LOCUS       NM_024691               3742 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens zinc finger protein 419 (ZNF419), transcript variant
            2, mRNA.
ACCESSION   NM_024691
VERSION     NM_024691.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3742)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3742)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3742)
  AUTHORS   Martin,G., Selcuklu,S.D., Schouest,K., Nembaware,V., McKeown,P.C.,
            Seoighe,C. and Spillane,C.
  TITLE     Allele-specific splicing effects on DKKL1 and ZNF419 transcripts in
            HeLa cells
  JOURNAL   Gene 598, 107-112 (2017)
   PUBMED   27826023
  REMARK    GeneRIF: previously unreported alternative splicing patterns in the
            genes ZNF419 and DKKL1
REFERENCE   4  (bases 1 to 3742)
  AUTHORS   Broen,K., Levenga,H., Vos,J., van Bergen,K., Fredrix,H.,
            Greupink-Draaisma,A., Kester,M., Falkenburg,J.H., de Mulder,P., de
            Witte,T., Griffioen,M. and Dolstra,H.
  TITLE     A polymorphism in the splice donor site of ZNF419 results in the
            novel renal cell carcinoma-associated minor histocompatibility
            antigen ZAPHIR
  JOURNAL   PLoS One 6 (6), e21699 (2011)
   PUBMED   21738768
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP336834.1, BC024259.1, AK026886.1 and AC003005.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_024691.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1,
            resulting in an isoform (2) that is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.31318.1, BC024259.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221735.12/ ENSP00000221735.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BP336834.1         40-54
            16-398              BC024259.1         1-383
            399-399             AK026886.1         411-411
            400-621             BC024259.1         385-606
            622-1770            AK026886.1         535-1683
            1771-1941           BC024259.1         1756-1926
            1942-2308           AK026886.1         1854-2220
            2309-2324           BC024259.1         2294-2309
            2325-3742           AC003005.1         23320-24737
FEATURES             Location/Qualifiers
     source          1..3742
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..3742
                     /gene="ZNF419"
                     /gene_synonym="ZAPHIR; ZNF419A"
                     /note="zinc finger protein 419"
                     /db_xref="GeneID:79744"
                     /db_xref="HGNC:HGNC:20648"
                     /db_xref="MIM:617410"
     exon            1..234
                     /gene="ZNF419"
                     /gene_synonym="ZAPHIR; ZNF419A"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1734
                     /gene="ZNF419"
                     /gene_synonym="ZAPHIR; ZNF419A"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein 419A"
                     /codon_start=1
                     /product="zinc finger protein 419 isoform 2"
                     /protein_id="NP_078967.3"
                     /db_xref="CCDS:CCDS54326.1"
                     /db_xref="GeneID:79744"
                     /db_xref="HGNC:HGNC:20648"
                     /db_xref="MIM:617410"
                     /translation="MAAAALRDPAQVPVAADLLTDHEEGYVTFEDVAVYFSQEEWRLL
                     DDAQRLLYRNVMLENFTLLASLGLASSKTHEITQLESWEEPFMPAWEVVTSAIPRGCW
                     HGAEAEEAPEQIASVGLLSSNIQQHQKQHCGEKPLKRQEGRVPVLRSCKVHLSEKSLQ
                     SREVGKALLISSGVLKHQVTHTGEKSHRSSKSREAFHAGKRHYKCSECGKAFGQKYLL
                     VQHQRLHAGKKTYECSECGKLFRDMSNLFIHQIVHTGERPYGCSNCGKSFSRNAHLIE
                     HQRVHTGEKPFTCSECGKAFRHNSTLVQHHKIHTGVRPYECSECGKLFSFNSSLMKHQ
                     RIHTGERPYKCSECGKFYSHKSNLIKHWRVHTGERPYKCSDCGKFFTQCSSLMQHQKV
                     HTGEKPFKCNECGRFFRENSTLVRHQRVHTGAKPYECRECGKFFSQSSTLMQHRKVHI
                     GEKPFKCNECGRLFRENSSLVKHQRVHTGAKPYECRECGKFFRHNSSLFKHRRIHTGE
                     MQ"
     exon            235..273
                     /gene="ZNF419"
                     /gene_synonym="ZAPHIR; ZNF419A"
                     /inference="alignment:Splign:2.1.0"
     exon            274..400
                     /gene="ZNF419"
                     /gene_synonym="ZAPHIR; ZNF419A"
                     /inference="alignment:Splign:2.1.0"
     exon            401..499
                     /gene="ZNF419"
                     /gene_synonym="ZAPHIR; ZNF419A"
                     /inference="alignment:Splign:2.1.0"
     exon            500..3742
                     /gene="ZNF419"
                     /gene_synonym="ZAPHIR; ZNF419A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2288..2293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF419"
                     /gene_synonym="ZAPHIR; ZNF419A"
                     /note="hexamer: AATAAA"
     polyA_site      2316
                     /gene="ZNF419"
                     /gene_synonym="ZAPHIR; ZNF419A"
                     /note="major polyA site"
     regulatory      3077..3082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF419"
                     /gene_synonym="ZAPHIR; ZNF419A"
                     /note="hexamer: AATAAA"
     polyA_site      3095
                     /gene="ZNF419"
                     /gene_synonym="ZAPHIR; ZNF419A"
     regulatory      3713..3718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF419"
                     /gene_synonym="ZAPHIR; ZNF419A"
                     /note="hexamer: AATAAA"
     regulatory      3717..3722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF419"
                     /gene_synonym="ZAPHIR; ZNF419A"
                     /note="hexamer: AATAAA"
     polyA_site      3728
                     /gene="ZNF419"
                     /gene_synonym="ZAPHIR; ZNF419A"
     polyA_site      3742
                     /gene="ZNF419"
                     /gene_synonym="ZAPHIR; ZNF419A"
ORIGIN      
        1 ggtattcact ttcgcgactc aggtgaacta acctgcgaga agctggttgt gcgctgaggc
       61 gaccagcgcc ggaaggcacg gtggcgactc acgctgttct cgccgctcag aggcgggtct
      121 gaggctcggt ggcggcgccc agggtggccc gggccctttc ctcggtcatt gtctcccctc
      181 cagctctact cacaggctcc gatggcggcg gccgccctga gggaccccgc tcaggttcct
      241 gtggctgcag acttgcttac agaccatgag gagggctatg tgacctttga ggatgtggct
      301 gtctacttct cccaggagga atggagattg cttgatgacg ctcagaggct cctctaccgc
      361 aatgtgatgc tggagaactt tacacttctg gcctctctgg gacttgcatc ttccaagacc
      421 catgaaataa cccagctgga gtcatgggag gagcccttca tgcctgcttg ggaagttgtg
      481 acttcagcca taccgagagg ttgttggcat ggagccgagg ctgaggaggc tcctgagcag
      541 attgcttctg taggactgct cagttcaaac attcagcaac accagaagca gcactgtgga
      601 gagaaaccct taaaaagaca agagggcagg gtcccagttt tgaggagttg caaagttcac
      661 ctatcagaga agtccttgca aagcagggag gttgggaagg ccctcctgat cagctcaggt
      721 gttctcaagc accaggtgac tcacacagga gagaagtcac ataggagctc caaaagtagg
      781 gaggcctttc atgctggaaa aaggcattac aaatgcagtg aatgtgggaa agcctttggt
      841 cagaaatatt tacttgttca gcaccagaga ctacatgctg ggaaaaagac gtatgaatgc
      901 agtgaatgtg ggaagttatt tagagatatg tccaaccttt ttatacacca aatagttcac
      961 actggagaaa ggccttacgg gtgtagtaac tgtggaaaat cctttagccg taatgctcac
     1021 ctcattgaac accagagagt tcacactgga gaaaagcctt ttacatgcag tgaatgtgga
     1081 aaagctttca ggcataattc cacacttgtt cagcatcaca aaatccacac tggagtaagg
     1141 ccttatgagt gcagtgaatg tggaaaattg tttagtttca actccagcct catgaaacat
     1201 cagagaattc acactggaga aagaccttat aagtgcagtg aatgtggaaa attctatagc
     1261 cacaagtcca accttatcaa acattggcgt gttcatactg gagaaaggcc ttacaagtgc
     1321 agcgactgtg ggaaattttt tacccaatgc tcaagcctca tgcaacatca aaaagttcac
     1381 actggagaaa agccttttaa gtgcaatgaa tgtgggagat tctttagaga gaattccacc
     1441 ctagttagac atcagagggt tcacactgga gcaaagcctt atgagtgcag ggaatgtggg
     1501 aaatttttta gccaaagctc aaccctcatg caacatcgaa aagttcacat tggagaaaag
     1561 ccttttaagt gcaatgaatg tgggagattg tttagagaga attccagcct tgttaaacat
     1621 cagagggttc acactggagc aaagccttat gagtgcaggg aatgtgggaa gttttttcgc
     1681 cacaactcca gtctttttaa acatcgaagg attcacactg gagaaatgca gtgattgtgt
     1741 gaaatccttt agccagcgtt tcaacctcat tcaacaccag aaagttcaca gtggaaaaaa
     1801 tcttgaaggt aacagatgga aatccgttag ccacacctcc agtctcattc aacactggac
     1861 agtttacaat gtggacaatg tagtgaatat ggaaaaaggt ttcagccaaa ggcctaaccc
     1921 tattcaacac cagaaagttt acactggaga aaggccttag ggtgacaggt tatgtactgt
     1981 ctctgaatca atatgacctc acttaaaaca gaaactctga ggatggcctt tatgagggag
     2041 ctggcaattg aacatcattc atctaaatat gcacactgga ggcaagatga gaattcctga
     2101 cagattgtcc ttcctgagaa gacagccctc tgccttggag ctccagagag agggagccct
     2161 gtattcttgg ctgtacccgt cgaatggagt tttgatctcg ctgagtttgg agttggggga
     2221 ggaaaggagt ggtcttggtt caaatgtgac tcacttttgc tgttcttgtg aatgttagat
     2281 cttctttaat aaatatttat ttcccataca cccttatgac catttccaga gactgaattg
     2341 tgtttttata attttcaccc ttttggctgt gtaacaggtc tgcaaagctc ctcattcagt
     2401 tattctgtaa gttgatccaa atgtttcaaa ttttaagaac ttgccaaatt gtgttctaaa
     2461 tggttagcat ttcatatttc ctcctggaat atattagatt ttccatttct tcacattact
     2521 gacagtttat atgtgtagaa gtcataggcc attcatttta gccatgttac taagtgtgaa
     2581 gtagtatttc attgtagttc ttaatttgta tttttccgat gactcagttt tgagcatttt
     2641 ttaatgtgtt tacttgtcac ccatatatct tctttagtca aatgtatttt ttgcctgttt
     2701 tttaaaacat ttggttggtt acaagttctt aatatttctg gagacaaatt ccttatttga
     2761 tataagcatt gtcaatattt tctcatggtc catggctttt gttttctttt cttttttaaa
     2821 atttagagat gaggtcgtgc tatgttgcac agactagtct ctaactcctg gcctcaagtg
     2881 atcatcctgc ctcagcctcc caaagtgctg ggattacagg catgagccac catgcttggc
     2941 cttgttttca gttcttaaca gtatctttcc tagagcagat tgtcttaatt ttatggagcc
     3001 caatttatcc atttgttatt ttattcattg tgcatttggt gttgcatcct cttactatac
     3061 catatctttg cctataaata aaagccttga ctgagtgcgg tggctcacgc ctgtaatccc
     3121 aacactttgg gaggccaagg cgggtggatc acgaggtcag gagattgaga ccatcctggc
     3181 taacacagtg aaactccctc tcaactaaaa atacaaaaaa ttagctgggc gtggtggcgg
     3241 ctgcctgtag ttccagctat cctggaggct gaggcaggag aatggtgtga gcccgggagg
     3301 cggagcttgc agtgagccga gattgcgcca ctgcactcca gcctggggca caaagccaga
     3361 ctctgtctca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaagccttat
     3421 gtgagtatgc tactgtaatc ttatgaatct ttttaaatat ccaacttctg aaatatttgt
     3481 aggtttaact acaaataaat aattcaatat atagataaat gtgtacatat tccctatctt
     3541 tactgagagc ctagcaagcc atggcattcc agtagttttg agcacattta atacccagtt
     3601 attggtttat atcatttttt aataaaagga accagaactc cttagagaag aggctgtttt
     3661 caagttgtgg cagaaaaggt acaacatgat ttgaggaaat actgcattgg aaaataaata
     3721 aatgttcaca gaataatgtt ga
//
