LOCUS       NM_001135178            5259 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 397 (ZNF397), transcript variant
            1, mRNA.
ACCESSION   NM_001135178
VERSION     NM_001135178.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5259)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5259)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5259)
  AUTHORS   Helleboid,P.Y., Heusel,M., Duc,J., Piot,C., Thorball,C.W.,
            Coluccio,A., Pontis,J., Imbeault,M., Turelli,P., Aebersold,R. and
            Trono,D.
  TITLE     The interactome of KRAB zinc finger proteins reveals the
            evolutionary history of their functional diversification
  JOURNAL   EMBO J 38 (18), e101220 (2019)
   PUBMED   31403225
REFERENCE   4  (bases 1 to 5259)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5259)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 5259)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   7  (bases 1 to 5259)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   8  (bases 1 to 5259)
  AUTHORS   Bailey,S.L., Chang,S.C., Griffiths,B., Graham,A.N., Saffery,R.,
            Earle,E., Choo,K.H. and Kalitsis,P.
  TITLE     ZNF397, a new class of interphase to early prophase-specific,
            SCAN-zinc-finger, mammalian centromere protein
  JOURNAL   Chromosoma 117 (4), 367-380 (2008)
   PUBMED   18369653
  REMARK    GeneRIF: ZNF397, a new class of interphase to early
            prophase-specific, SCAN-zinc-finger, mammalian centromere protein.
REFERENCE   9  (bases 1 to 5259)
  AUTHORS   Wu,Y., Yu,L., Bi,G., Luo,K., Zhou,G. and Zhao,S.
  TITLE     Identification and characterization of two novel human SCAN
            domain-containing zinc finger genes ZNF396 and ZNF397
  JOURNAL   Gene 310, 193-201 (2003)
   PUBMED   12801647
REFERENCE   10 (bases 1 to 5259)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI772202.1, BC006172.1,
            AF533250.2 and AC011815.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001135178.2.
            
            Summary: This gene encodes a protein with a N-terminal SCAN domain,
            and the longer isoform contains nine C2H2-type zinc finger repeats
            in the C-terminal domain. The protein localizes to centromeres
            during interphase and early prophase, and different isoforms can
            repress or activate transcription in transfection studies. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. Additional variants have been described, but their
            biological validity has not been determined. [provided by RefSeq,
            Oct 2009].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1), also known as ZNF397-fu.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF533250.2, SRR5189664.55667.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330501.12/ ENSP00000331577.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BI772202.1         5-25
            22-104              BC006172.1         1-83
            105-1373            AF533250.2         102-1370
            1374-2148           AC011815.7         106790-107564
            2149-2640           AF533250.2         2146-2637
            2641-5259           AC011815.7         108057-110675
FEATURES             Location/Qualifiers
     source          1..5259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..5259
                     /gene="ZNF397"
                     /gene_synonym="ZNF47; ZSCAN15"
                     /note="zinc finger protein 397"
                     /db_xref="GeneID:84307"
                     /db_xref="HGNC:HGNC:18818"
                     /db_xref="MIM:609601"
     exon            1..76
                     /gene="ZNF397"
                     /gene_synonym="ZNF47; ZSCAN15"
                     /inference="alignment:Splign:2.1.0"
     exon            77..570
                     /gene="ZNF397"
                     /gene_synonym="ZNF47; ZSCAN15"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1761
                     /gene="ZNF397"
                     /gene_synonym="ZNF47; ZSCAN15"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 47; zinc finger and SCAN domain-containing
                     protein 15"
                     /codon_start=1
                     /product="zinc finger protein 397 isoform 1"
                     /protein_id="NP_001128650.1"
                     /db_xref="CCDS:CCDS45852.1"
                     /db_xref="GeneID:84307"
                     /db_xref="HGNC:HGNC:18818"
                     /db_xref="MIM:609601"
                     /translation="MAVESGVISTLIPQDPPEQELILVKVEDNFSWDEKFKQNGSTQS
                     CQELFRQQFRKFCYQETPGPREALSRLQELCYQWLMPELHTKEQILELLVLEQFLSIL
                     PEELQIWVQQHNPESGEEAVTLLEDLEREFDDPGQQVPASPQGPAVPWKDLTCLRASQ
                     ESTDIHLQPLKTQLKSWKPCLSPKSDCENSETATKEGISEEKSQGLPQEPSFRGISEH
                     ESNLVWKQGSATGEKLRSPSQGGSFSQVIFTNKSLGKRDLYDEAERCLILTTDSIMCQ
                     KVPPEERPYRCDVCGHSFKQHSSLTQHQRIHTGEKPYKCNQCGKAFSLRSYLIIHQRI
                     HSGEKAYECSECGKAFNQSSALIRHRKIHTGEKACKCNECGKAFSQSSYLIIHQRIHT
                     GEKPYECNECGKTFSQSSKLIRHQRIHTGERPYECNECGKAFRQSSELITHQRIHSGE
                     KPYECSECGKAFSLSSNLIRHQRIHSGEEPYQCNECGKTFKRSSALVQHQRIHSGDEA
                     YICNECGKAFRHRSVLMRHQRVHTIK"
     exon            571..712
                     /gene="ZNF397"
                     /gene_synonym="ZNF47; ZSCAN15"
                     /inference="alignment:Splign:2.1.0"
     exon            713..5259
                     /gene="ZNF397"
                     /gene_synonym="ZNF47; ZSCAN15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5237..5242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF397"
                     /gene_synonym="ZNF47; ZSCAN15"
                     /note="hexamer: ATTAAA"
     polyA_site      5259
                     /gene="ZNF397"
                     /gene_synonym="ZNF47; ZSCAN15"
                     /note="major polyA site"
ORIGIN      
        1 gtacgcgcac ttccggtctt tgtggcttgc agctcggggt gggtggctca tttcctggcc
       61 gctcctgggc ttcgcggaaa gaagagatta ctcacactcc ttcgcaagca cagaaccagt
      121 tgtactgagc tttttgctaa gctgtttcag ccaagaatgg ctgtggaatc tggagtgatt
      181 tcaaccctga tacctcagga tcctccggaa caagaactaa tactagtgaa agtagaagat
      241 aacttttcct gggatgagaa atttaagcag aatgggagta ctcaatcctg ccaagaattg
      301 tttcgtcagc aattcagaaa attttgctac caggagacac ctgggccccg ggaggctctg
      361 agccgactcc aggaactttg ctatcagtgg ctaatgccag agttgcacac aaaggagcag
      421 atcttagaac tgctggtact ggagcagttc ctgagcattc tgcctgagga gctgcagatc
      481 tgggttcagc aacataatcc agaaagcggc gaggaagctg tgaccctgtt ggaggattta
      541 gagagggagt ttgatgaccc agggcagcag gtcccagcta gtccacaggg accagcagtg
      601 ccatggaagg atttaacatg tctcagagca tcccaagagt caacagacat ccacctccag
      661 cccttaaaga cacagctgaa atcctggaaa ccatgccttt cccctaaaag tgattgtgag
      721 aacagtgaaa cagcaacaaa agagggcatc tcagaagaaa aatcacaggg actccctcag
      781 gaaccttcat ttcgaggaat tagtgagcat gaaagcaatt tagtgtggaa gcaaggaagt
      841 gctacagggg agaaactaag atctccttcc caagggggca gttttagtca agtgatcttc
      901 acaaacaaat ctctaggaaa gagagacctt tatgatgagg ctgaaagatg cttgattcta
      961 actacagact ctataatgtg tcagaaagtt cctccagaag agagacctta tagatgtgat
     1021 gtatgtgggc acagcttcaa gcagcattcc tctctaacac aacatcagag aatccatact
     1081 ggagaaaagc cctataaatg taaccagtgt gggaaggcct ttagtttgag gtcctatctt
     1141 attattcatc agagaattca tagtggtgag aaagcatatg aatgtagtga atgtgggaaa
     1201 gctttcaatc agagctcagc cctcattaga catcggaaaa tccatactgg tgagaaagct
     1261 tgtaaatgta atgagtgtgg caaagcattc agtcaaagtt catatctcat tatacatcaa
     1321 agaattcaca ctggtgagaa accttatgag tgtaatgaat gtgggaaaac ctttagccag
     1381 agctcaaaac tcattagaca tcagcgaatt cacacaggag agagacccta tgaatgtaat
     1441 gaatgtggaa aagctttcag gcagagctca gagctgatta ctcatcagag aatacatagt
     1501 ggagagaaac cctatgaatg tagtgaatgt ggaaaagctt tcagtttgag ctcaaacctt
     1561 atcagacatc agagaattca tagtggggag gaaccttatc agtgtaatga atgtggcaaa
     1621 actttcaaaa ggagctcagc ccttgttcag catcagagaa ttcattctgg ggatgaagct
     1681 tatatatgta atgaatgtgg gaaggctttc aggcacagat cggtccttat gcgccatcaa
     1741 agagtccaca ctataaagta atttgtgaat actgtgaata gtgtaaatac ttcagtcaga
     1801 tttttaagtt tgttagtcaa aagagtttac tttggagcaa aactccataa aggttataaa
     1861 atactaggtc ttgagtctag cttgctttgt gcagcatttc ccagtgctaa tgtaaagtgt
     1921 cccttgaaag cttttcctgt gactaatcag aacagaatac agaagaatca ttacttccag
     1981 ctcttctctt attaggaata ctcaggaaat acgaaaagtg ggaatgtaac attgaaacct
     2041 cattttgtat gaaagtgtca tgaatatagc aacccaggct ctgtcactgc atctgattgt
     2101 tagtgtgcca ggttatgggg ctggtgtgga ctgtgtgagg cacttcgtct caggaactaa
     2161 aaaaaaaaaa aaaactgacc caataaagaa cagtgacaga gcagcaggaa aggtggggaa
     2221 atggcttcat caatgatttg ttgagcccag ggcaggccag gaattagata ggcatgagaa
     2281 gaaagaatat aatttaccca aaggttattt tttgagtacc tactttgtcc caggaactag
     2341 gaatacagtg gaaaacaaga ctgtagtctc tacagtctaa tgggcaaggc agccagacag
     2401 gcagtgaaag tggaatgctc ctatgtgacc ttaaggagca cctgactcag ccttggataa
     2461 ggaaatgggg gaaatggcct gaaggatgag gaggagttag ccaaggtggt actctaggga
     2521 agtggtaccc cagtaaagaa cagtagccaa aggccagaaa caaagtgtgg agcattcctt
     2581 gagttcctgt tgtagtgagg tcttgtctgt cagagaagtc tgggtctggc cagactctta
     2641 agcagtgcca atggagaagt tcctgttaat agacaaaacc tggagccctt gggccacagg
     2701 gtagtcaaga gctttgtctt ggtttatgtg accccaggga aagggcaaat atgtggtttc
     2761 cttgcccaac ctgtaggcta tcctagaact tccatgaggg tggtggtggg aatgagggtg
     2821 agaaagagcc cagcctatac ctcaagagtc tgctagagtg ttaagactct attctccttt
     2881 gattctaaag acaatatcag agctgctgtc aggtttctta aaattcccaa cgctctggat
     2941 cagaagctgc catatcattt gtttctgggg ctatacgccc acaattccta gtacattccc
     3001 ttgggctttg gtgctcaaaa aatatttgtc agttgctggg tctgtgacat tctttgggca
     3061 cctcgcacat gttcagtttt gtcttatgtc accagtattt cacaatatct tttgcaattt
     3121 tttttttttt tttttttttt ttgagatgga gttcgctctt gtccaggctg gagtgcaatg
     3181 gcacgatctt ggctcaccgc aaactctgcc tcctgggttc aagcgattct cctgcctcag
     3241 ccttctgagt agctgggatt acaggcatgc accaccacag ctggctaatt ttgtattttt
     3301 aggaaagaca gggtttctcc atgttggtca ggctggtctc gaattctcga tctcaggtga
     3361 tccgcccgcc tcggcccccc aaagtgctgg gattacaggc gtgagccatg gcgcccaacc
     3421 atcttttgca aattttatta aagacaatgc taaaaggaag tgacaactga aactaatggt
     3481 cacagtcagt caagacttcc cttttctgag gggcctagca ggaagagaat atttagactg
     3541 atgcttagtg taagaaggaa tgttgtacag gttaaccagc aacacaaaga catattcaaa
     3601 agacctaata ggtcagaaga ataacatacc acaccaaaaa caaatctgta tggaaatcta
     3661 gaatcatgtg catagaaaaa gaattttcat gaggataaaa agaagcaaag agaagtaatg
     3721 ctcttattgg ggcgtgcatc agtggacatg tgctaaccag taagaacagc aggaggccta
     3781 aatgcccatg tttagggaga gaatatggaa aaaatggatg ggattatttg gaaaagatgt
     3841 aagagattaa aatacgtggt aagagctact caactcttgt ttttctcctt ttccatagat
     3901 aaagacctga acaaactgaa aaggtaggac gtaaagtagg aattgtaaaa cggaaatact
     3961 ctttatataa gaaagctcta ctgtatgtca gaaagcaatg taatagatag accaagcaca
     4021 gtggctcaca cctataatgc cagcactttg ggaggccaag gctggaggat tgcttgagtc
     4081 taggagttca agccgagcct gggcagcata gtgagacccc atctctacaa aaaataaaca
     4141 gaatttgcca gacgtggtag tgcatgcctg tagacccaag tatttgggag gctgaggtga
     4201 gaggttcgct tgagccctgg aagtcgaggc ttcagtgagg caagatcaca ccactgcact
     4261 ccagcctggg agagcaagac cctgtctcca aaccaaaaaa aaaggaaaaa agtaaatgta
     4321 atagatactt gctaagggct ttgtatatac ttattattgt tatttctcag cacgtatgta
     4381 gcagatgagg aaatgaaggc taaaggtcat atatctacaa agtggggagg tcagactttg
     4441 aacccacaac ctgactgtgg agccacttca gtatactctc tccccataag aaagttccaa
     4501 tagaaaaaaa atgctactta agtagggaaa tcacaaaata agtgccaatg aacaataaat
     4561 gttcaacctc actacagtta aaatgtatat taaagcaaga gttgagatga cacttttcct
     4621 tataaaacag acagggattc agggacattg ggactctaat gctgctggta agacatgaat
     4681 aaatacatac catctctggc aatcaatacc agaagcttta agcattgcct tttgactttg
     4741 aaattgtacc tggaaatgta tgtttcagta accatcatga atgtacacaa aatcctgaaa
     4801 ctcttaaaac tgatgtcaca ggccaggcac agtggctcat gcctgtaatc ccagcacttt
     4861 gggaggctga ggcgggtgga tcacctgaga tcaggagttc gagaccagcc tgaccaatat
     4921 ggtgaaaccc cgtctctact aaaaatacaa aacaattagc tggtgtggtg gcatgtgcct
     4981 gtagtcccag ctacttggga ggctgagaca ggagaattgc atgaacccgg gaggtggagg
     5041 ttgcagtgag ccgagattgt accactgtat tccagcctgg gtgacagagt gagactgtgt
     5101 ctcaaaaaaa aaaaaaaaaa aaaaaaaaac actgatgtca attaatatta aatgaagtat
     5161 tcatgatata ttgttaagta aaaatattac aaaacaatat gtacagtatg atcctatgta
     5221 aaatatatat ttatgtatta aaaatactga aaacataaa
//
