LOCUS       NM_001379286            7968 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 423 (ZNF423), transcript variant
            4, mRNA.
ACCESSION   NM_001379286 XM_017023076
VERSION     NM_001379286.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7968)
  AUTHORS   Dang,T.N., Tiongco,R.P., Brown,L.M., Taylor,J.L., Lyons,J.M.,
            Lau,F.H. and Floyd,Z.E.
  TITLE     Expression of the preadipocyte marker ZFP423 is dysregulated
            between well-differentiated and dedifferentiated liposarcoma
  JOURNAL   BMC Cancer 22 (1), 300 (2022)
   PUBMED   35313831
  REMARK    GeneRIF: Expression of the preadipocyte marker ZFP423 is
            dysregulated between well-differentiated and dedifferentiated
            liposarcoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7968)
  AUTHORS   Deshpande,O., Lara,R.Z., Zhang,O.R., Concepcion,D. and
            Hamilton,B.A.
  TITLE     ZNF423 patient variants, truncations, and in-frame deletions in
            mice define an allele-dependent range of midline brain
            abnormalities
  JOURNAL   PLoS Genet 16 (9), e1009017 (2020)
   PUBMED   32925911
  REMARK    GeneRIF: ZNF423 patient variants, truncations, and in-frame
            deletions in mice define an allele-dependent range of midline brain
            abnormalities.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7968)
  AUTHORS   Baker,E., Sims,R., Leonenko,G., Frizzati,A., Harwood,J.C.,
            Grozeva,D., Morgan,K., Passmore,P., Holmes,C., Powell,J.,
            Brayne,C., Gill,M., Mead,S., Bossu,P., Spalletta,G., Goate,A.M.,
            Cruchaga,C., Maier,W., Heun,R., Jessen,F., Peters,O., Dichgans,M.,
            FroLich,L., Ramirez,A., Jones,L., Hardy,J., Ivanov,D., Hill,M.,
            Holmans,P., Allen,N.D., Morgan,B.P., Seshadri,S.,
            Schellenberg,G.D., Amouyel,P., Williams,J. and Escott-Price,V.
  CONSRTM   GERAD/PERADES; CHARGE; ADGC; EADI; IGAP consortia
  TITLE     Gene-based analysis in HRC imputed genome wide association data
            identifies three novel genes for Alzheimer's disease
  JOURNAL   PLoS One 14 (7), e0218111 (2019)
   PUBMED   31283791
  REMARK    GeneRIF: Gene-based analysis in HRC imputed genome wide association
            data identifies three novel genes for Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7968)
  AUTHORS   Chaiprasert,T., Armartmuntree,N., Techasen,A., Sakonsinsiri,C.,
            Pinlaor,S., Ungarreevittaya,P., Khuntikeo,N., Namwat,N. and
            Thanan,R.
  TITLE     Roles of Zinc Finger Protein 423 in Proliferation and Invasion of
            Cholangiocarcinoma through Oxidative Stress
  JOURNAL   Biomolecules 9 (7), 263 (2019)
   PUBMED   31284679
  REMARK    GeneRIF: The present study denoted that ZNF423 is an oxidative
            stress-responsive gene with an oncogenic property contributing to
            the regulation of CCA genesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7968)
  AUTHORS   Hata,A., Seoane,J., Lagna,G., Montalvo,E., Hemmati-Brivanlou,A. and
            Massague,J.
  TITLE     OAZ uses distinct DNA- and protein-binding zinc fingers in separate
            BMP-Smad and Olf signaling pathways
  JOURNAL   Cell 100 (2), 229-240 (2000)
   PUBMED   10660046
REFERENCE   6  (bases 1 to 7968)
  AUTHORS   Tsai,R.Y. and Reed,R.R.
  TITLE     Cloning and functional characterization of Roaz, a zinc finger
            protein that interacts with O/E-1 to regulate gene expression:
            implications for olfactory neuronal development
  JOURNAL   J Neurosci 17 (11), 4159-4169 (1997)
   PUBMED   9151733
REFERENCE   7  (bases 1 to 7968)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   8  (bases 1 to 7968)
  AUTHORS   Stokman,M., Lilien,M. and Knoers,N.
  TITLE     Nephronophthisis-Related Ciliopathies
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27336129
REFERENCE   9  (bases 1 to 7968)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
REFERENCE   10 (bases 1 to 7968)
  AUTHORS   Parisi,M. and Glass,I.
  TITLE     Joubert Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007603.5, AC027348.8,
            AC007607.6 and AC007861.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 27, 2020 this sequence version replaced XM_017023076.2.
            
            Summary: The protein encoded by this gene is a nuclear protein that
            belongs to the family of Kruppel-like C2H2 zinc finger proteins. It
            functions as a DNA-binding transcription factor by using distinct
            zinc fingers in different signaling pathways. Thus, it is thought
            that this gene may have multiple roles in signal transduction
            during development. Mutations in this gene are associated with
            nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Oct 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.359224.1,
                                           SRR14038192.3706116.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000563137.7/ ENSP00000455588.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               AC007603.5         162898-163275
            379-438             AC027348.8         60014-60073
            439-639             AC027348.8         118589-118789
            640-3854            AC007607.6         14465-17679
            3855-3939           AC007607.6         27085-27169
            3940-4071           AC007861.5         15211-15342
            4072-4187           AC007861.5         16966-17081
            4188-7968           AC007861.5         49401-53181
FEATURES             Location/Qualifiers
     source          1..7968
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..7968
                     /gene="ZNF423"
                     /gene_synonym="Ebfaz; hOAZ; JBTS19; NPHP14; OAZ; Roaz;
                     Zfp104; ZFP423"
                     /note="zinc finger protein 423"
                     /db_xref="GeneID:23090"
                     /db_xref="HGNC:HGNC:16762"
                     /db_xref="MIM:604557"
     exon            1..378
                     /gene="ZNF423"
                     /gene_synonym="Ebfaz; hOAZ; JBTS19; NPHP14; OAZ; Roaz;
                     Zfp104; ZFP423"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..4217
                     /gene="ZNF423"
                     /gene_synonym="Ebfaz; hOAZ; JBTS19; NPHP14; OAZ; Roaz;
                     Zfp104; ZFP423"
                     /note="isoform 4 is encoded by transcript variant 4; early
                     B-cell factor associated zinc finger protein; OLF-1/EBF
                     associated zinc finger; Smad- and Olf-interacting zinc
                     finger protein; olf1/EBF-associated zinc finger protein"
                     /codon_start=1
                     /product="zinc finger protein 423 isoform 4"
                     /protein_id="NP_001366215.1"
                     /db_xref="CCDS:CCDS92157.1"
                     /db_xref="GeneID:23090"
                     /db_xref="HGNC:HGNC:16762"
                     /db_xref="MIM:604557"
                     /translation="MSRRKQAKPRSVKVEEGEASDFSLAWDSSVTAAGGLEGEPECDQ
                     KTSRALEDRNSVTSQEERNEDDEDMEDESIYTCDHCQQDFESLADLTDHRAHRCPGDG
                     DDDPQLSWVASSPSSKDVASPTQMIGDGCDLGLGEEEGGTGLPYPCQFCDKSFIRLSY
                     LKRHEQIHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCHECEAAFSRSDHLK
                     IHLKTHSSSKPFKCTVCKRGFSSTSSLQSHMQAHKKNKEHLAKSEKEAKKDDFMCDYC
                     EDTFSQTEELEKHVLTRHPQLSEKADLQCIHCPEVFVDENTLLAHIHQAHANQKHKCP
                     MCPEQFSSVEGVYCHLDSHRQPDSSNHSVSPDPVLGSVASMSSATPDSSASVERGSTP
                     DSTLKPLRGQKKMRDDGQGWTKVVYSCPYCSKRDFNSLAVLEIHLKTIHADKPQQSHT
                     CQICLDSMPTLYNLNEHVRKLHKNHAYPVMQFGNISAFHCNYCPEMFADINSLQEHIR
                     VSHCGPNANPSDGNNAFFCNQCSMGFLTESSLTEHIQQAHCSVGSAKLESPVVQPTQS
                     FMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKKSKAEQSPVSSDVEVSSPK
                     RQRLSASANSISNGEYPCNQCDLKFSNFESFQTHLKLHLELLLRKQACPQCKEDFDSQ
                     ESLLQHLTVHYMTTSTHYVCESCDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSK
                     VSIQVHLAVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSHLGNPAKAHKCIFCGETF
                     STEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFDAATENGTANGVPPM
                     ATKKAEPADLQGMLLKNPEAPNSHEASEDDVDASEPMYGCDICGAAYTMEVLLQNHRL
                     RDHNIRPGEDDGSRKKAEFIKGSHKCNVCSRTFFSENGLREHLQTHRGPAKHYMCPIC
                     GERFPSLLTLTEHKVTHSKSLDTGTCRICKMPLQSEEEFIEHCQMHPDLRNSLTGFRC
                     VVCMQTVTSTLELKIHGTFHMQKLAGSSAASSPNGQGLQKLYKCALCLKEFRSKQDLV
                     KLDVNGLPYGLCAGCMARSANGQVGGLAPPEPADRPCAGLRCPECSVKFESAEDLESH
                     MQVDHRDLTPETSGPRKGTQTSPVPRKKTYQCIKCQMTFENEREIQIHVANHMIEEGI
                     NHECKLCNQMFDSPAKLLCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFAVHGQ
                     EDKIYDCSQCPQKFFFQTELQNHTMSQHAQ"
     exon            379..438
                     /gene="ZNF423"
                     /gene_synonym="Ebfaz; hOAZ; JBTS19; NPHP14; OAZ; Roaz;
                     Zfp104; ZFP423"
                     /inference="alignment:Splign:2.1.0"
     exon            439..639
                     /gene="ZNF423"
                     /gene_synonym="Ebfaz; hOAZ; JBTS19; NPHP14; OAZ; Roaz;
                     Zfp104; ZFP423"
                     /inference="alignment:Splign:2.1.0"
     exon            640..3854
                     /gene="ZNF423"
                     /gene_synonym="Ebfaz; hOAZ; JBTS19; NPHP14; OAZ; Roaz;
                     Zfp104; ZFP423"
                     /inference="alignment:Splign:2.1.0"
     exon            3855..3939
                     /gene="ZNF423"
                     /gene_synonym="Ebfaz; hOAZ; JBTS19; NPHP14; OAZ; Roaz;
                     Zfp104; ZFP423"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4071
                     /gene="ZNF423"
                     /gene_synonym="Ebfaz; hOAZ; JBTS19; NPHP14; OAZ; Roaz;
                     Zfp104; ZFP423"
                     /inference="alignment:Splign:2.1.0"
     exon            4072..4187
                     /gene="ZNF423"
                     /gene_synonym="Ebfaz; hOAZ; JBTS19; NPHP14; OAZ; Roaz;
                     Zfp104; ZFP423"
                     /inference="alignment:Splign:2.1.0"
     exon            4188..7968
                     /gene="ZNF423"
                     /gene_synonym="Ebfaz; hOAZ; JBTS19; NPHP14; OAZ; Roaz;
                     Zfp104; ZFP423"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4768..4773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF423"
                     /gene_synonym="Ebfaz; hOAZ; JBTS19; NPHP14; OAZ; Roaz;
                     Zfp104; ZFP423"
                     /note="hexamer: ATTAAA"
     polyA_site      4791
                     /gene="ZNF423"
                     /gene_synonym="Ebfaz; hOAZ; JBTS19; NPHP14; OAZ; Roaz;
                     Zfp104; ZFP423"
     regulatory      4863..4868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF423"
                     /gene_synonym="Ebfaz; hOAZ; JBTS19; NPHP14; OAZ; Roaz;
                     Zfp104; ZFP423"
                     /note="hexamer: AATAAA"
     polyA_site      4888
                     /gene="ZNF423"
                     /gene_synonym="Ebfaz; hOAZ; JBTS19; NPHP14; OAZ; Roaz;
                     Zfp104; ZFP423"
                     /note="major polyA site"
     regulatory      7940..7945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF423"
                     /gene_synonym="Ebfaz; hOAZ; JBTS19; NPHP14; OAZ; Roaz;
                     Zfp104; ZFP423"
                     /note="hexamer: AATAAA"
     polyA_site      7968
                     /gene="ZNF423"
                     /gene_synonym="Ebfaz; hOAZ; JBTS19; NPHP14; OAZ; Roaz;
                     Zfp104; ZFP423"
ORIGIN      
        1 cataactcgg ctcggccgag tggcctccgg actccccgcg ccgctgggac cgccgcttgg
       61 atcgggagcc ccggactgcc gcattgcaac aggcagggcc ccggcgcgcc ccccgggcct
      121 ccccccgcct tcgagcggcc tcggccggcc cgggctgccc ccccaaggga ggccgccccg
      181 gacctgcggt ccgctcccca cagccgccaa ccgggctgca aaaaaaaaag tttccaagag
      241 acaggcggag gagaaggggg agaagggctg cccggagcgg cggggggcgg cggggggagc
      301 cggctgcgga gggcgacgga gcgcccggag ccccggacat gtccaggcgg aagcaggcga
      361 agccgcgctc ggtgaaagtt gaagaggggg aggcctcaga cttctcgctg gcctgggatt
      421 cctccgtgac agcagcagga ggcctagaag gagagccaga gtgcgatcag aaaaccagcc
      481 gtgcgctgga agacaggaac agcgtgacaa gtcaagagga gagaaatgag gatgatgaag
      541 acatggagga tgaatcaatt tacacctgcg atcactgtca gcaggacttc gagtctctgg
      601 cagacctgac ggaccaccgg gcccaccgct gtcctggaga tggtgatgac gacccacaac
      661 tctcctgggt ggcctcgtct ccctccagca aggatgttgc gtcacccacg cagatgatcg
      721 gagatggttg tgacctcggc ctcggcgagg aggaaggggg cacgggcctg ccataccctt
      781 gccagttctg cgacaagtcc ttcatccgct tgagctactt gaagaggcac gagcagatcc
      841 acagcgacaa gctgccgttc aagtgcacct actgcagccg cctcttcaag cacaagagga
      901 gccgtgaccg gcacatcaag ctgcatacgg gcgacaagaa gtatcactgc cacgagtgcg
      961 aggcagcctt ctcccgcagc gaccacctca agatccacct gaagacccac agctccagca
     1021 agcccttcaa gtgcactgtg tgcaagcgcg gcttctcctc caccagctcg ctgcagagcc
     1081 acatgcaggc ccacaaaaag aacaaggagc atctggccaa gtcggagaag gaagccaaga
     1141 aggacgactt catgtgcgac tactgcgagg acaccttcag ccagacggag gagctggaga
     1201 agcacgtgct cacccgccac ccgcagctgt ccgagaaggc ggacctgcag tgcattcact
     1261 gccctgaggt cttcgtcgac gagaacacac tgctcgccca tatccaccaa gcccacgcca
     1321 accagaaaca caagtgcccc atgtgccctg agcagttctc ctcagtggaa ggtgtctact
     1381 gccacctgga cagccaccgg cagcccgact ccagcaacca cagtgtcagt cccgaccctg
     1441 tactgggcag cgtggcctcc atgagcagcg ccacacccga ctccagcgcc tctgtggagc
     1501 gtggctccac cccggactcc accttgaagc cgctgcgggg gcagaagaag atgcgggatg
     1561 acgggcaggg ctggaccaag gtggtctata gctgccccta ttgttccaag cgggacttta
     1621 acagcctggc cgtgctggag atccacctga agaccatcca cgcggacaag ccccagcaga
     1681 gccacacatg tcagatctgc ctggactcca tgcccaccct ctacaacctc aacgagcacg
     1741 ttcgcaagct gcacaagaac catgcctacc ctgtgatgca gtttggcaac atctctgcct
     1801 tccactgcaa ctactgcccc gagatgttcg ccgacatcaa tagcctgcag gagcacatcc
     1861 gcgtctccca ctgcggcccc aacgccaacc cctctgacgg taataatgct ttcttctgca
     1921 accagtgctc catgggtttc cttactgagt cctccctcac cgagcacatc cagcaggccc
     1981 actgcagtgt gggcagtgcc aaactagagt ctccggtggt gcagcccacg cagtccttca
     2041 tggaggtcta ttcctgcccc tactgcacca actcccccat ctttggctcc atcctgaaac
     2101 tcaccaagca catcaaggag aaccacaaga acattccact ggcccacagc aagaagtcca
     2161 aggccgagca gagcccagtc tcgtccgatg tggaggtgtc ttccccgaag cggcagcggc
     2221 tctcagcaag cgccaactcc atctccaatg gggagtatcc ttgcaatcaa tgcgacctca
     2281 agttctccaa ctttgagagc ttccagaccc acctgaagct gcacctggag ctgctgctgc
     2341 ggaagcaagc gtgcccccag tgcaaagagg actttgactc ccaggagtcc ctcctgcagc
     2401 acctgacagt gcattacatg accacgtcga cccactatgt gtgcgagagc tgcgacaagc
     2461 aattttcctc ggtggatgac ctgcagaagc acctgctgga catgcacacc tttgtgttgt
     2521 accactgcac cctgtgtcag gaggtcttcg actccaaggt gtccatccag gtgcacctgg
     2581 cggtgaagca cagcaatgag aagaagatgt accgctgcac ggcctgcaac tgggacttcc
     2641 gcaaggaggc tgacctgcag gtgcacgtca aacacagcca cctgggcaac ccggccaagg
     2701 ctcacaagtg catcttctgt ggggagacct tcagcaccga ggtggagctg cagtgccaca
     2761 tcaccacaca cagcaagaag tataactgta agttctgcag caaggccttc cacgccatca
     2821 tcctgctgga gaagcacctg cgggagaagc actgtgtgtt tgatgctgcg accgagaacg
     2881 gcacggccaa tggggtaccc ccaatggcca ccaagaaagc tgagcctgct gacctgcagg
     2941 gcatgctgct taagaaccct gaggcaccta acagccatga ggccagcgag gatgacgtgg
     3001 acgcgtcgga gcccatgtac ggctgtgaca tctgtggggc ggcctacacc atggaggtgc
     3061 tgctgcagaa tcaccggctg cgggaccaca atatccggcc gggcgaggat gatggctcac
     3121 gcaagaaggc tgagtttatc aagggcagtc acaagtgcaa cgtttgttca cggactttct
     3181 tctcggagaa cgggctacgg gagcacctgc agacgcaccg gggccctgcc aagcactaca
     3241 tgtgtcccat ctgtggtgag cgcttccctt cgctgctgac gctcaccgaa cacaaggtga
     3301 cccacagcaa gagcctggac acgggcacct gtcgcatctg caagatgccc ctgcagagcg
     3361 aggaggagtt tattgagcac tgccagatgc accctgacct gcgcaactca ctcacgggct
     3421 tccgctgtgt ggtctgcatg cagacagtca cttccacgct tgagctcaag atccatggca
     3481 ccttccacat gcagaagctg gcgggcagct cagcggcgtc ctcccccaat ggccaggggc
     3541 tgcagaagct ctacaagtgc gccctgtgcc tcaaggagtt ccgcagcaag caggacctgg
     3601 tgaagcttga cgtcaatggg ctgccctacg gcctctgcgc cggctgcatg gcccgcagcg
     3661 ccaacggaca ggtgggtggc ctggccccgc ccgagcccgc cgaccggccc tgtgccggcc
     3721 tccgttgccc cgagtgcagt gtcaagtttg agagtgccga agacctggag agccacatgc
     3781 aggtggacca ccgtgacctc acgccggaga ccagtgggcc ccggaaaggc acccagacat
     3841 cgccagtgcc ccggaaaaag acataccagt gcatcaagtg ccagatgacc ttcgagaacg
     3901 agagagagat ccaaatccac gttgccaacc acatgattga ggaaggcatc aaccacgagt
     3961 gtaagctgtg caaccagatg ttcgactccc cggccaagct cctctgtcac ctcattgagc
     4021 acagcttcga gggcatgggc ggcaccttca aatgccccgt gtgtttcaca gtcttcgtcc
     4081 aggccaacaa gttgcagcag cacatctttg ccgtgcacgg gcaggaggac aagatctacg
     4141 actgctcaca gtgccctcag aagttcttct tccagaccga gctgcagaac cacacgatga
     4201 gccagcacgc acagtgaggg atcgctcaac aggacacctc tccgcagaag gcttgccgga
     4261 gacgccgtgg ggagggccat ttgaacatta catccaatca aagtgtcatt tgcaacccag
     4321 atgtaaaact ctaatgattt ggccatgagg cgctgctatt ataagcagct ggaaatgaat
     4381 attaatggca gagattaaaa gtattccatg ctcagtattt tttattgtcc tgctacagct
     4441 agtgtgcttt tagactttcc gccgcagact acatttctag agttagagaa acctgctttt
     4501 taaggctatt gtcctttgtt ccttcatgta ttatattgat agtttttaaa aaagaattag
     4561 tgtgattttt tttctttgct tctttttttt ctttcttgtt tttcttcccc cccacccccc
     4621 acccccttcg gttaactact ttttaattgc aattctaggt aattgtgcat cgtgatgtga
     4681 ttgcttggct attgtctgaa tatttccttt taatttttta attaaagact aatgctttga
     4741 ttggatttgc cagttcaccg gacagtgatt aaaactatgt aatgaatata atcggtttca
     4801 gtgcaactgg atggtctgct tttaaatgtg acttaatctg actgcagtaa ctagtacagt
     4861 tcaataaagg gaatccatgc gattagcatc cggctgcctg gttctctcct ccccagccta
     4921 gggccgcgtg gggggctgtc agctcctgta aggtgtgttc ccctacaagt tcctgtgggc
     4981 ttgcacacgc ccttggggac ctgcacacaa tagaccctgc tccccttgga aaagaatcgt
     5041 agtaacctaa tgcatgcaga ctggacaggc tggcagtggc cacaggagtc aaagcagaag
     5101 accccttaat gatggaatac cctgatcttc ccactcttgg atggggaaac agaggcccaa
     5161 gggtaacgtg cagctttccc aaggccacgc agcaggttgg tcaccatgct gattgtgaag
     5221 tcttcttggc tttcccttca gggttggctt tcccctttgt tggatacagg caggcaagtg
     5281 ggtagccctt cccttgccag gactccaggt ggcacttggg ttctgaggca cggagatgtg
     5341 tgactgggga ctgcagagca gagccaggta ggagccgcag gttcccagtc atagagatca
     5401 gtaggatgtg agagcattga gactggtggc gggggccagg tctggagtga ggcaggcagg
     5461 ggcctggggt acattatttc agggggcact cgctctcagg gcccccctac acctgcaagt
     5521 gctgggaatg ggtgtcctct tgcattttac actctaggca ccttgcttat ttcacctact
     5581 cctggccctg ctggcctccc agggcccacc cagcagcctt ggtctccagg cctcctccat
     5641 gttacctccc acacctccat catgctggtg ctcagctgac ttgccaatca gaggccagaa
     5701 cttgcacggg gaaacccttc cttgctaact tttcacaagg ggcaaggaaa ttggttatta
     5761 ccctctgcag agcggaaatg aaacaggcag acagattgca cctaattata atgtaatact
     5821 aagtcacggg tgtggaattt ggagcaatta tacccatcat cttctagaag actcccatat
     5881 caaggggctt ctggtgacct ataagagttc ccctttcttt ctgtcacctc atgtaatgtt
     5941 ctcacgcggg tggggctttc agtttttcaa aaggcatctt acatatgtga atcatagagc
     6001 agaccctgcc agtagtgggc tgttgcctcc tggaaactga aggctgtgaa tgccaatttt
     6061 cagcctcctg gagacctggc agttttgggg gaagacccca gggtagacac cagtgttcct
     6121 ctaagtgtgc ccacccgtgg actggggctt ggggcctggg gctggggcta tgtctgagtg
     6181 aggctgccac acatccacag ccaggcctac cttttgggca gtgctgggac tgtcgatggg
     6241 accagtatgt cccggggcct gccacatctc cgtctcaggg ccctctccag ctctggattt
     6301 atcccaaacc ccatggagcc caggtgagcc ctcagtaact accaatagaa gattcgattt
     6361 gacggttggt ggcgtagggc taaattagtc actgccccca ttaaaaatac agcggggggt
     6421 ttaagagctt ttcacgccat gtgggaatca gcagcgaagc cggctgatgc cttgggtaag
     6481 gagagaggcg gcctagggga ccgtgaggta atgaggttta tggcggtgac aaggcagcca
     6541 gggaacccca ccgactcccc cctcaccccg gccgcattgt tctccggctg gctctgtccc
     6601 tgctgctacg gctgagagcc cctcgtgact ttgtgtgggg agggggctgg cagtggggac
     6661 cctgaggccc ttcctgggac tggcattctt taccatcagg tggtattagg gttggggagc
     6721 agtgtagggt tataaacctg tgcctcggag aactcactaa ccccttccag aggaaaggtc
     6781 tggagctggg atgagacact tgcctttcaa ctgtgagggg ccttagaggg tctctgggag
     6841 gcttgtatga agtgatgcct gacaaagggc tgcacacaga gacctgtaag cagcatggtc
     6901 atcaatgatg gtgccaggca tcctgcagga gggcaccttt tcagccagga gggcgcgatg
     6961 gaatcagcct ctcatttgga tttggctttg gggagtgggc gaggtgactg aaagcctaag
     7021 gttcattgct gctgtattta gatgtacaaa ttgtcagttt ctagcggctc tctgggcaga
     7081 ggaattttgc ccaggctggg aaatggacca ggacccttgg gccacaggcc cctgtcatgg
     7141 aacacctgcc cagagtgccc agaagcaggc aggtaagggt ttcagtctca gtggagaaac
     7201 tgtcatggga gaaatcttct cgagttcccc agccttaaag aacgctcctt ttaaattcac
     7261 agttgtgtaa tattgaactt ttcacctgtt tttcttccct cctaaggtgt gtgttcctag
     7321 ggatggaacc tgtacctata aatattcagt aaataggacc aaaactcaaa tccatccctt
     7381 cctctactca tccattcagc aagtatttac tgagctgccc ccaggtgcca ggcactgcac
     7441 agggcactgg ggataaggag atgaccagca gatgtggtcc ctggcctcat ggaggccaca
     7501 gtggcacagg caagcatgcc agtaaatgca tagccacacc tggtcatgag tgccgtgatg
     7561 gcaaagccag aagctgccag ggattaatgg agggacccgt gtatgagaca caggggtgca
     7621 ttaaggaagg ccttgctgag gcaggggctt gagacctgaa gaaataaggg aggtgggcag
     7681 tccaagagca gtgggaagag aacactgcaa atgcagaagc cgtgagctgg aaacgagcca
     7741 gaagtaccct tagagagctg tattcctatg gagtttcaat tctaggtggc ttaaaacaat
     7801 cccagagaag ttcagaatct tgtccaagat cataccattc aggatagact tgcgactata
     7861 acttgggtgc ctcaccttcc agcctggggt gtctgactcc attgttaatt ttattataac
     7921 aatcatgatg acaacgatga ataaagtgaa attgtactgt acaggaaa
//
