LOCUS       NM_017757               8071 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 407 (ZNF407), transcript variant
            1, mRNA.
ACCESSION   NM_017757 XM_005266726
VERSION     NM_017757.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8071)
  AUTHORS   Zahra,Q., Cakmak,C., Koprulu,M., Shuaib,M., Sobreira,N.,
            Kalsner,L., Sobreira,J., Guillen Sacoto,M.J., Malik,S. and Tolun,A.
  TITLE     Biallelic ZNF407 mutations in a neurodevelopmental disorder with
            ID, short stature and variable microcephaly, hypotonia, ocular
            anomalies and facial dysmorphism
  JOURNAL   J Hum Genet 65 (12), 1115-1123 (2020)
   PUBMED   32737394
  REMARK    GeneRIF: Biallelic ZNF407 mutations in a neurodevelopmental
            disorder with ID, short stature and variable microcephaly,
            hypotonia, ocular anomalies and facial dysmorphism.
REFERENCE   2  (bases 1 to 8071)
  AUTHORS   Tan,X., Chen,S., Wu,J., Lin,J., Pan,C., Ying,X., Pan,Z., Qiu,L.,
            Liu,R., Geng,R. and Huang,W.
  TITLE     PI3K/AKT-mediated upregulation of WDR5 promotes colorectal cancer
            metastasis by directly targeting ZNF407
  JOURNAL   Cell Death Dis 8 (3), e2686 (2017)
   PUBMED   28300833
  REMARK    GeneRIF: WDR5 shows a direct binding to the ZNF407 promoter.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8071)
  AUTHORS   Kapoor,M., Wang,J.C., Wetherill,L., Le,N., Bertelsen,S.,
            Hinrichs,A.L., Budde,J., Agrawal,A., Almasy,L., Bucholz,K.,
            Dick,D.M., Harari,O., Xiaoling,X., Hesselbrock,V., Kramer,J.,
            Nurnberger,J.I. Jr., Rice,J., Schuckit,M., Tischfield,J.,
            Porjesz,B., Edenberg,H.J., Bierut,L., Foroud,T. and Goate,A.
  TITLE     Genome-wide survival analysis of age at onset of alcohol dependence
            in extended high-risk COGA families
  JOURNAL   Drug Alcohol Depend 142, 56-62 (2014)
   PUBMED   24962325
REFERENCE   4  (bases 1 to 8071)
  AUTHORS   Ren,C.M., Liang,Y., Wei,F., Zhang,Y.N., Zhong,S.Q., Gu,H.,
            Dong,X.S., Huang,Y.Y., Ke,H., Son,X.M., Tang,D. and Chen,Z.
  TITLE     Balanced translocation t(3;18)(p13;q22.3) and points mutation in
            the ZNF407 gene detected in patients with both moderate
            non-syndromic intellectual disability and autism
  JOURNAL   Biochim Biophys Acta 1832 (3), 431-438 (2013)
   PUBMED   23195952
  REMARK    GeneRIF: Data indicate that mutations in the ZNF407 gene contribute
            to the pathogenesis of a group of intellectual disability (ID)
            patients with autism.
REFERENCE   5  (bases 1 to 8071)
  AUTHORS   Prescott,J., Thompson,D.J., Kraft,P., Chanock,S.J., Audley,T.,
            Brown,J., Leyland,J., Folkerd,E., Doody,D., Hankinson,S.E.,
            Hunter,D.J., Jacobs,K.B., Dowsett,M., Cox,D.G., Easton,D.F. and De
            Vivo,I.
  TITLE     Genome-wide association study of circulating estradiol,
            testosterone, and sex hormone-binding globulin in postmenopausal
            women
  JOURNAL   PLoS One 7 (6), e37815 (2012)
   PUBMED   22675492
REFERENCE   6  (bases 1 to 8071)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 8071)
  AUTHORS   McDonough,C.W., Bostrom,M.A., Lu,L., Hicks,P.J., Langefeld,C.D.,
            Divers,J., Mychaleckyj,J.C., Freedman,B.I. and Bowden,D.W.
  TITLE     Genetic analysis of diabetic nephropathy on chromosome 18 in
            African Americans: linkage analysis and dense SNP mapping
  JOURNAL   Hum Genet 126 (6), 805-817 (2009)
   PUBMED   19690890
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 8071)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from FP565322.5, AC138660.6,
            AC091589.8, AC023380.9, AC100783.2 and AC015819.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Jun 18, 2020 this sequence version replaced
            XM_005266726.5, NM_017757.2.
            
            Summary: This gene encodes a zinc finger protein whose exact
            function is not known. It may be involved in transcriptional
            regulation. Several alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2694727.1,
                                           SRR11853567.14649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299687.10/ ENSP00000299687.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                FP565322.5         35086-35153
            69-4808             AC138660.6         23285-28024         c
            4809-4923           AC138660.6         17869-17983         c
            4924-4998           AC091589.8         157120-157194
            4999-5165           AC023380.9         38767-38933         c
            5166-5249           AC023380.9         35011-35094         c
            5250-5370           AC023380.9         26092-26212         c
            5371-5549           AC100783.2         68701-68879
            5550-8071           AC015819.5         60855-63376         c
FEATURES             Location/Qualifiers
     source          1..8071
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.3"
     gene            1..8071
                     /gene="ZNF407"
                     /gene_synonym="SIMHA"
                     /note="zinc finger protein 407"
                     /db_xref="GeneID:55628"
                     /db_xref="HGNC:HGNC:19904"
                     /db_xref="MIM:615894"
     exon            1..68
                     /gene="ZNF407"
                     /gene_synonym="SIMHA"
                     /inference="alignment:Splign:2.1.0"
     exon            69..4808
                     /gene="ZNF407"
                     /gene_synonym="SIMHA"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..6868
                     /gene="ZNF407"
                     /gene_synonym="SIMHA"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 407 isoform 1"
                     /protein_id="NP_060227.2"
                     /db_xref="CCDS:CCDS45885.1"
                     /db_xref="GeneID:55628"
                     /db_xref="HGNC:HGNC:19904"
                     /db_xref="MIM:615894"
                     /translation="MMDSENKPENDEDEKINKEAQDLTKLSSHNEDGGPVSDVIASFP
                     ENSMGKRGFSESSNSDSVVIGEDRNKHASKRRKLDEAEPLKSGKQGICRLETSESSVT
                     EGGIALDETGKETFLSDCTVGGTCLPNALSPSCNFSTIDVVSLKTDTEKTSAQEMVSL
                     DLERESPFPPKEISVSCTIGNVDTVLKCSICGHLFSSCSDLEKHAESHMQQPKEHTCC
                     HCSHKAESSSALHMHIKQAHGPQKVFSCDLCGFQCSEENLLNAHYLGKTHLRRQNLAA
                     RGGFVQILTKQPFPKKSRTMATKNVHSKPRTSKSIAKNSDSKGLRNVGSTFKDFRGSI
                     SKQSGSSSELLVEMMPSRNTLSQEVEIVEEHVTSLGLAQNPENQSRKLDTLVTSEGLL
                     EKLESTKNTLQAAHGNSVTSRPRPERNILVLGNSFRRRSSTFTLKGQAKKRFNLLGIK
                     RGTSETQRMYMKHLRTQMKTHDAESVLKHLEACSSVQRVCVTTSETQEAEQGQGSARP
                     PDSGLHSLTVKPASGSQTLCACTDCGQVATNRTDLEIHVKRCHAREMKFYCRTCDFSS
                     MSRRDLDEHLHSNQHQQTASVLSCQCCSFISLDEINLRDHMKEKHNMHFLCTPCNLFF
                     LSEKDVEEHKATEKHINSLVQPKTLQSSNSDLVLQTLPLSTLESENAKESMDDSGKAS
                     QEEPLKSRVSHGNEVRHSSKPQFQCKKCFYKTRSSTVLTRHIKLRHGQDYHFLCKACN
                     LYSLSKEGMEKHIKRSKHLENAKKNNIGLSFEECIERVCIGANDKKEEFDVSGNGRIE
                     GHIGVQLQEHSYLEKGMLASEELSQSGGSTKDDELASTTTPKRGRPKGNISRTCSHCG
                     LLASSITNLTVHIRRKHSHQYSYLCKVCKYYTVTKGDMERHCATKKHKGRVEIEASGK
                     HSSDIIVGPEGGSLEAGKKNAGSAVTMSDEHANKPAESPTSVLEKPDRGNSIEAEVEN
                     VFHSLDGEVNSHLLDKKEQISSEPEDFAQPGDVYSQRDVTGTGENKCLHCEFSAHSSA
                     SLELHVKRKHTKEFEFYCMACDYYAVTRREMTRHAATEKHKMKRQSYLNSANVEAGSA
                     DMSKNIIMPEEEHQQNSEEFQIISGQPSDTLKSRNAADCSILNENTNLDMSKVLCAAD
                     SVEVETEEESNFNEDHSFCETFQQAPVKDKVRKPEEMMSLTMSSNYGSPSRFQNENSG
                     SSALNCETAKKNHEISNDAGELRVHCEGEGGNAGDGGGVVPHRHLCPVTLDGERSAES
                     PVLVVTRITREQGNLESGGQNRVARGHGLEDLKGVQEDPVLGNKEILMNSQHETEFIL
                     EEDGPASDSTVESSDVYETIISIDDKGQAMYSFGRFDSSIIRIKNPEDGELIDQSEEG
                     LIATGVRISELPLKDCAQGVKKKKSEGSSIGESTRIRCDDCGFLADGLSGLNVHIAMK
                     HPTKEKHFHCLLCGKSFYTESNLHQHLASAGHMRNEQASVEELPEGGATFKCVKCTEP
                     FDSEQNLFLHIKGQHEELLREVNKYIVEDTEQINREREENQGNVCKYCGKMCRSSNSM
                     AFLAHIRTHTGSKPFKCKICHFATAQLGDARNHVKRHLGMREYKCHVCGVAFVMKKHL
                     NTHLLGKHGVGTPKERKFTCHLCDRSFTEKWALNNHMKLHTGEKPFKCTWPTCHYSFL
                     TASAMKDHYRTHTGEKSFLCDLCGFAGGTRHALTKHRRQHTGEKPFKCDECNFASTTQ
                     SHLTRHKRVHTGEKPYRCPWCDYRSNCAENIRKHILHTGKHEGVKMYNCPKCDYGTNV
                     PVEFRNHLKEQHPDIENPDLAYLHAGIVSKSYECRLKGQGATFVETDSPFTAAALAEE
                     PLVKEKPLRSSRRPAPPPEQVQQVIIFQGYDGEFALDPSVEETAAATLQTLAMAGQVA
                     RVVHITEDGQVIATSQSGAHVGSVVPGPILPEQLADGATQVVVVGGSMEGHGMDESLS
                     PGGAVIQQVTKQEILNLSEAGVAPPEASSALDALLCAVTELGEVEGRAGLEEQGRPGA
                     KDVLIQLPGQEVSHVAADPEAPEIQMFPQAQESPAAVEVLTQVVHPSAAMASQERAQV
                     AFKKMVQGVLQFAVCDTAAAGQLVKDGVTQVVVSEEGAVHMVAGEGAQIIMQEAQGEH
                     MDLVESDGEISQIIVTEELVQAMVQESSGGFSEGTTHYILTELPPGVQDEPGLYSHTV
                     LETADSQELLQAGATLGTEAGAPSRAEQLASVVIYTQEGSSAAAAIQSQRESSELQEA
                     "
     exon            4809..4923
                     /gene="ZNF407"
                     /gene_synonym="SIMHA"
                     /inference="alignment:Splign:2.1.0"
     exon            4924..4998
                     /gene="ZNF407"
                     /gene_synonym="SIMHA"
                     /inference="alignment:Splign:2.1.0"
     exon            4999..5165
                     /gene="ZNF407"
                     /gene_synonym="SIMHA"
                     /inference="alignment:Splign:2.1.0"
     exon            5166..5249
                     /gene="ZNF407"
                     /gene_synonym="SIMHA"
                     /inference="alignment:Splign:2.1.0"
     exon            5250..5370
                     /gene="ZNF407"
                     /gene_synonym="SIMHA"
                     /inference="alignment:Splign:2.1.0"
     exon            5371..5549
                     /gene="ZNF407"
                     /gene_synonym="SIMHA"
                     /inference="alignment:Splign:2.1.0"
     exon            5550..8071
                     /gene="ZNF407"
                     /gene_synonym="SIMHA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8048..8053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF407"
                     /gene_synonym="SIMHA"
                     /note="hexamer: AATAAA"
     polyA_site      8071
                     /gene="ZNF407"
                     /gene_synonym="SIMHA"
                     /note="major polyA site"
ORIGIN      
        1 aaagggaaga cggtgagccg gaggagtcag tcagaggggc gagcaggagc gattccgtcg
       61 ccaaacaggt tatgagtgcc agtgagccgc cttagataga agcatcgtca gcactttatt
      121 aatgatggat agtgagaata aacccgaaaa tgatgaggat gaaaagataa acaaagaagc
      181 acaagacttg acaaagcttt catcccataa tgaagacggt gggcctgtat ctgatgtgat
      241 agcaagtttc cctgagaatt ctatgggcaa aagaggtttt tcagaatcat cgaactctga
      301 tagtgttgtt ataggagaag acagaaataa acatgcttcc aaacgcagga aattagatga
      361 ggcagagccc cttaaatctg gaaagcaagg tatttgtaga ttagaaactt ctgagagctc
      421 agtcacagaa gggggtattg cattagatga aacagggaag gagacctttc tgagtgactg
      481 cacagttgga ggcacatgtc tcccaaatgc cctctcccct tcttgcaatt ttagcactat
      541 tgatgttgtt tctctgaaaa cagacactga aaaaacatct gctcaggaaa tggtttccct
      601 tgatctggaa agagaatctc ctttcccccc gaaagaaatt agtgttagtt gtaccattgg
      661 gaatgtagat acagttctca aatgcagcat ctgtgggcat ttgttttctt cttgctctga
      721 cttggaaaaa catgctgagt ctcacatgca gcagcctaag gaacatacct gttgtcactg
      781 cagccacaaa gcagagagca gctcagcact acatatgcat atcaaacaag cacatgggcc
      841 acagaaggtc ttttcctgtg atctttgtgg ttttcagtgt tcagaagaaa acttgttgaa
      901 tgcacattat cttggcaaaa cacatctccg tcgtcagaat ctggctgctc gtggaggatt
      961 tgtacagatc ttaacaaaac aaccttttcc taaaaaatca cgtacaatgg caacaaaaaa
     1021 tgttcactca aaaccaagaa cttctaaatc aatagcaaag aatagtgatt caaaaggatt
     1081 acgaaatgtg ggaagcacgt ttaaagattt cagaggaagt atttctaaac aaagtggtag
     1141 tagcagtgag cttcttgttg aaatgatgcc ttccagaaat actttgtcac aggaagtaga
     1201 gattgttgaa gaacatgtta cttcccttgg tctagctcag aatcctgaaa accagagtag
     1261 aaagctagac accttagtaa cctcagaggg tctcttagag aaattggaat ctacaaaaaa
     1321 tacccttcag gcagcacacg gtaacagtgt aacctcgagg ccaagacctg agcgaaatat
     1381 tctcgtgttg ggtaatagct ttcgtcgacg aagcagcact ttcaccttga agggccaggc
     1441 aaagaaaagg tttaatcttt taggaattaa aagaggtaca agtgaaactc agaggatgta
     1501 tatgaaacac ttgagaacac agatgaaaac acacgatgca gaatcagtgc tgaaacacct
     1561 ggaagcgtgc agcagtgtgc agagagtgtg tgtgactacc tcagaaaccc aggaggcaga
     1621 gcagggccag gggagtgccc gtcctccgga ctccgggctg cattccctga cagtgaagcc
     1681 agcttctggc tctcagacgt tgtgtgcttg tacagactgt gggcaagtag ctacaaatag
     1741 gacagatttg gaaatccatg tgaaaaggtg ccatgccaga gagatgaaat tttactgccg
     1801 tacttgtgac ttctctagta tgtcaagaag ggacttagat gaacatttgc acagtaacca
     1861 gcatcagcaa actgcttctg tcctgagttg tcagtgttgt tcatttatat ccttggatga
     1921 aataaatctt agagaccaca tgaaggaaaa gcacaatatg cattttcttt gcaccccttg
     1981 taatctgttc tttttgtctg aaaaagatgt ggaagaacac aaagccaccg agaagcatat
     2041 taattcattg gttcaaccaa agactttgca atcatctaac agtgatttgg ttttacagac
     2101 tttacctttg agtactttag aatcagaaaa cgcaaaagag tctatggatg actcaggaaa
     2161 agcatctcag gaagaacctc tgaagtccag ggtaagccat ggtaatgaag tgaggcattc
     2221 cagtaagcct cagtttcagt gtaagaagtg tttttataaa acaagatctt ctactgttct
     2281 cacgagacat ataaagcttc ggcatggtca agactatcat tttctttgta aagcttgtaa
     2341 tctttattca ttgagcaaag aaggaatgga gaaacacatt aaaagaagca agcatcttga
     2401 aaatgctaag aaaaataata ttggcttaag ctttgaagaa tgtattgaaa gggtatgtat
     2461 aggtgcaaat gataaaaaag aagagtttga tgtttccgga aatggaagga ttgaaggcca
     2521 tataggtgtg caattacaag agcattccta tcttgagaag ggcatgctgg cgtctgagga
     2581 actgtcacag tctggtggta gcaccaaaga tgatgaatta gcttcaacca ctactccaaa
     2641 gagagggaga cctaaaggta acatctcacg gacgtgttca cactgtggcc ttttggcctc
     2701 tagtattaca aacttgactg ttcacattag acgaaaacac agtcaccagt atagttattt
     2761 atgcaaagtg tgtaagtatt acactgtaac taagggagat atggaacgtc attgtgccac
     2821 caagaaacat aaaggacggg tagaaataga agcaagtgga aaacacagtt cagatatcat
     2881 tgttggccct gaagggggta gccttgaagc tggtaaaaag aatgctggct cagcagtgac
     2941 catgtcagat gaacatgcta acaaaccagc tgagtcaccc acctccgttt tagagaagcc
     3001 agatcgtgga aactcaattg aagctgaagt tgaaaatgta tttcattctc tagatggaga
     3061 agttaacagc catcttcttg ataaaaagga gcaaatatct tcagagccag aggacttcgc
     3121 ccagccgggg gatgtgtact cccagagaga tgttacaggc acaggtgaga ataagtgttt
     3181 gcactgtgag tttagtgctc actcctctgc ttctctagag ctgcatgtaa aacggaaaca
     3241 tacaaaagag tttgagtttt attgcatggc atgcgattac tacgcggtga ctcgtcgcga
     3301 gatgaccagg catgcagcaa cagagaagca caaaatgaaa aggcagtctt atctcaactc
     3361 tgctaatgta gaagctggtt ctgcagacat gtccaaaaac atcattatgc ctgaagaaga
     3421 gcatcaacaa aattctgagg aatttcaaat aatttcaggt caaccatctg atactcttaa
     3481 atctagaaat gctgcagatt gctctatttt aaatgagaat actaatttag atatgtctaa
     3541 agtgctctgc gctgctgact ctgtagaagt tgagactgaa gaagaatcta atttcaatga
     3601 agaccattcc ttttgtgaga ctttccaaca ggctcctgtc aaggataaag ttaggaaacc
     3661 tgaggagatg atgtcactta ctatgtcctc aaactatggc tccccaagca gatttcaaaa
     3721 tgaaaattca ggaagctctg ccttaaattg tgagacagca aagaaaaacc atgagatatc
     3781 gaatgatgca ggtgagctgc gtgtccattg tgagggtgaa ggaggaaacg caggagacgg
     3841 tggaggtgtt gtcccccaca gacacctgtg ccctgtgacg ctcgatgggg agcgctcggc
     3901 tgaaagccct gtgctcgttg tgacaagaat aaccagagaa cagggaaatc tggagagcgg
     3961 gggtcagaac agagttgcac gtgggcatgg tttggaagac ttgaaaggtg tccaagaaga
     4021 tcccgttctg gggaataagg aaattctgat gaattcacaa catgaaacag aatttatttt
     4081 ggaggaggat ggcccagctt ctgatagcac agttgaaagt agtgatgtct atgaaactat
     4141 aattagtatt gatgataaag ggcaggccat gtacagtttt ggtcgatttg actcctccat
     4201 aataagaata aagaaccctg aagatggtga gttgatagac cagtctgaag agggcttgat
     4261 agcaacggga gtgagaatta gtgagctgcc cttgaaagac tgtgctcaag gtgtgaaaaa
     4321 gaagaaatct gagggcagtt ccattggtga gtctacacga attcgctgtg atgattgtgg
     4381 cttcttagca gatggactga gtggactgaa tgttcacata gccatgaagc atcctacaaa
     4441 agagaagcac ttccattgtt tactctgtgg aaagtcgttc tataccgaaa gcaaccttca
     4501 ccagcatctg gctagtgccg gccacatgag aaatgagcag gccagtgtgg aggagcttcc
     4561 ggagggaggg gccaccttta aatgtgtcaa gtgcacagag ccctttgatt ctgaacagaa
     4621 tttattttta catattaaag gacagcatga ggaattgctg cgggaggtga ataagtatat
     4681 agtggaagac actgagcaaa tcaaccgcga gagggaggaa aaccagggaa acgtctgcaa
     4741 gtattgtggg aagatgtgtc gaagcagcaa ctcgatggcc ttcctggcac acattcgcac
     4801 tcacacagga tcaaaaccat tcaagtgcaa gatatgccat tttgcaacag ctcagcttgg
     4861 agatgccaga aaccatgtga aaaggcacct tgggatgagg gaatacaagt gtcatgtctg
     4921 tggggttgct tttgtaatga agaagcactt aaatactcat ctactaggca agcatggagt
     4981 tggcacccca aaagaaagga aatttacatg ccacttatgt gatagaagtt tcacagagaa
     5041 gtgggccctg aacaaccaca tgaaactcca cacgggagaa aagccgttta aatgtacctg
     5101 gcccacgtgc cattactcat tcctcacagc ctccgcaatg aaagaccact acaggacgca
     5161 cacaggcgag aagtcgtttc tgtgtgacct ctgcggcttt gccggcggga cccgccacgc
     5221 cctcaccaag catcgcagac agcacacagg agaaaaacct ttcaagtgcg atgagtgtaa
     5281 ctttgcctcc acaactcagt cccatttgac tcggcataaa cgtgtccaca ctggagaaaa
     5341 gccctacaga tgcccctggt gtgactacag gtcaaactgt gctgaaaata tccgcaaaca
     5401 cattctgcat actggcaaac atgaaggagt caagatgtac aactgtccca agtgtgacta
     5461 cgggaccaac gtcccggtgg agttccggaa ccatttgaag gaacagcatc ctgacatcga
     5521 aaacccggac ctcgcttacc tgcatgctgg cattgtttcc aagtcgtacg agtgccgtct
     5581 aaagggacaa ggagccacct tcgtggagac agacagcccc ttcaccgcgg cggccttggc
     5641 agaagagccc ctcgtcaagg agaagcccct cagaagcagc aggaggccag cgccgccccc
     5701 tgagcaggtg cagcaggtca tcatcttcca gggctacgac ggggagtttg ccctggaccc
     5761 ctcggtggag gagacggccg ccgccacgct gcagacgctg gccatggccg gccaggtggc
     5821 ccgggtggtg catatcacgg aggatggcca ggtcatcgcc acgagtcaga gcggggcaca
     5881 tgtaggcagc gtggtgcccg gacccatcct ccccgagcag ctggctgatg gagccaccca
     5941 ggtggtcgtc gtggggggct ccatggaagg ccacggcatg gatgagtccc tcagtccagg
     6001 tggcgctgtg atacaacagg tgaccaagca ggagatttta aacctctcgg aggctggagt
     6061 cgctcccccc gaggcatcct cagccctgga tgcattgctc tgtgcggtca ctgaattagg
     6121 ggaggtggag ggcagggctg ggctcgagga gcaaggcagg cccggcgcca aagacgtgct
     6181 gatccagctg cccgggcagg aggtctccca tgtggctgcc gaccccgagg cccccgagat
     6241 ccagatgttc ccacaggccc aggagagccc ggccgccgtg gaggtgctca cccaggtggt
     6301 ccatccctca gcagccatgg cctctcagga gcgggcacag gtggccttca agaagatggt
     6361 ccagggcgtc ctccagtttg ctgtgtgtga cacggccgcg gccggccagt tggtcaagga
     6421 cggtgtcacc caggtggtgg tgagcgaaga gggtgccgtc cacatggtcg ccggggaggg
     6481 tgcccagatc atcatgcagg aggcgcaggg cgagcacatg gatctggtgg agtccgacgg
     6541 ggagatctcg cagatcatcg tgacggagga gctggtccag gccatggtgc aggagtccag
     6601 tggcggcttc tccgagggca ccacgcacta catcctgaca gagctgcccc caggggtgca
     6661 ggacgagccg ggcctgtact cccacaccgt gctggagact gcggactcgc aggaactcct
     6721 gcaggccggg gccacgctag gcacagaggc cggggcccca agcagggcag agcagctggc
     6781 cagcgtggtc atctacaccc aggagggctc ctcggccgcg gcggcaattc agagccaaag
     6841 agaaagcagc gaactccagg aagcatgaga cgcgcggcac ctttactcag cacagggcag
     6901 gtgtgggaag gtccagcttc ggtgggggac cgtgttccct gagcttcatc tgaaaccttc
     6961 aaaaccatga ggacaaggct cccgtgagct ctgagcatgc cctcccagcg agagtcacac
     7021 tggccaccag ccaggcgccc acagagggta ccgtgggctg ggcctcgggg agcaggctgc
     7081 caagtgcagg ggagggccgg gcgcaggccg cacagggagc tccggtccac tgggggccct
     7141 tcgatcagtg gcctcccgct tcgtcctggc cgctgtgctg aagagaagcc aagtgttgtt
     7201 ggtgtttttc tctcccaagt gttttcccat ttcagttatc agaaggtcat ggccgtgggg
     7261 aaagtggtga agatacccct cctggcttgg ggtgcacctg cttgtgcagt cagcatgtag
     7321 ctgcctttcc atttcattct ctactgggct aaaaattgca gctacaagtg ttaccatctt
     7381 gaagcagtcc acttccattc aatttttttt ttttaatttt agaataacag tgtccccata
     7441 ccaaaggaag cctgctagct catttcatgt ataaatttcc catcttcaaa cagtttaggt
     7501 gtatttgttg ctctggtcac attctgcata aaagaaatcc tcttaagcct atggttaaga
     7561 aaagccttga agtttatatt cagttaaaat atatgtcggt ggagatagcc agtgcttcta
     7621 attttgactt agtttcatac agtaaagcct aaatgtgaaa cgcacacgct ggaagatatt
     7681 gttcctatca atattttgct ttttataaca agggtttgtt catattgatg ccatttttgc
     7741 aggatttctt cgtgatttct gtccatatga aaatgctgac attaaacatt aacacatgga
     7801 gaccgtgccc tgtggccctg ccgtggctgc cagcatggtc tgtgtttcct tgtggattca
     7861 cctgtggccc tgctgtggcc accagcatgg tctgtgtcct cgtggattca ctgcagctgt
     7921 cggatgcgag tttctgtcat aatcatttgt ttcctgatac aattgttctt attcttttcc
     7981 aaaactgtaa aataatctcc tccctcaaat gcaaaggttg tttttgttct gtttctgttt
     8041 tctttgaaat aaaattataa cgttaaaaga t
//
