LOCUS       NM_001324144            4999 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 41 (ZNF41), transcript variant 8,
            mRNA.
ACCESSION   NM_001324144 XM_005272665
VERSION     NM_001324144.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4999)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4999)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   3  (bases 1 to 4999)
  AUTHORS   Piton,A., Redin,C. and Mandel,J.L.
  TITLE     XLID-causing mutations and associated genes challenged in light of
            data from large-scale human exome sequencing
  JOURNAL   Am J Hum Genet 93 (2), 368-383 (2013)
   PUBMED   23871722
  REMARK    Erratum:[Am J Hum Genet. 2013 Aug 8;93(2):406]
REFERENCE   4  (bases 1 to 4999)
  AUTHORS   Shoichet,S.A., Hoffmann,K., Menzel,C., Trautmann,U., Moser,B.,
            Hoeltzenbein,M., Echenne,B., Partington,M., Van Bokhoven,H.,
            Moraine,C., Fryns,J.P., Chelly,J., Rott,H.D., Ropers,H.H. and
            Kalscheuer,V.M.
  TITLE     Mutations in the ZNF41 gene are associated with cognitive deficits:
            identification of a new candidate for X-linked mental retardation
  JOURNAL   Am J Hum Genet 73 (6), 1341-1354 (2003)
   PUBMED   14628291
  REMARK    GeneRIF: ZNF41 is critical for cognitive development
REFERENCE   5  (bases 1 to 4999)
  AUTHORS   Rosati,M., Franze,A., Matarazzo,M.R. and Grimaldi,G.
  TITLE     Coding region intron/exon organization, alternative splicing, and
            X-chromosome inactivation of the KRAB/FPB-domain-containing human
            zinc finger gene ZNF41
  JOURNAL   Cytogenet Cell Genet 85 (3-4), 291-296 (1999)
   PUBMED   10449920
REFERENCE   6  (bases 1 to 4999)
  AUTHORS   Knight,J.C., Grimaldi,G., Thiesen,H.J., Bech-Hansen,N.T.,
            Fletcher,C.D. and Coleman,M.P.
  TITLE     Clustered organization of Kruppel zinc-finger genes at Xp11.23,
            flanking a translocation breakpoint at OATL1: a physical map with
            locus assignments for ZNF21, ZNF41, ZNF81, and ELK1
  JOURNAL   Genomics 21 (1), 180-187 (1994)
   PUBMED   8088786
REFERENCE   7  (bases 1 to 4999)
  AUTHORS   Rosati,M., Marino,M., Franze,A., Tramontano,A. and Grimaldi,G.
  TITLE     Members of the zinc finger protein gene family sharing a conserved
            N-terminal module
  JOURNAL   Nucleic Acids Res 19 (20), 5661-5667 (1991)
   PUBMED   1945843
REFERENCE   8  (bases 1 to 4999)
  AUTHORS   Franze,A., Archidiacono,N., Rocchi,M., Marino,M. and Grimaldi,G.
  TITLE     Isolation and expression analysis of a human zinc finger gene
            (ZNF41) located on the short arm of the X chromosome
  JOURNAL   Genomics 9 (4), 728-736 (1991)
   PUBMED   2037297
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z84466.2, AL590283.7 and
            AL590223.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001324144.1.
            
            Summary: This gene encodes a protein that contains KRAB-A and
            KRAB-B domains multiple zinc finger DNA binding motifs and finger
            linking regions characteristic of the Kruppel family. An initial
            study suggested that this gene may be associated with X-linked
            cognitive disability, but a later study has called this finding
            into question (PMID:23871722).[provided by RefSeq, Apr 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.731885.1,
                                           SRR14038194.1078880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684689.1/ ENSP00000508254.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               Z84466.2           120753-120880
            129-479             AL590283.7         19022-19372         c
            480-606             AL590283.7         7884-8010           c
            607-702             AL590283.7         7533-7628           c
            703-4999            AL590223.12        35121-39417         c
FEATURES             Location/Qualifiers
     source          1..4999
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.3"
     gene            1..4999
                     /gene="ZNF41"
                     /gene_synonym="MRX89"
                     /note="zinc finger protein 41"
                     /db_xref="GeneID:7592"
                     /db_xref="HGNC:HGNC:13107"
                     /db_xref="MIM:314995"
     exon            1..128
                     /gene="ZNF41"
                     /gene_synonym="MRX89"
                     /inference="alignment:Splign:2.1.0"
     exon            129..479
                     /gene="ZNF41"
                     /gene_synonym="MRX89"
                     /inference="alignment:Splign:2.1.0"
     CDS             408..2747
                     /gene="ZNF41"
                     /gene_synonym="MRX89"
                     /note="isoform a is encoded by transcript variant 8"
                     /codon_start=1
                     /product="zinc finger protein 41 isoform a"
                     /protein_id="NP_001311073.1"
                     /db_xref="CCDS:CCDS14279.1"
                     /db_xref="GeneID:7592"
                     /db_xref="HGNC:HGNC:13107"
                     /db_xref="MIM:314995"
                     /translation="MAANGDSPPWSPALAAEGRGSSCEASVSFEDVTVDFSKEEWQHL
                     DPAQRRLYWDVTLENYSHLLSVGYQIPKSEAAFKLEQGEGPWMLEGEAPHQSCSGEAI
                     GKMQQQGIPGGIFFHCERFDQPIGEDSLCSILEELWQDNDQLEQRQENQNNLLSHVKV
                     LIKERGYEHKNIEKIIHVTTKLVPSIKRLHNCDTILKHTLNSHNHNRNSATKNLGKIF
                     GNGNNFPHSPSSTKNENAKTGANSCEHDHYEKHLSHKQAPTHHQKIHPEEKLYVCTEC
                     VMGFTQKSHLFEHQRIHAGEKSRECDKSNKVFPQKPQVDVHPSVYTGEKPYLCTQCGK
                     VFTLKSNLITHQKIHTGQKPYKCSECGKAFFQRSDLFRHLRIHTGEKPYECSECGKGF
                     SQNSDLSIHQKTHTGEKHYECNECGKAFTRKSALRMHQRIHTGEKPYVCADCGKAFIQ
                     KSHFNTHQRIHTGEKPYECSDCGKSFTKKSQLHVHQRIHTGEKPYICTECGKVFTHRT
                     NLTTHQKTHTGEKPYMCAECGKAFTDQSNLIKHQKTHTGEKPYKCNGCGKAFIWKSRL
                     KIHQKSHIGERHYECKDCGKAFIQKSTLSVHQRIHTGEKPYVCPECGKAFIQKSHFIA
                     HHRIHTGEKPYECSDCGKCFTKKSQLRVHQKIHTGEKPNICAECGKAFTDRSNLITHQ
                     KIHTREKPYECGDCGKTFTWKSRLNIHQKSHTGERHYECSKCGKAFIQKATLSMHQII
                     HTGKKPYACTECQKAFTDRSNLIKHQKMHSGEKRYKASD"
     exon            480..606
                     /gene="ZNF41"
                     /gene_synonym="MRX89"
                     /inference="alignment:Splign:2.1.0"
     exon            607..702
                     /gene="ZNF41"
                     /gene_synonym="MRX89"
                     /inference="alignment:Splign:2.1.0"
     exon            703..4999
                     /gene="ZNF41"
                     /gene_synonym="MRX89"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3449..3454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF41"
                     /gene_synonym="MRX89"
                     /note="hexamer: AATATA"
     polyA_site      3476
                     /gene="ZNF41"
                     /gene_synonym="MRX89"
                     /note="major polyA site"
     regulatory      4972..4977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF41"
                     /gene_synonym="MRX89"
                     /note="hexamer: AATAAT"
     polyA_site      4999
                     /gene="ZNF41"
                     /gene_synonym="MRX89"
ORIGIN      
        1 ctggcctaaa tctgacacgc acgactcccc ccgcggcaac tgcacaggtt cggtgacagc
       61 cgagacgccg agtgtttccc gcagccggcc ggggtccagg tcggaaatgt agccagtggg
      121 gccgccagca tccagcacag tgagcggccc ctgggcacca ccagaaaaca tttgtgagtg
      181 aacgtggagt gatgaccatg tggacactgt ctttccaggg tttcttggag cctctgcaga
      241 gtctgggggc caggcttctt agtggaaact gcaggatctt ccttctgacc cctgcttgcc
      301 tcgccccagc agctccggtt gagtccacag atgccagctc agcttccagc ttggggaaga
      361 gtggggttgt cagcaggaga gcctgagggc tgaggcccag cgtgaacatg gcagctaatg
      421 gggactctcc cccatggtcc ccggccctgg ctgcagaggg acgtggcagc tcatgtgagg
      481 cttcagtgtc atttgaggac gtgactgtgg acttcagcaa ggaggagtgg cagcacttgg
      541 accctgccca gagacgcctg tactgggatg tgacactaga gaactacagc cacctgctct
      601 cagtggggta ccaaattccc aagtcagagg ctgccttcaa gttggagcaa ggagaggggc
      661 catggatgct ggagggggaa gccccacatc agagctgttc aggtgaggct attgggaaaa
      721 tgcagcaaca gggaattcct ggaggaattt tcttccactg tgagagattt gatcaaccca
      781 taggagaaga ttcattatgt tctattttag aagaactgtg gcaagataat gaccagctag
      841 agcaacgtca ggaaaaccag aataaccttt taagtcatgt gaaagtattg attaaggaga
      901 ggggctatga acataaaaac attgaaaaaa taattcatgt gactaccaag cttgttcctt
      961 caattaaaag actccataac tgtgacacaa ttttgaagca tactttaaac tcacataatc
     1021 ataatagaaa cagtgcaaca aagaaccttg gcaagatttt tggaaatggt aacaatttcc
     1081 cccatagccc ttcctctact aagaatgaga atgctaaaac aggagcaaat tcctgtgaac
     1141 atgaccacta tgaaaaacat ctcagccaca aacaagctcc cacccaccat cagaaaattc
     1201 atcctgagga gaagctttat gtgtgtactg aatgtgtaat gggcttcact cagaagtcac
     1261 atctgtttga gcatcagaga attcatgctg gagaaaagtc ccgtgaatgt gacaaaagca
     1321 acaaagtctt cccccagaaa ccccaggttg atgtacatcc aagtgtttat acaggagaaa
     1381 aaccctatct gtgtactcaa tgtgggaaag tctttaccct caaatcaaac ctcattacac
     1441 atcaaaaaat tcataccggg cagaaaccct acaaatgcag tgaatgtgga aaagcctttt
     1501 tccagagatc agacctcttt agacatctga gaattcatac aggagaaaaa ccttatgaat
     1561 gcagtgaatg tggaaaaggc ttctcccaga actcagacct cagtatacat cagaaaactc
     1621 ataccggaga gaaacactat gaatgcaatg aatgtgggaa ggctttcaca agaaaatcag
     1681 cactcaggat gcatcagaga atccacacgg gagagaaacc ttatgtatgc gctgactgtg
     1741 ggaaggcctt catccagaaa tcacatttca acacacatca gagaattcat actggagaaa
     1801 agccgtatga atgcagtgac tgtgggaaat ccttcactaa gaagtcacaa ctccatgtgc
     1861 atcaaagaat tcacaccgga gagaaaccct atatatgtac agaatgtgga aaggtcttca
     1921 ctcacaggac aaacctcacc acacatcaga aaactcatac tggggaaaaa ccctatatgt
     1981 gtgctgaatg tggaaaggct tttactgacc agtcaaatct cattaaacac cagaaaactc
     2041 acactggaga gaaaccctat aagtgcaatg gctgtggaaa agccttcata tggaagtcgc
     2101 gcctcaaaat acatcagaaa tctcatattg gagagagaca ctatgaatgc aaggactgcg
     2161 ggaaagcctt catccagaaa tcaacactaa gcgtgcatca gagaatccat acaggagaga
     2221 aaccgtacgt ttgtcctgaa tgcgggaagg cctttatcca gaaatcgcac ttcattgcgc
     2281 atcatagaat ccatactgga gagaagcctt atgaatgcag cgactgtggg aaatgcttca
     2341 ctaagaagtc acaactccgt gtgcatcaga aaatccacac aggtgagaag cccaatatat
     2401 gtgctgaatg tggaaaggcc ttcactgacc gatcaaatct cataacacat cagaaaatcc
     2461 acactaggga gaaaccctat gaatgtggtg actgcgggaa aaccttcacc tggaagtcac
     2521 gcctcaatat acatcagaag tctcatactg gagaaagaca ctatgaatgt agtaaatgtg
     2581 ggaaagcttt catccagaaa gccacactaa gtatgcatca gataattcat acaggaaaga
     2641 aaccttatgc ttgtacagaa tgtcagaagg cctttactga cagatcgaat ctcattaaac
     2701 accagaaaat gcatagtgga gaaaaacgct ataaagccag tgactgagaa agtcttcacc
     2761 tggaaatcac aactgggtat gcatcaggta tctaatagca gggaggagga aggcctgttg
     2821 ctgcaatcat tgtacagggg gaaatgggta tgagagactg aggcttgagt gaactgaagg
     2881 caaacagagc caagtatcct tcagtccact ggaaagacaa gttcctgcat caccacagtg
     2941 tatatgcaat tctatgcata ggaagagcct ttagagaaag catttgagcg aaagtcatgt
     3001 ttggtgacat gattcataca gacctcttga gctcctggaa atagtagaat taagacctga
     3061 ggagatgact cgtcatctct tatgcttcac tttttggata aagaactttt taaattcagt
     3121 actgattggt tcagcatatc ctgggacata aaaatactca ctactgggaa aaactttttc
     3181 aaatttctag gttgaggaga agagttttca ttgtccaaac actggcaggg cactgacatc
     3241 aaggcagaaa acctacttgg gaatgcagat atctgttttt gtgatcattg gcacttaaga
     3301 catagaaaag atttccatga aaaacttttt tcttttccct tgggaagtcc tcatggtata
     3361 tatattttaa gtgcaatgga atttttaaat ttaaagatat aactttatga attgagaaat
     3421 taggcctagc tctaggctat gttacagaaa tatagtcatt gaatgataca gacatataaa
     3481 ggtagtagtt gtctcattat taattccctg ctgggagagc agatgagtca taccctataa
     3541 gaagtatgca tgccttctaa cctatgtccc caaagctgtc atttgcataa gctgcaggcc
     3601 atagattcct gattccctca gtaactgacc ctacgacaat ggaactgatc cacggcactc
     3661 tagattttca ggctaaccca ccaacacccc tgctttcctt gggatttcct gaaaaagaat
     3721 ggttgaaaaa ttgagtttca cttcctaata ttttgttttt cttcctattt ggttaaggta
     3781 tattcatttc ctacatgcac attaagggta gttttgtgta gactgctatg tgataaagtc
     3841 atgttgcatt gcaattagtt attctaagac ataattacag tttatcatag ttgaataact
     3901 ggaagacttc tcaagaaaga gcactgctct tttttaacac tgatatatag acacgttctc
     3961 attttccctt aaacattttt tacaatactc ataaaaagga actttctttc tagcatgcaa
     4021 ttgtattttt attttatttt aaaatctttt tattaaacta taatgtatac agaaaatgca
     4081 tatatcataa acatacagct cagtgcattc tcaaaaactg aacatactca gatcaagaaa
     4141 cagaacatga ccagcacccc agaagccttc cccactttcc cttccaggca agcccccaag
     4201 ggtatacatt atcctggctt ctcacagcat agattcattt tgcctgtttt gtattttata
     4261 taaattgagt caattatata tcatataatt gagccatata ctctttagca tctgtcttct
     4321 gtcattcaca ttatgtatgt gagagtcatc catatgttgc atatagttgt agataattca
     4381 ttttcattgt catgttgtat cccattctgt gaatatgctg caatataatt tatccattct
     4441 actgtttgta gacatttggg ttgtttgcag cttgggctat taggaattgt gttgctgtgt
     4501 attggtgaac atatgtatgt attcctgtta ggtatgtacc taagtgtatc catatgttca
     4561 gctatatgtt ataaaaccag ttttcaagtg gttgtaccaa tgtacactcc caccaaccca
     4621 gtatgcgagt tctagtgctc cacatacttg ccaacatttg gcattttcca tcttttttac
     4681 tatagccatt agtggtgggc atatagtgat atgtcagttt tagttttcgg ttttattttc
     4741 ttgtcctcca aaccattgta gtatctcccc aggatagatg agtgatggct gagacctgag
     4801 acctaggcct gttcctcaca tgactgcacc attttacatt ctatcaatgt atgaggtttc
     4861 cggtttctcc acatccttac caactcttat tattattagt cttttttatt atagctatcc
     4921 tagtacatgt gaagttatat tgtgatatta atttacactg ccctaatgat taataatatt
     4981 gatcatcttt tattgagaa
//
