LOCUS       NM_001033719            1849 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 404 (ZNF404), mRNA.
ACCESSION   NM_001033719 XM_292765
VERSION     NM_001033719.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1849)
  AUTHORS   Masoodi,T.A., Banaganapalli,B., Vaidyanathan,V., Talluri,V.R. and
            Shaik,N.A.
  TITLE     Computational Analysis of Breast Cancer GWAS Loci Identifies the
            Putative Deleterious Effect of STXBP4 and ZNF404 Gene Variants
  JOURNAL   J Cell Biochem 118 (12), 4296-4307 (2017)
   PUBMED   28422318
  REMARK    GeneRIF: The deleterious SNPs localized in STXBP4 and ZNF404 genes
            were identified which might play a role in breast cancer
            development by dysregulating its gene expression.
REFERENCE   2  (bases 1 to 1849)
  AUTHORS   Liu,Y., Walavalkar,N.M., Dozmorov,M.G., Rich,S.S., Civelek,M. and
            Guertin,M.J.
  TITLE     Identification of breast cancer associated variants that modulate
            transcription factor binding
  JOURNAL   PLoS Genet 13 (9), e1006761 (2017)
   PUBMED   28957321
  REMARK    GeneRIF: We used The Cancer Genome Atlas breast cancer patient data
            to identify ANKLE1 and ZNF404 as the target genes of candidate TF
            binding site SNPs in the 19p13.11 and 19q13.31 GWAS-identified
            loci. These SNPs are associated with the expression of ZNF404 and
            ANKLE1 in breast tissue.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1849)
  AUTHORS   Davis,O.S., Band,G., Pirinen,M., Haworth,C.M., Meaburn,E.L.,
            Kovas,Y., Harlaar,N., Docherty,S.J., Hanscombe,K.B.,
            Trzaskowski,M., Curtis,C.J., Strange,A., Freeman,C., Bellenguez,C.,
            Su,Z., Pearson,R., Vukcevic,D., Langford,C., Deloukas,P., Hunt,S.,
            Gray,E., Dronov,S., Potter,S.C., Tashakkori-Ghanbaria,A.,
            Edkins,S., Bumpstead,S.J., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A., Duncanson,A., Jankowski,J.A., Markus,H.S.,
            Mathew,C.G., Palmer,C.N., Rautanen,A., Sawcer,S.J., Trembath,R.C.,
            Viswanathan,A.C., Wood,N.W., Barroso,I., Peltonen,L., Dale,P.S.,
            Petrill,S.A., Schalkwyk,L.S., Craig,I.W., Lewis,C.M., Price,T.S.,
            Donnelly,P., Plomin,R. and Spencer,C.C.
  CONSRTM   Wellcome Trust Case Control Consortium 2
  TITLE     The correlation between reading and mathematics ability at age
            twelve has a substantial genetic component
  JOURNAL   Nat Commun 5, 4204 (2014)
   PUBMED   25003214
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1849)
  AUTHORS   Shannon,M., Hamilton,A.T., Gordon,L., Branscomb,E. and Stubbs,L.
  TITLE     Differential expansion of zinc-finger transcription factor loci in
            homologous human and mouse gene clusters
  JOURNAL   Genome Res 13 (6A), 1097-1110 (2003)
   PUBMED   12743021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC101333.1, AC011508.5 and BQ188692.1.
            
            On May 17, 2019 this sequence version replaced NM_001033719.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101333.1, SRR1660805.101295.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146, SAMEA2467150
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000587539.2/ ENSP00000466051.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1008              BC101333.1         1-1008
            1009-1009           AC011508.5         79995-79995         c
            1010-1709           BC101333.1         1010-1709
            1710-1849           BQ188692.1         446-585
FEATURES             Location/Qualifiers
     source          1..1849
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..1849
                     /gene="ZNF404"
                     /note="zinc finger protein 404"
                     /db_xref="GeneID:342908"
                     /db_xref="HGNC:HGNC:19417"
     CDS             1..1659
                     /gene="ZNF404"
                     /codon_start=1
                     /product="zinc finger protein 404"
                     /protein_id="NP_001028891.2"
                     /db_xref="CCDS:CCDS59394.1"
                     /db_xref="GeneID:342908"
                     /db_xref="HGNC:HGNC:19417"
                     /translation="MARVPLTFSDVAIDFSQEEWEYLNSDQRDLYRDVMLENYTNLVS
                     LDFNFTTESNKLSSEKRNYEVNAYHQETWKRNKTFNLMRFIFRTDPQYTIEFGRQQRP
                     KVGCFSQMIFKKHKSLPLHKRNNTREKSYECKEYKKGFRKYLHLTEHLRDHTGVIPYE
                     CNECGKAFVVFQHFIRHRKIHTDLKPYECNGCEKAFRFYSQLIQHQIIHTGMKPYECK
                     QCGKAFRRHSHLTEHQKIHVGLKPFECKECGETFRLYRHMCLHQKIHHGVKPYKCKEC
                     GKAFGHRSSLYQHKKIHSGEKPYKCEQCEKAFVRSYLLVEHQRSHTGEKPHECMECGK
                     AFGKGSSLLKHKRIHSSEKLYDCKDCGKAFCRGSQLTQHQRIHTGEKPHECKECGKTF
                     KLHSYLIQHQIIHTDLKPYECKQCGKAFSRVGDLKTHQSIHAGEKPYECKECGKTFRL
                     NSQLIYHQTIHTGLKPYVCKECKKAFRSISGLSQHKRIHTGEKPYECKECDKAFNRSD
                     RLTQHETIHTGVKPQKCKECGKAFSHCYQLSQHQRFHHGERLLM"
     exon            1..9
                     /gene="ZNF404"
                     /inference="alignment:Splign:2.1.0"
     exon            10..136
                     /gene="ZNF404"
                     /inference="alignment:Splign:2.1.0"
     exon            137..1849
                     /gene="ZNF404"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1830..1835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF404"
                     /note="hexamer: AATAAA"
     polyA_site      1849
                     /gene="ZNF404"
                     /note="major polyA site"
ORIGIN      
        1 atggcccggg tgccattgac attcagcgat gttgccatag acttctctca ggaggagtgg
       61 gaatatttaa actcggatca gagggatttg tacagagatg tgatgttgga gaattatact
      121 aacttggtct cattggactt taatttcaca actgaaagca acaagttatc ttcagaaaaa
      181 agaaattatg aagtaaatgc gtaccatcag gagacatgga aaagaaataa aaccttcaac
      241 cttatgaggt ttattttcag aactgaccca cagtacacaa ttgaatttgg gagacaacag
      301 agacctaaag tgggatgttt tagtcaaatg atattcaaaa aacataaatc ccttcctcta
      361 cataagagaa ataacacaag agagaaatca tatgagtgta aggaatataa gaagggcttt
      421 agaaaatatt tgcaccttac tgaacatctg agagaccata ctggtgtgat accctatgaa
      481 tgtaatgaat gtggaaaagc atttgtagtt ttccagcatt ttattagaca tcgaaaaatc
      541 cacactgatt tgaaacccta tgaatgcaat ggatgtgaga aggcctttag gttttattca
      601 cagcttattc agcatcagat aattcatact ggtatgaaac cctatgaatg taagcaatgc
      661 gggaaggctt ttagacgtca ttctcacctt acagaacatc agaaaattca tgttggcttg
      721 aaaccctttg aatgtaagga atgtggggaa acgtttagat tatatcgaca tatgtgtctg
      781 catcagaaaa ttcatcatgg tgtgaaaccc tacaaatgta aagaatgtgg aaaggctttt
      841 ggtcatcgtt caagtcttta ccaacataag aaaattcatt ctggtgagaa accatataaa
      901 tgtgaacaat gtgaaaaggc ctttgttcgc agctatctac ttgttgaaca tcaaagaagt
      961 catactggtg agaaacctca tgaatgcatg gaatgtggaa aggcttttgg taagggctca
     1021 agccttctta aacataagag aattcatagt agtgagaaac tctatgattg taaggattgt
     1081 ggaaaggcct tttgtagagg ctctcaactt acacagcatc agagaattca tactggtgag
     1141 aagccacatg aatgtaaaga atgtgggaag acttttaagc ttcattcata tcttattcaa
     1201 catcagataa ttcatactga tttgaagcca tatgaatgta agcaatgtgg gaaagccttc
     1261 agtcgtgttg gagaccttaa gacacatcaa tcaattcatg ctggggagaa accctatgaa
     1321 tgtaaggaat gtggaaaaac ctttagactt aattctcaac taatttatca tcagacaatt
     1381 catactggtt tgaaacccta tgtatgtaaa gaatgtaaga aggcctttcg ttctatctca
     1441 ggtctttctc aacataagag aattcatact ggtgaaaaac cctatgaatg taaagaatgt
     1501 gataaggcct ttaatcgcag tgatcgactt actcaacatg agacaattca tactggtgtg
     1561 aaaccacaga aatgcaaaga atgtggtaag gcctttagtc attgctatca acttagtcaa
     1621 catcaaagat ttcaccatgg tgagagactc ttaatgtaat gagagggaaa gcctttagcc
     1681 atggcacatt tttactgttg tcactattat gatgctatag tgaagattaa actagttaat
     1741 atagaatata aatacttgga aaggcatctg gcacatcgta tttgcttact aaatacatta
     1801 tttttatgat aattgttaga attactaaaa ataaatctta tagaaggaa
//
