LOCUS       NM_152520               3395 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 385B (ZNF385B), transcript variant
            1, mRNA.
ACCESSION   NM_152520
VERSION     NM_152520.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3395)
  AUTHORS   Liang,S., Wang,X.L., Zou,M.Y., Wang,H., Zhou,X., Sun,C.H., Xia,W.,
            Wu,L.J., Fujisawa,T.X. and Tomoda,A.
  TITLE     Family-based association study of ZNF533, DOCK4 and IMMP2L gene
            polymorphisms linked to autism in a northeastern Chinese Han
            population
  JOURNAL   J Zhejiang Univ Sci B 15 (3), 264-271 (2014)
   PUBMED   24599690
  REMARK    GeneRIF: The study found significant associations between autism
            and two SNPs of the ZNF533 gene.
REFERENCE   2  (bases 1 to 3395)
  AUTHORS   Iijima,K., Yamada,H., Miharu,M., Imadome,K., Miyagawa,Y.,
            Akimoto,S., Kobayashi,K., Okita,H., Nakazawa,A., Fujiwara,S.,
            Fujimoto,J. and Kiyokawa,N.
  TITLE     ZNF385B is characteristically expressed in germinal center B cells
            and involved in B-cell apoptosis
  JOURNAL   Eur J Immunol 42 (12), 3405-3415 (2012)
   PUBMED   22945289
  REMARK    GeneRIF: The direct binding of ZNF385B with p53 has suggested the
            involvement of ZNF385B in B-cell apoptosis via modulation of p53
            transactivation
REFERENCE   3  (bases 1 to 3395)
  AUTHORS   Elgaaen,B.V., Olstad,O.K., Sandvik,L., Odegaard,E., Sauer,T.,
            Staff,A.C. and Gautvik,K.M.
  TITLE     ZNF385B and VEGFA are strongly differentially expressed in serous
            ovarian carcinomas and correlate with survival
  JOURNAL   PLoS One 7 (9), e46317 (2012)
   PUBMED   23029477
  REMARK    GeneRIF: ZNF385B and VEGFA are strongly differentially expressed in
            serous ovarian carcinomas and correlate with survival.
REFERENCE   4  (bases 1 to 3395)
  AUTHORS   Aouizerat,B.E., Vittinghoff,E., Musone,S.L., Pawlikowska,L.,
            Kwok,P.Y., Olgin,J.E. and Tseng,Z.H.
  TITLE     GWAS for discovery and replication of genetic loci associated with
            sudden cardiac arrest in patients with coronary artery disease
  JOURNAL   BMC Cardiovasc Disord 11, 29 (2011)
   PUBMED   21658281
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3395)
  AUTHORS   Wu,J., Zheng,Q., Huang,Y.Q., Wang,Y., Li,S., Lu,D.W., Shi,B. and
            Chen,H.Q.
  TITLE     Significant evidence of association between polymorphisms in
            ZNF533, environmental factors, and nonsyndromic orofacial clefts in
            the Western Han Chinese population
  JOURNAL   DNA Cell Biol 30 (1), 47-54 (2011)
   PUBMED   20849254
  REMARK    GeneRIF: the relationship between ZNF533, environmental factors,
            and the etiology of nonsyndromic orofacial clefts
            GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   6  (bases 1 to 3395)
  AUTHORS   Maestrini,E., Pagnamenta,A.T., Lamb,J.A., Bacchelli,E., Sykes,N.H.,
            Sousa,I., Toma,C., Barnby,G., Butler,H., Winchester,L.,
            Scerri,T.S., Minopoli,F., Reichert,J., Cai,G., Buxbaum,J.D.,
            Korvatska,O., Schellenberg,G.D., Dawson,G., de Bildt,A.,
            Minderaa,R.B., Mulder,E.J., Morris,A.P., Bailey,A.J. and
            Monaco,A.P.
  CONSRTM   IMGSAC
  TITLE     High-density SNP association study and copy number variation
            analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4
            gene region in autism susceptibility
  JOURNAL   Mol Psychiatry 15 (9), 954-968 (2010)
   PUBMED   19401682
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3395)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092642.2, AC093604.4, AC068042.5 and BC092423.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152520.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092423.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000410066.7/ ENSP00000386845.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-512               AC092642.2         102678-103189       c
            513-664             AC092642.2         12098-12249         c
            665-964             AC092642.2         11080-11379         c
            965-1107            AC093604.4         1830-1972           c
            1108-1218           AC068042.5         146148-146258       c
            1219-1381           AC068042.5         110892-111054       c
            1382-1627           AC068042.5         74145-74390         c
            1628-1806           AC068042.5         73170-73348         c
            1807-1908           AC068042.5         72496-72597         c
            1909-3394           AC068042.5         69603-71088         c
            3395-3395           BC092423.1         3122-3122
FEATURES             Location/Qualifiers
     source          1..3395
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.2-q31.3"
     gene            1..3395
                     /gene="ZNF385B"
                     /gene_synonym="ZNF533"
                     /note="zinc finger protein 385B"
                     /db_xref="GeneID:151126"
                     /db_xref="HGNC:HGNC:26332"
                     /db_xref="MIM:612344"
     exon            1..512
                     /gene="ZNF385B"
                     /gene_synonym="ZNF533"
                     /inference="alignment:Splign:2.1.0"
     exon            513..664
                     /gene="ZNF385B"
                     /gene_synonym="ZNF533"
                     /inference="alignment:Splign:2.1.0"
     exon            665..964
                     /gene="ZNF385B"
                     /gene_synonym="ZNF533"
                     /inference="alignment:Splign:2.1.0"
     CDS             667..2127
                     /gene="ZNF385B"
                     /gene_synonym="ZNF533"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 533"
                     /codon_start=1
                     /product="zinc finger protein 385B isoform 1"
                     /protein_id="NP_689733.4"
                     /db_xref="CCDS:CCDS33339.2"
                     /db_xref="GeneID:151126"
                     /db_xref="HGNC:HGNC:26332"
                     /db_xref="MIM:612344"
                     /translation="MRYSLSPDNHLEDGIMNMANFLRGFEEKGIKNDRPEDQLSKEKK
                     KILFSFCEVCNIQLNSAAQAQVHSNGKSHRKRVKQLSDGQPPPPAQASPSSNSSTGST
                     CHTTTLPALVRTPTLMMQPSLDIKPFMSFPVDSSSAVGLFPNFNTMDPVQKAVINHTF
                     GVSIPPKKKQVISCNVCQLRFNSDSQAEAHYKGSKHAKKVKALDATKNKPKMVPSKDS
                     AKANPSCSITPITGNNSDKSEDKGKLKASSSSQPSSSESGSFLLKSGTTPLPPGAATS
                     PSKSTNGAPGTVVESEEEKAKKLLYCSLCKVAVNSLSQLEAHNTGSKHKTMVEARNGA
                     GPIKSYPRPGSRLKMQNGSKGSGLQNKTFHCEICDVHVNSEIQLKQHISSRRHKDRVA
                     GKPLKPKYSPYNKLQRSPSILAAKLAFQKDMMKPLAPAFLSSPLAAAAAVSSALSLPP
                     RPSASLFQAPAIPPALLRPGHGPIRATPASILFAPY"
     exon            965..1107
                     /gene="ZNF385B"
                     /gene_synonym="ZNF533"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1218
                     /gene="ZNF385B"
                     /gene_synonym="ZNF533"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1381
                     /gene="ZNF385B"
                     /gene_synonym="ZNF533"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1627
                     /gene="ZNF385B"
                     /gene_synonym="ZNF533"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1806
                     /gene="ZNF385B"
                     /gene_synonym="ZNF533"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1908
                     /gene="ZNF385B"
                     /gene_synonym="ZNF533"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..3395
                     /gene="ZNF385B"
                     /gene_synonym="ZNF533"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3374..3379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF385B"
                     /gene_synonym="ZNF533"
                     /note="hexamer: AATAAA"
     polyA_site      3395
                     /gene="ZNF385B"
                     /gene_synonym="ZNF533"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgtcaa cgagcccccg aacggttccg cctcattccc tctctgtgtg cctcgcaagt
       61 ctctgcttag taaaccgtca cagcttcggc gcgcgagagt ggcgttggca cgtccaaacc
      121 ccggggtcct cggccaggcc aggggggcgg gcgtgcggcg gggccgggcc gggccgggcg
      181 cgcccagcgg gctccgggca cacgcccctc acctgggcga ggcccggtgc gcaggcgctc
      241 agcgcggggg cagcggccgg gcgcttaagc ccggcgcggg caagagttgg acagttcagg
      301 ggccgcgccg ggccgagctg tcgcccgcgc cacctccacc gccgccgctg ctaccgccac
      361 cgccaccgcc tgggctgcag cagatcgcgg gagaacgtct gcgcgaagcc ccggtgcagc
      421 cctggcggga ccgcagcaac caccggagcg tgagcaacag cttcccggct ggaggagcca
      481 ctgccccacg cgcccgcggc ccgcgcgccg agatgttcta catttcaact ccatcaaata
      541 ttaaattgat gtttatgggc taacctggaa accgaaaaac agtttgtttc actacaagaa
      601 taagaaaata tgtccaaatt cctgtcagct gacttataaa gggactttta gaacacaacc
      661 caatgcatga ggtactcctt aagccctgac aaccatcttg aagatggaat catgaatatg
      721 gcaaattttc tacggggctt tgaagaaaag gggataaaga acgacaggcc tgaggaccag
      781 ttgagcaaag agaaaaagaa aattcttttc tccttctgtg aggtgtgcaa catccagctg
      841 aactctgcag cccaggctca ggtgcattcc aacggcaaat cccaccgcaa acgagtgaag
      901 cagctgagtg atgggcagcc cccaccaccc gcccaggcca gccccagcag caacagcagc
      961 acaggcagta catgccacac tactaccctt cctgctcttg tgcgcacacc taccctgatg
     1021 atgcagcctt cactggatat caaaccattt atgtcttttc cagtggacag tagttctgct
     1081 gttgggctct ttccaaattt taacacaatg gatcctgtgc aaaaagcggt tattaaccat
     1141 acatttggag tatccattcc cccaaagaag aaacaagtta tttcttgtaa tgtctgtcag
     1201 cttcgcttta actcagatag ccaggccgag gcccactaca aaggaagtaa acatgccaag
     1261 aaggtcaaag cactagacgc aacgaaaaat aaacccaaaa tggttccttc caaggacagc
     1321 gcaaaggcta atcccagctg ctccatcact ccaatcacag gcaacaactc tgacaaatca
     1381 gaagataaag ggaagttaaa agccagcagt tccagtcagc catcaagctc tgaaagtggc
     1441 tcatttctcc tcaaatctgg cacaacaccc ctgccacctg gagcagccac ttctccctcc
     1501 aagagcacaa atggagctcc cggtactgtt gttgaatcag aagaagaaaa agccaaaaaa
     1561 ttactttatt gttcactatg caaagtggct gtgaactccc tgtcacagct agaggcacac
     1621 aacacaggat ctaaacacaa gaccatggtt gaagctcgta atggggctgg tccaattaaa
     1681 tcctatccta gacctggatc aagattaaag atgcagaatg gcagtaaggg gtcaggacta
     1741 cagaacaaga catttcattg tgaaatctgt gatgttcatg ttaattcaga aattcaactc
     1801 aaacagcaca tttctagccg aaggcataaa gatcgagttg cagggaaacc actgaagcca
     1861 aaatacagcc cttacaacaa actccagcgg agcccgagta ttctagcagc aaaacttgca
     1921 ttccagaaag atatgatgaa gcctttggcc ccagccttcc tgtcctcacc tctcgcagcg
     1981 gcggcagccg tgtcctcagc gctgtcactc ccaccccggc cctctgcctc gctcttccag
     2041 gctccagcca ttcctccagc tcttctgagg cctgggcatg ggcccatccg cgccactcct
     2101 gcctccatcc tctttgctcc gtactaacgt ctgcaaaccc caagacgttt gaggccagta
     2161 ggaagttgag aaagaaagcc acaaggattc agcaatttaa gcagtttgtg ttgcagtacc
     2221 ccccattcac ccacaaaatg cagcccacca cccagtcccc caattccaga gagaaacaca
     2281 tcactagatt gacgagggct tttagagact gctcctataa ttgaggaatc agcagcatag
     2341 gctttatctc cctacttcct cccccaccct accgcgttca atttgtgtat ctcagatatt
     2401 tgatttcttg agcatgtatt ggtcagaaag aaaaagaaag aaaaccattc tctatttttc
     2461 catgggtatg atctggctta aaacaatatg gaatattttc ctgacagact tgaaaactag
     2521 gatcttcctc agatgtctgt aaataactct ggtatccaac tgggtgtatt ctagtgtgga
     2581 acaaaaaaca gtgaacacaa gtgcttactt gtggatacta tcttaccaac ggatcacaaa
     2641 gttctctttt tggtgtactg ttgttgacag ggattgtgta ctgtttcgac ccaagtactg
     2701 ctgtatcctg tgtagtacta gatctgtatc tcttgtctga attaaacatt tttagttgct
     2761 gtgtaaatgt taggaagcaa agtagctttg aattttctct gtaagagaat aaaagataaa
     2821 ataatgtatt ttctttattt cacattttat ttggagatat ttaaatgaaa tagaaagcca
     2881 tataacatag ctataattac tacctgtttg ctatttttgt ttaacttatt ttgtagcttc
     2941 ctcactggtt tgtgttgcta agcaaacgta tacaaacaga aaaagagctt cctaaattgc
     3001 acatttttgc acctcttgtg cattctgcaa gaagacaatg aatccatgta tttctatata
     3061 agtatcttct tcatttttaa cctgttttca tttgtaatga tgctacataa ttttgtggct
     3121 ccctaatgca ataatgtaca gaagataaaa aaatttataa ttgaacaatt tgtctttctg
     3181 ttcgctgaat atattgcagg tcatgctccc atgcccccct ttctaagccg atatcaacaa
     3241 gactggaatg tttgtgatat caggggcaag agttatcata gaacaacaaa atagagtgga
     3301 ctcttttaga gcatctatat ctgcaacctg taaatggtaa aatgtctgtg tattttttta
     3361 aatgtacctt ttcaataaaa gtacaaaaaa taaaa
//
