LOCUS       NM_001146175            2307 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 414 (ZNF414), transcript variant
            1, mRNA.
ACCESSION   NM_001146175
VERSION     NM_001146175.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2307)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 2307)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2307)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2307)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2307)
  AUTHORS   Vuorinen,E.M., Rajala,N.K., Rauhala,H.E., Nurminen,A.T.,
            Hytonen,V.P. and Kallioniemi,A.
  TITLE     Search for KPNA7 cargo proteins in human cells reveals MVP and
            ZNF414 as novel regulators of cancer cell growth
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1863 (1), 211-219 (2017)
   PUBMED   27664836
  REMARK    GeneRIF: KPNA7 binding and nuclear transfer was validated for two
            proteins, MVP and ZNF414. MVP and ZNF414 have a key role in the
            regulation of pancreatic cancer cell growth.
REFERENCE   6  (bases 1 to 2307)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092298.2, DA257941.1, BC007310.1, AK225034.1, BQ773835.1 and
            BU621653.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001146175.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074191.1, AK225034.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393927.9/ ENSP00000377504.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC092298.2         18686-18688         c
            4-19                DA257941.1         1-16
            20-314              BC007310.1         1-295
            315-315             AK225034.1         308-308
            316-825             BC007310.1         297-806
            826-1405            BQ773835.1         19-598              c
            1406-1407           BU621653.1         18-19               c
            1408-2307           AC092298.2         14199-15098         c
FEATURES             Location/Qualifiers
     source          1..2307
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2307
                     /gene="ZNF414"
                     /gene_synonym="ZFP414"
                     /note="zinc finger protein 414"
                     /db_xref="GeneID:84330"
                     /db_xref="HGNC:HGNC:20630"
                     /db_xref="MIM:620980"
     exon            1..124
                     /gene="ZNF414"
                     /gene_synonym="ZFP414"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1294
                     /gene="ZNF414"
                     /gene_synonym="ZFP414"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 414 isoform 1"
                     /protein_id="NP_001139647.1"
                     /db_xref="CCDS:CCDS54211.1"
                     /db_xref="GeneID:84330"
                     /db_xref="HGNC:HGNC:20630"
                     /db_xref="MIM:620980"
                     /translation="MEEKPSGPIPDMLATAEPSSSETDKEVLSPAVPAAAPSSSMSEE
                     PGPEQAATPPVWERGGAGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPRRR
                     PPPGKQIPCSSPGCCLSFPSVRDLAQHLRTHCPPTQSLEGKLFRCSALSCTETFPSMQ
                     ELVAHSKLHYKPNRYFKCENCLLRFRTHRSLFKHLHVCAEHAQSPAPPPPPALDREPP
                     APERPPEVDPASAPGLPFPLLEPFTTPAPAPTGPFLPYLNPAPFGLSPPRLRPFLAAA
                     PGPPASSAAVWKKSQGAGSSPRRPQGGSDAPSGHAAPSRIVWEHTRGRYSCMQCAFST
                     ASRPAMTLHLEDHRPGAPAAPAAGPPRPDAPADPAPLAPKVSPLLSEGELPVFSQL"
     exon            125..437
                     /gene="ZNF414"
                     /gene_synonym="ZFP414"
                     /inference="alignment:Splign:2.1.0"
     exon            438..545
                     /gene="ZNF414"
                     /gene_synonym="ZFP414"
                     /inference="alignment:Splign:2.1.0"
     exon            546..651
                     /gene="ZNF414"
                     /gene_synonym="ZFP414"
                     /inference="alignment:Splign:2.1.0"
     exon            652..995
                     /gene="ZNF414"
                     /gene_synonym="ZFP414"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1046
                     /gene="ZNF414"
                     /gene_synonym="ZFP414"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1220
                     /gene="ZNF414"
                     /gene_synonym="ZFP414"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..2307
                     /gene="ZNF414"
                     /gene_synonym="ZFP414"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1380..1385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF414"
                     /gene_synonym="ZFP414"
                     /note="hexamer: AATAAA"
     polyA_site      1407
                     /gene="ZNF414"
                     /gene_synonym="ZFP414"
                     /note="major polyA site"
     regulatory      2286..2291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF414"
                     /gene_synonym="ZFP414"
                     /note="hexamer: AATAAA"
     regulatory      2290..2295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF414"
                     /gene_synonym="ZFP414"
                     /note="hexamer: AAGAAA"
     polyA_site      2303
                     /gene="ZNF414"
                     /gene_synonym="ZFP414"
     polyA_site      2307
                     /gene="ZNF414"
                     /gene_synonym="ZFP414"
                     /note="major polyA site"
ORIGIN      
        1 gagagctgag aggtggaaaa tggcgctgac gtgagcgcga actcgcactg cccagagggt
       61 ggccgccgcc taagctgcag ccgccggagc cgcagaaaca agaggccgag ccgtgtcgaa
      121 gatggaggag aaaccctcag ggcccatccc agacatgctg gccactgcag agcccagctc
      181 cagtgagacc gacaaggagg tgttgtcccc ggctgtgcca gctgcagccc cttcctcctc
      241 catgtcggag gagccaggcc ctgagcaggc agccacaccg ccagtgtggg aacgtggagg
      301 ggctggaggg atgcagcagg gctcctcccc agccccagac agctgccagc ctggccccgg
      361 acccagccct ggcctgacca gcatagtctc cgggaccagc gaggacctgc ggcctcccag
      421 acgacgccca cctccaggga agcaaatccc ttgctccagc cctggctgct gcctcagttt
      481 tcccagcgtc cgtgacctgg cacagcatct gcgaacccac tgcccgccca cacagtccct
      541 ggaaggcaag ctcttccgct gctcagccct gagctgcacc gagaccttcc ccagcatgca
      601 ggagctggtg gctcacagca aactgcacta caaacccaat cgctacttca agtgtgagaa
      661 ctgcctcctg cgcttccgca cgcaccgctc gctcttcaag cacctgcatg tttgcgcgga
      721 gcatgcgcag agcccagccc cgccgccacc cccggccctg gaccgagagc cgcccgcgcc
      781 ggagcgcccc ccggaggttg accccgcatc agcgccgggc ctgccgttcc cgctgctgga
      841 acccttcacg acccccgccc ctgcccccac cggaccgttc ctgccctact tgaaccctgc
      901 gccctttggc ctaagccccc cgcgcctgcg ccccttcctg gccgctgcac ccgggccgcc
      961 ggcttccagc gccgccgtct ggaaaaagag ccaaggtgct ggcagcagcc cccgaagacc
     1021 ccagggcggc tccgacgcgc cctcagggca cgcggccccg agccgcatcg tgtgggagca
     1081 cacacgcggc cgctactcgt gcatgcagtg cgccttctcc acggcctcgc ggcccgccat
     1141 gaccctgcac ctggaggacc accgccccgg cgcccccgcg gcccccgcgg ccgggccgcc
     1201 gcgccccgac gcccccgcgg atccggcccc gcttgcaccc aaggtgtcgc cgctgctgtc
     1261 agagggggag cttccagtgt tctcgcagct ctgaatcccg ccgctttggg ggtgggccat
     1321 gggatgtggg tagttttgtc atttggaggg ggctgcaggg aaggggggct ggggtggaca
     1381 ataaagaagg cgccatgagc cagcctatgc tgtgttccca tcccttgtcc atccaaagca
     1441 tagtgggctc gagcccagca gtcatggatt gatcacatct tgggaggacc acctgggtcc
     1501 acaggtgcag gcctcacagc ccacctgtgt cctgtcttcc catcacccca atcctgggac
     1561 ccaggtcccc acctccagct gtggttgagg tccccagtac ccactgtggc agcgttctcc
     1621 cttgtccaga aaccaaatgg gatggggact ctccagtttt cttttttttt ttttttcttt
     1681 tttttttttt cttttttgag acagtcttgc tctgtctccc aggccggagt gcagtggcac
     1741 aatctcctct cactgcaagc tccacctcct gggttcacgc cattctcctg cttcagcctc
     1801 ccaagtagct gggattacag gtgcccacca ctatgcccgg ctaatttttt gtatttttaa
     1861 tagagatgga gtttcaccgc gttagccagg atggtctcga tctcctgacc tcatgatccg
     1921 cccgccttag actcccaaag tgctggaatt acaggcgtga gccaccacgc ccggtctcca
     1981 gttttctttt aagaagtccc ggccgggcac agtggctcac gcctgtaatc ccagcacttt
     2041 gggaggctgg ggcaggtgga gcacctgagg tcaggagttc gagaccagcc tgacttacat
     2101 ggtaaaaccc catctctact aaacacaaaa aattagccag gtgtggtggc gcacacctgt
     2161 agtcccagct acttgggagg ctgaggcagg agaatcactt gaacctggga ggtggaagtt
     2221 gcagtgagct gagattgtgc tattgcactc cagtctgggc aatacgagtg gaactccatc
     2281 tcaaaaataa agaaaattaa aaagcaa
//
