LOCUS       NM_170686               5460 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 398 (ZNF398), transcript variant
            1, mRNA.
ACCESSION   NM_170686
VERSION     NM_170686.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5460)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5460)
  AUTHORS   Zorzan,I., Pellegrini,M., Arboit,M., Incarnato,D., Maldotti,M.,
            Forcato,M., Tagliazucchi,G.M., Carbognin,E., Montagner,M.,
            Oliviero,S. and Martello,G.
  TITLE     The transcriptional regulator ZNF398 mediates pluripotency and
            epithelial character downstream of TGF-beta in human PSCs
  JOURNAL   Nat Commun 11 (1), 2364 (2020)
   PUBMED   32398665
  REMARK    GeneRIF: The transcriptional regulator ZNF398 mediates pluripotency
            and epithelial character downstream of TGF-beta in human PSCs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5460)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5460)
  AUTHORS   Helleboid,P.Y., Heusel,M., Duc,J., Piot,C., Thorball,C.W.,
            Coluccio,A., Pontis,J., Imbeault,M., Turelli,P., Aebersold,R. and
            Trono,D.
  TITLE     The interactome of KRAB zinc finger proteins reveals the
            evolutionary history of their functional diversification
  JOURNAL   EMBO J 38 (18), e101220 (2019)
   PUBMED   31403225
REFERENCE   5  (bases 1 to 5460)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5460)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 5460)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   8  (bases 1 to 5460)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 5460)
  AUTHORS   Conroy,A.T., Sharma,M., Holtz,A.E., Wu,C., Sun,Z. and Weigel,R.J.
  TITLE     A novel zinc finger transcription factor with two isoforms that are
            differentially repressed by estrogen receptor-alpha
  JOURNAL   J Biol Chem 277 (11), 9326-9334 (2002)
   PUBMED   11779858
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004890.2, AK026380.1 and
            AY049744.1.
            
            On May 17, 2019 this sequence version replaced NM_170686.2.
            
            Summary: This gene encodes a member of the Kruppel family of
            C2H2-type zinc-finger transcription factor proteins. The encoded
            protein acts as a transcriptional activator. Two transcript
            variants encoding distinct isoforms have been identified for this
            gene. Other transcript variants have been described, but their full
            length sequence has not been determined. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1), also known as p71-ZER6,
            represents the shorter transcript, and encodes the longer isoform
            a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            this RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.14416.1, AY049744.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000475153.6/ ENSP00000420418.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC004890.2         12888-12902
            16-274              AK026380.1         2-260
            275-5218            AY049744.1         2-4945
            5219-5460           AC004890.2         48236-48477
FEATURES             Location/Qualifiers
     source          1..5460
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..5460
                     /gene="ZNF398"
                     /gene_synonym="P51; P71; ZER6"
                     /note="zinc finger protein 398"
                     /db_xref="GeneID:57541"
                     /db_xref="HGNC:HGNC:18373"
                     /db_xref="MIM:618593"
     exon            1..314
                     /gene="ZNF398"
                     /gene_synonym="P51; P71; ZER6"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..2219
                     /gene="ZNF398"
                     /gene_synonym="P51; P71; ZER6"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger DNA binding protein ZER6; zinc finger-estrogen
                     receptor interaction, clone 6; zinc finger DNA binding
                     protein p52/p71"
                     /codon_start=1
                     /product="zinc finger protein 398 isoform a"
                     /protein_id="NP_733787.1"
                     /db_xref="CCDS:CCDS5894.1"
                     /db_xref="GeneID:57541"
                     /db_xref="HGNC:HGNC:18373"
                     /db_xref="MIM:618593"
                     /translation="MAEAAPAPTSEWDSECLTSLQPLPLPTPPAANEAHLQTAAISLW
                     TVVAAVQAIERKVEIHSRRLLHLEGRTGTAEKKLASCEKTVTELGNQLEGKWAVLGTL
                     LQEYGLLQRRLENLENLLRNRNFWILRLPPGIKGDIPKVPVAFDDVSIYFSTPEWEKL
                     EEWQKELYKNIMKGNYESLISMDYAINQPDVLSQIQPEGEHNTEDQAGPEESEIPTDP
                     SEEPGISTSDILSWIKQEEEPQVGAPPESKESDVYKSTYADEELVIKAEGLARSSLCP
                     EVPVPFSSPPAAAKDAFSDVAFKSQQSTSMTPFGRPATDLPEASEGQVTFTQLGSYPL
                     PPPVGEQVFSCHHCGKNLSQDMLLTHQCSHATEHPLPCAQCPKHFTPQADLSSTSQDH
                     ASETPPTCPHCARTFTHPSRLTYHLRVHNSTERPFPCPDCPKRFADQARLTSHRRAHA
                     SERPFRCAQCGRSFSLKISLLLHQRGHAQERPFSCPQCGIDFNGHSALIRHQMIHTGE
                     RPYPCTDCSKSFMRKEHLLNHRRLHTGERPFSCPHCGKSFIRKHHLMKHQRIHTGERP
                     YPCSYCGRSFRYKQTLKDHLRSGHNGGCGGDSDPSGQPPNPPGPLITGLETSGLGVNT
                     EGLETNQWYGEGSGGGVL"
     exon            315..710
                     /gene="ZNF398"
                     /gene_synonym="P51; P71; ZER6"
                     /inference="alignment:Splign:2.1.0"
     exon            711..837
                     /gene="ZNF398"
                     /gene_synonym="P51; P71; ZER6"
                     /inference="alignment:Splign:2.1.0"
     exon            838..951
                     /gene="ZNF398"
                     /gene_synonym="P51; P71; ZER6"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1065
                     /gene="ZNF398"
                     /gene_synonym="P51; P71; ZER6"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..5460
                     /gene="ZNF398"
                     /gene_synonym="P51; P71; ZER6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4737..4742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF398"
                     /gene_synonym="P51; P71; ZER6"
                     /note="hexamer: AATAAA"
     polyA_site      4759
                     /gene="ZNF398"
                     /gene_synonym="P51; P71; ZER6"
                     /note="major polyA site"
     regulatory      5184..5189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF398"
                     /gene_synonym="P51; P71; ZER6"
                     /note="hexamer: AATAAA"
     polyA_site      5220
                     /gene="ZNF398"
                     /gene_synonym="P51; P71; ZER6"
                     /note="major polyA site"
ORIGIN      
        1 gcactcgctg cccacaaagc gccagctgag gggccgctgc gggtggagtg cggcggagtc
       61 ggcctcgcga ccccagcttg atccgccgcc tgctgcaccg cgcctccgcc gcgttcctgc
      121 gcgtcccgag ccccgacggc cgcgtgagtc ccgtccgtgc ggggaaggca gggccgggtc
      181 ggcgccgcct gtggagagga cccggcggcc gggcctgctt ggagccgggc gcggtggcag
      241 cggcggcagc ggcggcgact tccgaggccc gggctagaca gcgcagggcc atggctgagg
      301 cggccccggc cccgacatct gaatgggact ccgagtgcct tacatccctg cagccccttc
      361 ctcttcctac acccccagca gcaaatgagg cacacctgca gacagcagct atctctctgt
      421 ggacagtggt ggccgccgtg caggctatag agaggaaggt ggagatccac agccggcgac
      481 tcctacacct ggaaggtcgg acagggacag cagagaagaa actagccagc tgtgaaaaga
      541 cagttaccga gcttgggaac cagctggagg gcaagtgggc cgtgctggga accctgctgc
      601 aggagtacgg gctgctgcag aggcggctgg agaacttgga gaacctgctg cgcaacagga
      661 acttctggat cctgcggctc cctccaggta ttaagggaga tatcccaaag gtgcctgtgg
      721 catttgatga tgtctccatc tacttttcca ctccagagtg ggaaaaatta gaagaatggc
      781 aaaaggaact ttacaagaat atcatgaagg gcaactacga gtctctcatc tccatggatt
      841 atgctataaa tcaacctgat gtcttatctc agattcaacc agaaggggaa cataatacag
      901 aggaccaggc agggccagag gaaagtgaga ttcccacaga ccccagtgaa gagcctggta
      961 tttcaacatc agatattctg tcttggatta aacaagaaga agagcctcag gttggggccc
     1021 caccggagtc caaggagagt gacgtgtaca aaagcactta tgctgatgaa gagcttgtca
     1081 tcaaagctga aggccttgct agatcctcgt tgtgccctga ggttccagtc cctttctctt
     1141 ctccaccagc agcagcaaag gatgcttttt cagatgtggc tttcaaaagc cagcagtcta
     1201 catccatgac accttttgga cgtccagcca ctgacctgcc tgaagcctct gagggacaag
     1261 tgacttttac tcagttgggt agctatcccc tcccacctcc agttggcgag caggtgttct
     1321 catgccacca ctgtggcaag aatctcagcc aagacatgtt gctgacccac caatgtagcc
     1381 atgctactga gcacccctta ccctgtgccc agtgccctaa gcactttact ccacaggcgg
     1441 acctcagcag cacctcccag gaccatgcca gcgagacacc ccccacctgc ccacactgtg
     1501 ccaggacttt tactcaccca tcaagactta cctaccatct tcgggtccat aacagcactg
     1561 agcgtccttt cccctgtcct gattgcccca agcgctttgc tgaccaggct cgactcacca
     1621 gccaccggag agctcatgca agcgaaaggc ccttccgctg tgcccagtgc ggcaggagct
     1681 tcagcttgaa aatcagcctc ctgctccacc agcggggtca tgcacaagag cgccctttct
     1741 cctgccctca gtgtggcatt gacttcaacg gccactcggc cctgatccgc caccagatga
     1801 tccacacagg cgagcgtcct tacccctgca ctgactgcag taagagcttc atgcgcaagg
     1861 agcacctgct gaaccaccgg cggctgcaca caggcgagcg gcccttcagt tgtcctcact
     1921 gtggcaagag cttcatccgc aagcaccacc taatgaaaca ccagcgcatc cacaccgggg
     1981 agcggcccta cccctgctcc tactgtggca ggagcttccg ctacaaacag acactcaagg
     2041 accacctccg ttcaggccac aatggaggct gtgggggtga tagtgaccca tcaggtcagc
     2101 cacccaaccc accaggtccc ctcataactg ggcttgaaac ttctggcctg ggtgtcaaca
     2161 ctgaaggtct agagaccaac cagtggtatg gggaagggag tggaggggga gttttgtaaa
     2221 tccaaatctc tgtggcttca tgcttgtata tgctcacagc agggcacaaa atccaagaga
     2281 aggtctgtga gccccatcca acacccacag taattattat ctggcacatc aatgaatttg
     2341 gggtcctata cacttgacta gagacatgct tgtgttttgg aatttcacac ccttacaaga
     2401 ataccacatt ttgaaaccca gaaagacctg gaaaggagcc cagcatgtcc atcttttcaa
     2461 agatacaaca aaagcagaag ttacaagaat attgcggaga ggttggaaag caggatttaa
     2521 cctctagttc tcttgttctc agagaacagc aggttgatag tagattatgt ctctaggtag
     2581 agacagatac atgagaagag cctccaaaac tggaagccca tcataaggca tgagaatgtt
     2641 taactataaa gccttttatt agttctttga tagctaagat ggttgttgga gaaagtgctt
     2701 aagccactgt ttatgttgct gcctcctctc tcaaaaccag ccaagatctg ttcacacacc
     2761 tctgtggctg tctttccctg aaacatggta actcaagact gcctgcctag gtttcttaga
     2821 ttaattattc acataaattt tgtttaatat tggttgaaca agaaatctga ctttaaaaga
     2881 ttattaagga gaatattcct taactatact ggcttgattt gaaacaggct cttattgcca
     2941 tttaaactgc cagaaatctt tgccaaggtc ctggttaaaa aaattggaaa cggttttctt
     3001 agccccagct ttaaaagcta gagatctcag agaaatagct ggcttaacaa tgacagaaca
     3061 gcttaaaatt tgtgcctaca ccatgttctg agagtcgttc acatcaaatt cttatctttt
     3121 ccaagccagt aagttggctt ctccattcct ggtgtctgat attcttgaca atcatcagca
     3181 acaaagatca cagcactttc cagaagcatg gagcttcaga aagtgccagt gaactcttgg
     3241 tcctcagtag tgagatgata acagtgttat aatgcagctt ccttgagcca tcagagagag
     3301 tgtatgttca ccctatctgg ctgtatccca ttggcagtgg acagattgag gaaattccta
     3361 gatcactgag agctaagcac catgcataga caacagtttg ttcttgcctg tgttgctttt
     3421 agggactttg actaccacat gttcttttct tggggtgatt taatcacctg ggagcatctg
     3481 agtctgctcc taagtggctt tgcaactggg cctaagttct gtttccttta tggatctcaa
     3541 attttcatct gcacaatgag gctgttgaaa ggaaaaaaag tgagcctcta ggaattattc
     3601 aaaaaaagtc tgtgatacat tccttttcct gccaaagttc tgtctctgtc tttggcttct
     3661 gtccaggcaa agctaaataa gacagcaaag tcaaagcaga taaattcttg ttgaaacttg
     3721 actaaaattt atttgatttg ttgttttact cccacttgga atcctgaggt agaagacaga
     3781 atgcagaagt cttacatctt gggcaggaaa ctggtttatt cctatactct tgtttcctct
     3841 gcttcttcct gaggtctaga acaaggtctg gaaatgttta gacaggatat tttcttgatg
     3901 aagtgataag gaaaggaccc atttttttgc tcatcaccta gcccatcctt cactctctct
     3961 agttatgcat aacaacacta gaagaaggtg ttagcccagc taactttgct tctgggaagg
     4021 ctatgtctga acatgttgct ctgtaggata atcacactta gaaaacatct gctccatgac
     4081 attcacaata ccagggacca tgggagacac aagaaatgtg tgtctgctgt cataacttac
     4141 agtgaaaaag cccaataata cagaacaaga catgatgggc aataccctag catattggga
     4201 ttaagagctt tctagccaga atctggacct ataccatggg aaaatttagg ggtgctggga
     4261 atcccaaagc caaggttctg gcttcattgg caacccacta ggaacttgaa tgtgagattc
     4321 agctctagtt tgcaccttga tttccccagt gaaaagggag aagagccaaa gtattgtcta
     4381 ggtgctgagt tcccttttct gagtggattt caagcatttg ccagggtatg ctggaggagg
     4441 gactcctaaa gtaggtgaga tgtgggacta ggtaacactt taaatacttt tttactcaaa
     4501 gatttgccaa gaacacagct tattagtgaa agagacctgt ggattgaaat ggctgcagat
     4561 agatcccgca gtcccttctg aaaggaactg tgtagccagc agggacctaa actttggcaa
     4621 aaagtgaaca caattcaaat acgaatgaag gaagagccct cagatggaac gaaaggcgat
     4681 gtgcaaggcc atcccagaga gacggaagca ggtgcgatac taagcctcag cccaagaata
     4741 aaagagagtt caactgttac tcttttcttt catcaatccc ctatcagtta gaactgcagg
     4801 ccagttccaa agagtgtttg cttaagattc aaaagtgggt aagtaaaatg gatcagtggg
     4861 aaggataagg tgtccaacag aaagtgtgga ggagaaactc ttggcctatc aagtgctcct
     4921 gagagaaacc atgcaattta acacttcagt taaagaaata catgagaact gcttgtcatg
     4981 accagacaag ataggaaagg ggaaacccca gaaacgtgct cttcatctgt cagccttttg
     5041 gaccaagaag ctgtcactat cacacataag caccattccc ttagagtgga tccaggtgtt
     5101 gactataacc agatttactc tttgcttact aggttttcca ttgtcaccat tggatgaacc
     5161 tctggtttag ccacagttgt gaaaataaat ggaagttggt tgattgtcta gaaagtgcaa
     5221 gaagatggcc ctgctccttt tctgctgaac atttagtatt ggaaactcct acttcccttt
     5281 tcattaataa tgtgtgcaag tttcctatta gcggggaagg tgtggggctc tgctgggctt
     5341 ctcttgagca tatctgagaa gtgatgttca tgtctatctc aaccaggacc agaccctgtg
     5401 acttactcgg taataacagt ccacacaagc ctcgttgata ttaaaaaaaa aaaaaaaaaa
//
