LOCUS       NM_021188               2623 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 410 (ZNF410), transcript variant
            2, mRNA.
ACCESSION   NM_021188
VERSION     NM_021188.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2623)
  AUTHORS   Vinjamur,D.S., Yao,Q., Cole,M.A., McGuckin,C., Ren,C., Zeng,J.,
            Hossain,M., Luk,K., Wolfe,S.A., Pinello,L. and Bauer,D.E.
  TITLE     ZNF410 represses fetal globin by singular control of CHD4
  JOURNAL   Nat Genet 53 (5), 719-728 (2021)
   PUBMED   33859416
  REMARK    GeneRIF: ZNF410 represses fetal globin by singular control of CHD4.
REFERENCE   2  (bases 1 to 2623)
  AUTHORS   Lan,X., Ren,R., Feng,R., Ly,L.C., Lan,Y., Zhang,Z., Aboreden,N.,
            Qin,K., Horton,J.R., Grevet,J.D., Mayuranathan,T., Abdulmalik,O.,
            Keller,C.A., Giardine,B., Hardison,R.C., Crossley,M., Weiss,M.J.,
            Cheng,X., Shi,J. and Blobel,G.A.
  TITLE     ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal
            Hemoglobin Expression
  JOURNAL   Mol Cell 81 (2), 239-254 (2021)
   PUBMED   33301730
  REMARK    GeneRIF: ZNF410 Uniquely Activates the NuRD Component CHD4 to
            Silence Fetal Hemoglobin Expression.
REFERENCE   3  (bases 1 to 2623)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2623)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2623)
  AUTHORS   Chen,Y., Liu,R., Chu,Z., Le,B., Zeng,H., Zhang,X., Wu,Q., Zhu,G.,
            Chen,Y., Liu,Y., Sun,F., Lu,Z., Qiao,Y. and Wang,J.
  TITLE     High glucose stimulates proliferative capacity of liver cancer
            cells possibly via O-GlcNAcylation-dependent transcriptional
            regulation of GJC1
  JOURNAL   J Cell Physiol 234 (1), 606-618 (2018)
   PUBMED   30078215
  REMARK    GeneRIF: The HG-stimulated proliferative capacity was abolished
            upon decreasing O-GlcNAcylation, which could be reversed gradually
            by the simultaneous overexpression of APA1 and GJC1. Therefore,
            GJC1 could be a potential target for preventing liver cancer in
            patients with diabetes.
REFERENCE   6  (bases 1 to 2623)
  AUTHORS   Castelan-Martinez,O.D., Vivanco-Munoz,N., Falcon-Ramirez,E.,
            Valdes-Flores,M. and Clark,P.
  TITLE     [Apa1 VDR polymorphism and osteoporosis risk in postmenopausal
            Mexican women]
  JOURNAL   Gac Med Mex 151 (4), 472-476 (2015)
   PUBMED   26290023
  REMARK    GeneRIF: No association was found between Apa1 genotypes and
            osteoporosis
REFERENCE   7  (bases 1 to 2623)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   8  (bases 1 to 2623)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 2623)
  AUTHORS   Hubner,R.A., Muir,K.R., Liu,J.F., Logan,R.F., Grainge,M.J. and
            Houlston,R.S.
  CONSRTM   Members of UKCAP Consortium
  TITLE     Dairy products, polymorphisms in the vitamin D receptor gene and
            colorectal adenoma recurrence
  JOURNAL   Int J Cancer 123 (3), 586-593 (2008)
   PUBMED   18470879
  REMARK    GeneRIF: VDR polymorphism genotypes and haplotypes did not directly
            alter recurrence risk, but the reduction in risk associated with
            high dairy product intake was confined to individuals with ApaI
            aA/AA genotype.
REFERENCE   10 (bases 1 to 2623)
  AUTHORS   Benanti,J.A., Williams,D.K., Robinson,K.L., Ozer,H.L. and
            Galloway,D.A.
  TITLE     Induction of extracellular matrix-remodeling genes by the
            senescence-associated protein APA-1
  JOURNAL   Mol Cell Biol 22 (21), 7385-7397 (2002)
   PUBMED   12370286
  REMARK    GeneRIF: APA1 has a role in inducing extracellular matrix
            remodeling genes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK223261.1, AC005480.3 and AA652386.1.
            
            On Jun 2, 2019 this sequence version replaced NM_021188.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, and it also lacks an exon that
            results in a frameshift in the 3' coding region, compared to
            variant 1. The encoded isoform (b) has a distinct C-terminus and is
            shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.283924.1,
                                           SRR1803611.237932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000555044.6/ ENSP00000451763.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1269              AK223261.1         1-1269
            1270-1270           AC005480.3         88307-88307         c
            1271-1685           AK223261.1         1271-1685
            1686-2349           AC005480.3         77100-77763         c
            2350-2390           AA652386.1         12-52               c
            2391-2623           AC005480.3         76826-77058         c
FEATURES             Location/Qualifiers
     source          1..2623
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..2623
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /note="zinc finger protein 410"
                     /db_xref="GeneID:57862"
                     /db_xref="HGNC:HGNC:20144"
                     /db_xref="MIM:619427"
     exon            1..57
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /inference="alignment:Splign:2.1.0"
     exon            58..239
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1643
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /note="isoform b is encoded by transcript variant 2;
                     clones 23667 and 23775 zinc finger protein; another
                     partner for ARF 1; zinc finger protein APA-1"
                     /codon_start=1
                     /product="zinc finger protein 410 isoform b"
                     /protein_id="NP_067011.1"
                     /db_xref="CCDS:CCDS9821.1"
                     /db_xref="GeneID:57862"
                     /db_xref="HGNC:HGNC:20144"
                     /db_xref="MIM:619427"
                     /translation="MLSDELESKPELLVQFVQNTSIPLGQGLVESEAKDITCLSLLPV
                     TEASECSRLMLPDDTTNHSNSSKEVPSSAVLRSLRVNVGPDGEETRAQTVQKSPEFLS
                     TSESSSLLQDLQPSDSTSFILLNLTRAGLGSSAEHLVFVQDEAEDSGNDFLSSESTDS
                     SIPWFLRVQELAHDSLIAATRAQLAKNAKTSSNGENVHLGSGDGQSKDSGPLPQVEKK
                     LKCTVEGCDRTFVWPAHFKYHLKTHRNDRSFICPAEGCGKSFYVLQRLKVHMRTHNGE
                     KPFMCHESGCGKQFTTAGNLKNHRRIHTGEKPFLCEAQGCGRSFAEYSSLRKHLVVHS
                     GEKPHQCQVCGKTFSQSGSRNVHMRKHHLQLGAAGSQEQEQTAEPLMGSSLLEEASVP
                     SKNLVSMNSQPSLGGESLNLPNTNSILGVDDEVLAEGSPRSLSSVPDVTHHLVTMQSG
                     RQSYEVSVLTAVNPQELLNQGDLTERRT"
     exon            240..375
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..594
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..786
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..937
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1119
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1209
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1335
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1476
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1604
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..2623
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2359..2364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /note="hexamer: AATAAA"
     polyA_site      2380
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /note="major polyA site"
     regulatory      2594..2599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
                     /note="hexamer: AATAAA"
     polyA_site      2623
                     /gene="ZNF410"
                     /gene_synonym="APA-1; APA1"
ORIGIN      
        1 gtgtgtggac ggaattcggg accgactgac ggccggccgg cttcccggaa ctggaaggtt
       61 acattgatta cccacctagt acaacatctt acgggaagag catagtattt cctagaggaa
      121 tatgaacata acaggaaggt atcattggct ctgaattaaa tttgaacttg tcccctgaat
      181 agctacaggt tttggaagct gaatcaatgt tatcagatga gttagaatcc aaaccagagc
      241 tcctggtaca gtttgttcag aatacgtcca tcccattggg acaggggctt gtagaatcag
      301 aagctaaaga tattacttgc ttgtccctcc ttcccgtgac tgaagcctca gaatgcagtc
      361 ggctaatgtt accagatgat actacaaatc attctaactc ctccaaggag gtcccttcct
      421 cagctgtttt gagaagcctt cgggtgaatg tgggtccaga cggagaggag acgagagctc
      481 agactgtaca gaaatccccg gagtttttgt ccacttcaga gtcttctagc ttgttgcaag
      541 atctacagcc aagtgatagc acttctttta ttcttcttaa cctaacaaga gcaggtctgg
      601 gctcttcagc tgagcactta gtgtttgtac aggatgaggc agaagattca gggaatgatt
      661 tcctctccag tgagagcaca gacagtagca ttccatggtt cctccgggtt caggagttgg
      721 cccatgacag tttgattgct gctactcgtg cacaactggc aaagaatgca aaaaccagca
      781 gcaatggaga aaatgtccac cttggttctg gtgatgggca gtcaaaagat tctgggcccc
      841 ttcctcaagt ggaaaagaag ctcaagtgta cagttgaagg ttgtgaccgg acatttgtat
      901 ggccagctca ctttaaatac cacctcaaga ctcatcgaaa tgaccgctcc ttcatctgtc
      961 ctgcagaagg ttgtgggaaa agcttctatg tgctgcagag gctgaaggtg cacatgagga
     1021 cccacaatgg agagaagccc tttatgtgcc atgagtctgg ctgtggtaag cagtttacta
     1081 cagctggaaa cctgaagaac caccggcgca tccacacagg agagaaacct ttcctttgtg
     1141 aagcccaagg atgtggccgt tcctttgctg agtattctag cctccgaaaa catctggtgg
     1201 ttcactcagg agagaagcct catcagtgcc aagtctgtgg gaagaccttc tctcagagtg
     1261 gaagcaggaa tgtgcatatg agaaagcatc acctgcagct gggagcagct gggagtcaag
     1321 agcaggagca aactgctgag ccactaatgg gcagtagttt gcttgaagag gcttcagtac
     1381 ccagtaaaaa cctggtgtct atgaattccc agcccagcct tggtggagag tccttgaacc
     1441 taccaaatac caattctatc ctgggagttg atgatgaggt gcttgctgaa ggatccccac
     1501 gttccctgtc ttcagtgcct gatgtgacac atcacctggt gaccatgcag tcagggaggc
     1561 aatcatatga agtttctgtc ttaactgcag taaatccaca agagttacta aaccaaggag
     1621 atttaactga aagacggaca tgagcgtggg tgctgactcc tggaagagca actctatctg
     1681 atctcaaaat gcgtatactg ggaacaggat gccttagccc acaacagaac cagaatgaat
     1741 ctttgaaggc acaagactct gcttttgcca ctcttcctct ttcctggtat agaagatgga
     1801 tgtaggagag cttcttttct aactaccatc tgatcagaca aggaatgaag caatgactgt
     1861 gggctgggaa actgtaccta cctctcttcc cactgcaaat ttctgggata gaccaaaagt
     1921 gaatttgatt atgtgttggc tgaagttctt cattctgact gttgagggga ggttttcctt
     1981 tgaagagttt tcatcccaga ctcagctgtc ttttcacatg gatgaaataa ttcctgctac
     2041 caacaacaga gcttcaccag gaagttgagt tttcaagatg ccttgttgct ttgaagaagg
     2101 gagtgatgtc aattctcttg ttacattctc cctttagcaa cctgagtaag agactctctg
     2161 ccactgggct gcaaaaaaat aaattacttg aatctcccct tggcccaggc tgaggtacta
     2221 tcttgtccta tacacttcta cttggtcact ttgctttctt cgttaatgga acatacagta
     2281 gcatgttaag agggatttca tgtttttgtt tttttaaagt taaaaattac atgatgcaga
     2341 gattcaggtt ttcctttaaa taaacaaaac agcccagtca gttctttggc tcttgtttta
     2401 tacaaaattt gttttcttag agattaagaa tttaatcttt ccctttaaaa tagtgtattg
     2461 atttaccctt aggattccat accagtaaaa ctgaaccgag gagtcttagg aaacaacaag
     2521 aacatcttca tttcttaagc ccaggtgata gttactctgt caccaccaaa aaagacgcat
     2581 ctgagaaaat ggcaataaaa acagatactt ctgaattttt cca
//
