LOCUS       NM_001076781            4042 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 391 (ZNF391), transcript variant
            2, mRNA.
ACCESSION   NM_001076781 XM_294077 XM_940234
VERSION     NM_001076781.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4042)
  AUTHORS   Ren,H., Meng,Y., Zhang,Y., Wang,Q., Deng,W., Ma,X., Zhao,L., Li,X.,
            Wang,Y., Sham,P. and Li,T.
  TITLE     Spatial Expression Pattern of ZNF391 Gene in the Brains of Patients
            With Schizophrenia, Bipolar Disorders or Major Depressive Disorder
            Identifies New Cross-Disorder Biotypes: A Trans-Diagnostic,
            Top-Down Approach
  JOURNAL   Schizophr Bull 47 (5), 1351-1363 (2021)
   PUBMED   33822213
  REMARK    GeneRIF: Spatial Expression Pattern of ZNF391 Gene in the Brains of
            Patients With Schizophrenia, Bipolar Disorders or Major Depressive
            Disorder Identifies New Cross-Disorder Biotypes: A
            Trans-Diagnostic, Top-Down Approach.
REFERENCE   2  (bases 1 to 4042)
  AUTHORS   Brayer,K.J. and Segal,D.J.
  TITLE     Keep your fingers off my DNA: protein-protein interactions mediated
            by C2H2 zinc finger domains
  JOURNAL   Cell Biochem Biophys 50 (3), 111-131 (2008)
   PUBMED   18253864
  REMARK    Review article
REFERENCE   3  (bases 1 to 4042)
  AUTHORS   Klotz,L.O., Kroncke,K.D. and Sies,H.
  TITLE     Singlet oxygen-induced signaling effects in mammalian cells
  JOURNAL   Photochem Photobiol Sci 2 (2), 88-94 (2003)
   PUBMED   12664966
  REMARK    Review article
REFERENCE   4  (bases 1 to 4042)
  AUTHORS   Fuchs,O., Babusiak,M., Vyoral,D. and Petrak,J.
  TITLE     Role of zinc in eukaryotic cells, zinc transporters and
            zinc-containing proteins. Review article
  JOURNAL   Sb Lek 104 (2), 157-170 (2003)
   PUBMED   14577126
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK294965.1, CN294872.1, BM906507.1, BC035154.2, BX400006.2,
            DB297905.1 and AL031118.22.
            
            On Aug 13, 2020 this sequence version replaced NM_001076781.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 all encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.3613724.1,
                                           SRR14038194.1013309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244576.9/ ENSP00000244576.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1824              AK294965.1         1-1824
            1825-2366           CN294872.1         76-617
            2367-2937           BM906507.1         70-640
            2938-3289           BC035154.2         922-1273
            3290-3365           BC035154.2         1275-1350
            3366-3512           BX400006.2         482-628             c
            3513-4041           DB297905.1         1-529               c
            4042-4042           AL031118.22        35171-35171
FEATURES             Location/Qualifiers
     source          1..4042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..4042
                     /gene="ZNF391"
                     /gene_synonym="dJ153G14.3"
                     /note="zinc finger protein 391"
                     /db_xref="GeneID:346157"
                     /db_xref="HGNC:HGNC:18779"
     exon            1..317
                     /gene="ZNF391"
                     /gene_synonym="dJ153G14.3"
                     /inference="alignment:Splign:2.1.0"
     exon            318..426
                     /gene="ZNF391"
                     /gene_synonym="dJ153G14.3"
                     /inference="alignment:Splign:2.1.0"
     exon            427..4042
                     /gene="ZNF391"
                     /gene_synonym="dJ153G14.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             505..1581
                     /gene="ZNF391"
                     /gene_synonym="dJ153G14.3"
                     /codon_start=1
                     /product="zinc finger protein 391"
                     /protein_id="NP_001070249.1"
                     /db_xref="CCDS:CCDS43429.1"
                     /db_xref="GeneID:346157"
                     /db_xref="HGNC:HGNC:18779"
                     /translation="MESLRGNTAQGPTNEEDYKNEGQLSRQTKCPAQKKSSFENTVVR
                     KVSVTLKEIFTGEEGPESSEFSLSPNLDAQQKIPKGHGSPISRKNSKDNSDLIKHQRL
                     FSQRKPCKCNECEKAFSYQSDLLVHSRIHGGEKPFECNKCGKSFSRSTHLIEHQRTHT
                     GEKPYECNECGKAFSRSTHLSLHQRIHTGEKPYECSECGKAFSRSTNLSQHQRTHTQE
                     RPYKCNECGKAFGDRSTIIQHQRIHTGENPYECSKCGKAFSWISSLTEHQRTHTGENP
                     YECSECGKVFSRSSSLTEHQRIHSGEKPHECRVCGKGFSRSSSLIIHQRTHTGEKPYK
                     CNDCGKAFCQSSTLIRHQHLHTKE"
     regulatory      4009..4014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF391"
                     /gene_synonym="dJ153G14.3"
                     /note="hexamer: AATAAA"
     polyA_site      4042
                     /gene="ZNF391"
                     /gene_synonym="dJ153G14.3"
                     /note="major polyA site"
ORIGIN      
        1 agtgtggtct ctgttttgca actggtcgtc cgcgtcagga gacttaggtc caggcgactg
       61 cccagacaat gactggtccc gcataccgag cagagcatga tcagcagcag tctgagtgga
      121 agagtgcctg tgatcttagg gaacctgatg ggcgttggag cagcggttcg acgcatgggt
      181 ttctctttaa tccttccgac ttccccaagc ccagcgcact caggttccgc tccaagtgcg
      241 ggacccgccc ggggtgtgtc gggggtactc ggccggaggc ggccggtgag tgaggcttac
      301 agggccccgg gaccaaggaa ccccagcatg ttaattgaac ttgatcaccc agttgaagga
      361 agaataatag tagatgttgg atcttcagga agctgaagag ggcagtgccc agaaatacct
      421 gtcttgatag ggggatttga gctgaaccaa agcatcaaca ccaatcagac tgtttccgaa
      481 gaactagagt tttctgggtc agcaatggaa agcctcagag ggaatactgc tcagggtcct
      541 acaaatgaag aagactataa aaacgaaggc caattatcaa ggcaaacaaa atgtcctgca
      601 cagaagaaat cctcttttga gaacacagtg gtcagaaaag tgtcagtgac actcaaagaa
      661 attttcacag gggaggaagg ccctgaatcc agtgaattta gtctaagccc aaaccttgac
      721 gcacaacaga aaattccaaa gggacatgga tccccaatat ctaggaaaaa ctccaaagat
      781 aattcagact taattaaaca ccaaagactt ttctcacaaa gaaaaccttg taaatgcaat
      841 gaatgtgaaa aagcctttag ttaccaatca gaccttcttg tacacagtag aattcatggt
      901 ggagaaaagc cttttgaatg caacaaatgt gggaaatctt tcagccgaag tacacacctt
      961 attgaacatc aaagaactca cactggagag aaaccttatg aatgcaatga atgtggaaaa
     1021 gcttttagcc ggagcacaca tcttagtcta catcagagaa tccatactgg agaaaaacca
     1081 tatgaatgta gtgaatgtgg aaaagccttt agccgaagca ctaaccttag tcagcatcag
     1141 cgaactcata ctcaagaaag gccttacaaa tgtaatgaat gtgggaaagc cttcggtgac
     1201 cgttcaacca taattcagca tcaacgaata cacactggag agaatcccta tgaatgcagt
     1261 aaatgtggaa aagctttcag ttggatctca tcgcttactg aacatcagag aacacacact
     1321 ggggagaacc cctatgagtg cagtgaatgt gggaaagtgt tcagtcgaag ctcgtctctt
     1381 acagaacatc agagaatcca cagtggagaa aagcctcacg agtgtagagt gtgtggaaag
     1441 ggcttcagtc gaagctcatc ccttattatt catcagagaa ctcataccgg ggagaagccg
     1501 tacaaatgta atgactgtgg aaaagccttc tgtcagagtt caactctgat cagacatcag
     1561 caccttcata ctaaagagta atatctgagc ttttattaat gttagcataa gaacacatat
     1621 acctaacctc ccaccactga aatatatata tttcaagtat atatatactt gttctaattt
     1681 tcttttatta gatacctata cccgttttaa gctttcattc gttctttcca tccatctatc
     1741 cttctttcgt ctcccctccc ttcttccctc cttccctcct tcctactttt tctccctctc
     1801 cctgttcttt ctttctcttt tctcaaataa gttcacaata aaacaaaggg atgactcaaa
     1861 aaacataaca tatgaaatct aatattctga agggctccaa ctttagagta taaagctatc
     1921 tgacaccttg tagtttctct gctaatctat tccttcaagc gtgggtcccc gaaccaccag
     1981 gttctcctct gttttctaac cacatcagcc cctgcacatg aagagaaaat cctgtgtgtg
     2041 tgtcttcata cttgctggct ctagtaccag aagagaggga tctggcttca gagcaggact
     2101 gaaaacttct caccagtctg gggataatag tgttgaggca aattcattct cttgacttgc
     2161 aaaaacagat ttttctcatc ttcctccttc tctcaccttt tttgcagtag catttttcct
     2221 caaagtacaa ctcatttttt tactaacgcc taactaatcc tagtgttatt ttatcatatt
     2281 tttaccaaga atgttctaaa aatcttggag acgttcctcc atgatcttgg gaaaaaaagt
     2341 tgccaaatgc tgtgctgttt tttttgtttg tttttaattt tctttcattt acagatttca
     2401 tgaaacttat attctgtggc tttgaccctc accaatcttg gaagattgat ctctcaagga
     2461 caaacccagt gcctatttct cagtcctttt tctacttgac atttgcagaa ttggcacttt
     2521 ttgccactgt tatgccttaa atcttgagct tctttcagga tccatgattc tgtgctgatc
     2581 tacacttttc ctacctctca gcatttcttt gattgtcaat gatcagctct gtgatttggg
     2641 gcaagggtta ggccagaatt atctcatttt atcaagttat aaaacttgag gtagtgcaac
     2701 tagattatac acttcttgaa gacagaaatc ttggtttgtt tgttgtttta tttttgagag
     2761 aaggtcttgc tgtgttgccc aggctggagt gcaatggcac aatcatagct cactgtagcc
     2821 ttgaacttct gggctcctgc cacagcctcc tgagtagcta gggctgcaag tgtgtaccac
     2881 cacacccaca attttaaagt ttttttgtgg agacaggatc tcactatatt ggcaaggctg
     2941 gcctccatct cctgaactca aacaattctc ccacctcggc ttccgaaaac actgacatta
     3001 caggtgtgag ccaccacacc tgccagaaat cttgtttttg attgatataa aacatcacaa
     3061 agtactgagt agacactaaa tgctctgtaa ttattgctca ctgattcctc tttatctgta
     3121 atcaatcaac ttgactttat ttgatatgga ttaataattg atttctttct ctctttctac
     3181 tgctgcttcc aagttcttgg taccttgtgc ctagattact aaattgatca ctgttgactc
     3241 actaccatta tctagctcct tactaaacta ctactttgtt aaaaaaaaat agtcgtttcc
     3301 cagtgacctc tgccccaaat gtaaacttct ttaacctaaa ggtctttcat agtttgatct
     3361 acttacttac ttcctttctc ttctcaaaga taatacatgc gggcaggcct gttttgtccc
     3421 tactataccc tcttctcaca cttttcttct tttcaaactg ttccttggca cttctacatg
     3481 tcctactttc ttcgttgtat tccagaaacc ctatccaccc ttttttaaag gccatgctca
     3541 tatcctggct ctgtgacact ttcagtcccc tgccttctta gaaatccttt gtagtgatgg
     3601 tttgcattat tctcctgtat tagacacctt ctttactgtt ttctggttct ttcacaagta
     3661 cttttttaca taagctgttt tgaagttgta aatcatccta aatcttttat aagcctcata
     3721 taatacatag tacaatgcca gcctggactc tagttttaat ctaaatacat agggtttaat
     3781 ttagcagcat aatcttttta gtcttttgaa tgatgaggta acctcatagg tattttggcc
     3841 cattttgttt ttccttgaat tacatatata actgactatt tagactgact cctttagatc
     3901 tcctgggatg ctgacctctt ggctttccaa ttcatgagac tattgtaaag aataagtgag
     3961 ttcattcatg taaagtagta aaacagtgcc tgacaaaagt aaatgctcaa taaattctaa
     4021 ttgttatgat tctagtgatt ca
//
