LOCUS       NM_024697              10478 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 385D (ZNF385D), mRNA.
ACCESSION   NM_024697
VERSION     NM_024697.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10478)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   2  (bases 1 to 10478)
  AUTHORS   Teumer,A., Holtfreter,B., Volker,U., Petersmann,A., Nauck,M.,
            Biffar,R., Volzke,H., Kroemer,H.K., Meisel,P., Homuth,G. and
            Kocher,T.
  TITLE     Genome-wide association study of chronic periodontitis in a general
            German population
  JOURNAL   J Clin Periodontol 40 (11), 977-985 (2013)
   PUBMED   24024966
REFERENCE   3  (bases 1 to 10478)
  AUTHORS   Eicher,J.D., Powers,N.R., Miller,L.L., Akshoomoff,N., Amaral,D.G.,
            Bloss,C.S., Libiger,O., Schork,N.J., Darst,B.F., Casey,B.J.,
            Chang,L., Ernst,T., Frazier,J., Kaufmann,W.E., Keating,B.,
            Kenet,T., Kennedy,D., Mostofsky,S., Murray,S.S., Sowell,E.R.,
            Bartsch,H., Kuperman,J.M., Brown,T.T., Hagler,D.J. Jr., Dale,A.M.,
            Jernigan,T.L., St Pourcain,B., Davey Smith,G., Ring,S.M. and
            Gruen,J.R.
  CONSRTM   Pediatric Imaging, Neurocognition, and Genetics Study
  TITLE     Genome-wide association study of shared components of reading
            disability and language impairment
  JOURNAL   Genes Brain Behav 12 (8), 792-801 (2013)
   PUBMED   24024963
  REMARK    GeneRIF: ZNF385D is a candidate gene for reading disability and
            language impairment.
REFERENCE   4  (bases 1 to 10478)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   5  (bases 1 to 10478)
  AUTHORS   Velez Edwards,D.R., Naj,A.C., Monda,K., North,K.E., Neuhouser,M.,
            Magvanjav,O., Kusimo,I., Vitolins,M.Z., Manson,J.E.,
            O'Sullivan,M.J., Rampersaud,E. and Edwards,T.L.
  TITLE     Gene-environment interactions and obesity traits among
            postmenopausal African-American and Hispanic women in the Women's
            Health Initiative SHARe Study
  JOURNAL   Hum Genet 132 (3), 323-336 (2013)
   PUBMED   23192594
REFERENCE   6  (bases 1 to 10478)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   7  (bases 1 to 10478)
  AUTHORS   Kasperaviciute,D., Catarino,C.B., Heinzen,E.L., Depondt,C.,
            Cavalleri,G.L., Caboclo,L.O., Tate,S.K., Jamnadas-Khoda,J.,
            Chinthapalli,K., Clayton,L.M., Shianna,K.V., Radtke,R.A.,
            Mikati,M.A., Gallentine,W.B., Husain,A.M., Alhusaini,S.,
            Leppert,D., Middleton,L.T., Gibson,R.A., Johnson,M.R.,
            Matthews,P.M., Hosford,D., Heuser,K., Amos,L., Ortega,M.,
            Zumsteg,D., Wieser,H.G., Steinhoff,B.J., Kramer,G., Hansen,J.,
            Dorn,T., Kantanen,A.M., Gjerstad,L., Peuralinna,T., Hernandez,D.G.,
            Eriksson,K.J., Kalviainen,R.K., Doherty,C.P., Wood,N.W.,
            Pandolfo,M., Duncan,J.S., Sander,J.W., Delanty,N., Goldstein,D.B.
            and Sisodiya,S.M.
  TITLE     Common genetic variation and susceptibility to partial epilepsies:
            a genome-wide association study
  JOURNAL   Brain 133 (Pt 7), 2136-2147 (2010)
   PUBMED   20522523
REFERENCE   8  (bases 1 to 10478)
  AUTHORS   Pelak,K., Goldstein,D.B., Walley,N.M., Fellay,J., Ge,D.,
            Shianna,K.V., Gumbs,C., Gao,X., Maia,J.M., Cronin,K.D.,
            Hussain,S.K., Carrington,M., Michael,N.L. and Weintrob,A.C.
  CONSRTM   Infectious Disease Clinical Research Program HIV Working Group;
            National Institute of Allergy and Infectious Diseases Center for
            HIV/AIDS Vaccine Immunology (CHAVI)
  TITLE     Host determinants of HIV-1 control in African Americans
  JOURNAL   J Infect Dis 201 (8), 1141-1149 (2010)
   PUBMED   20205591
  REMARK    Erratum:[J Infect Dis. 2010 Aug 15;202(3):501]
REFERENCE   9  (bases 1 to 10478)
  AUTHORS   Lasky-Su,J., Neale,B.M., Franke,B., Anney,R.J., Zhou,K.,
            Maller,J.B., Vasquez,A.A., Chen,W., Asherson,P., Buitelaar,J.,
            Banaschewski,T., Ebstein,R., Gill,M., Miranda,A., Mulas,F.,
            Oades,R.D., Roeyers,H., Rothenberger,A., Sergeant,J.,
            Sonuga-Barke,E., Steinhausen,H.C., Taylor,E., Daly,M., Laird,N.,
            Lange,C. and Faraone,S.V.
  TITLE     Genome-wide association scan of quantitative traits for attention
            deficit hyperactivity disorder identifies novel associations and
            confirms candidate gene associations
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (8), 1345-1354 (2008)
   PUBMED   18821565
REFERENCE   10 (bases 1 to 10478)
  AUTHORS   Ferreira,M.A., O'Donovan,M.C., Meng,Y.A., Jones,I.R.,
            Ruderfer,D.M., Jones,L., Fan,J., Kirov,G., Perlis,R.H., Green,E.K.,
            Smoller,J.W., Grozeva,D., Stone,J., Nikolov,I., Chambert,K.,
            Hamshere,M.L., Nimgaonkar,V.L., Moskvina,V., Thase,M.E., Caesar,S.,
            Sachs,G.S., Franklin,J., Gordon-Smith,K., Ardlie,K.G.,
            Gabriel,S.B., Fraser,C., Blumenstiel,B., Defelice,M., Breen,G.,
            Gill,M., Morris,D.W., Elkin,A., Muir,W.J., McGhee,K.A.,
            Williamson,R., MacIntyre,D.J., MacLean,A.W., St,C.D., Robinson,M.,
            Van Beck,M., Pereira,A.C., Kandaswamy,R., McQuillin,A.,
            Collier,D.A., Bass,N.J., Young,A.H., Lawrence,J., Ferrier,I.N.,
            Anjorin,A., Farmer,A., Curtis,D., Scolnick,E.M., McGuffin,P.,
            Daly,M.J., Corvin,A.P., Holmans,P.A., Blackwood,D.H., Gurling,H.M.,
            Owen,M.J., Purcell,S.M., Sklar,P. and Craddock,N.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Collaborative genome-wide association analysis supports a role for
            ANK3 and CACNA1C in bipolar disorder
  JOURNAL   Nat Genet 40 (9), 1056-1058 (2008)
   PUBMED   18711365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK026072.1 and AC104183.2.
            
            On Nov 23, 2018 this sequence version replaced NM_024697.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.550922.1,
                                           SRR3476690.1065026.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281523.8/ ENSP00000281523.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1307              AK026072.1         115-1421
            1308-10478          AC104183.2         114357-123527       c
FEATURES             Location/Qualifiers
     source          1..10478
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.3"
     gene            1..10478
                     /gene="ZNF385D"
                     /gene_synonym="ZNF659"
                     /note="zinc finger protein 385D"
                     /db_xref="GeneID:79750"
                     /db_xref="HGNC:HGNC:26191"
     exon            1..316
                     /gene="ZNF385D"
                     /gene_synonym="ZNF659"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..1482
                     /gene="ZNF385D"
                     /gene_synonym="ZNF659"
                     /note="zinc finger protein 659"
                     /codon_start=1
                     /product="zinc finger protein 385D"
                     /protein_id="NP_078973.1"
                     /db_xref="CCDS:CCDS2636.1"
                     /db_xref="GeneID:79750"
                     /db_xref="HGNC:HGNC:26191"
                     /translation="MRNIMYFGGTCQSPALPALVRPPAPPLQPSLDIKPFLPFPLDTA
                     AAVNLFPNFNAMDPIQKAVINHTFGVPLPHRRKQIISCNICQLRFNSDSQAAAHYKGT
                     KHAKKLKALEAMKNKQKSVTAKDSAKTTFTSITTNTINTSSDKTDGTAGTPAISTTTT
                     VEIRKSSVMTTEITSKVEKSPTTATGNSSCPSTETEEEKAKRLLYCSLCKVAVNSASQ
                     LEAHNSGTKHKTMLEARNGSGTIKAFPRAGVKGKGPVNKGNTGLQNKTFHCEICDVHV
                     NSETQLKQHISSRRHKDRAAGKPPKPKYSPYNKLQKTAHPLGVKLVFSKEPSKPLAPR
                     ILPNPLAAAAAAAAVAVSSPFSLRTAPAATLFQTSALPPALLRPAPGPIRTAHTPVLF
                     APY"
     exon            317..459
                     /gene="ZNF385D"
                     /gene_synonym="ZNF659"
                     /inference="alignment:Splign:2.1.0"
     exon            460..570
                     /gene="ZNF385D"
                     /gene_synonym="ZNF659"
                     /inference="alignment:Splign:2.1.0"
     exon            571..733
                     /gene="ZNF385D"
                     /gene_synonym="ZNF659"
                     /inference="alignment:Splign:2.1.0"
     exon            734..967
                     /gene="ZNF385D"
                     /gene_synonym="ZNF659"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1146
                     /gene="ZNF385D"
                     /gene_synonym="ZNF659"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1248
                     /gene="ZNF385D"
                     /gene_synonym="ZNF659"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..10478
                     /gene="ZNF385D"
                     /gene_synonym="ZNF659"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4247..4252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF385D"
                     /gene_synonym="ZNF659"
                     /note="hexamer: AATAAA"
     polyA_site      4273
                     /gene="ZNF385D"
                     /gene_synonym="ZNF659"
                     /note="major polyA site"
     regulatory      9600..9605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF385D"
                     /gene_synonym="ZNF659"
                     /note="hexamer: ATTAAA"
     polyA_site      9619
                     /gene="ZNF385D"
                     /gene_synonym="ZNF659"
     regulatory      10455..10460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF385D"
                     /gene_synonym="ZNF659"
                     /note="hexamer: AGTAAA"
     polyA_site      10478
                     /gene="ZNF385D"
                     /gene_synonym="ZNF659"
ORIGIN      
        1 agtcctgatg tcacaggcgc ggcaaggaca tcgcaaggag gagtcggatt acagtaagga
       61 tgggcagtgc agcaggcagc ccgagcgcac tctccagccg ccggggatct tagccctgga
      121 aaggcagcct gcaaggcgct catcccgcgg aggaggcacg ctctcggcgc tcactgctct
      181 ccacgccggg gacatttcca ccgaatgtag catgaaaggg ctctgctcta cgtgccagcc
      241 ttgggtgaga gctgatgctg aagacaccgc ggtgggattc cagctgtctg attaatgaga
      301 aacataatgt attttggtgg tacatgccag agtcctgctc tcccggccct tgtccgtcca
      361 ccagcccctc ctttgcaacc atcgctggat attaaaccat ttcttccctt tcctcttgac
      421 actgcagctg cagtcaacct cttccccaat ttcaatgcga tggacccgat tcagaaagct
      481 gtaataaacc atacattcgg ggttcctctt ccccaccgaa gaaagcaaat catatcatgc
      541 aacatttgcc agttgagatt taattctgat agccaggctg cggcccacta caaaggcacg
      601 aaacatgcca agaagctcaa agcactggaa gccatgaaaa ataagcagaa atctgtaact
      661 gccaaggaca gcgcaaagac taccttcacc tccatcacta ccaataccat caataccagc
      721 tctgacaaaa cagacggtac tgcagggaca ccagcaatat caacgacgac aactgtggaa
      781 atccgcaaaa gcagtgttat gacaactgag atcacctcta aagtggaaaa aagcccaacg
      841 acagccactg gcaatagctc atgtccttct actgagaccg aggaagaaaa ggcaaaacgg
      901 cttctttact gttcgctatg caaggttgct gtcaactctg cctcgcagct ggaggcgcac
      961 aacagtggta ctaagcacaa aaccatgtta gaagcccgga atggaagtgg cactatcaaa
     1021 gcctttccta gggcaggagt gaaaggcaaa ggacctgtta ataaaggaaa cacaggcctc
     1081 caaaataaaa catttcactg tgaaatctgt gatgtgcacg tcaactcgga aacgcaactt
     1141 aaacagcaca ttagcagtag aaggcacaaa gacagagctg ctgggaagcc cccgaaacct
     1201 aaatacagtc cttacaacaa actacagaag acagcacatc cactgggggt aaaattagta
     1261 ttttcaaaag aaccttcaaa gccattggct ccacgaattc taccaaatcc tctagcagct
     1321 gcagcagccg cagcagcagt ggcagtgagt tcccccttca gtcttcgaac tgctccagca
     1381 gcaacactgt tccagacttc cgcgcttcct ccggcactcc tgcggccagc tcctggaccc
     1441 attcggaccg cccacactcc tgtgctgttt gctccttact aaattccaaa taggagtaat
     1501 tgtactgcaa taatttttca aaaaacaaaa aacaaaacaa acaaaagaga actatgcagt
     1561 gtttatttat agtttaaagt atatctgaag agccaggact tttgatagtg aattgaaaag
     1621 gttataaaaa agtgggggag gtttgggggt gggagggagg gagtggtatt ttctccaaat
     1681 taaagcattc ctcttgaacg ctgattgttt tagaagtgat ctccagcatt gatttgtagt
     1741 ggtatctaga ccttctgaag cctctgtgac tgtgcttttg ggcacctatt tccctctgca
     1801 ttgtctgtcc tgctttatga aacaactata cattgtctaa gggcattaac tggttccaat
     1861 gtatataaaa taatttactc tgtagattaa aatcgtacaa aaaaaaagga aaaaaacaaa
     1921 aacaaaagca acactgtgaa tagtactacc cgtgctggtc ctcttgctat gacggcaatt
     1981 actgggtatt tatcccaaca aaagtagata cagtagatgt cttgtaaaac aatagtgctg
     2041 tgtctcaatc tatgccacta ggttttaaag aattgcaaag gtagaatgaa caactatttc
     2101 ataccaataa gcagtcaaaa aataaacata caccggatgg tgtcatggag gtctccctgg
     2161 tcagcattct cccctcctgt ctagcttgaa gatataacag ggctaagctt agagatgggg
     2221 gaggcattaa taaaggtgat ttcttataaa gtagtaactt cccaccctga agatatattg
     2281 ctggaaacag ggaagtgttt ataatgaacc tatatctgaa agcagagaaa cccatgcatc
     2341 atgagtgtta agaaagaaat caatacaact cttctatttc aaggatgaag aatcataacc
     2401 tagaatgata atgcaaagta aagatctttc atttagtaca tatccagtaa aaacggagaa
     2461 tgttgcatct ctgcagtatc ccctttatat cataccagta gggttgtttc ttaggcaaag
     2521 gtttctgctt taagtatgat ggtagaatta agcattagct atttttatgg gtttttcttg
     2581 ttttttagat tacctgctga catgatataa acaattaata tatatttaaa tgttaataac
     2641 aacaggaaat atgaatctga gttaattgca caccaatgac atagtgttaa aaaatactgg
     2701 taagttccac tcgacaatta tttctccagt ggagttgtga aatactgaga gcctttgata
     2761 ttcaccatca ggctgaaaga agttgatgtt ttacctttaa aacaagattt atcaggggta
     2821 tatataaata tatgtatatt gtatatatgt tagaaagatt aagagaataa gttataaaaa
     2881 gaaaaaatct atataaaata attatataac catccagtgt tacatgttat cattaaattg
     2941 gtaacaaatg gcataaaaat agctgtgcct ttaatttgtg ataaaggcta tttgcttttt
     3001 cccatagaaa gctgacatat acctatcaaa atggtggggt ttgatgcagc cagtctgttg
     3061 cattaataag agcaatgaca ctgaaactta gaataatgac aaaacataca tgatttaggt
     3121 ttagagaaaa aactattttt gaaaaggttt tctaaagact atttaaaaat atagggaagg
     3181 attgggtgtg gccttcctga aactgctctc aaagtgttgt aacccttgga gaggtataaa
     3241 gaatcaagag gaaaccattt gagacatagg tatttagcat ttatcatttt atatttaaga
     3301 aacaccatag cgtgcttggt gctcaacatt aaacatggtt ttttggagtt cttctccacc
     3361 atctagctat agaaatttgt catataaatg aatctttaaa gcagttggct ttatatatcc
     3421 tttgttaacc aaccaaaaca aaaacaaaaa aaaagaagga aagaaggaag gaaggaagga
     3481 agaatggaag gaaggaagga agaaaggagg gaaggaagga aggaaaggag atggggaagg
     3541 gaagaaaagg aaggaaggaa gaaaggaaga taatgtgttc catcagtatt ctggtagaaa
     3601 gaatttcaaa ccatgcttct ctggttaaat atattgatta gcattaaaat ttgttttgaa
     3661 agtatctggt gattttgcat ttaccagcat ctctattctc tagttttagc aagtgtttcc
     3721 tttttcacct acagaccctg gtagttcagc caggtggata gttgcccata agtctgttgt
     3781 ttggggctct gtctgtatcc catgtgacca gcttctaacc attttgaact ttagtttccc
     3841 ttttctgcta tgtcaaatat tttgattttc cataatcatc ctgagtccct atccaacaac
     3901 ctttacaact gatacagcct cactttctgt tagataactt agtgttaatt aaagcagtct
     3961 cactaaaacg tgcttttgct gttctttccc attttcacca aagtgaatga gccagtccac
     4021 taaaaatcag ggcctatggg atacacagtg tcctgggtca caaggcatta ctgtctttaa
     4081 tgatttgctg ggaacaaacg aatcagccat attttctcca tcagccatat aagaaatctc
     4141 agaaatacct ggatcccttc tgcctcactt cgctatggaa ccatttttgt ttaaatggtc
     4201 ttttaaattg gagttgtaag catcagttgt cttttattca ctacctaata aaggatgaag
     4261 cctaaccaca gaacttacag tggattctct gtgagttgtt tcccccacac tccatatatt
     4321 taccaatacc agattaacat ccattatagt tcaggctgcc ataaaactgt atcttttccc
     4381 ttagggaact tttttcatga ataaagatcc acaatttaga ttggtcagca gtgtgctgtg
     4441 aaaatccctg agggtggtct gactttatgg ttttacattc cttcccatgc atcacaccat
     4501 ggcaaggaaa gtgatagaga aagcagctct gattcatttg aaacaaatat aaatgcattg
     4561 cagaagccaa atgcctctgg aaaaagcatt gttgcacctc aatcagatcg tccagacaaa
     4621 tgggaaacag tcattgggga ggtactgtat ttctcttatg agaaaacagg caattacaca
     4681 tgataaattg ctcctctcac tggacctcaa ctttgaagag tacttttttt attcacataa
     4741 gcaaacatac ttggcttttg gcaatttata tcacccctgc ctcatttgaa aggatttcta
     4801 tctttaggta ctatttggct tctcctgatc tatcgcagta attcactgcc attatcatca
     4861 gagatgaaat ttggtttttc taaaggtgct acatattttg ttgccaagaa actagttagc
     4921 aaaggagtat ttatatgtac ttgaaaatta aaagagcagg aaatcataaa agactaagaa
     4981 ttaaaagaca gcagaagttt caaaatagaa tcaaagaggc tgtgcctatt tgagtttcta
     5041 aggcacaaac caacacatag tagacatgag caataaatat caccaattac aattaaattt
     5101 taaattaata tctttgtctt tgtaccagtg taatgtttca attgttctga agaaatcaga
     5161 tcagaaagct aaaaggtaac tgaagtggta tataggcctg tttctttaga tctgaattga
     5221 agtagaaaat tacctttcta tacataagca tggatgacat tgtattaata actttgttca
     5281 cccaaaagcc gcatgaagtg gtgggaaaag caatgaggag ccttagagta gccagagtct
     5341 attgtagact ttgtccctga ccaacagggt aacttaaata gtcaactaat gccttgccct
     5401 taatttcttc atcagtaaaa tggatgacag tgattaatag ctaagctggt ttaatacatc
     5461 agcactagag gggcattgct tttatcctct caggaataaa aattctttat tcgagtgacc
     5521 aatgcagcta ctcacatact tgcatatgtc cagaaaaata ttctgtattc ctttccatcc
     5581 tgagtgtaag ccatattgta ggtcattcat atgctcaacc agaatgtaca tttcaccaat
     5641 attggagtag ttgctaattc acttagtact cacttattat gatcgcactt atgccaacat
     5701 catgtaagat atgctacttc tattttccca gtcaagaatg taataaattc tgaacaaaac
     5761 caaccctgaa aaaggcaata gacagctggc agtgggggtg tggaagggaa caacaattta
     5821 aatgcatcat ccttatttct tttgttgcac tttctctctt caataggaag gggtcccgac
     5881 taagccataa ctaattctgt cctgcgtttg catgtatttt aactaatggt tgccttatta
     5941 agaccatctc ttccacagac aagtatatca gttatgcgct cttgtcattg ttacaggaat
     6001 tatttaaact gagtcctaac agtgaaagtt ttacctgact tttgctgatt tttttttctt
     6061 tctacatggg gagatttatc tctggagcat ctcttgtgtt tttgtatggt ttgcttcagt
     6121 agctagagag gctactatca ggaagtgaaa tggatcattt ctaatggtag gtctccattg
     6181 cctacatggt atttctgaga gtggtatcag ggtgtccagt gaaagacgga taggttgaca
     6241 tgtcatgctc atttggccta aaggttgtta ctgccaggaa tggacttaca acttaccaga
     6301 atgtgaatgg tgacaaaagg caggttctac tctggaaaaa tatgtgttat tttattagaa
     6361 gttcatggcc gggcgcggtg gctcacgcct gtaatcccag cactttggga ggccgaggcg
     6421 ggtggatcat gaggtcagga gatcgagacc atcctggcta acaaggtgaa accccgtctc
     6481 tactaaaaat acaaaaaatt agccgggcgc ggtggcgggc gcctgtagtc ccagctactc
     6541 gggaggctga ggcaggagaa tggcgtgaac ccgggaagcg gagcttgcag tgagccgaga
     6601 ttgcgccact gcagtccgca gtccgacctg ggcgacagag cgagactccg tctcaaaaaa
     6661 aaaaaaaaaa aaaaaaaaaa gaagttcatg caggtcatga agagtcacag agtttaaaga
     6721 attctctggt tgggtcatca atgttcagat gtcaagggac tgaacattac cttcaatttg
     6781 agggtcttct ctttcctctt ctcagtgatg gaaactcatc cttcctaggt ggctaagttg
     6841 actgtagaaa ctgctaaaat gtatttgtca aacgaagtaa aatctgacta ttaatatata
     6901 tgatcaggta gagtatctta gagtttggtt aactaagaca gccgataatg gggtcatgtt
     6961 attttcagac tggcaggtca tctctaaagg caatttttaa agattagggc taaaatgatt
     7021 tgtgagcaaa gaagtataat taaaaataag taatagtata gtgacgagtt ctaaggttaa
     7081 tgcttatata cgcacacaca tacagaattg taaaaatatg agtcttagta cctgtcattc
     7141 ttttacaaag ccatggtaaa atcattttat tttcaatgat taggttggtt ttactttaac
     7201 aaaaggaact ccaatgtcac acttgggagt cttaatcatt ttggggcatt aatcatttta
     7261 gggcattgga ggggctggga agtagatata atgttaagat gttatgcact ctagcaagac
     7321 tattatgcta acagtttgag ttgggtcata caattgtatc atttcacatc agctactgac
     7381 tttgagtact gactttgaat gcttataaaa tcttcctcaa atccaggtag tgtgcaggac
     7441 atggtataac aagacaacgg aaaattagca gagagagcct tcattggaaa cccagattgt
     7501 atttttgcca gtacaacaaa tattattttt aaagtctctc actaatagga ttgttcaaca
     7561 taaatctatt gagaaacaat gatgtcagag agttttaaag ctatagtgaa gtgtgttaaa
     7621 ttttgttaac caaaataatg atatgggttt tattggacgt ttgtcaaccc aacttaacac
     7681 acattgttat ataatttcag tataggaccc tagggctagg ggcaactaat attggataaa
     7741 gacccttcgt gagatgcttt atgtctctta tgatgttatg ctaacattag tagagatgaa
     7801 aaaggaattg agttcgtgag atcctggaaa gtttaacttt tatcaaatag tcaagaaaaa
     7861 ttccatttta tggcatctgg tttttaaatg gattatagaa aaatgtgtgg aagtactgga
     7921 tattggcgaa aaagccttgt ggccaaggga tctgggcaca agatcgagca tcacagaaca
     7981 gtgaacacag ttgttggctt cactaccaat catctacgag gaaactgggc caattcactt
     8041 gacattttga tgattctctc tgataaaaat agggataatg actgattaca gaaatgtgct
     8101 tttaaaaaag ctgaatttag taaaagcaag tcatttgcta ctcaaaatag ctccaaaatc
     8161 taagccatat ttctataaat ttcataaagt cgttttaaaa tgtgacttat agttacagcg
     8221 tttatattac tacatattta agatggaact gacctgatgc caaagctaca tcatttgtag
     8281 ctatattagc tttctctttt gtcctgaaaa aaggttggag tgtttttaaa aatatagttt
     8341 ttaatctgca catggagcta tatgcaaaga acattgtttc ttcggggaat atttttagtc
     8401 atagtttctt tcatttattt tatcagcaaa aatcttatgt cagtttcaac taaggtctcc
     8461 taactgaact tttttttgtt ttgttttgtt ttgttttgtt ttgttttgta aatccacagc
     8521 aatttttatt aaataaaagc ctaggtgaga aaaataagtt atatcctagc acatgaaact
     8581 tagtcaataa tttcttctaa taatatttaa ttcactgaaa ttttacaaca aattttaaat
     8641 cgactaccaa gagtggtcag tcggggaaaa tttagtgtta tccaatgtat gatgaaatat
     8701 tcagctctca caaaaactgg atgtttggct attttaaaat ggctgttctt cacaataaaa
     8761 ctacaaacag acactgtcga ataaattgag tgataagtat gtctatttac taacatgagc
     8821 caatttgaac tttagttttg agatctaaaa atattttaat ccacatgcat ttagtgacta
     8881 taaattgaag gcagtgttct tttgacaacc aagcttattg aaaactttgg cattaatgtt
     8941 cacaaacatg agcactattt tgaaattaaa aatagactat ggtttgctct acatgcttgt
     9001 gaccctgcaa aaaataaagg aaaaatattc atgctatttt tctcctctta tattcttatg
     9061 gcttaaaaaa tataaccagg gttttatcta atatcaatct cttggcaaag gatcatataa
     9121 ggttttacct gctaacaaga atacctcatt tgaaagagca ttaccacaag cattggaggg
     9181 aggtacagtt gacatggtga atttgatttt acaaaaacta acaaagctgg ggggtggcaa
     9241 agcattgact taactataat cactagtcac accaatgtga gattccgaat cattggtcag
     9301 ccacagtgat gccaccttgg catcaaactt gcctgttcca tctttatcaa tgtatctgga
     9361 agtctgactt gagtaccaga agccaaaacg ctcagaatgc taatttgtgc caccttaatg
     9421 gcccatgtgt tcggtaaata aatttgcttt ttacatctcg tcaaatctta ctgaataaac
     9481 ctttcatcag agttctacat atccccaggt gggcttggaa acgtgagata ggattttatt
     9541 gtgttttata ttatgatagt tgaatgatga ttctatatgt tattgttata tttgttttca
     9601 ttaaaaaccc aaagaactac cctttgtata ccagtaaagt actatttttt cttgaaaaaa
     9661 agtaataata ataataatta aggcaattca catagtttgt tttatgccag tcttctgttt
     9721 taagtcatgt gataacatct ccccaaacat caatttctca ccctacatga tatgtgataa
     9781 aatcccccat atgccaataa tttcccccac tataaaatga agctgcttcc aatattattg
     9841 actcagaaat gtaaaatata gcacagttta tcttgtctgt ggtcctgtac taagttaaac
     9901 ttgcagctgt gaacaaatta atatttattt ttattaggaa ttctttaaga tgaattttca
     9961 gttttagtaa aagaaagaca ccagtgatat ttttatggat gaaagctctc tggttccttc
    10021 agcagctcta ggaacatcct tagccattat atcctctctc tttgacaata tcaaaattgt
    10081 ccaggtaaat gtaatattgc cagtggtgtc aagacattgg tctgttcatg tccttattct
    10141 tcgcttggtt tgtggaatca aaatggttgc ttattttcct ctcttctgta gataatccat
    10201 aggcaatgtt ttcaatttgg gaaacttttt ttttcaactt ggtttaagtt tgaaggctct
    10261 aaggaagagg aatattagaa caaattatgt attctctatg ttctattcca cttgtttgta
    10321 atatactcct gttctgagag ttatggtaaa cctatataac acgactgttc caagtgccaa
    10381 gtgagaattg tagtgactca cagaacacgt ctcatgacta tttatcaaaa gaaatgtgct
    10441 gattaaagaa aaaaagtaaa atatcttatt ttcattca
//
