LOCUS       NM_025189               3886 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 430 (ZNF430), transcript variant
            1, mRNA.
ACCESSION   NM_025189
VERSION     NM_025189.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3886)
  AUTHORS   Chen,S., Lu,F.F., Seeman,P. and Liu,F.
  TITLE     Quantitative proteomic analysis of human substantia nigra in
            Alzheimer's disease, Huntington's disease and Multiple sclerosis
  JOURNAL   Neurochem Res 37 (12), 2805-2813 (2012)
   PUBMED   22926577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290475.1, DB255551.1 and AC012627.4.
            
            On Nov 22, 2018 this sequence version replaced NM_025189.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.141046.1,
                                           SRR1660805.44872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261560.10/ ENSP00000261560.4
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AK290475.1         38-126
            90-216              DB255551.1         90-216
            217-2282            AK290475.1         254-2319
            2283-3886           AC012627.4         42083-43686
FEATURES             Location/Qualifiers
     source          1..3886
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..3886
                     /gene="ZNF430"
                     /note="zinc finger protein 430"
                     /db_xref="GeneID:80264"
                     /db_xref="HGNC:HGNC:20808"
     exon            1..147
                     /gene="ZNF430"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1857
                     /gene="ZNF430"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 430 isoform 1"
                     /protein_id="NP_079465.3"
                     /db_xref="CCDS:CCDS32978.1"
                     /db_xref="GeneID:80264"
                     /db_xref="HGNC:HGNC:20808"
                     /translation="MENLKSGVYPLKEASGCPGADRNLLVYSFYEKGPLTFRDVAIEF
                     SLEEWQCLDTAQQDLYRKVMLENYRNLVFLAGIAVSKPDLITCLEQGKEPWNMKRHAM
                     VDQPPVTYSHFAQDLWPEQGIKDSFQEVILRRYGKCGHEDLQLRTGCKSVDECNLHKE
                     CYDELNQCLTTTQSEIFQYDKYVNVFYKFSNPNIQKIRHTGKKPFKCKKCDKSFCMLL
                     HLTQHKRIHIRENSYQCEECGKVFNWFSTLTRHRRIHTGEKPYKCEQCGKAFKQSSTL
                     TTHKIIHTGEKPYRCEECGKTFNRSSHLTTHKRIHTGEKPYRCEECGRAFNRSSHLTT
                     HKIIHTGEKPYKCEECGKAFNQSSTLTTHKIIHAGEKPYKCEECGKAFYRFSYLTKHK
                     IIHTGEKFYKCEECGKGFNWSSTLTKHKRIHTGEKPYKCEQCGKAFNESSNLTAHKII
                     HTGEKPYKCEECGKAFNRSPKLTAHKVIHSGEKPYKCEECGKAFNQFSNLTKHKITHI
                     GDTSYKYLECDKAFSQSSTLTKHKVIHTGEKPYNCEEYGKAFNQSSNLIEQSNSYWRE
                     TLQM"
     exon            148..240
                     /gene="ZNF430"
                     /inference="alignment:Splign:2.1.0"
     exon            241..367
                     /gene="ZNF430"
                     /inference="alignment:Splign:2.1.0"
     exon            368..466
                     /gene="ZNF430"
                     /inference="alignment:Splign:2.1.0"
     exon            467..3886
                     /gene="ZNF430"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3862..3867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF430"
                     /note="hexamer: AATAAA"
     polyA_site      3886
                     /gene="ZNF430"
                     /note="major polyA site"
ORIGIN      
        1 gtccctcgct gtggcctgag ctccaggtct cgtcttcagc gctctgtgtc ctctgctcct
       61 agaggtccag gctctgtggc cctgtgaccc gcaggtattg ggagatctac agctaagacg
      121 ccaggaaccc ctggaagcct agaaatggag aacctgaagt ctggagtgta tcctctcaag
      181 gaagcaagtg gatgccctgg ggctgacagg aatcttctgg tgtactcttt ttatgaaaag
      241 gggccattga catttaggga tgtggccata gaattttctc tggaggagtg gcaatgcctg
      301 gacactgctc agcaggattt gtatagaaaa gtgatgttag agaactacag aaacctggtc
      361 ttcttggcag gtattgctgt ttctaagcca gacctgatca cctgtctaga gcaaggaaaa
      421 gagccctgga atatgaagag acatgcgatg gtagatcaac ccccagttac atattctcat
      481 tttgcccaag acctttggcc agagcagggc ataaaagatt ctttccaaga agtcatattg
      541 agaagatatg gaaaatgtgg acatgaagat ttacagttaa gaacaggctg taaaagtgtg
      601 gatgagtgta atctgcacaa agaatgttat gatgaactaa accagtgttt gacaactacc
      661 cagagtgaaa tatttcaata tgataaatat gtgaatgtct tttataaatt ttcaaatcca
      721 aatatacaaa agataagaca tactggaaag aagcctttca aatgtaaaaa atgtgacaaa
      781 tcgttttgca tgcttttaca cctaactcaa cataaaagaa ttcatattag ggaaaattct
      841 taccaatgtg aagaatgtgg taaagtcttt aactggttct caacccttac tagacacaga
      901 agaattcata ctggagagaa accctacaaa tgtgaacaat gtggcaaagc ttttaagcag
      961 tcctcaaccc ttactacaca taagataatt catactggag agaaacccta cagatgtgaa
     1021 gaatgtggca aaacctttaa ccggtcctca caccttacta cacataaaag aattcatact
     1081 ggagagaaac cctacagatg tgaagaatgt ggcagagctt ttaaccggtc ctcacacctt
     1141 actacacata agattattca tactggagag aaaccctaca aatgtgaaga atgtggcaaa
     1201 gcttttaacc aatcctcaac ccttactaca cataagataa ttcatgctgg agagaaacct
     1261 tacaaatgtg aagaatgtgg caaagctttt taccgattct cataccttac taaacataag
     1321 ataattcata ctggagagaa attctacaaa tgtgaagaat gtggcaaagg ctttaattgg
     1381 tcctcgaccc ttactaaaca taaaagaatt catactggag agaaacccta caaatgtgaa
     1441 caatgtggca aagcttttaa tgagtcctca aaccttactg cacataagat aattcatact
     1501 ggagagaaac cctacaaatg tgaagaatgt ggcaaagcct ttaaccggtc cccaaaactt
     1561 actgcacata aggtaattca ttctggagag aaaccctaca aatgtgaaga atgtggcaaa
     1621 gcttttaacc aattctcaaa ccttactaaa cataagataa ctcatattgg agatacatct
     1681 tacaaatacc tagaatgtga taaagccttt agccagtctt caactcttac taaacataag
     1741 gtaattcata ctggagagaa accctacaac tgtgaagaat acggcaaagc tttcaaccag
     1801 tcctcaaacc ttattgaaca aagtaattca tactggagag aaaccctaca aatgtgaaga
     1861 ttgtggcaaa gcctctaacc cgtcctgaat tcttactaaa cataagaaca ttcatactga
     1921 agaggaaccc tatgagtgtg aagaatatgg caaagccttc aacaagtcct caattcttac
     1981 cagacataag ataattctgg ctgggtgcgg tggctcacac ctgtaatccc agcactttgg
     2041 gaggctgaga cgggtgaatt acatgaggtt gggagttcga gaccagcctg accaacatgg
     2101 tgaaatcctg tctctactaa aaatacaaaa ttagccatgc gtagtggtgc atgcctgtaa
     2161 tcccagctac tcgggaggct gaggcaggag aattgcttga acccgggagg cagaggttga
     2221 agtgagctga gatcgcgcca ttgcactcca gcctgggcaa caagagtggc actccatctc
     2281 agaaaaaaaa aaaaaagata attcatactg aaaagaaact ctacaaactt gaaagatgtg
     2341 acagtgcttt tgacaacacc taaaactttt aaacataaaa aatcatactg gtgagaaatc
     2401 ctagaaatgt aaagaatgtg acaaggcctt taaatggttg tcacacttca ttataggtaa
     2461 gatagttcat actgaagaaa acttctacaa gtgtgaacag tgtggcaaaa cttttaatga
     2521 atgctcacac cttattgcac aggagagcat ttatacttga aaaaaattgt acaaatataa
     2581 agaccatgaa aaagccatta atatctattc acatcttacc actggagagt tcatacttaa
     2641 taaaaggaat ataagtgcaa ttactgtcaa aagatctttc agaaaatata aacctttaaa
     2701 gcgaagaagg tatttatttt gaagatgaac actacaaatg tgaagagggt tgtagtacct
     2761 ttatttgtat cacagatttt attgtacaca ttttgtacta gaagaaaact ctgaagtagt
     2821 tgctcaaact ttgttcaaca tcagggaatt tatattgaag aaaaactttg caaatttaat
     2881 aaattttaaa aaacactttt tcaaaaagta cagcttagaa gacaccagag ttcatactaa
     2941 aatatatttt tgcagatgca gtaaaaatga aaatatttaa tccaaaatta agtctatgta
     3001 aatatcagag aatttactgt agaaatatat aaggcactga gacttcagat attatactaa
     3061 atcagagtgc tgagtataga aaataaaact gaagttgggg ccaggtgcag tggctcacac
     3121 ctgtaatcca gcactttggg aggccgagaa gggtggatca cctgaggtca ggagtttgag
     3181 accagcctga ctaacatgga gaaaacacgg ctctactaaa aatacaaaat tagccagctg
     3241 tggtggtgta tgcctgtaat cacagctact cgagaggctg aggcaggaga attgcttgaa
     3301 cccgggaggt ggagagtgca gtgaactgaa attgcgccat tgcactccag cctgggcaac
     3361 aagagtgaaa ctccatttca aaaaaaaaaa aaaaaaaaca actaaagttg gtagaaaaat
     3421 tatttgtata taactttaaa aggagtagaa gggctttttg cagagttatt acgtttgaag
     3481 tatactttat ttcttgaaaa aattacagat tttttgtaaa taatgatgta attcaactct
     3541 caaaatattt cctactgttt ctttattcca gttgtattca catgtgaaag catgtgatca
     3601 gttattgctg cattaaaaac atgagtcttt tttattaggt ggccattatt tatgatcttt
     3661 tctatgaaag agtaaggaca ttaaaatgta agatgcatga tgaaaaatta agtgaagagg
     3721 ctctttatgg ttaatttata ttgaataatg cattaggtag gtgttcagag taatattttg
     3781 cgttgtgaga acatttttaa ttttatttaa aattaaatga aaataaatta gtatattatt
     3841 gtactaattg tacttttgta taataaaatc cagtgtattt taaaaa
//
