LOCUS       NM_018660               4797 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 395 (ZNF395), mRNA.
ACCESSION   NM_018660 NM_017606
VERSION     NM_018660.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4797)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4797)
  AUTHORS   Kurogi,S., Hijiya,N., Hidano,S., Sato,S., Uchida,T., Tsukamoto,Y.,
            Nakada,C., Yada,K., Hirashita,T., Inomata,M., Murakami,K.,
            Takahashi,N., Kobayashi,T. and Moriyama,M.
  TITLE     Downregulation of ZNF395 Drives Progression of Pancreatic Ductal
            Adenocarcinoma through Enhancement of Growth Potential
  JOURNAL   Pathobiology 88 (5), 374-382 (2021)
   PUBMED   33794543
  REMARK    GeneRIF: Downregulation of ZNF395 Drives Progression of Pancreatic
            Ductal Adenocarcinoma through Enhancement of Growth Potential.
REFERENCE   3  (bases 1 to 4797)
  AUTHORS   Yao,X., Tan,J., Lim,K.J., Koh,J., Ooi,W.F., Li,Z., Huang,D.,
            Xing,M., Chan,Y.S., Qu,J.Z., Tay,S.T., Wijaya,G., Lam,Y.N.,
            Hong,J.H., Lee-Lim,A.P., Guan,P., Ng,M.S.W., He,C.Z., Lin,J.S.,
            Nandi,T., Qamra,A., Xu,C., Myint,S.S., Davies,J.O.J., Goh,J.Y.,
            Loh,G., Tan,B.C., Rozen,S.G., Yu,Q., Tan,I.B.H., Cheng,C.W.S.,
            Li,S., Chang,K.T.E., Tan,P.H., Silver,D.L., Lezhava,A., Steger,G.,
            Hughes,J.R., Teh,B.T. and Tan,P.
  TITLE     VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear
            Cell Renal Cell Carcinoma
  JOURNAL   Cancer Discov 7 (11), 1284-1305 (2017)
   PUBMED   28893800
  REMARK    GeneRIF: epigenomic profiling of clear cell renal cell carcinoma
            (ccRCC) establishes a compendium of somatically altered
            cis-regulatory elements, uncovering new potential targets including
            ZNF395. Loss of VHL, a ccRCC signature event, causes pervasive
            enhancer malfunction, with binding of enhancer-centric HIF2a and
            recruitment of histone acetyltransferase p300 at preexisting
            lineage-specific promoter-enhancer complexes
REFERENCE   4  (bases 1 to 4797)
  AUTHORS   Schroeder,L., Herwartz,C., Jordanovski,D. and Steger,G.
  TITLE     ZNF395 Is an Activator of a Subset of IFN-Stimulated Genes
  JOURNAL   Mediators Inflamm 2017, 1248201 (2017)
   PUBMED   28316371
  REMARK    GeneRIF: The transcriptional activation of CXCL10 and CXCL11 by
            ZNF395 was abolished after inhibition of IKK by BMS-345541, which
            increased the stability of ZNF395. ZNF395 encodes at least two
            motifs that mediate the enhanced degradation of ZNF395 in response
            to IKK activation. Thus, IKK is required for ZNF395-mediated
            activation of transcription and enhances its turn-over to keep the
            activity of ZNF395 low.
REFERENCE   5  (bases 1 to 4797)
  AUTHORS   Pang,F., Zha,R., Zhao,Y., Wang,Q., Chen,D., Zhang,Z., Chen,T.,
            Yao,M., Gu,J. and He,X.
  TITLE     MiR-525-3p enhances the migration and invasion of liver cancer
            cells by downregulating ZNF395
  JOURNAL   PLoS One 9 (3), e90867 (2014)
   PUBMED   24599008
  REMARK    GeneRIF: miR-525-3p promotes liver cancer cell migration and
            invasion by directly targeting ZNF395.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4797)
  AUTHORS   Sichtig,N., Korfer,N. and Steger,G.
  TITLE     Papillomavirus binding factor binds to SAP30 and represses
            transcription via recruitment of the HDAC1 co-repressor complex
  JOURNAL   Arch Biochem Biophys 467 (1), 67-75 (2007)
   PUBMED   17897615
  REMARK    GeneRIF: PBF binds to SAP30 and represses transcription via
            recruitment of the HDAC1 co-repressor complex
REFERENCE   7  (bases 1 to 4797)
  AUTHORS   Sichtig,N., Silling,S. and Steger,G.
  TITLE     Papillomavirus binding factor (PBF)-mediated inhibition of cell
            growth is regulated by 14-3-3beta
  JOURNAL   Arch Biochem Biophys 464 (1), 90-99 (2007)
   PUBMED   17531190
  REMARK    GeneRIF: PBF is a new cellular factor mediating the effects of
            PI3K/Akt signaling and 14-3-3 on cell growth
REFERENCE   8  (bases 1 to 4797)
  AUTHORS   Tsukahara,T., Nabeta,Y., Kawaguchi,S., Ikeda,H., Sato,Y.,
            Shimozawa,K., Ida,K., Asanuma,H., Hirohashi,Y., Torigoe,T.,
            Hiraga,H., Nagoya,S., Wada,T., Yamashita,T. and Sato,N.
  TITLE     Identification of human autologous cytotoxic T-lymphocyte-defined
            osteosarcoma gene that encodes a transcriptional regulator,
            papillomavirus binding factor
  JOURNAL   Cancer Res 64 (15), 5442-5448 (2004)
   PUBMED   15289353
  REMARK    GeneRIF: PBF is an osteosarcoma-associated antigen recognized by
            autologous cytotoxic T-lymphocyte clone in the context of
            HLA-B*5502.
REFERENCE   9  (bases 1 to 4797)
  AUTHORS   Tanaka,K., Shouguchi-Miyata,J., Miyamoto,N. and Ikeda,J.E.
  TITLE     Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal
            cell-specific cis-regulatory element in the promoter for the human
            Huntington's disease gene
  JOURNAL   J Biol Chem 279 (8), 7275-7286 (2004)
   PUBMED   14625278
  REMARK    GeneRIF: HDBP1 and HDBP2 are novel transcription factors shuttling
            between nucleus and cytoplasm and bind to the specific GCCGGCG,
            which is an essential cis-element for HD gene expression in
            neuronal cells
REFERENCE   10 (bases 1 to 4797)
  AUTHORS   Boeckle,S., Pfister,H. and Steger,G.
  TITLE     A new cellular factor recognizes E2 binding sites of
            papillomaviruses which mediate transcriptional repression by E2
  JOURNAL   Virology 293 (1), 103-117 (2002)
   PUBMED   11853404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK023418.1, BG759384.1, BI917232.1, BG249131.1, CB960515.1,
            AK026076.1, BC008870.2, AL137588.1 and AI049727.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018660.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023418.1, AB073627.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344423.10/ ENSP00000340494.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1516              AK023418.1         1-1516
            1517-2001           BG759384.1         241-725
            2002-2103           BI917232.1         620-721
            2104-2114           BG249131.1         658-668
            2115-2122           BI917232.1         733-740
            2123-2462           CB960515.1         170-509
            2463-3417           AK026076.1         330-1284
            3418-3638           BC008870.2         684-904
            3639-4609           AL137588.1         957-1927
            4610-4623           AI049727.1         189-202             c
            4624-4797           AI049727.1         11-184              c
FEATURES             Location/Qualifiers
     source          1..4797
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.1"
     gene            1..4797
                     /gene="ZNF395"
                     /gene_synonym="HDBP-2; HDBP2; HDRF-2; PBF; PRF-1; PRF1;
                     Si-1-8-14"
                     /note="zinc finger protein 395"
                     /db_xref="GeneID:55893"
                     /db_xref="HGNC:HGNC:18737"
                     /db_xref="MIM:609494"
     exon            1..68
                     /gene="ZNF395"
                     /gene_synonym="HDBP-2; HDBP2; HDRF-2; PBF; PRF-1; PRF1;
                     Si-1-8-14"
                     /inference="alignment:Splign:2.1.0"
     exon            69..366
                     /gene="ZNF395"
                     /gene_synonym="HDBP-2; HDBP2; HDRF-2; PBF; PRF-1; PRF1;
                     Si-1-8-14"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1668
                     /gene="ZNF395"
                     /gene_synonym="HDBP-2; HDBP2; HDRF-2; PBF; PRF-1; PRF1;
                     Si-1-8-14"
                     /note="Huntington's disease gene regulatory region-binding
                     protein 2; papillomavirus regulatory factor PRF-1;
                     HD-regulating factor 2; papillomavirus-binding factor;
                     papillomavirus regulatory factor 1; HD gene regulatory
                     region-binding protein 2; huntington disease gene
                     regulatory region-binding protein 2"
                     /codon_start=1
                     /product="zinc finger protein 395"
                     /protein_id="NP_061130.1"
                     /db_xref="CCDS:CCDS6067.1"
                     /db_xref="GeneID:55893"
                     /db_xref="HGNC:HGNC:18737"
                     /db_xref="MIM:609494"
                     /translation="MASVLSRRLGKRSLLGARVLGPSASEGPSAAPPSEPLLEGAAPQ
                     PFTTSDDTPCQEQPKEVLKAPSTSGLQQVAFQPGQKVYVWYGGQECTGLVEQHSWMEG
                     QVTVWLLEQKLQVCCRVEEVWLAELQGPCPQAPPLEPGAQALAYRPVSRNIDVPKRKS
                     DAVEMDEMMAAMVLTSLSCSPVVQSPPGTEANFSASRAACDPWKESGDISDSGSSTTS
                     GHWSGSSGVSTPSPPHPQASPKYLGDAFGSPQTDHGFETDPDPFLLDEPAPRKRKNSV
                     KVMYKCLWPNCGKVLRSIVGIKRHVKALHLGDTVDSDQFKREEDFYYTEVQLKEESAA
                     AAAAAAAGTPVPGTPTSEPAPTPSMTGLPLSALPPPLHKAQSSGPEHPGPESSLPSGA
                     LSKSAPGSFWHIQADHAYQALPSFQIPVSPHIYTSVSWAAAPSAACSLSPVRSRSLSF
                     SEPQQPAPAMKSHLIVTSPPRAQSGARKARGEAKKCRKVYGIEHRDQWCTACRWKKAC
                     QRFLD"
     exon            367..599
                     /gene="ZNF395"
                     /gene_synonym="HDBP-2; HDBP2; HDRF-2; PBF; PRF-1; PRF1;
                     Si-1-8-14"
                     /inference="alignment:Splign:2.1.0"
     exon            600..709
                     /gene="ZNF395"
                     /gene_synonym="HDBP-2; HDBP2; HDRF-2; PBF; PRF-1; PRF1;
                     Si-1-8-14"
                     /inference="alignment:Splign:2.1.0"
     exon            710..945
                     /gene="ZNF395"
                     /gene_synonym="HDBP-2; HDBP2; HDRF-2; PBF; PRF-1; PRF1;
                     Si-1-8-14"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1046
                     /gene="ZNF395"
                     /gene_synonym="HDBP-2; HDBP2; HDRF-2; PBF; PRF-1; PRF1;
                     Si-1-8-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1359
                     /gene="ZNF395"
                     /gene_synonym="HDBP-2; HDBP2; HDRF-2; PBF; PRF-1; PRF1;
                     Si-1-8-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1452
                     /gene="ZNF395"
                     /gene_synonym="HDBP-2; HDBP2; HDRF-2; PBF; PRF-1; PRF1;
                     Si-1-8-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1556
                     /gene="ZNF395"
                     /gene_synonym="HDBP-2; HDBP2; HDRF-2; PBF; PRF-1; PRF1;
                     Si-1-8-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..4797
                     /gene="ZNF395"
                     /gene_synonym="HDBP-2; HDBP2; HDRF-2; PBF; PRF-1; PRF1;
                     Si-1-8-14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4776..4781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF395"
                     /gene_synonym="HDBP-2; HDBP2; HDRF-2; PBF; PRF-1; PRF1;
                     Si-1-8-14"
                     /note="hexamer: AATAAA"
     polyA_site      4797
                     /gene="ZNF395"
                     /gene_synonym="HDBP-2; HDBP2; HDRF-2; PBF; PRF-1; PRF1;
                     Si-1-8-14"
                     /note="major polyA site"
ORIGIN      
        1 aagtgcgcat gtgcgcgagg agtcgctcgg gcacttattg agcgccgact gtctacgggc
       61 ggccgggggt gatgggcaga ggcttcagtg tccccttcgc ctccgcagga gaggagaggc
      121 agcagcatgg cgagtgtcct gtcccgacgc cttggaaagc ggtccctcct gggagcccgg
      181 gtgttgggac ccagtgcctc ggaggggccc tcggctgccc caccctcgga gccactgcta
      241 gaaggggccg ctccccagcc tttcaccacc tctgatgaca ccccctgcca ggagcagccc
      301 aaggaagtcc ttaaggctcc cagcacctcg ggccttcagc aggtggcctt tcagcctggg
      361 cagaaggttt atgtgtggta cgggggtcaa gagtgcacag gactggtgga gcagcacagc
      421 tggatggagg gtcaggtgac cgtctggctg ctggagcaga agctgcaggt ctgctgcagg
      481 gtggaggagg tgtggctggc agagctgcag ggcccctgtc cccaggcacc acccctggag
      541 cccggagccc aggccctggc ctacaggccc gtctccagga acatcgatgt cccaaagagg
      601 aagtcggacg cagtggaaat ggatgagatg atggcggcca tggtgctgac gtccctgtcc
      661 tgcagccctg ttgtacagag tcctcccggg accgaggcca acttctctgc ttcccgtgcg
      721 gcctgcgacc catggaagga gagtggtgac atctcggaca gcggcagcag cactaccagc
      781 ggtcactgga gtgggagcag tggtgtctcc accccctcgc ccccccaccc ccaggccagc
      841 cccaagtatt tgggggatgc ttttggttct ccccaaactg atcatggctt tgagaccgat
      901 cctgaccctt tcctgctgga cgaaccagct ccacgaaaaa gaaagaactc tgtgaaggtg
      961 atgtacaagt gcctgtggcc aaactgtggc aaagttctgc gctccattgt gggcatcaaa
     1021 cgacacgtca aagccctcca tctgggggac acagtggact ctgatcagtt caagcgggag
     1081 gaggatttct actacacaga ggtgcagctg aaggaggaat ctgctgctgc tgctgctgct
     1141 gctgccgcag gcaccccagt ccctgggact cccacctccg agccagctcc cacccccagc
     1201 atgactggcc tgcctctgtc tgctcttcca ccacctctgc acaaagccca gtcctccggc
     1261 ccagaacatc ctggcccgga gtcctccctg ccctcagggg ctctcagcaa gtcagctcct
     1321 gggtccttct ggcacattca ggcagatcat gcataccagg ctctgccatc cttccagatc
     1381 ccagtctcac cacacatcta caccagtgtc agctgggctg ctgccccctc cgccgcctgc
     1441 tctctctctc cggtccggag ccggtcgcta agcttcagcg agccccagca gccagcacct
     1501 gcgatgaaat ctcatctgat cgtcacttct ccaccccggg cccagagtgg tgccaggaaa
     1561 gcccgagggg aggctaagaa gtgccgcaag gtgtatggca tcgagcaccg ggaccagtgg
     1621 tgcacggcct gccggtggaa gaaggcctgc cagcgctttc tggactgagc tgtgctgcag
     1681 gttctactct gttcctggcc ctgccggcag ccactgacaa gaggccagtg tgtcaccagc
     1741 cctcagcaga aaccgaaaga gaaagaacgg aaacacggag tttgggctct gttggctaag
     1801 gtgtaacact taaagcaatt ttctcccatt gtgcgaacat tttatttttt aaaaaaaaga
     1861 aacaaaaata tttttccccc taaaatagga gagagccaaa actgaccaag gctattcagc
     1921 agtgaaccag tgaccaaaga attaattacc ctccgtttcc cacatcccca ctctctaggg
     1981 gattagcttg tgcgtgtcaa aagaaggaac agctcgttct gcttcctgct gagtcggtga
     2041 attctttgct ttctaaactc ttccagaaag gactgtgagc aagatgaatt tacttttctt
     2101 aaaaaaaaaa aaaaaaaaaa aaaaaaagag tttctggctg atgggtgact cagagtgcag
     2161 gactgcctgg ccgtggggca gaggggtttg cccttctcgg agggtacctc ctgttccctg
     2221 tctgagcatc ctgcatggaa gtcaaaggaa atccctttct tggtgacgac ttaaatctgg
     2281 gttccctcag acattgggtt gcaccccaac aaatattaaa tggcttcttc ttaaagccca
     2341 gagaaagagg ttttttaaaa gactgtcgcc aaatagctga gccaaaaggc tgatcagaat
     2401 tcactttttg gaatgtggca gttaaacact accttgatca ttctctcctc tttcctcgag
     2461 gaactcctgg agggtttgag cgtctggaaa ctctctgctc tgacccgagg aagcaccctc
     2521 ctgacgccgc cttcctccgg ttattgaaag gacgcctcag aaatgctttg ttttctttta
     2581 cgatgtattc agaagccttt actgattaaa gttttctttt atttgggtgg ccgggagaga
     2641 cccagggagg ttctggaggt tcctttctgt ctcctggccc caccagggat ttccccattt
     2701 ctgtttgctg cctgaaagca ggatgaggaa ggccaaggag agtccttgca cccgtgagcg
     2761 tcaggatgag gaaatgacag gaggaagacg tgggtttggg ttagtggctg ctggcgtttt
     2821 ggcccttggt gtttctggag cctccaggga tctaggggag cctgggctgc gtgcatgtcg
     2881 ataagcagag ctgttcttgg ggagaaggag ggaggtctcg ggagtgtagc accatgccaa
     2941 ccagccctgc gcgaagacag agtgagccac gcccggatgg cagggcatgt ttctgttttg
     3001 gtgtctcact ttcctcccag cgtgacttat ttggggattc ctcagggcct actggaatgt
     3061 gactgcccac tgcccagctg cctcgggtac aagtcctggc cctatgtccc agctgtcagg
     3121 ggctcaggga atcctaccca gccacctgtc ctgggatgga gtgtcagcat ccaccccttg
     3181 gttgtcatcg aggccgccct cccagtcctg ggtgaagata tttgggccac cagggctccc
     3241 ttggcccctt cacgtaggaa atagacacgt gctttttaat gcaggacact ttgagtgtta
     3301 caaaatctgt agacctggca gtagggtcat gatgttggga agggtgtagt gccctaggtt
     3361 ggtgacagaa gggacagaca cttgtgcaca ggtgtctttg gtgatggggt tttttttttt
     3421 ataacttagt aaaaaaaaaa aaatgtatgt ggaattctgt ctcttggtaa agctcaaagc
     3481 caggctagcc tgaggtggcg cagggctctc cttcctgtcc cttcgatctc cttgagaatt
     3541 aagagctggc agctgctgat ggtgtttccc aacccccctc acttcccaag acaaccccca
     3601 gcttcaggtc ctcatgggga ggggagggca cgttcttgac acatgggaac ttcgctcagg
     3661 agggcctccc cttcccctct ccctcagagt tttcactgcc gtctcgtctt tagaaagctg
     3721 tttgaattcc ccccgccccc agtttggacc gtgtagatat aactggatat acggattttt
     3781 ctctttgtgc aggcttctta tgccgttggt atacagggca ggaaagagag gaataaaggg
     3841 agagagcagt gtggaaacca cggtggtttt gctttgttct tactaggttt tggtgccacc
     3901 ttccctgcct gcgcttgtgc cccctctcct ccttggcact ggcggcctcc ttgcctccct
     3961 tccacccgtg ctgccatccc gtgcctgtcg tgttggttct tcacacgtgc tctgttctcg
     4021 gggttgttcc attcatgcct tcttggaggg tgagggtggc ttgggaaccg acccagtgat
     4081 catgcctact ttcttctttg tatctccctc cttcccagcc cacccgggca gcagactctg
     4141 atggaaggaa ggtgccgtag gtgggctttt agaaactaac gggactggtt ttcaaagcag
     4201 ttatcttggg aaactgttta ttccagcgat gtgacttttt tcagaatatt tcttggaatc
     4261 atattcagag tctggggctg tgtgttgagc agccttaagg atgctagaca ctcatttagt
     4321 gcccagggag tccagcgaat gacgtctgtg gccaagcgag gtctcaggtg caaagcaaaa
     4381 ggaccattta aagtaaaata gcttggattc aatcatgtga cttttaaatt ggctcagaaa
     4441 gcaattttgt aatttcagag agtgttttga gccatggcca cgttgtcatt gtgagtctat
     4501 agcttgactc cttggagaac aatattcatt tggttgtgga gactgatttg ctgggagaaa
     4561 tctgtcctgt tactttctgg tcatcccagg ttctgacttt taccaggggc aaaaaaaaaa
     4621 aaagcaagag ggagataaat cccatctgtg agtttgtctt attggcgcct ttttcctcag
     4681 ctgtcttcca agtattattt ttactgttaa aaaatttttt aaaaatgtga aatgtaatgt
     4741 ttttacagca acaatatgaa atatatttta taaggaataa aatggtacct tgtctga
//
