LOCUS       NM_018355               2288 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 415 (ZNF415), transcript variant
            2, mRNA.
ACCESSION   NM_018355
VERSION     NM_018355.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2288)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2288)
  AUTHORS   Kobayashi,Y., Umemoto,T., Takeshita,Y., Kohyama,N., Ohbayashi,M.,
            Sanada,Y. and Yamamoto,T.
  TITLE     Functional characterization and substrate specificity of a novel
            gene encoding zinc finger-like protein, ZfLp, in Xenopus laevis
            oocytes
  JOURNAL   J Toxicol Sci 37 (4), 699-709 (2012)
   PUBMED   22863851
  REMARK    GeneRIF: ZfLp is a zinc finger protein that functions as a drug
            carrier protein.
REFERENCE   3  (bases 1 to 2288)
  AUTHORS   Cheng,Y., Wang,Y., Li,Y., Deng,Y., Hu,J., Mo,X., Li,N., Li,Y.,
            Luo,N., Yuan,W., Xiao,J., Zhu,C., Wu,X. and Liu,M.
  TITLE     A novel human gene ZNF415 with five isoforms inhibits AP-1- and
            p53-mediated transcriptional activity
  JOURNAL   Biochem Biophys Res Commun 351 (1), 33-39 (2006)
   PUBMED   17055453
  REMARK    GeneRIF: ZNF415 isoforms in COS-7 cells inhibits the
            transcriptional activities of AP-1 and p53, suggesting that the
            ZNF415 protein may be involved in AP-1- and p53-mediated
            transcriptional activity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA692431.1, AK002053.1, BC069668.1, AA125787.1 and R40095.1.
            
            On Aug 13, 2020 this sequence version replaced NM_018355.3.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR and an alternate exon containing a distinct start
            codon, compared to variant 1. The resulting isoform (2) is the same
            length as but has a distinct N-terminus, compared to isoform 1.
            Variants 2, 3 and 21 encode the same protein (isoform 2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY283600.1, AK002053.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243643.9/ ENSP00000243643.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DA692431.1         11-28
            19-662              AK002053.1         1-644
            663-2066            BC069668.1         855-2258
            2067-2255           AA125787.1         34-222              c
            2256-2288           R40095.1           16-48               c
FEATURES             Location/Qualifiers
     source          1..2288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..2288
                     /gene="ZNF415"
                     /gene_synonym="Pact; ZfLp"
                     /note="zinc finger protein 415"
                     /db_xref="GeneID:55786"
                     /db_xref="HGNC:HGNC:20636"
                     /db_xref="MIM:619506"
     exon            1..55
                     /gene="ZNF415"
                     /gene_synonym="Pact; ZfLp"
                     /inference="alignment:Splign:2.1.0"
     exon            56..137
                     /gene="ZNF415"
                     /gene_synonym="Pact; ZfLp"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1790
                     /gene="ZNF415"
                     /gene_synonym="Pact; ZfLp"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 415 isoform 2"
                     /protein_id="NP_060825.2"
                     /db_xref="CCDS:CCDS12860.1"
                     /db_xref="GeneID:55786"
                     /db_xref="HGNC:HGNC:20636"
                     /db_xref="MIM:619506"
                     /translation="MAFTQLTFRDVAIEFSQDEWKCLNSTQRTLYRDVMLENYRNLVS
                     LDLSRNCVIKELAPQQEGNPGEVFHTVTLEQHEKHDIEEFCFREIKKKIHDFDCQWRD
                     DERNCNKVTTAPKENLTCRRDQRDRRGIGNKSIKHQLGLSFLPHPHELQQFQAEGKIY
                     ECNHVEKSVNHGSSVSPPQIISSTIKTHVSNKYGTDFICSSLLTQEQKSCIREKPYRY
                     IECDKALNHGSHMTVRQVSHSGEKGYKCDLCGKVFSQKSNLARHWRVHTGEKPYKCNE
                     CDRSFSRNSCLALHRRVHTGEKPYKCYECDKVFSRNSCLALHQKTHIGEKPYTCKECG
                     KAFSVRSTLTNHQVIHSGKKPYKCNECGKVFSQTSSLATHQRIHTGEKPYKCNECGKV
                     FSQTSSLARHWRIHTGEKPYKCNECGKVFSYNSHLASHRRVHTGEKPYKCNECGKAFS
                     VHSNLTTHQVIHTGEKPYKCNQCGKGFSVHSSLTTHQVIHTGEKPYKCNECGKSFSVR
                     PNLTRHQIIHTGKKPYKCSDCGKSFSVRPNLFRHQIIHTKEKPYKRN"
     exon            138..258
                     /gene="ZNF415"
                     /gene_synonym="Pact; ZfLp"
                     /inference="alignment:Splign:2.1.0"
     exon            259..2288
                     /gene="ZNF415"
                     /gene_synonym="Pact; ZfLp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2261..2266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF415"
                     /gene_synonym="Pact; ZfLp"
                     /note="hexamer: ATTAAA"
     polyA_site      2288
                     /gene="ZNF415"
                     /gene_synonym="Pact; ZfLp"
                     /note="major polyA site"
ORIGIN      
        1 agtttcctac aggcccggaa acggatcgcg ttgggtgaag gtgacggcgt cgagccattg
       61 acttccaaag actcctggca catgaggaag aaacccagaa gaggagagca aaggagtcag
      121 gaatggcttt tactcagttg acattcaggg acgtggccat cgaattctct caagatgagt
      181 ggaaatgcct gaactctaca cagaggactt tatacaggga tgtgatgttg gagaactaca
      241 ggaacctggt ctccctggat ctgtctcgta actgtgtaat caaggaacta gcaccacaac
      301 aggaaggtaa cccaggagaa gtattccaca cagtgacatt ggaacaacat gaaaaacatg
      361 acattgaaga gttttgcttc agggaaatca agaaaaaaat acacgacttt gactgtcagt
      421 ggagagatga tgaaagaaat tgcaacaaag tgactacggc cccaaaagaa aatcttactt
      481 gtaggagaga ccaacgcgat agaagaggta taggaaacaa gtctattaaa catcagcttg
      541 gattaagctt tctaccacat ccccatgaac tgcagcagtt tcaagctgaa gggaaaattt
      601 atgaatgtaa ccatgttgag aagtctgtca accatggttc ctcagtttca ccaccccaaa
      661 taatttcttc taccatcaaa acccatgttt ctaataaata tgggactgat ttcatctgtt
      721 cttcattact cacacaagaa cagaaatcat gcattaggga aaaaccttac agatatattg
      781 agtgcgacaa agccttgaat catggctcac acatgactgt acgtcaggta agtcattctg
      841 gagagaaagg atataaatgt gatctgtgtg gcaaggtctt tagtcaaaaa tcaaaccttg
      901 cgcgtcattg gagagttcat actggagaga aaccatacaa atgtaatgaa tgtgacagaa
      961 gtttcagtcg caactcatgc cttgcactac atcggagagt tcacactgga gagaaacctt
     1021 acaaatgtta tgagtgtgac aaggtcttca gtcgaaattc atgccttgca ctacatcaga
     1081 aaactcatat tggagagaaa ccttacacat gtaaagagtg tggcaaagcc tttagtgtga
     1141 ggtcaacact taccaaccat caggtaattc atagtggcaa gaaaccttac aaatgcaatg
     1201 aatgtggcaa ggtgttcagt cagacttcaa gccttgcaac tcatcagaga attcacactg
     1261 gggagaaacc atacaagtgt aatgaatgtg gtaaagtctt cagtcagact tcaagccttg
     1321 caaggcattg gagaattcat actggagaga aaccttacaa atgcaatgaa tgtggtaagg
     1381 ttttcagtta caattcacac cttgcgagtc atcggagagt tcatactgga gagaaacctt
     1441 acaagtgtaa tgagtgtggg aaagccttta gtgtgcattc gaacttaact acccatcagg
     1501 tcatccatac tggagagaag ccttacaaat gtaatcaatg tggcaaaggc ttcagtgtgc
     1561 attcaagcct aactacccat caggtcatcc atactggaga aaaaccttac aaatgtaatg
     1621 agtgtggcaa atcctttagt gtgcgcccaa acctcactag acatcagata atccatactg
     1681 gaaagaaacc ttacaaatgt agtgattgtg ggaagtcctt tagtgtgcgc ccaaacctct
     1741 tcagacatca aattatccat actaaggaga aaccttataa aagaaattaa tatggcaagg
     1801 tcttcagtca aagtttaaat cctgtgagtc atcaaagaat ttatatcaga gagaaaccat
     1861 acaagtataa taaatgtggc aaggttttca gtcacaattc actcctacac agcatcagag
     1921 aatttcattc ttgagagaat ccttacgagt acagcaaacc cttcatcaca agttcaagca
     1981 ttcattgaca tcagagtcca tgctaaagag aaatcatata cacctaactg tgtggcagag
     2041 gcttcattta ggtctcacaa ctcactagac atcaaaatgt gtaaacatct ttgtatattt
     2101 tgtgcatgtt gaagctatta accaaggatc aaaactgtaa cacatccaag gatttatgtg
     2161 aggaataatt cagtctagtt gtgctgataa acttttcata ttacacattg tagaacaaat
     2221 gcaagcccaa atatgttaaa actcacacaa catgatatat attaaaggtt gcaggatgtt
     2281 tgaagtca
//
