LOCUS       NM_001322286            3661 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 396 (ZNF396), transcript variant
            1, mRNA.
ACCESSION   NM_001322286 XM_005258236
VERSION     NM_001322286.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3661)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3661)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 3661)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 3661)
  AUTHORS   Bai,J., Kito,Y., Okubo,H., Nagayama,T. and Takeuchi,T.
  TITLE     Expression of ZNF396 in basal cell carcinoma
  JOURNAL   Arch Dermatol Res 306 (4), 399-404 (2014)
   PUBMED   24445935
  REMARK    GeneRIF: ZNF396 might repress Notch-Hes1 signaling axis and prevent
            tumor cells from undergoing squamous differentiation in basal cell
            carcinoma.
REFERENCE   5  (bases 1 to 3661)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3661)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 3661)
  AUTHORS   Wu,Y., Yu,L., Bi,G., Luo,K., Zhou,G. and Zhao,S.
  TITLE     Identification and characterization of two novel human SCAN
            domain-containing zinc finger genes ZNF396 and ZNF397
  JOURNAL   Gene 310, 193-201 (2003)
   PUBMED   12801647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007998.10 and AF533251.2.
            
            On Nov 24, 2018 this sequence version replaced NM_001322286.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.148209.1,
                                           SRR1803614.74691.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267781 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000589332.7/ ENSP00000466500.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC007998.10        39796-39814         c
            20-1884             AF533251.2         20-1884
            1885-3661           AC007998.10        29171-30947         c
FEATURES             Location/Qualifiers
     source          1..3661
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..3661
                     /gene="ZNF396"
                     /gene_synonym="ZSCAN14"
                     /note="zinc finger protein 396"
                     /db_xref="GeneID:252884"
                     /db_xref="HGNC:HGNC:18824"
                     /db_xref="MIM:609600"
     exon            1..60
                     /gene="ZNF396"
                     /gene_synonym="ZSCAN14"
                     /inference="alignment:Splign:2.1.0"
     exon            61..549
                     /gene="ZNF396"
                     /gene_synonym="ZSCAN14"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1140
                     /gene="ZNF396"
                     /gene_synonym="ZSCAN14"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger and SCAN domain-containing protein 14"
                     /codon_start=1
                     /product="zinc finger protein 396 isoform 1"
                     /protein_id="NP_001309215.1"
                     /db_xref="CCDS:CCDS82247.1"
                     /db_xref="GeneID:252884"
                     /db_xref="HGNC:HGNC:18824"
                     /db_xref="MIM:609600"
                     /translation="MSAKLGKSSSLLTQTSEECNGILTEKMEEEEQTCDPDSSLHWSS
                     SYSPETFRQQFRQFGYQDSPGPHEALSRLWELCHLWLRPEVHTKEQILELLVLEQFLA
                     ILPKELQAWVQKHHPENGEETVTMLEDVERELDGPKQIFFGRRKDMIAEKLAPSEITE
                     ELPSSQLMPVKKQLQGASWELQSLRPHDEDIKTTNVKSASRQKTSLGIELHCNVSNIL
                     HMNGSQSSTYRGTYEQDGRFEKRQGNPSWKKQQKCDECGKIFSQSSALILHQRIHSGK
                     KPYACDECAKAFSRSAILIQHRRTHTGEKPYKCHDCGKAFSQSSNLFRHRKRHIRKKV
                     P"
     exon            550..694
                     /gene="ZNF396"
                     /gene_synonym="ZSCAN14"
                     /inference="alignment:Splign:2.1.0"
     exon            695..3661
                     /gene="ZNF396"
                     /gene_synonym="ZSCAN14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2720..2725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF396"
                     /gene_synonym="ZSCAN14"
                     /note="hexamer: ATTAAA"
     polyA_site      2754
                     /gene="ZNF396"
                     /gene_synonym="ZSCAN14"
                     /note="major polyA site"
     polyA_site      3493
                     /gene="ZNF396"
                     /gene_synonym="ZSCAN14"
                     /note="major polyA site"
     regulatory      3641..3646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF396"
                     /gene_synonym="ZSCAN14"
                     /note="hexamer: AGTAAA"
     polyA_site      3661
                     /gene="ZNF396"
                     /gene_synonym="ZSCAN14"
ORIGIN      
        1 agaaccggaa gttgttgcgc agctggcagt tccccggttt ctccccgacg gcgtcgggag
       61 gagtgtccat caggacagct tcacctcctt gaggattaaa gcctaacagt actgagctat
      121 ttgtctgtca aaatgtctgc aaaattggga aagtcatcat cactcctaac acaaacttca
      181 gaggagtgta atgggattct gacagagaag atggaagagg aagagcagac ctgtgatcca
      241 gactctagcc tccactggag cagcagctac agcccagaga ccttccgcca gcaattcagg
      301 cagtttggct accaggattc acctgggccc catgaggctc tgagccggct ctgggaactt
      361 tgtcatctct ggctgaggcc ggaagtgcac accaaggagc agatcctgga gctgctggtg
      421 ctggagcagt tcctggccat cctcccaaaa gagcttcagg cctgggtgca gaagcatcat
      481 ccagagaatg gagaggaaac tgtgactatg ctggaggatg tggagagaga gcttgatgga
      541 ccaaagcaga tcttttttgg acgaaggaag gacatgattg cagagaagct agcaccttca
      601 gaaatcactg aggaattgcc aagtagccag ctcatgcccg tgaagaagca gctccaggga
      661 gcatcatggg agcttcagtc cttaagacca catgatgaag acatcaaaac tacaaatgtg
      721 aaatctgctt caaggcaaaa gacttcttta ggcatagaac tgcattgcaa tgtttccaat
      781 atccttcata tgaatggctc ccagagttcc acatatagag gaacctatga acaagatggt
      841 aggtttgaaa agagacaagg aaacccttct tggaaaaaac aacagaaatg tgatgaatgt
      901 ggcaaaatct ttagtcagag ctcagccctt attttacatc agagaatcca cagtggaaag
      961 aaaccttatg catgtgacga gtgtgcaaag gcattcagcc gaagcgcaat tctgattcag
     1021 catcgacgaa cccatactgg tgagaagccc tacaagtgtc atgactgtgg caaagccttt
     1081 agtcagagct caaatctttt tagacatagg aaaagacaca ttagaaaaaa agtcccataa
     1141 gtatcatgag ggaatcaaag catttactca gagctatttc agcacaaggg aagacaccag
     1201 atgcaaacgc tccttagtac aaatcagtgg tcttagtaag caccagtctc ctttcaagac
     1261 tcatgaaagc cacaggagag aaggttgaag atctcaggtc agcattattt gcttttctgc
     1321 ttatcaatgc agtctcaatt ctgacgtttg caattccaaa gcttaattca gatttccatc
     1381 cctatgcagg ccttgaaaag gcattctcag acatgttcta ctattttcat tattaacaca
     1441 tataatgaat tagtatatat ctttttagac aagtatgttt tttccctcat tgagaaggaa
     1501 tgtgtgagtt actcagtgta aaaatagaca ttctcctcca tttcataact tgagcactag
     1561 aattctaaag accaaaaatt aaagcactca aaaagaattc ctggctgggt gcggttggct
     1621 catgcctgta atcctagcac tttgggaggc cgaggcaggc agattgcctg aactcaggag
     1681 ttcaagacca gcctggacaa cacggcgaaa ccccgtctct actaaaattc aaaaaattag
     1741 ccaggcatgg caacgtgtac ctgtaatccc agctactagg gaggctgagg caggaaaatt
     1801 gcttgaaccg ctcagacaga gcaagactcc gtctttaaaa taaataaata aataaataaa
     1861 taaataaata aaaataaaaa taaattccta ttttgtcttc tgttactaga ttcaaaatat
     1921 gaacatgcga ttgcagaggc ccaaaagaat atgtacttca agactaggct gaagtgcccc
     1981 aggtcacttt caggaggcag ataaataaag gccttatctt atgaaagcac acaagagcct
     2041 ccatactatt aatatcaagt taatttcccg tgttggaaaa aaataatctc ctttgcaatg
     2101 taatttggaa ataagtcaat ggaaacatga aaatgactgc ttgtctacaa ggagtcagct
     2161 aaacataagg aatgttttca taacaatatt aatctatggg tgcttctgta agatggatga
     2221 tcatcttaat ataaagaaaa aagggagatg aacaaaattg tcaaacaaga ctgatgtacc
     2281 acaagtgttg tcaagtacag tgtgtgtcgg agagatgtac cacagcttaa ctggaagagg
     2341 aagcccgtaa ctgctgatga caatactttc agtgtcccct tttctggcat aaatcaacta
     2401 tgaatatgtt tcaagcatca caagacaacc ttttcagagt cttctgtatt cttagtaaga
     2461 tgagtttcta gacacgctgt catgaaatga gaccctggat tttgatgctc ttgtacatat
     2521 ggacaaatca ctgaagttca atttaaaggg tccactgcag tcccttataa acaattgttg
     2581 aacctaacca ttatagttta taagttttaa gacatttatg ggatatctta tttggcttat
     2641 ctatgggata tgagtaacta tgttttacct gcatttaatt cagccagatt ccctgtttaa
     2701 aattactgaa tcgtacatta ttaaaattat tctgacagta tacaaacaac aaaattatct
     2761 attttccaga gattcttgat aaaactctgt aatgttacta caataataca tgtattgtgt
     2821 tttccatggt gctacagtta cacaatatgg aggcaaacat cagaaatcaa agtccttgga
     2881 ataagggaag agactcatag taaacttctt tgtctggttg ggttcctcat aaagtataaa
     2941 acatttcatt ctcagaaaat ccaaccatat cttagagtat ctccagaaac tggcttagag
     3001 gagctccaaa tatgtggaat taccacactc tgcttagtta gtatgctgat aaatgtaaga
     3061 ttagtaggag gagaagtgaa tgtaaatttt attatagaat tttctgatag tgattatgat
     3121 ttgtagctct agtgaatatg aattttatat tgagttgtgt gtatcttgag tcactaaaaa
     3181 tgtaggatac tttttatttg gggctcattg tctttgtaat tacggagagg aacaaaccat
     3241 ctattgaaac aacaagtgcc tcagagatgt atatattgtg aattactgct taattacgga
     3301 aagagtttct taggttctat gtgaataaga tggcagaatc taaatcaagt attttgaagg
     3361 aagcacccat cttcacttgg tgctgccatc aactttgtaa gattgcattc tatttattgt
     3421 gaataatttg agtgtttcca caggaaagtg gtatgaatca tatcgtctaa gtatatgatg
     3481 aatctttaaa gggtgtctct gtgtactttg aattattttg cagttatgta ggtatcctaa
     3541 tgagtgaatg gtactagttt atataaaagg agaattcatt gagctaacct tggttttaaa
     3601 aattagcatt agcaccccca ttatattaat tttcagggat agtaaatact ccaaaatgaa
     3661 a
//
