag accaggtgac caacatggag
     5401 aaactccatc tctactaaaa aatacaaaat tagcccggtg tggtggcgca tgcctgtaat
     5461 cccagctact cgggagactg aggcaggaga atcgcttgaa cacgacaggt ggaggttgca
     5521 gtgtggcgag attgcaccat tgcactccag tctgggcgac aagagggaaa ctccatctga
     5581 aaaaaaagag aaattctttt attttctact tctcttcaga tttgtcttat gcattttcca
     5641 actatgtatg catcacagct attctttttc tgagttatag ctacagtttt cttactgttg
     5701 tcttcatgcc atttcatttc acatggtact ttgtagattt tgatgaggaa gttggtattt
     5761 ttagtgcaca caaaaattgg ttttaactgt agagtttgct tatcagaaca gttaaaaggc
     5821 agccaggtgt ggctcacgcc tgtaatccca gcactgagat aggccaagga gggtggatca
     5881 cttgaggtca ggagtttgag accagcctga ccaacatggt gaaaccctgt gtctactaaa
     5941 aatacaaatt tagccacgcg tggtgacgca cgcctgtaat cccagctact cggaaggccg
     6001 agggagcaga atcgcttgaa cctgggaggt agaggttgcg gtgagccgag actgggccac
     6061 tgcacttcag cctgggcaac aagagcgaaa ttctgtctaa aaaaaaaaaa aaaagataaa
     6121 aggtgcaata ctgtccacag gtaagataat taaattagtc agctttgttt ttaaaagaaa
     6181 aatcttacta gattcttata caaagtgtgg caaatataaa acttgcttga aaatacagaa
     6241 attaaatttt taagagagtt aatggtaagt aaacaatttt aaagttaatt ttctatgata
     6301 tacttacagc acaacttata tttccatgca gaatctttta tttttaagtg tgagtgttaa
     6361 aggttacaaa ataatgaaat gacttcagtg gatttaaaat tttgaaaaat aatgtctttt
     6421 ctatattgat tttacaattt ggagaaattt ttcactcatt ttttatatat tttttagtgg
     6481 gagaggttta gtctacagtt tttattttta gtcaccaaac tgtagccaac tcttgggtca
     6541 ttttctctga aaaacatttg gagatcatga cagcgtttgg attaaaacat ttctgttact
     6601 ttgcatgcaa actagtttac tgtgttcaca gagtggccag tcatgggacc ataagcaaca
     6661 cctgctcttt gagtgtcttt cataccgtta ccatcagcac cagaaactcc aggtgcccca
     6721 agcttaaagt aaaaatccta aagtacgttg gctcctccca tgcaatgtgc tgggtccaaa
     6781 ccatgctgtt aaatatcaga agtttctatg gttatgatta aaaaattaaa tgacaataat
     6841 agccccaaaa ctatatattt ttgatactat ttaaccaaga ttatcacaaa gacacagtat
     6901 ttgacacatt gttattcttc tatgttttat aaatatttta atgtgacagg tagaatctgt
     6961 actttttctg tagaacgtaa tattttgaag tatatatata gttaaattat tatttctagg
     7021 taattaataa tttatctcac attggtcaga catgatggct catgcttgta atcccagcaa
     7081 tttgggaggc cgaggcaggc agatcacatg aggtcaggag ttcgggacca gcctggcgac
     7141 catggggaaa ccctgtctct actaaaaata caaaataagc agcgtgtggt gacacatgcc
     7201 tgtaatccag ctaccctgga ggctaaggca ggaaaatggc tcaaatctgg gaggtggttg
     7261 ttgcagggag ccgagattgc accactgcac tccagactgg gggacagagt gactatcaaa
     7321 aaaaaaaaaa actttacctc atatggtgaa catttttgtt ttgagaccac atgacactgt
     7381 catcattttt caaaaatcca aatacattat tatgaactat agtcaccatg ttgtgcaata
     7441 aatctcttga acttatttct tccatttgac tataattatg tattatttca caaacatgtt
     7501 tccagccttc catttcttat aaataacttg catctgatgg tcaccatttt actctctaca
     7561 tcaatgggat taagtttttt ggaatccatg tgtaagtgaa attatgagac actaatcttt
     7621 ctgtgccttg cttatcccaa ctaatacaat gtcctccaac ttcatccatg tgattgagaa
     7681 taatagtttt tgtttttttt ttaaggccag gagtggtggc tcacacctgt aatcccagct
     7741 ctgggaggcc aaggccagtg gattgcttga gcccaggagt ttgagaccag cctggacaac
     7801 gtggaaaaac cccatctcta ctaaaaatac aaaaacaaca aaacaaaaac aaaaaacacc
     7861 tcagctgggt gtggtggtgc aggcctgtaa tctcagctac tccagaggct gaggcatgag
     7921 aatcccttga accacagatg cagaggttgc agtgaactga gatcatgcca ctgcactcca
     7981 tcctgggcaa cagagtgaga ctcggtctca agagggaaaa taaggcattt ttctcattta
     8041 aataataaat agtattccat tatgtatatc aaccacattg tctttattta ctcattagat
     8101 gttgaactgt ttattctgta ttttggctat tgtgaaacaa gtgctgcaaa cagaagtgca
     8161 aatgtttctt tattcttatt ttgttttgga tatataccca gtagtgcgat tgctgtatta
     8221 cctggtagtt tttttgataa atctgtattt tgtttttcgt aatggctatc ctcatttacg
     8281 ttcacaccaa cagtgtgcaa ggattccgtt ttcttcacat ctttaccaac acttttttct
     8341 ttttctttta ataagagtta ttctaacagg aatgagttga tatagggatt ttttttttgg
     8401 cttgtctttt tgtgataata gtcaacattg agcatttaaa aatatatccg ttggacatat
     8461 gtatgacttt tcttgaaaaa tatttatttc agctatttcc tttttttttt ttttcttttt
     8521 gagatggagt tttgttcttg ttgcccaggc tggagtgcaa tggcacaatc tcggctcact
     8581 gcaacccttg cctcccggat caagtgattg tcctgcctca gcctctcaag tagctgggat
     8641 tacaggcaaa tgccactgcg cccagctaat tttgtatttt tagtagagac ggggtttttc
     8701 tatattggtc aggctggtct cgaacttctg acctctggtg cccacctcag cctcccaaag
     8761 tgctgagatt acaggcatga gccaccgcgt ccggcctatt atttttaata attttttatt
     8821 gttgtcattt taaatacact tttgatatta acctcttgtc acatgtataa tttgcaaatt
     8881 ttttctccca tgttctagtt gtcacattct gttgattgta tcagattttg tccagcagct
     8941 ttttaatttg aagtgatctg acttattttt ccttttgtgt cctgggatgt ttaggttaaa
     9001 tcaaaaaact tgcggccagg cgcagtggct cacacctgta atcccagcac tttgggaggc
     9061 cgaggcaggt ggatcacgag gtcagaagtt cgagaccagc ctgaccaaca tggtgaaatc
     9121 ctgtctctac taaaaataca aatattagcc gggcgtggtt gcacgtgtct ataatctcag
     9181 ctactcagga ggctgaggca ggggaacggc ttaaacccag aggcggaggt tgtagtgagc
     9241 caaggtcatg ccactgcact ccagccttgg caacagaatg aaactctgtc tcaaaaaaaa
     9301 aaaaaaattt gctgcccaga acaatgttat agggcttttg ctctatattt tggcagtagt
     9361 agtttcagag tgtcaggcct tacatttaag tactaattta tttcgagttt atttttacat
     9421 atggtgtgag atgagggtct caatttttat ctctgcatgt ggatataaag ttttcttaat
     9481 tgaagattct gttctttccc tttaaagtca cctgtattta aaatcaactg taaatacatg
     9541 gatatatttc tgctgttttt ttcttctgct ccattgacct atgtctctgt ttttattcaa
     9601 gtaccatact gttggttacc atagctatgt agtgtatttc aaagttagtc acttcttttg
     9661 tcttgattgc tttggctatt cagggtcttt tgtgatacca tatgaatttt agatatactt
     9721 ttaaaacttt tctatgaagt atatcacgta tttcgataga ggttgcatta tacctgtagg
     9781 tcattttgtg taatacaaat attaatgtca gttcatgaat agtccattta tgtattaatt
     9841 tctatttaga atgtaaggcg tttcaacttt ttggttaaat ttatttcaaa ctatagttat
     9901 tgtagatgta attgtttttg aatttcattt tgggatagtt attaatgtag agaaatgctg
     9961 tgactttttg atggtgcttt tgtattttga aagtttaata aattttgttt atttatttat
    10021 ttattttgag atggagtctc ggtctgtcac gcaggctcga gtgcagtggc acgatcttgg
    10081 ctcactgcaa cctctgcctc cctggctgaa gcggttctcc tgcctcagct tcctaagtag
    10141 ctgaaactac aggcgcctcc tactacaccc agctaatttt tttatttcta tagagatggg
    10201 gtttccctac gttggccaga ctggtcttga actcctgacc ttgtgatccg cccacctcgg
    10261 cctcccaaag tgctggaatt acaggcagga gtcactgcac cttgcctgtt tataattttt
    10321 aagatttact aaggtcttag gcttttttat acttcagatt atgtataggg ataaaagaaa
    10381 attatacagg aataattcct tttcctcaat ttggatgcct ttgatttttt tctctaattt
    10441 ctttgtcttg gatatttagt accatgttta gtaagtctga ctagagtggg catccttgcc
    10501 ttgttctagc tcttagagta aaagcttaca acatatccct gtttagtatg ttgttagcag
    10561 tttttttggt tatatatggc atttattggc tgaagtgcat ttgttctata cctaattttt
    10621 tcagcgattt atcataaggg aatgtcaaat tctgtcaaac ttctattgtg catccatttt
    10681 tttctctttg cactctgcat atatttaagt tttagagatg tgaaatcaca actaattctg
    10741 catacataca aaaaaagtca gagactacta tgaacatctc tatgcctgca aaatagaaaa
    10801 tttggagaaa ataaataaac tcctggaaac atacaacttt ccaggattaa accaggaagg
    10861 aacagaactc ttgaacaggg caaaaatgta taaaatatat aatgaaattg aattaataat
    10921 ttaaaaaacc taccaactat aaggagccct ggattatata aaatcacagc cgaattttaa
    10981 cacatataca gagatgagct ggtattactt ctactgaatg tattactgaa tgtattccaa
    11041 aaaatccagg tggagttcca ccctaactca ttatataaaa tctgtatcgc tgcacgaggt
    11101 ggctcacgcc tgtaatccca gcactttgga aggccgaggt gggcgggtca cctgaggtcg
    11161 ggagtttgag accagcctgc ccaacgtggt gaaaccccat ctctgctaaa atacaaaatt
    11221 agccaggcgt ggtggcatat gtctgtaatc ccagctactc gggaggctga ggcaggaaaa
    11281 tcgcttgaac ccgggaggtg gaggttgcag tgagccgaga tcgcgccatt gcactccagc
    11341 ctaggcaatg agtgaaactc catctcaaaa taaattaatt aataaaataa aaacctgtgt
    11401 catcttgata ccgaagtcta gtgaagacaa caacaacaaa actataggcc aatattttgg
    11461 gtgaacattg aaacaaaaat cctccatgaa ataatagcaa gctgagttca caggcaaatc
    11521 aaaaagttat tttgccacac ttgtgaactt tatatcacat gtgcaaggat gtttcatcat
    11581 atacaagtca ataagtgtgt ttcaccatac aattaaaagc aaaaatttat atgattaaca
    11641 caatagatgc agaaaaagca ttcaagaaaa tccagtattc atttatgaaa atattctcta
    11701 agcaatgatg aaacatacct cacaataata agagccatct atgacaaatc ctcagctaac
    11761 atactgaaca gacaaaaggg gcatgcattt ctcattagaa aaaaaataag actatctaaa
    11821 caattctatt taacatagtt ctggaagtgc tggataaatc taacaaaatg aaaaaataaa
    11881 tggcatccaa ataggaaaag aagaagtgaa attaccttca ctcatgatat aattctctac
    11941 ctagaaaact ttaaggattt taccaaaaga ctcctaaggt taaaaatgac ttcagcaaag
    12001 tctcaggata caaaattgat atacaaaaat gaatagcatt gccttacacc aataacattc
    12061 aagctgagaa caaaatcaag aacagttttc tttacaatag ccataaacaa aaaataatat
    12121 acttagaaat acatcaaacc agggaggtaa aatatctcta caagaactag aaaacattac
    12181 tgaaagtaat cagagacaat tcaaataaaa aagctttcta tgctcatgga tttgaagaat
    12241 gaatagaaaa tgtctatgct gcctagagca gcctacaaaa taagtttttg tttttttatc
    12301 aaaatgtcga ttactttttt tttttttttg agacagtgtt gctctgtggc ctaggctgga
    12361 gtgcagtggt gcgatcttgg ctcactgtaa cctccacctc ctgggttcaa gtgagtctcc
    12421 tacctcagcc tcccaagtag ctgggattac aggtgcccac cagcacacct ggctaatttt
    12481 tatgttttta gtagagatcg agttttgctg tgttggccag gctggtctca aactcccggc
    12541 gtcccaaagt gctgggatta caggtgcgac ccaccatgcc tggcccaacc ccatattatt
    12601 tctggtaaca aagcacagaa acatgatttc tcgaattttg ctaggatttt aatttacaaa
    12661 agaaaggtga atgccattaa aaggtgttta atacactccc accagaaaca agaggcaagg
    12721 caggccctgg gggcctcaca aaggcggtct tatgcaaggg tgagaaagca gagttatcag
    12781 ggaggtggga ctattgcttt atgaacgtga tgattggaag caaaaacgtg gggctttttc
    12841 ctattgaata caaagtaaaa taatgaatgc tggtgtcagt ggttgggaat aacaacattt
    12901 gcaggctcat gagagctgcc tgacaaaaag cgtgtaaaca acagtgattg ctcctgtggc
    12961 cctgtgattc agcaggttta tggagcagtt aagaatcgca gatgtcaaat ggccaacaca
    13021 gaatctaacg acatgcttaa tacaaattat tattagtaga aatgctgaat tgcttcattt
    13081 ctgcaatttc tgctgcttct taagatgctt ttaatgaata aaatctgcct taaaatttga
    13141 tacctggtaa cttctctctg tgagttttga attggctgat gtaaccaaaa tgccagctct
    13201 tgccatctaa ctaccattaa aaggaacttc taaagctccg aagtggtcaa cagtttcact
    13261 tccaactttt ttaaaagata cacaattttc taaaaaattt ttctttatgg gcgattgaat
    13321 agttgggctt tggctaattc ctcattagca atagaattat gtatattttg caaactctaa
    13381 tacagaacac ttaatgtatc agacaaccat gattatgatg tatatacctg gtataaacaa
    13441 tcttttttgc atattgaatt ctgcattttt ttcttccttg atacgtatga gattcaccag
    13501 taccagtttt tctcttgtgg tggcatatag ttgattgtca tttgcattat ctattaaaaa
    13561 cctgtggcag ctcatggtat tattgaccat atgttctagt gtcttcttgc agatttaaat
    13621 attttattgc agtgtaaagt ttaatattta gatgtgtgat acatctttgg ataatctgta
    13681 attaaattga tcttttgtaa tggtgatagt gattagcaca cactgaaaat ccagcaaagc
    13741 aattattttt ctctttttaa ctggaaatca tattcgtaag ttgtggtaga tattatcatc
    13801 agtgtattca tgattcgatt tatattttgt gttatctggt tataaatttt atatagcatt
    13861 caatttgaca aaatataaat ctatttgatt tgaa
//
