LOCUS       NM_024106               7104 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 426 (ZNF426), transcript variant
            1, mRNA.
ACCESSION   NM_024106 XM_005260075
VERSION     NM_024106.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7104)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 7104)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7104)
  AUTHORS   Blandin,G., Marchand,S., Charton,K., Daniele,N., Gicquel,E.,
            Boucheteil,J.B., Bentaib,A., Barrault,L., Stockholm,D., Bartoli,M.
            and Richard,I.
  TITLE     A human skeletal muscle interactome centered on proteins involved
            in muscular dystrophies: LGMD interactome
  JOURNAL   Skelet Muscle 3 (1), 3 (2013)
   PUBMED   23414517
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7104)
  AUTHORS   Yang,Z., Wen,H.J., Minhas,V. and Wood,C.
  TITLE     The zinc finger DNA-binding domain of K-RBP plays an important role
            in regulating Kaposi's sarcoma-associated herpesvirus RTA-mediated
            gene expression
  JOURNAL   Virology 391 (2), 221-231 (2009)
   PUBMED   19592062
  REMARK    GeneRIF: These findings suggest that the DNA-binding activity of
            K-RBP plays an important role in repressing viral promoter
            activity.
REFERENCE   5  (bases 1 to 7104)
  AUTHORS   Yang,Z., Yan,Z. and Wood,C.
  TITLE     Kaposi's sarcoma-associated herpesvirus transactivator RTA promotes
            degradation of the repressors to regulate viral lytic replication
  JOURNAL   J Virol 82 (7), 3590-3603 (2008)
   PUBMED   18216089
  REMARK    GeneRIF: It was found that herpesvirus 8 RTA can induce K-RBP
            degradation through the ubiquitin-proteasome pathway and that two
            regions in RTA are responsible.
REFERENCE   6  (bases 1 to 7104)
  AUTHORS   Yang,Z. and Wood,C.
  TITLE     The transcriptional repressor K-RBP modulates RTA-mediated
            transactivation and lytic replication of Kaposi's
            sarcoma-associated herpesvirus
  JOURNAL   J Virol 81 (12), 6294-6306 (2007)
   PUBMED   17409159
REFERENCE   7  (bases 1 to 7104)
  AUTHORS   Wang,S., Liu,S., Wu,M.H., Geng,Y. and Wood,C.
  TITLE     Identification of a cellular protein that interacts and synergizes
            with the RTA (ORF50) protein of Kaposi's sarcoma-associated
            herpesvirus in transcriptional activation
  JOURNAL   J Virol 75 (24), 11961-11973 (2001)
   PUBMED   11711586
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP245135.1, BC001791.1 and
            AC008567.5.
            
            On Nov 23, 2018 this sequence version replaced NM_024106.2.
            
            Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) can be
            reactivated from latency by the viral protein RTA. The protein
            encoded by this gene is a zinc finger transcriptional repressor
            that interacts with RTA to modulate RTA-mediated reactivation of
            KSHV. While the encoded protein can repress KSHV reactivation, RTA
            can induce degradation of this protein through the
            ubiquitin-proteasome pathway to overcome the repression. Several
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.183926.1, BC001791.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253115.7/ ENSP00000253115.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BP245135.1         1-18
            19-2336             BC001791.1         1-2318
            2337-7104           AC008567.5         110705-115472       c
FEATURES             Location/Qualifiers
     source          1..7104
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..7104
                     /gene="ZNF426"
                     /gene_synonym="K-RBP"
                     /note="zinc finger protein 426"
                     /db_xref="GeneID:79088"
                     /db_xref="HGNC:HGNC:20725"
     exon            1..71
                     /gene="ZNF426"
                     /gene_synonym="K-RBP"
                     /inference="alignment:Splign:2.1.0"
     exon            72..158
                     /gene="ZNF426"
                     /gene_synonym="K-RBP"
                     /inference="alignment:Splign:2.1.0"
     exon            159..307
                     /gene="ZNF426"
                     /gene_synonym="K-RBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..1947
                     /gene="ZNF426"
                     /gene_synonym="K-RBP"
                     /note="isoform 1 is encoded by transcript variant 1; KSHV
                     RTA binding protein; CTC-543D15.7"
                     /codon_start=1
                     /product="zinc finger protein 426 isoform 1"
                     /protein_id="NP_077011.1"
                     /db_xref="CCDS:CCDS12215.1"
                     /db_xref="GeneID:79088"
                     /db_xref="HGNC:HGNC:20725"
                     /translation="MAAADLSHGHYLSGDPVCLHEEKTPAGRIVADCLTDCYQDSVTF
                     DDVAVDFTQEEWTLLDSTQRSLYSDVMLENYKNLATVGGQIIKPSLISWLEQEESRTV
                     QGGVLQGWEMRLETQWSILQQDFLRGQTSIGIQLEGKHNGRELCDCEQCGEVFSEHSC
                     LKTHVRTQSTGNTHDCNQYGKDFLTLCEKTSTGEKLSEFNQSEKIFSLTPNIVYQRTS
                     TQEKSFECSHCGKSFINESYLQAHMRTHNGEKLYEWRNYGPGFIDSTSLSVLIETLNA
                     KKPYKCKECGKGYRYPAYLSIHMRTHTGEKPYECKECGKAFNYSNSFQIHGRTHTGEK
                     PYVCKECGKAFTQYSGLSMHVRSHSGDKPYECKECGKSFLTSSRLIQHIRTHTGEKPF
                     VCVECGKAFAVSSNLSGHLRTHTEEKACECKICGKVFGYPSCLNNHMRTHSAQKPYTC
                     KECGKAFNYSTHLKIHMRIHTGEKPYECKQCGKAFSHSSSFQIHERTHTGEKPYECKE
                     CGKAFTCSSSFRIHEKTHTEEKPYKCQQCGKAYSHPRSLRRHEQIH"
     exon            308..399
                     /gene="ZNF426"
                     /gene_synonym="K-RBP"
                     /inference="alignment:Splign:2.1.0"
     exon            400..526
                     /gene="ZNF426"
                     /gene_synonym="K-RBP"
                     /inference="alignment:Splign:2.1.0"
     exon            527..607
                     /gene="ZNF426"
                     /gene_synonym="K-RBP"
                     /inference="alignment:Splign:2.1.0"
     exon            608..690
                     /gene="ZNF426"
                     /gene_synonym="K-RBP"
                     /inference="alignment:Splign:2.1.0"
     exon            691..7104
                     /gene="ZNF426"
                     /gene_synonym="K-RBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7081..7086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF426"
                     /gene_synonym="K-RBP"
                     /note="hexamer: AATAAA"
     polyA_site      7104
                     /gene="ZNF426"
                     /gene_synonym="K-RBP"
                     /note="major polyA site"
ORIGIN      
        1 ccttttgtga cgccggctgt gagcgcctga gagtcttttt gcctttcaga gttaaggcct
       61 cactggcctg ggaaaataat tgctgccttt tgcatccgcg ttggctccgt ccccaggatc
      121 ttcccggttc agggacctgg cgatttctga gtgttccgga atcccaataa ccctgtttaa
      181 agaggaatgg agattgccac tgtccattta gattaatgag gtgtcctgaa gtgatggtga
      241 catcaatgaa aggagggttc tgacacgttc tcacctcgcg ggatggcagc tgctgatttg
      301 tcccatggac attatctttc tggggaccca gtttgccttc atgaagaaaa gacaccagca
      361 ggaagaatag tggctgactg cctaacagat tgttatcagg attcagtgac ctttgacgat
      421 gtggctgtgg acttcaccca ggaggagtgg actttactgg actcaactca gagaagcctc
      481 tacagtgacg tgatgctgga gaactacaag aacctggcca cagtaggagg tcagatcatc
      541 aaacccagtc taatctcttg gttggaacaa gaagagtcaa ggacagttca gggaggagtt
      601 ctccaaggat gggaaatgcg acttgaaacc cagtggtcta tacttcagca ggactttttg
      661 aggggtcaga catccattgg gatacaattg gaaggaaaac acaatggaag ggaactctgt
      721 gactgtgagc aatgtggaga agtcttcagt gaacactcat gccttaagac gcacgtgaga
      781 actcaaagta cagggaacac tcatgactgt aatcagtatg gaaaagattt ccttaccctg
      841 tgtgagaaaa cctctactgg tgagaaactt tctgagttta atcagagtga aaaaatcttc
      901 agcctgacac caaatattgt ataccagaga actagcacac aagaaaagtc atttgaatgt
      961 agtcactgtg gaaaatcctt cattaatgag tcataccttc aggcacatat gagaactcac
     1021 aatggagaaa aactctacga atggaggaat tatgggccag gttttattga ctctacaagc
     1081 ctttctgtgc ttatagaaac cctcaatgca aaaaagccct acaaatgtaa ggaatgtgga
     1141 aaaggctata gatacccagc ctacctcagt attcacatgc gaacccacac tggggagaaa
     1201 ccatatgaat gtaaggaatg tgggaaagcc ttcaattatt ccaactcatt tcagatacat
     1261 ggaagaactc acactggaga gaaaccctat gtatgtaagg aatgtgggaa agccttcact
     1321 cagtactcgg gccttagtat gcatgtacga tctcacagtg gagacaagcc ctatgaatgt
     1381 aaggaatgtg ggaaatcctt ccttacatcc tcacgcctta ttcaacatat aagaactcac
     1441 actggagaga agccttttgt atgtgttgaa tgtgggaaag cctttgcagt ttcctcaaat
     1501 cttagtggac atttgagaac tcacactgaa gagaaggcct gtgagtgtaa gatatgtggg
     1561 aaagtatttg ggtatccctc atgtcttaat aatcacatgc gaacgcacag tgcccagaaa
     1621 ccatacacct gtaaggaatg tgggaaggct tttaactatt ccacccacct taaaattcac
     1681 atgcgaatcc acactggaga aaaaccctat gagtgtaaac aatgtggaaa ggccttcagt
     1741 cattccagtt catttcaaat acatgaaagg actcacactg gagagaaacc ctatgaatgc
     1801 aaggagtgtg ggaaagcctt cacgtgttcc agttccttta gaattcatga aaaaactcac
     1861 acagaagaga aaccctataa atgtcagcaa tgcgggaaag cttacagtca tccccgttca
     1921 cttcgaagac atgaacaaat tcactagtga gaaactgtcc atgtaataaa tgtgggaaag
     1981 ctctcatttg ttccagttca ctttaaagac atgaatgaac tcactctgga gagaagaagc
     2041 tgcatgaaaa ttacttaatt cctgtaatcc cagcattttg agaggctgag gtgggtggat
     2101 cacttgaggt caggagtttg agaccaccct ggccaacatg gtgaaacctt gtctctactg
     2161 aaaatacaaa aaatttagcc aggtgtggtg ggcacctgta atcccagcta cttgggaggc
     2221 tgaggcaagt gaatcacttg aacccaggaa gcagaggttg cagtgagcag agatcatgcc
     2281 actgcactcc agcctgggcg atggagtgag actccatctc aaaaaaaaaa aaaaaagaaa
     2341 attatttgat taaattgagt ctgttagagt acatccctaa tccaatatga ttggtgtccc
     2401 tataagaaga gaaagacaca actgagacaa caaatagaag atgatgtgaa gtcatcagat
     2461 gatggccatc tgcaagccaa agacagagca ctgggacaga tccttctatc aaagccacca
     2521 accctgctgg caccttcatc ttgggcttcc agaactttga acaaataaaa ttctcttgtt
     2581 tgagccaccc agtctgtggt attttgttgt ggtggctcta gcaagtgaat acagtaagca
     2641 ataagcaaaa acgtttatag attgtccaaa agccttaata ttcacatgca aagccacact
     2701 ggagagaaac tatatgaatg taagacgtgg gagagccttc attgagtctt cagtcctttc
     2761 tacatacagg agaaatcaca taggagagaa attgtatgaa tgtaaggagc atgaaaaagc
     2821 ctgtgaatgt tcactatatt ttaatattca catgcaagtt gtctggtcgt agaccatgtg
     2881 aaaatagagg agaaaaaagg aaagaaagtt tcttttactg tgaacgcaag gaatgtgacc
     2941 ccatacacca tactggaact tggagtggac tgaaatccca ttaggattgt ggaaaagctt
     3001 acattaatgt tttctacctt ctagaaggtg taagaagtcg aactggagag aagcctttta
     3061 cctgtaatgc atgtaggaag ccttacatta attccacaga atttttttta cacatgtaaa
     3121 attacctcag aaccctggga aggtaaggaa tatggtataa cctttaaata tttcacatgc
     3181 cataataagt acatgaattc tgataatact gtaccgtttc ttgagtagtg ttagtacctt
     3241 atactatcaa aataatccta aatcctccct ctcagacctt ccatcattac tatatttcac
     3301 ttttatgcct ataaacacac acaaattagc atatgtaatc taatacattg tagctatttt
     3361 tcagaagtta tcagatcaat taagtattag aaaaataaac atttttattt taccttcact
     3421 tcttccttct atgctcaaag ttggatgtaa ttcttatact tgatcctcaa tacttaaagc
     3481 atttcccccc ctctggcttc tatgaaaatt ttttgttatc tttgatattc tgttattttt
     3541 aaatgatatg cctaggtata ggtttttggt gctcgtcctt cttggtgttt gcttagcctc
     3601 ctggatttgc gttttggtgt ctgagttaat tttgagaaat tctgtcattg tttccctttt
     3661 tttttctttc catctggtat ttcctttata tgtaggatac atcttttgta gttatcccac
     3721 agttcttata tcttgttttt ttattcttct ctttgctttt caggtgtgga tgtttctgct
     3781 gatatattct caagctcttt agttggctgt ttcttggcca ataataagcc taccaaagac
     3841 attcttcatt tctgttacac tgtcttcaat ttctagcatt tctttgtggt tcttagaatt
     3901 tccatctctg tgtttacact gcctgtctgt tcttggatgc tgtctgcttt atccagtaga
     3961 acccatggca tatcaatcat aattgtttta aattcccagt ctgataattt cagcaatcct
     4021 gctatatctg gttctggttc ttactctttc tctttaaact aacttttgcc ttttagtatg
     4081 cttgtaattt ttccttagct ggacatggca tactggataa gaggaaatgc tgtaagcagg
     4141 cctctagtaa tcatgataag ctgtggggag aggggcagca ttctattgtc cagggattag
     4201 atgtcagtct tgcagtgagt ctgtgcttct gcactgtgaa cttcagtttt tcccaccctt
     4261 tagttgggtc aggatgtata gagttggctg gagttggata tttcccttcc tccaggtcac
     4321 tgaagctctg actaaaactc caggtgtggt ggcttatgcc tgtaatacca gcactttggg
     4381 aggccaaggc aggtggatca cctgaggttg ggagttcatg accagcctga attgcttgaa
     4441 tccaggaggt ggaggtcaca gtgagccgag attgtgatac tgcactccag cctgggaaac
     4501 agtgagacac tgtctcaaaa aaataaataa ataaataaaa ggctaggcgc agtggctcaa
     4561 ccctgtaatc ccagcacttt gggaggcaga ggtgggtgga tcatgaggtc aggagatcga
     4621 gaccatcctg gccaacatgg tgaaaccccg tctctactaa aaatacaaaa aaattagctg
     4681 ggtgtggtgg cgggcacctg tagtcccagc tacttgggag gctgaggcag gagaatggtg
     4741 tgaacccagg aggtggagct tgcagtgagc cgagatcacg ccactgcact ccagcctggg
     4801 tgacagagtg agactctgtc tcaaaacaac aacaacaaca acaacaacaa aaacccatca
     4861 tcaatgctca gcctttctta aacatgaact catggtggac agagccctat gaatgtaagg
     4921 aatatagaga agccatcact agttactcaa accttattga atgtgtgaaa atttactctg
     4981 gagagatgcc ctttcagcat aagaaatgtt gaaaaggatt tatataatcc ttccttttta
     5041 tttttatttt tatttttatt tttattttta ttttttttga gacggagtct cgctctgtcg
     5101 cccaggctgg agtgcagtgg tgcgatctcg gctcactgca agctccgcct cccgggttca
     5161 cgccattctc ctgcctcagc ctcccgagta gctgggacta caggcgcccg ctaccacgcc
     5221 cggctaattt tttgtatttt tagtagagac ggggtttcac tgtgttagcc aggatggtct
     5281 cgatctcctg acctcgtgat ccgcccgcct cggcctccca aagtgctggg attacaggcg
     5341 tgagccaccg cgcccagcca atccttcctt tttaatatcc acatacaaac tcactgaaga
     5401 aaaaccctga aaatgtaaag caatgttgaa aaacctagtt atttaaattc atttcaagta
     5461 tatgaactca catggtaaag aaaccctgtg aatataagta gtatgataaa ttcttgaatt
     5521 tttttttttt tttttttttt tttttgaggc agagttttgc tcttgttgcc caggctggag
     5581 tgcaatggct caatcttggc tcactacaac ctctatcacc caggttcaag tgattattct
     5641 gcctcagcct cccaagtagc tgggattaca ggcatgtacc accatgccca gctaattttg
     5701 tatttttagt gaaggcaggg attctccatg ttgatcaggc tggtctcgaa ctcctgacct
     5761 ccagtgatct gcctggtttg acctcccaaa gtgctgagat tacaggcatg agccatcacg
     5821 cccagccagt tcttcaattc ttacagtccc tttccatgtc attaaagaac tcacactgga
     5881 gagaaatctt atcaatgtta gaattgtggt aaagctctct gttgttccca tttacatgaa
     5941 agatgtgaac agtcacattg tagaaaaatg ctgtgagagt tgggaatctg gaaccacttc
     6001 tttattatct caggtcataa tgaacttgta agaattcaca gtggcaggaa accctatgta
     6061 aatggaaaat atgggaaagg cttcatttaa tccataggac tgataccaca aaactcccac
     6121 taggagaaaa cctatgttta tacggaatgt gggaaaatct tcacttattt ctcaagcctt
     6181 aaagtgtatg tcaggattcc cagtggagag aagccatatt gatgtaagga atgtgggaaa
     6241 gcccttgcct gccacttagt ccttgataaa cattttagaa cacaaactgg agagaaacta
     6301 tgaattcaag gattgtggga aaaccctttt atgttccaca agctttaata ttcatatgca
     6361 atgtatgctg gagaataact tgatgactat aataagtgga atggcctagg tcagggatcc
     6421 ccaaacccct gggccatgga ctggtactgg tctgtggcct gctaggatcc agggtgcaca
     6481 gcaggaggtg aatgtaggat gagcaaacat tactgcctga gctcaacttt ctgtcagatc
     6541 agcagtggca ttagattctc ataggagcat gaactttatt gtgaactgca catgcaaggg
     6601 atctaggttg cacactcctt atgagaatct aatgcctgat gatctgaact ggaacagttt
     6661 aatccccaac tccagtccgt gggaaaaatg tcttccacga aactggtccc tggtgccaaa
     6721 aagttagggg accactgatt tagattatgt cacatgtccc atccactcat taacattaag
     6781 gctttcatcc ctgggacctc aagataatgg tggtatttag agatgtggtt ttttaaagag
     6841 gtgattttaa aatgaggcag ttagaatggg gccctcattc aatatgactg gtttccttat
     6901 aagaagtgaa agagatacca gggtagcagg cacagaattt tatgtgaagt gaccggaaat
     6961 ggttaccttc aaggcaaaga gagattcctg gaggagatcc ttcttttaag gctcattata
     7021 gaggaaatca tccttatcta cactttgatc ctggacttcc agcctcaaaa attatgagca
     7081 aataaatttc tgttgtttaa gcca
//
