LOCUS       NM_001001661            3198 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 425 (ZNF425), mRNA.
ACCESSION   NM_001001661 XM_088140 XM_374579
VERSION     NM_001001661.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3198)
  AUTHORS   Wang,Y., Ye,X., Zhou,J., Wan,Y., Xie,H., Deng,Y., Yan,Y., Li,Y.,
            Fan,X., Yuan,W., Mo,X. and Wu,X.
  TITLE     A novel human KRAB-related zinc finger gene ZNF425 inhibits
            mitogen-activated protein kinase signaling pathway
  JOURNAL   BMB Rep 44 (1), 58-63 (2011)
   PUBMED   21266108
  REMARK    GeneRIF: Over-expression of ZNF425 inhibits the transcriptional
            activities of SRE, AP-1, and SRF. Deletion analysis indicates that
            the C2H2 domain is the main region responsible for the repression.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073422.8 and AY621067.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001001661.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY621067.1, SRR1660809.107645.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378061.7/ ENSP00000367300.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC073422.8         70465-70502         c
            39-3198             AY621067.1         1-3160
FEATURES             Location/Qualifiers
     source          1..3198
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..3198
                     /gene="ZNF425"
                     /note="zinc finger protein 425"
                     /db_xref="GeneID:155054"
                     /db_xref="HGNC:HGNC:20690"
                     /db_xref="MIM:619507"
     exon            1..129
                     /gene="ZNF425"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..2370
                     /gene="ZNF425"
                     /codon_start=1
                     /product="zinc finger protein 425"
                     /protein_id="NP_001001661.1"
                     /db_xref="CCDS:CCDS34773.1"
                     /db_xref="GeneID:155054"
                     /db_xref="HGNC:HGNC:20690"
                     /db_xref="MIM:619507"
                     /translation="MAEPASVTVTFDDVALYFSEQEWEILEKWQKQMYKQEMKTNYET
                     LDSLGYAFSKPDLITWMEQGRMLLISEQGCLDKTRRTTSPPTDEQLNMKNTGKLLCFD
                     DEGTPRTKEEDCRLNGPQKQDLCAALRGKERKILLAQTATFQSPSLRETEILNKKVSI
                     TAYDPDKKDLRHKPRETPGRLEIPTGPRCYSCYVCRKVFQVRRDLLKHKRSHSKSQLC
                     RYPKYKNSSRGKSELRRTQRLLCQKKRFQCSECEKSYFLKGSLVTHQVVHTGQRPYPC
                     PECDKTFRYRANLKKHLCLHRGERPFCCGECGRAFVQQCELTEHLRLHSGEKPFQCPQ
                     CDRCFRLKRGMKVHLTQHSGKRPFHCPECGRSFSRKAALKTHQRTHSEEKPFSCGECG
                     RKFIYKIKLDEHIRVHTGEKPFSCPECNKSFRLKRSLKAHGLQHIGKRPFQCPECSRG
                     FFWRNAMRAHQRLHSEQKPFPCAECGKRFTRPSKLACHTRVHDRQKEFPCGECKKTFS
                     QQSRLTQHLKVHTTEKPFSCAECGRSFRRRAHLTEHTRLHSGEEPFQCPECDKSFSWK
                     ASMKFHQRMHRDEKPFACGECDKTYTHQSQLTEHLRLHSGEKPYQCPECEKTFRLKGN
                     LKSHLLQHSGQKPFSCVMCGKSFTQQYRLTEHIRVHSGEKPFQCPECDKSYCIRGSLK
                     VHLYKHSGERPFQCPECGKGFLQKRSLKAHLCLHSGERPFSCDECGRSFTYVGALKTH
                     IAVHAKEKPSSL"
     exon            130..256
                     /gene="ZNF425"
                     /inference="alignment:Splign:2.1.0"
     exon            257..415
                     /gene="ZNF425"
                     /inference="alignment:Splign:2.1.0"
     exon            416..3198
                     /gene="ZNF425"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3166..3171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF425"
                     /note="hexamer: AATAAA"
     polyA_site      3198
                     /gene="ZNF425"
                     /note="major polyA site"
ORIGIN      
        1 gcgcccggcc ggctctgcct ttgggggcca gcagggctgt acctgggagt tgggttgggg
       61 cggagcggag gggaggccgt gccaggcagg gccggttcgt gcggaaccgc catggccgag
      121 ccggcttcgg taactgtgac atttgatgat gtggccttat atttttcgga acaagagtgg
      181 gagatcctgg agaagtggca gaagcaaatg tataagcaag agatgaagac caattacgag
      241 acccttgatt ccctggggta tgctttttcc aagccagatt tgatcacatg gatggaacaa
      301 gggagaatgc tattaatcag cgaacaggga tgcttagata aaacaagaag gacaactagc
      361 cctcctactg atgaacagtt gaacatgaag aatactggaa agttgctatg ttttgatgac
      421 gaaggaactc ccaggacaaa agaagaggat tgccgtttaa atggtcctca aaaacaggac
      481 ttgtgtgctg ccttacgagg gaaagagaga aagattttat tagctcaaac agccaccttc
      541 cagtctccaa gtctccgaga aacagagatt ctaaataaaa aagtcagcat cacagcatat
      601 gatccagaca agaaagacct gcggcataag cctcgggaga ccccagggcg cttagaaatt
      661 cccacagggc caagatgcta ttcctgctat gtctgtagga aagtcttcca agtaaggagg
      721 gatttgctaa agcacaaacg gagccactcc aagagccagc tctgcagata cccaaagtac
      781 aaaaactcgt ccagagggaa gtccgaactc aggcggacgc agaggctcct gtgtcagaag
      841 aagcggttcc agtgcagtga gtgtgagaag agctacttcc tgaagggcag cctcgtcact
      901 catcaggttg tccacaccgg ccagcggccc tacccatgcc ctgagtgcga caagaccttc
      961 cggtacaggg ccaacctgaa gaagcacctg tgtctacacc gcggggagcg gccgttctgc
     1021 tgcggggagt gcggccgggc cttcgtgcag cagtgcgagc tcacggagca cttgcggctg
     1081 cacagcggag agaagccctt ccagtgtccg cagtgtgacc ggtgcttccg cctgaagagg
     1141 ggcatgaagg tccatctgac ccagcacagc gggaagaggc ccttccactg tcccgagtgt
     1201 ggccggagct tctcccggaa ggctgccctg aagacccacc agaggacgca cagcgaggaa
     1261 aagccgtttt cttgtggtga atgtggcagg aaattcatct acaagattaa gctggacgag
     1321 cacatcagag ttcacacggg agagaagccc ttttcgtgtc ccgagtgtaa caaaagtttc
     1381 cgcctcaaga gaagcctgaa agcccacggg ctgcagcaca ttgggaagcg gcccttccag
     1441 tgcccggagt gcagcagggg cttcttctgg aggaacgcca tgcgcgccca ccagcgcctg
     1501 cacagcgagc aaaagccctt cccctgcgcc gagtgcggca agcgcttcac gcggccttcc
     1561 aagctcgcct gccacaccag agtccacgac aggcagaagg agtttccctg cggcgagtgc
     1621 aaaaagacct tttctcagca gtcgcggctc acgcagcacc tgaaggtcca caccacggaa
     1681 aagccgttct cctgcgccga gtgcggccgc agtttccgcc gacgcgcgca tctcacagag
     1741 cacacgaggc ttcacagtgg cgaggagccc ttccagtgtc ccgagtgcga caagagcttc
     1801 tcctggaagg cctccatgaa gttccaccag cggatgcaca gggacgagaa gcccttcgcg
     1861 tgcggtgagt gtgacaagac ctacacgcat cagtctcagc tcaccgagca cctgaggctg
     1921 cacagtggag agaagcccta ccagtgtcct gaatgcgaga agactttccg cctcaaggga
     1981 aacctgaaaa gccacctgct gcagcacagt ggccaaaagc cattctcttg tgtgatgtgc
     2041 ggcaaaagtt tcactcaaca gtaccggctc acagaacaca ttcgagtcca cagcggggag
     2101 aagcccttcc agtgtccgga gtgtgacaag agctactgca tcaggggcag cttgaaggtc
     2161 cacttgtata agcacagtgg agagaggccc ttccagtgtc ccgagtgtgg caaaggcttc
     2221 ctccagaaga gaagcctgaa ggcccatctg tgccttcaca gtggggagag gcctttttct
     2281 tgtgatgagt gtggaaggag cttcacgtac gtgggggcgc tcaagaccca cattgcagtg
     2341 catgccaaag agaagccctc cagcctctag gtcaggccat gcagcagtca cgcagtcggc
     2401 tttcaggagg tgccagcagc tctgttggct caagttgagg caggttgaag gattcacagg
     2461 gtaagatcgg gcacagtggc tcccgcctgt aatcccatta ctttgggagg cccaggtggg
     2521 aggatcgctt gagcccagaa gtttgagacc agcctaggca acattgcaag actccatctc
     2581 tacaaaaaat ataaaagtca gccaggcgtt gtggtgcatg cttgtggtcc cagctacttt
     2641 gggaggttga ggcaggagga tcgcttgagc ccaggaggca gaggctgcag tgagccatgc
     2701 tcacaccact gcactccagc ctgggtgaca gagcaagatc ttgtctcaaa aaagaaaaaa
     2761 aatcacaaaa tactggctac agacacactg gacaggtgtg tggtctgcag aactctatgg
     2821 ctccttgaca aaagttccaa ataatccata gacagtcaaa gagacatctc cctcaataat
     2881 cgtcatagga aagacgtgcc agttgtggag gaaacattca cactgatctg ctagtccaac
     2941 gatctcttca gtgtcatcca ataatccctt cattaaattc agaaactaca gcctgagtga
     3001 agaaatgtta cagccaggaa catattcctc agtcagcttt tccattacca ggccatttta
     3061 cttaaatctg tattaaagtc ttcagttttc tctcatagtg gattttcatt ttctctcaga
     3121 tggtgagagg gcttctgttt cttggaatgt ttccatattg ctaaaaataa atgtcttcca
     3181 ctatctcatt tgttaaaa
//
