LOCUS       NM_032164               2163 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 394 (ZNF394), transcript variant
            1, mRNA.
ACCESSION   NM_032164
VERSION     NM_032164.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2163)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2163)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2163)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2163)
  AUTHORS   Huang,C., Wang,Y., Li,D., Li,Y., Luo,J., Yuan,W., Ou,Y., Zhu,C.,
            Zhang,Y., Wang,Z., Liu,M. and Wu,X.
  TITLE     Inhibition of transcriptional activities of AP-1 and c-Jun by a new
            zinc finger protein ZNF394
  JOURNAL   Biochem Biophys Res Commun 320 (4), 1298-1305 (2004)
   PUBMED   15249231
  REMARK    GeneRIF: Overexpression of ZNF394 in the cell inhibits the
            transcriptional activities of c-Jun and AP-1 reporters.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA962329.1 and BC051847.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032164.3.
            
            Summary: The protein encoded by this gene is a zinc finger protein
            that inhibits the transcription of mitogen-activated protein kinase
            signaling pathways. The encoded protein may be involved in cardiac
            function. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK022360.1, SRR3476690.169910.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337673.7/ ENSP00000337363.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DA962329.1         28-54
            28-2163             BC051847.1         1-2136
FEATURES             Location/Qualifiers
     source          1..2163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2163
                     /gene="ZNF394"
                     /gene_synonym="ZKSCAN14; ZSCAN46"
                     /note="zinc finger protein 394"
                     /db_xref="GeneID:84124"
                     /db_xref="HGNC:HGNC:18832"
                     /db_xref="MIM:619300"
     exon            1..644
                     /gene="ZNF394"
                     /gene_synonym="ZKSCAN14; ZSCAN46"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1874
                     /gene="ZNF394"
                     /gene_synonym="ZKSCAN14; ZSCAN46"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 99; zinc finger protein with KRAB and SCAN
                     domains 14"
                     /codon_start=1
                     /product="zinc finger protein 394 isoform 1"
                     /protein_id="NP_115540.2"
                     /db_xref="CCDS:CCDS5666.1"
                     /db_xref="GeneID:84124"
                     /db_xref="HGNC:HGNC:18832"
                     /db_xref="MIM:619300"
                     /translation="MNSSLTAQRRGSDAELGPWVMAARSKDAAPSQRDGLLPVKVEED
                     SPGSWEPNYPAASPDPETSRLHFRQLRYQEVAGPEEALSRLRELCRRWLRPELLSKEQ
                     ILELLVLEQFLTILPEELQAWVREHCPESGEEAVAVVRALQRALDGTSSQGMVTFEDT
                     AVSLTWEEWERLDPARRDFCRESAQKDSGSTVPPSLESRVENKELIPMQQILEEAEPQ
                     GQLQEAFQGKRPLFSKCGSTHEDRVEKQSGDPLPLKLENSPEAEGLNSISDVNKNGSI
                     EGEDSKNNELQNSARCSNLVLCQHIPKAERPTDSEEHGNKCKQSFHMVTWHVLKPHKS
                     DSGDSFHHSSLFETQRQLHEERPYKCGNCGKSFKQRSDLFRHQRIHTGEKPYGCQECG
                     KSFSQSAALTKHQRTHTGEKPYTCLKCGERFRQNSHLNRHQSTHSRDKHFKCEECGET
                     CHISNLFRHQRLHKGERPYKCEECEKSFKQRSDLFKHHRIHTGEKPYGCSVCGKRFNQ
                     SATLIKHQRIHTGEKPYKCLECGERFRQSTHLIRHQRIHQNKVLSAGRGGSRL"
     exon            645..771
                     /gene="ZNF394"
                     /gene_synonym="ZKSCAN14; ZSCAN46"
                     /inference="alignment:Splign:2.1.0"
     exon            772..2163
                     /gene="ZNF394"
                     /gene_synonym="ZKSCAN14; ZSCAN46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2137..2142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF394"
                     /gene_synonym="ZKSCAN14; ZSCAN46"
                     /note="hexamer: AATAAA"
     polyA_site      2163
                     /gene="ZNF394"
                     /gene_synonym="ZKSCAN14; ZSCAN46"
                     /note="major polyA site"
ORIGIN      
        1 gttttcggtt gtttgaccga gagagttgta ggcgcaaagc tgaggaaagg agagtgtgga
       61 gaggggcctg gtgtggtggg gcccggtgtt tgggaccgga gggtgttgac ggctgatgag
      121 ttccttgggt ttgctctttc ttcacctgaa aagaagactc caggaagggc agcacatgcc
      181 ggagaaagat gaattccagc ttgaccgccc agaggcgcgg cagtgacgcc gagttgggac
      241 cctgggtgat ggctgcgagg tccaaggacg cggcgccgtc ccaacgcgac ggacttttgc
      301 ccgtgaaagt ggaggaagac tcacccggaa gttgggagcc caactatccc gcggcttcgc
      361 cggaccccga aacttctcga ctgcacttta ggcagctgcg ttaccaggag gtggctggac
      421 cggaagaggc gctgagccgg ctccgagaac tctgtcgtcg gtggctgaga cccgagctgc
      481 tctccaagga gcagatcctg gagctgctgg tgctggagca gttcctcacc atcctgcccg
      541 aggagcttca agcctgggtg cgagagcact gcccagagag cggggaggag gcggtggccg
      601 tggtgcgggc tctgcagcga gcgctcgatg gaacctcatc ccaggggatg gtgactttcg
      661 aggacacggc tgtgtctcta acctgggagg agtgggagcg cctggaccca gcacggaggg
      721 acttctgcag agagagtgcg cagaaggatt ccgggagcac agttccgccg agtttggaaa
      781 gcagagtgga gaacaaagag ttgattccaa tgcaacaaat tttagaagaa gcggagccac
      841 aggggcaact acaagaagcg ttccagggga agcgccccct gttttctaag tgtggcagta
      901 cccatgagga cagggtggaa aagcagtccg gagacccctt gcccctgaaa cttgaaaatt
      961 ctcctgaagc agaaggactc aacagcatct cagatgtcaa taagaatggt tccatagaag
     1021 gggaagactc taaaaataat gaattgcaga acagtgccag gtgttccaac cttgttctat
     1081 gtcagcacat cccgaaagca gagaggccca ctgacagtga ggaacacggg aacaagtgca
     1141 agcaaagttt ccacatggtg acgtggcacg tgctgaaacc tcacaagtct gacagtggag
     1201 acagtttcca tcattccagc ctttttgaga cccagaggca gctccatgaa gaaagacctt
     1261 ataaatgtgg taactgtggg aagagtttca aacaacgctc tgacctcttt agacaccaga
     1321 gaatccacac aggtgagaaa ccctatggct gccaagaatg tgggaaaagc ttcagccaga
     1381 gtgctgccct gaccaagcac cagaggacac acacaggcga gaagccgtac acctgtctga
     1441 aatgtgggga gcgcttcagg cagaattcac acctaaatcg tcatcaaagt acccacagta
     1501 gagacaaaca ttttaaatgt gaggaatgcg gggaaacctg tcatatttcc aaccttttta
     1561 gacatcagag actacataaa ggggaaagac cctataagtg tgaagaatgc gagaagagct
     1621 tcaaacagcg ctctgacctc tttaaacacc acagaatcca cactggggag aagccctatg
     1681 gatgttccgt ctgtgggaaa cgcttcaatc agagtgcaac cctcattaaa caccagagaa
     1741 ttcacactgg ggaaaagcct tacaaatgtc ttgaatgtgg ggaaagattt agacaaagta
     1801 cacaccttat ccgacaccaa agaattcatc aaaataaagt gctgtcggct gggcgtggtg
     1861 gctcacgcct ataatcccag cactttggga ggccaaggca ggcagatcat ttgagatcag
     1921 gagtttgaaa ccagcctggc caacatggta aaatcctgtc tctactaaaa atacaaaaat
     1981 gagccgggca tggtggtgca tgcctgtaag cccagctatt cgggaggctg aggtaggaga
     2041 atcacttgaa cccaggaggc ggaagttgca gtgagctgag atcatgccac tgcactccag
     2101 cctgggcaac agagcgagac tccatctcaa aaaagaaata aagtgctgtc attttgatat
     2161 gtt
//
