LOCUS       NM_003423               5235 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens zinc finger protein 43 (ZNF43), transcript variant 4,
            mRNA.
ACCESSION   NM_003423
VERSION     NM_003423.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5235)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   2  (bases 1 to 5235)
  AUTHORS   Takahashi,T., Furuchi,T. and Naganuma,A.
  TITLE     Endocytic Ark/Prk kinases play a critical role in adriamycin
            resistance in both yeast and mammalian cells
  JOURNAL   Cancer Res 66 (24), 11932-11937 (2006)
   PUBMED   17178891
  REMARK    GeneRIF: Human embryo kidney cells that overexpressed AAK1 are
            adriamycin resistant
REFERENCE   3  (bases 1 to 5235)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   4  (bases 1 to 5235)
  AUTHORS   Bellefroid,E.J., Marine,J.C., Ried,T., Lecocq,P.J., Riviere,M.,
            Amemiya,C., Poncelet,D.A., Coulie,P.G., de Jong,P., Szpirer,C. et
            al.
  TITLE     Clustered organization of homologous KRAB zinc-finger genes with
            enhanced expression in human T lymphoid cells
  JOURNAL   EMBO J 12 (4), 1363-1374 (1993)
   PUBMED   8467795
REFERENCE   5  (bases 1 to 5235)
  AUTHORS   Lovering,R. and Trowsdale,J.
  TITLE     A gene encoding 22 highly related zinc fingers is expressed in
            lymphoid cell lines
  JOURNAL   Nucleic Acids Res 19 (11), 2921-2928 (1991)
   PUBMED   1711675
REFERENCE   6  (bases 1 to 5235)
  AUTHORS   Bellefroid,E.J., Poncelet,D.A., Lecocq,P.J., Revelant,O. and
            Martial,J.A.
  TITLE     The evolutionarily conserved Kruppel-associated box domain defines
            a subfamily of eukaryotic multifingered proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3608-3612 (1991)
   PUBMED   2023909
REFERENCE   7  (bases 1 to 5235)
  AUTHORS   Huebner,K., Druck,T., Croce,C.M. and Thiesen,H.J.
  TITLE     Twenty-seven nonoverlapping zinc finger cDNAs from human T cells
            map to nine different chromosomes with apparent clustering
  JOURNAL   Am J Hum Genet 48 (4), 726-740 (1991)
   PUBMED   2014798
REFERENCE   8  (bases 1 to 5235)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX471947.1, BC006528.2 and AC092364.3.
            
            On Jun 2, 2019 this sequence version replaced NM_003423.3.
            
            Summary: This gene belongs to the C2H2-type zinc finger gene
            family. The zinc finger proteins are involved in gene regulation
            and development, and are quite conserved throughout evolution. Like
            this gene product, a third of the zinc finger proteins containing
            C2H2 fingers also contain the KRAB domain, which has been found to
            be involved in protein-protein interactions. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (4) differs in the 5' UTR and
            initiates translation at an alternate start codon, compared to
            variant 1. The encoded isoform (2) is longer and has a distinct
            N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.83975.1,
                                           SRR1660807.55985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267762, SAMN03267768
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354959.9/ ENSP00000347045.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BX471947.1         28-34
            8-2719              BC006528.2         1-2712
            2720-5235           AC092364.3         166379-168894       c
FEATURES             Location/Qualifiers
     source          1..5235
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..5235
                     /gene="ZNF43"
                     /gene_synonym="HTF6; KOX27; ZNF39L1"
                     /note="zinc finger protein 43"
                     /db_xref="GeneID:7594"
                     /db_xref="HGNC:HGNC:13109"
                     /db_xref="MIM:603972"
     exon            1..147
                     /gene="ZNF43"
                     /gene_synonym="HTF6; KOX27; ZNF39L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2574
                     /gene="ZNF43"
                     /gene_synonym="HTF6; KOX27; ZNF39L1"
                     /note="isoform 2 is encoded by transcript variant 4; zinc
                     finger protein 39-like 1 (KOX 27); zinc finger protein
                     KOX27; zinc finger protein HTF6"
                     /codon_start=1
                     /product="zinc finger protein 43 isoform 2"
                     /protein_id="NP_003414.2"
                     /db_xref="CCDS:CCDS12413.2"
                     /db_xref="GeneID:7594"
                     /db_xref="HGNC:HGNC:13109"
                     /db_xref="MIM:603972"
                     /translation="MGPLTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLG
                     IAVSKPDLITCLEQEKEPWEPMRRHEMVAKPPVMCSHFTQDFWPEQHIKDPFQKATLR
                     RYKNCEHKNVHLKKDHKSVDECKVHRGGYNGFNQCLPATQSKIFLFDKCVKAFHKFSN
                     SNRHKISHTEKKLFKCKECGKSFCMLPHLAQHKIIHTRVNFCKCEKCGKAFNCPSIIT
                     KHKRINTGEKPYTCEECGKVFNWSSRLTTHKKNYTRYKLYKCEECGKAFNKSSILTTH
                     KIIRTGEKFYKCKECAKAFNQSSNLTEHKKIHPGEKPYKCEECGKAFNWPSTLTKHKR
                     IHTGEKPYTCEECGKAFNQFSNLTTHKRIHTAEKFYKCTECGEAFSRSSNLTKHKKIH
                     TEKKPYKCEECGKAFKWSSKLTEHKLTHTGEKPYKCEECGKAFNWPSTLTKHNRIHTG
                     EKPYKCEVCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKK
                     PYKCEECGKAFKWSSKLTEHKITHTGEKPYKCEECGKAFNHFSILTKHKRIHTGEKPY
                     KCEECGKAFTQSSNLTTHKKIHTGEKFYKCEECGKAFTQSSNLTTHKKIHTGGKPYKC
                     EECGKAFNQFSTLTKHKIIHTEEKPYKCEECGKAFKWSSTLTKHKIIHTGEKPYKCEE
                     CGKAFKLSSTLSTHKIIHTGEKPYKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECG
                     KAFNYSSHLNTHKRIHTKEQPYKCKECGKAFNQYSNLTTHNKIHTGEKLYKPEDVTVI
                     LTTPQTFSNIK"
     exon            148..274
                     /gene="ZNF43"
                     /gene_synonym="HTF6; KOX27; ZNF39L1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..373
                     /gene="ZNF43"
                     /gene_synonym="HTF6; KOX27; ZNF39L1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..5235
                     /gene="ZNF43"
                     /gene_synonym="HTF6; KOX27; ZNF39L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2834..2839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF43"
                     /gene_synonym="HTF6; KOX27; ZNF39L1"
                     /note="hexamer: AATAAA"
     polyA_site      2855
                     /gene="ZNF43"
                     /gene_synonym="HTF6; KOX27; ZNF39L1"
                     /note="major polyA site"
     regulatory      3549..3554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF43"
                     /gene_synonym="HTF6; KOX27; ZNF39L1"
                     /note="hexamer: ATTAAA"
     polyA_site      3570
                     /gene="ZNF43"
                     /gene_synonym="HTF6; KOX27; ZNF39L1"
     regulatory      5202..5207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF43"
                     /gene_synonym="HTF6; KOX27; ZNF39L1"
                     /note="hexamer: AATAAA"
     polyA_site      5235
                     /gene="ZNF43"
                     /gene_synonym="HTF6; KOX27; ZNF39L1"
                     /note="major polyA site"
ORIGIN      
        1 gtctctggct gcagttggag ctctgcgtct cgtcttcgtt cttctgtgtc ctctgctgct
       61 agaggtccag cctctgtggc tctgtgacct gcgggtattg ggggatccac agctaagacg
      121 ccaggacccc ccggaagcct agaaatggga ccattgacat ttatggatgt ggccatagaa
      181 ttctgtctgg aggagtggca atgcctggac attgcacagc agaatttata taggaatgtg
      241 atgttagaga actacagaaa cctggtcttc ctgggtattg ctgtctctaa gccagacctg
      301 atcacctgtc tggagcaaga aaaagagcct tgggagccta tgaggagaca tgaaatggta
      361 gccaaacccc cagttatgtg ttctcatttt acccaagact tttggccaga gcagcatata
      421 aaagatcctt tccaaaaagc gacactgaga agatataaaa actgtgaaca taaaaatgta
      481 catttaaaaa aagaccataa aagtgtggat gagtgtaagg tgcacagagg aggttataat
      541 ggatttaacc aatgtttgcc agctacccag agcaaaatat ttctatttga taaatgtgtg
      601 aaagcctttc ataaattttc aaattcaaac agacataaga taagccatac tgaaaaaaaa
      661 cttttcaaat gcaaagaatg tggcaaatca ttttgcatgc ttccacatct agctcaacat
      721 aaaataattc ataccagagt gaatttctgc aaatgtgaaa aatgtggaaa agcttttaac
      781 tgcccttcaa tcatcactaa acataagaga attaatactg gagagaaacc ctacacatgt
      841 gaagaatgtg gcaaagtctt taattggtcc tcacgcctta ctacacataa aaaaaattat
      901 actagataca aactctacaa atgtgaagaa tgtggcaaag cttttaacaa gtcctcaatc
      961 cttactaccc ataagataat tcgcactgga gagaaattct acaaatgtaa agaatgtgcc
     1021 aaagctttta accaatcctc aaaccttact gaacataaga aaattcatcc tggagagaaa
     1081 ccttacaaat gtgaagaatg tggcaaagcc tttaactggc cctcaactct tactaaacat
     1141 aagagaattc atactggaga gaaaccctac acatgtgaag aatgtggcaa agcctttaac
     1201 cagttctcaa accttactac acataagaga atccatactg cagagaaatt ctataaatgt
     1261 acagaatgtg gtgaagcttt tagccggtcc tcaaacctta ctaaacataa gaaaattcat
     1321 actgaaaaga aaccctacaa atgtgaagaa tgtggcaaag cttttaagtg gtcctcaaag
     1381 cttactgaac ataagttaac tcatactgga gagaaaccct acaaatgtga agaatgtggc
     1441 aaagccttta actggccctc aacccttact aaacataaca gaattcatac tggagagaaa
     1501 ccctacaaat gtgaagtatg tggcaaagcc tttaaccagt tctcaaacct tactacacat
     1561 aagagaattc atactgcaga aaaaccgtac aaatgtgaag aatgtggcaa agcttttagc
     1621 cggtcctcaa accttactaa acataagaaa attcacattg aaaagaaacc ctacaaatgt
     1681 gaagaatgtg gcaaagcttt taagtggtcc tcaaagctta ctgaacataa gataactcat
     1741 actggagaga aaccctacaa atgtgaagaa tgtggcaaag cttttaacca tttctcaatc
     1801 cttaccaaac ataagaggat tcatactgga gagaaaccct acaagtgtga agaatgtggc
     1861 aaagctttta cccaatcctc aaaccttact acacataaga aaattcatac tggagagaaa
     1921 ttctacaaat gtgaagaatg tggcaaagct tttacccaat cttcaaacct tactacacat
     1981 aaaaaaattc atactggagg aaaaccctac aaatgtgaag aatgtggcaa agcttttaac
     2041 cagttctcaa ctcttactaa acataagata attcacactg aggagaaacc ctacaaatgt
     2101 gaagaatgtg gcaaagcctt taagtggtcc tcaaccctta ctaaacataa gataattcat
     2161 actggagaga aaccctacaa atgtgaagaa tgtggcaaag cttttaaact gtcctcaacc
     2221 ctttctacac ataagattat tcatactgga gagaaaccct acaaatgtga aaaatgtggc
     2281 aaagctttta accgatcctc aaaccttatt gaacataaga aaattcatac tggagagcaa
     2341 ccctacaaat gtgaagaatg tggcaaagca tttaactatt cctcacacct taatacacat
     2401 aagagaattc atactaaaga gcaaccctac aaatgtaaag aatgtggcaa agctttcaac
     2461 caatattcaa accttactac acataacaaa attcatactg gagagaaact ctacaaacct
     2521 gaagatgtga cagtgatttt gacaacacct caaacttttt caaacataaa ataaattata
     2581 ctggtgagaa attctagaaa tgtaaagaat gtgataaagg ctttacatgg ttgtcacact
     2641 tgattgtagg taagataatt tacattggag taaacttcta caagtgtgaa gaatgtggca
     2701 aaacttttaa ttaatgctcg taccttattg cacaggaaag aatttttact tggaaaaagg
     2761 tatatacaca aagaatgtgg aaaagccatt aatatgtgct catatcttac tcaacatcag
     2821 agagtctgta cttaataaaa ccattataga tgcaactagt gtcaaaagat ctttcagaaa
     2881 ataaaagcct ttaaagtgaa gaagataatt cattctgaag acaaacatta caaatattaa
     2941 gagggttgta gtaccattac ttgcatcaca gatcttattg tacacatttt gtactaaaga
     3001 aaaccctgaa gcagttgctc aaatactgtt caacatcaga aaatttatat tggaaaaaac
     3061 ccctggaaaa tgtaataaat ttgtaaaaac agttttgaaa aactacagct tataaaacat
     3121 gagggtctat aatgcttggt tgatagtaca aagtttattc aacatcaggg aatttatatt
     3181 ggagaaaaac cctacaaatg taatcagttt ggaaaaacat ttttaaaaaa accacagcat
     3241 agaaaacacc acagggttca tactaaaata tgtttttgca gatgcagtaa aaatgaaaaa
     3301 aatttaatcc gaaattaagt ttatgtaaat atctgagaat tcacagtaga aatatctaag
     3361 gcgcggacac ttcagacatt acactaaatc agtgctaagt acagaaaaca acacaaaata
     3421 aaacttggtg gataaattat ttgtatataa cattaaaaga agtagaagat tttcagttat
     3481 aattacaatt aaagtatact tttatcttga aaaaattact gatttttaaa ttagtgaata
     3541 atgatgtaat taaactctca aataacttta tgctcttttt tcattcctgc tatattcaca
     3601 tgtgaaagca tgtgaccaat tgttgctgca ccaaagatat gagagattct tttattaggt
     3661 gggcattatt taaaacattt tttatggaac agtaaggata ttaaagtgta agatgcagcc
     3721 aggcatggtg gctcatgcct ataatcccag cactttggga ggctgaggcc ggtggatcac
     3781 ctgaggtcag gagtttgaga ccagcctgac caacatggtg aaaccctgtc tttactaaaa
     3841 atacaaaaat ttaccaggca cctataatcc cagctacttc aaaggctgaa gcaggagaat
     3901 cacttgaacc tggaaagtgg aggtctcagt gagccgaaat cataccattg cactccaacc
     3961 tgggcaacaa aagtcaaact ccatctcaaa aagaaaaaaa aaaaaaaaaa agatgcgtga
     4021 tgaaaatgta actggagagg ctctttgtgg ttaacttata aaggagtgat gcaggagata
     4081 ggttttcaga gtaatattct tctgcattat agtgacaaaa gttttttatt ttagttaaaa
     4141 ttggttaaat tagtaagtca ttttacttat tgtaatttta tgtaattaaa tgtacatttt
     4201 taaattttta gattacatgt aaatataact tttaaaaaaa tgtgttaaga ccattgtaca
     4261 ttcaatgaag cattattatg cttctaactt taacctattt caccttactc aagagtgtat
     4321 gtaaaagatg gtaacaatat actatttggt aacataatgg actaacattt ctattaatct
     4381 atttcaccag tggctttcaa ctgcaaataa gttaaagaat atttttctat aggttaaata
     4441 ttcttttttg tcttatttaa acttactgtt cttaatttct gtgggtacat agtatgattt
     4501 taattacctt attttattct ttgtgctatt cataattttt tttgtttgtt tggttttttt
     4561 ttttgagaca gagtcttgct ctcgcccagg ctggagtgca gtggcgcgat cttggctcac
     4621 tgcaagctcc gcctcccagg ttcactccat tctcctgcct cagcctccca agtagctggg
     4681 accacaggcg cccactactt gtttgggttt ttttttggag atggagtctc gctctgtcac
     4741 ccaggctgga gtacagtggc atgatcttgg ctcactgcaa cccccacctc cccggttcaa
     4801 gtgattctcc tgcctcagcc tcccgaatag ctgggattac aggcgtccac catcacacca
     4861 ggctaatttt tgtattttta gtagagatgg agtttcacca tgttggccag gatggtctcg
     4921 atcttctgac ctcatgatct gcctgcctcg gcctcccaga gttctgggac cacaggcatg
     4981 agccactgca cctggccaaa tgtgtatata tttatgcaat atataacatg ttttgataca
     5041 ggcatataat atgtattagt cacatcagga taaagtatct attaccttca gcatttatcc
     5101 tttgtattac aagccaattc tacacttcat tattttaatg tacaattaaa ttgttattga
     5161 ctacagggtc attttaatta taaaaattat atagaagtat aaataaagtc catacattcc
     5221 tgagtcatga ataaa
//
