LOCUS       NM_133460               3726 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens zinc finger protein 418 (ZNF418), transcript variant
            3, mRNA.
ACCESSION   NM_133460 XM_085836 XR_243900
VERSION     NM_133460.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3726)
  AUTHORS   Singh,S.R., Meyer-Jens,M., Alizoti,E., Bacon,W.C., Davis,G.,
            Osinska,H., Gulick,J., Reischmann-Dusener,S., Orthey,E.,
            McLendon,P.M., Molkentin,J.D., Schlossarek,S., Robbins,J. and
            Carrier,L.
  TITLE     A high-throughput screening identifies ZNF418 as a novel regulator
            of the ubiquitin-proteasome system and autophagy-lysosomal pathway
  JOURNAL   Autophagy 17 (10), 3124-3139 (2021)
   PUBMED   33249983
  REMARK    GeneRIF: A high-throughput screening identifies ZNF418 as a novel
            regulator of the ubiquitin-proteasome system and
            autophagy-lysosomal pathway.
REFERENCE   2  (bases 1 to 3726)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3726)
  AUTHORS   Pu,W., Wang,C., Chen,S., Zhao,D., Zhou,Y., Ma,Y., Wang,Y., Li,C.,
            Huang,Z., Jin,L., Guo,S., Wang,J. and Wang,M.
  TITLE     Targeted bisulfite sequencing identified a panel of DNA
            methylation-based biomarkers for esophageal squamous cell carcinoma
            (ESCC)
  JOURNAL   Clin Epigenetics 9, 129 (2017)
   PUBMED   29270239
  REMARK    GeneRIF: Integration analysis of esophageal squamous cell carcinoma
            (ESCC) identified five hyper-methylated CpG sites in STK3, ZNF418
            and ZNF542 that can be used for effective methylation-based testing
            for ESCC diagnosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3726)
  AUTHORS   Pan,L., Sheng,M., Huang,Z., Zhu,Z., Xu,C., Teng,L., He,L., Gu,C.,
            Yi,C. and Li,J.
  TITLE     Zinc-finger protein 418 overexpression protects against cardiac
            hypertrophy and fibrosis
  JOURNAL   PLoS One 12 (10), e0186635 (2017)
   PUBMED   29065170
  REMARK    GeneRIF: the deficiency of ZNF418 enhanced the phosphorylation
            level of c-jun, and overexpression of ZNF418 suppressed the
            phosphorylation level of c-jun in vivo and in vitro
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3726)
  AUTHORS   Li,Y., Yang,D., Bai,Y., Mo,X., Huang,W., Yuan,W., Yin,Z., Deng,Y.,
            Murashko,O., Wang,Y., Fan,X., Zhu,C., Ocorr,K., Bodmer,R. and Wu,X.
  TITLE     ZNF418, a novel human KRAB/C2H2 zinc finger protein, suppresses
            MAPK signaling pathway
  JOURNAL   Mol Cell Biochem 310 (1-2), 141-151 (2008)
   PUBMED   18084723
  REMARK    GeneRIF: These results suggest that ZNF418 is a member of the
            zincfinger transcription factor family and may act as a negative
            regulator in MAPK signaling pathway.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010326.7, AK293723.1 and AY695825.1.
            
            On Jun 2, 2019 this sequence version replaced NM_133460.2.
            
            Transcript Variant: This variant (3) lacks an alternate 5' exon and
            uses an alternate in-frame splice junction compared to variant 1.
            The resulting isoform (c) has a shorter and distinct N-terminus
            compared to isoform a. Variants 3 and 4 both encode the same
            isoform (c).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY695825.1, SRR1660809.243744.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145240, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396147.6/ ENSP00000379451.1
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC010326.7         89961-89975         c
            16-30               AK293723.1         1-15
            31-3724             AY695825.1         1-3694
            3725-3726           AC010326.7         76455-76456         c
FEATURES             Location/Qualifiers
     source          1..3726
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..3726
                     /gene="ZNF418"
                     /gene_synonym="ZFP418"
                     /note="zinc finger protein 418"
                     /db_xref="GeneID:147686"
                     /db_xref="HGNC:HGNC:20647"
                     /db_xref="MIM:619509"
     exon            1..242
                     /gene="ZNF418"
                     /gene_synonym="ZFP418"
                     /inference="alignment:Splign:2.1.0"
     exon            243..328
                     /gene="ZNF418"
                     /gene_synonym="ZFP418"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..2353
                     /gene="ZNF418"
                     /gene_synonym="ZFP418"
                     /note="isoform c is encoded by transcript variant 3"
                     /codon_start=1
                     /product="zinc finger protein 418 isoform c"
                     /protein_id="NP_597717.1"
                     /db_xref="CCDS:CCDS42642.1"
                     /db_xref="GeneID:147686"
                     /db_xref="HGNC:HGNC:20647"
                     /db_xref="MIM:619509"
                     /translation="MQGTVAFEDVAVNFSQEEWSLLSEVQRCLYHDVMLENWVLISSL
                     GCWCGSEDEEAPSKKSISIQRVSQVSTPGAGVSPKKAHSCEMCGAILGDILHLADHQG
                     THHKQKLHRCEAWGNKLYDSSNRPHQNQYLGEKPYRSSVEEALFVKRCKFHVSEESSI
                     FIQSGKDFLPSSGLLLQEATHTGEKSNSKPECESPFQWGDTHYSCGECMKHSSTKHVF
                     VQQQRLPSREECYCWECGKSFSKYDSVSNHQRVHTGKRPYECGECGKSFSHKGSLVQH
                     QRVHTGKRPYECGECGKSFSHKGSLVQHQRVHTGERPYECGECGKSFSQNGTLIKHQR
                     VHTGERPYECEECGKCFTQKGNLIQHQRGHTSERPYECEECGKCFSQKGTLTEHHRVH
                     TRERPYECGECGKSFSRKGHLRNHQRGHTGERPYECGECGKSFSRKGNLIQHQRSHTG
                     ERPYECRECRKLFRGKSHLIEHQRVHTGERPYECNECGKSFQDSSGFRVHQRVHTGEK
                     PFECSECGKSFPQSCSLLRHRRVHTGERPYECGECGKSFHQSSSLLRHQKTHTAERPY
                     ECRECGKFFSSLLEHRRVHTGERPYECRECGKTFTRRSAHFKHQRLHTRGKPYECSEC
                     GKSFAETFSLTEHRRVHTGERPYECSECGKSFHRSSSLLRHQRVHTERSPYK"
     exon            329..455
                     /gene="ZNF418"
                     /gene_synonym="ZFP418"
                     /inference="alignment:Splign:2.1.0"
     exon            456..2880
                     /gene="ZNF418"
                     /gene_synonym="ZFP418"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..2978
                     /gene="ZNF418"
                     /gene_synonym="ZFP418"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3726
                     /gene="ZNF418"
                     /gene_synonym="ZFP418"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3324..3329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF418"
                     /gene_synonym="ZFP418"
                     /note="hexamer: AATAAA"
     polyA_site      3347
                     /gene="ZNF418"
                     /gene_synonym="ZFP418"
                     /note="major polyA site"
     regulatory      3622..3627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF418"
                     /gene_synonym="ZFP418"
                     /note="hexamer: TATAAA"
     polyA_site      3645
                     /gene="ZNF418"
                     /gene_synonym="ZFP418"
     regulatory      3704..3709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF418"
                     /gene_synonym="ZFP418"
                     /note="hexamer: AATAAA"
     polyA_site      3726
                     /gene="ZNF418"
                     /gene_synonym="ZFP418"
ORIGIN      
        1 gggattctca gcgttctctg gtagcgacca ttttggttaa tgttgggtgt gtttctgcgg
       61 tttgtgaggt gagaggcgct ggagctatgg gtccgaaccg cggtgtctga acccagaagg
      121 tgaagagtcc ttcttgctgc acagaggcag atcttaggcc ccgtaacggc gcccgccgct
      181 cccggcagtg ctttccccgc gtactcggga tggcggcggc cgcgctgagg ctcccggctc
      241 aggcatcatc tggctgcaaa gaagagaaca cactgtgttt gagggaggag gaaggaggat
      301 cagagtttaa actcctgcca taatgcaggg cactgtggca tttgaagatg tggctgtgaa
      361 cttttcccag gaggagtgga gtctccttag tgaggttcag agatgccttt accatgacgt
      421 gatgctggag aactgggtac ttatatcctc cctgggttgt tggtgtggat cagaagatga
      481 ggaggcacct tctaagaaga gcatttctat acaaagagtg tctcaggtca gcactcctgg
      541 ggcaggtgtg tctcccaaga aggcccactc ttgtgaaatg tgtggcgcga tcttgggaga
      601 cattttgcac ttggcagatc atcaggggac acatcacaag cagaaactgc acaggtgtga
      661 ggcatggggg aataaattgt atgatagttc aaaccgtccg caccagaatc agtaccttgg
      721 agagaaaccc tatagaagca gtgttgagga agcattgttt gtgaagaggt gtaagttcca
      781 tgtgtcagag gagtcatcta tcttcattca gagtggaaag gactttttgc ccagctcagg
      841 attactgctg caggaggcca ctcacactgg ggagaagtca aacagcaaac ctgagtgtga
      901 gtctcccttt cagtggggag atactcatta cagctgtgga gaatgcatga aacattctag
      961 caccaaacac gtatttgttc aacagcagag acttccctct agagaggaat gttattgctg
     1021 ggaatgtggg aaatccttta gcaaatatga tagcgtcagt aatcatcaga gagttcacac
     1081 tgggaaaaga ccttatgaat gtggagaatg tgggaaatct tttagtcata agggcagcct
     1141 tgttcagcat cagcgagttc acactgggaa aagaccttat gaatgtggag aatgtgggaa
     1201 atcttttagt cataagggca gccttgttca gcatcagcga gttcatactg gagaaagacc
     1261 ttatgagtgt ggagaatgtg ggaaatcttt tagtcaaaat ggtactctca ttaaacatca
     1321 acgagttcac actggagaaa gaccttatga gtgtgaagaa tgtgggaaat gttttactca
     1381 gaagggcaat ctcattcaac atcaacgagg tcacactagt gaaagacctt atgagtgtga
     1441 agaatgtgga aaatgtttta gtcaaaaggg caccctaact gaacatcatc gagttcacac
     1501 tagagaacga ccttatgagt gtggagaatg tgggaaatct tttagtcgaa agggacacct
     1561 taggaaccat cagcgaggtc acactggaga aagaccttac gagtgtggag aatgtgggaa
     1621 atcttttagt cgaaagggca acctcattca gcatcagcga agccacactg gagaaaggcc
     1681 ttatgagtgt agagagtgta ggaaattatt taggggcaag tcccacctca ttgaacacca
     1741 gagagttcac actggagaaa ggccatatga atgtaatgaa tgtgggaaat catttcaaga
     1801 cagctctggg tttcgtgttc atcagagagt tcacactgga gaaaaaccgt ttgagtgtag
     1861 tgaatgtggg aagtcatttc ctcaaagctg ttccctcctt cgacatcgga gagttcatac
     1921 tggagaaagg ccttatgaat gtggagaatg tggaaagtca tttcatcaga gctcttccct
     1981 ccttcgacat cagaaaactc acactgcaga aagaccttat gagtgcagag aatgtgggaa
     2041 attcttctcc agtctccttg aacacaggag agttcacact ggagaaaggc cttatgaatg
     2101 cagggaatgt ggaaaaacat ttactcgaag gtctgcgcat tttaaacatc agagacttca
     2161 tactcgagga aagccttacg agtgcagcga atgtgggaaa tcctttgctg aaaccttcag
     2221 tcttactgaa cacaggagag tacacactgg agaaaggcct tatgagtgca gtgaatgtgg
     2281 aaaatcattt catcgaagct cttctctcct tcgacatcag agagttcaca cagaaagaag
     2341 tccttacaag tgaaaagaaa tttgggaaat tctttagcta aacctctgtg catcttcttg
     2401 atcagagggt tcttactgga tcaggacctt atgagtgtga caaacgtggg atattcttta
     2461 tgcagaagtc ttgttttatt acatacagaa gagctcccac tgcagaaggg cctcttgagt
     2521 gcgatgaatg tgagaaagcc ttctgccttc tgtcattgga taacagattg ttctcataag
     2581 gaaaacactg tacacgtaca ggaaatatta tttcttgtaa aacataacac tggaggagat
     2641 gccttatgac ggagccatct gcctaaattg acataccttc agcatctgca taaactcaat
     2701 tatgttggag ctgtgtggca tttttcaccc tgccgggttc ccttgccaga catgatgtcg
     2761 gttatctggc aaaagccatt ttatgtcggc cacgaggcag gtgttcactg tgcatcattc
     2821 attcacccca tgatgttctg gaagtaaacc ttggttgtct ttcgttggcc agaggaattg
     2881 aatgtccgtc tgtctgccca ggctggagtg gcacgatctc agctcactgc agcctccacc
     2941 tccagggttc aagcgattct cctgcctcag cctcccgggg atctcaaggg catttccctt
     3001 tgcccacctc accttttcat atttggtaaa ctgtatgcat ttgcctccag cccaagatta
     3061 taaatatgaa ctgattatga tctgcatgtt ctctctttgg gttcaagcat ttccttacag
     3121 aagagccacc gtggaagtca tgggtaaata tgtgttgaat tggtaactcc ctcttggaga
     3181 atttcttgtg aattacacag caatagggga actcatttaa ctggagacat aatctcaatt
     3241 tgtaaagtgt ggcccatttt ctaacatttt tattttgcat accctcccct ctcttctcga
     3301 ttgatgaaac taacaaagag gttaataaaa gcccatctcg tcatgtacag ggactcatgc
     3361 ctttaattcc agtgttttgg gagactaagg caagaacatc ctggaggcca ggagttcgac
     3421 actgtataac agatatatct gacagcagta actcaagcac accctaagaa tgaccctgtg
     3481 gtctaagaag agtgttggtt cagcgttcca aacgaagaaa tccaggagtg gccaacctgg
     3541 aggtttctga acccctggcc tgttccttgg aatgaggccc tttgttttga gctaggcgga
     3601 gggtgataag tgaaaatact atataaactg catgcttctt tcaaatgata gtggtttttt
     3661 tgtccagcct gccgctcctg gactgccctg tatctaagtc ctcaataaac cctatgtctc
     3721 attttc
//
