LOCUS       NM_015481               2440 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens zinc finger protein 385A (ZNF385A), transcript variant
            3, mRNA.
ACCESSION   NM_015481
VERSION     NM_015481.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2440)
  AUTHORS   Peng,Q., Li,J., Wu,Q., Wang,P., Kang,Z., Deng,Y., Xiao,Y.,
            Zheng,P., Ge,F. and Chen,Y.
  TITLE     ZNF385A and ZNF346 Serve as Prognostic Biomarkers Associated with
            an Inflamed Immunosuppressive Tumor Microenvironment in
            Hepatocellular Carcinoma
  JOURNAL   Int J Mol Sci 24 (4), 3155 (2023)
   PUBMED   36834567
  REMARK    GeneRIF: ZNF385A and ZNF346 Serve as Prognostic Biomarkers
            Associated with an Inflamed Immunosuppressive Tumor
            Microenvironment in Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2440)
  AUTHORS   Yu,L., Dawe,R.J., Boyle,P.A., Gaiteri,C., Yang,J., Buchman,A.S.,
            Schneider,J.A., Arfanakis,K., De Jager,P.L. and Bennett,D.A.
  TITLE     Association Between Brain Gene Expression, DNA Methylation, and
            Alteration of Ex Vivo Magnetic Resonance Imaging Transverse
            Relaxation in Late-Life Cognitive Decline
  JOURNAL   JAMA Neurol 74 (12), 1473-1480 (2017)
   PUBMED   29084334
  REMARK    GeneRIF: Brain gene expression of PADI2, ZNF385A, PSD2, and A2ML1
            and DNA methylation dysregulations are implicated in the alteration
            of brain tissue properties associated with late-life cognitive
            decline above and beyond the influence of common neuropathologic
            conditions.
REFERENCE   3  (bases 1 to 2440)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2440)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2440)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 2440)
  AUTHORS   Das,S., Raj,L., Zhao,B., Kimura,Y., Bernstein,A., Aaronson,S.A. and
            Lee,S.W.
  TITLE     Hzf Determines cell survival upon genotoxic stress by modulating
            p53 transactivation
  JOURNAL   Cell 130 (4), 624-637 (2007)
   PUBMED   17719541
REFERENCE   7  (bases 1 to 2440)
  AUTHORS   Sharma,S., Dimasi,D., Higginson,K. and Della,N.G.
  TITLE     RZF, a zinc-finger protein in the photoreceptors of human retina
  JOURNAL   Gene 342 (2), 219-229 (2004)
   PUBMED   15527981
  REMARK    GeneRIF: Results suggest that RZF is a shuttling regulatory protein
            expressed in photoreceptors of the human retina that may be
            involved in mRNA or protein regulation of photoreceptor-specific
            genes and therefore have role in retinal disease mechanisms.
REFERENCE   8  (bases 1 to 2440)
  AUTHORS   Kimura,Y., Hart,A., Hirashima,M., Wang,C., Holmyard,D., Pittman,J.,
            Pang,X.L., Jackson,C.W. and Bernstein,A.
  TITLE     Zinc finger protein, Hzf, is required for megakaryocyte development
            and hemostasis
  JOURNAL   J Exp Med 195 (7), 941-952 (2002)
   PUBMED   11927637
REFERENCE   9  (bases 1 to 2440)
  AUTHORS   Hidaka,M., Caruana,G., Stanford,W.L., Sam,M., Correll,P.H. and
            Bernstein,A.
  TITLE     Gene trapping of two novel genes, Hzf and Hhl, expressed in
            hematopoietic cells
  JOURNAL   Mech Dev 90 (1), 3-15 (2000)
   PUBMED   10585558
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079313.35, BP305142.1 and AF304052.1.
            
            On Jun 2, 2019 this sequence version replaced NM_015481.2.
            
            Summary: Zinc finger proteins, such as ZNF385A, are regulatory
            proteins that act as transcription factors, bind single- or
            double-stranded RNA, or interact with other proteins (Sharma et
            al., 2004 [PubMed 15527981]).[supplied by OMIM, Oct 2008].
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The resulting
            isoform (c) has a shorter N-terminus, compared to isoform a.
            Variants 3, 5, and 6 encode the same protein (isoform c).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF304052.1, SRR7346977.1162256.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394313.7/ ENSP00000377849.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC079313.35        16910-16912         c
            4-36                BP305142.1         1-33
            37-2440             AF304052.1         1-2404
FEATURES             Location/Qualifiers
     source          1..2440
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2440
                     /gene="ZNF385A"
                     /gene_synonym="HZF; RZF; ZFP385; ZNF385"
                     /note="zinc finger protein 385A"
                     /db_xref="GeneID:25946"
                     /db_xref="HGNC:HGNC:17521"
                     /db_xref="MIM:609124"
     exon            1..306
                     /gene="ZNF385A"
                     /gene_synonym="HZF; RZF; ZFP385; ZNF385"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1320
                     /gene="ZNF385A"
                     /gene_synonym="HZF; RZF; ZFP385; ZNF385"
                     /note="isoform c is encoded by transcript variant 3; zinc
                     finger protein 385; retinal zinc finger protein;
                     hematopoietic zinc finger protein"
                     /codon_start=1
                     /product="zinc finger protein 385A isoform c"
                     /protein_id="NP_056296.1"
                     /db_xref="CCDS:CCDS8879.1"
                     /db_xref="GeneID:25946"
                     /db_xref="HGNC:HGNC:17521"
                     /db_xref="MIM:609124"
                     /translation="MQPPLDLKQILPFPLEPAPTLGLFSNYSTMDPVQKAVLSHTFGG
                     PLLKTKRPVISCNICQIRFNSQSQAEAHYKGNRHARRVKGIEAAKTRGREPGVREPGD
                     PAPPGSTPTNGDGVAPRPVSMENGLGPAPGSPEKQPGSPSPPSIPETGQGVTKGEGGT
                     PAPASLPGGSKEEEEKAKRLLYCALCKVAVNSLSQLEAHNKGTKHKTILEARSGLGPI
                     KAYPRLGPPTPGEPEAPAQDRTFHCEICNVKVNSEVQLKQHISSRRHRDGVAGKPNPL
                     LSRHKKSRGAGELAGTLTFSKELPKSLAGGLLPSPLAVAAVMAAAAGSPLSLRPAPAA
                     PLLQGPPITHPLLHPAPGPIRTAHGPILFSPY"
     exon            307..417
                     /gene="ZNF385A"
                     /gene_synonym="HZF; RZF; ZFP385; ZNF385"
                     /inference="alignment:Splign:2.1.0"
     exon            418..580
                     /gene="ZNF385A"
                     /gene_synonym="HZF; RZF; ZFP385; ZNF385"
                     /inference="alignment:Splign:2.1.0"
     exon            581..823
                     /gene="ZNF385A"
                     /gene_synonym="HZF; RZF; ZFP385; ZNF385"
                     /inference="alignment:Splign:2.1.0"
     exon            824..993
                     /gene="ZNF385A"
                     /gene_synonym="HZF; RZF; ZFP385; ZNF385"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1089
                     /gene="ZNF385A"
                     /gene_synonym="HZF; RZF; ZFP385; ZNF385"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..2440
                     /gene="ZNF385A"
                     /gene_synonym="HZF; RZF; ZFP385; ZNF385"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2413..2418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF385A"
                     /gene_synonym="HZF; RZF; ZFP385; ZNF385"
                     /note="hexamer: AATAAA"
     polyA_site      2440
                     /gene="ZNF385A"
                     /gene_synonym="HZF; RZF; ZFP385; ZNF385"
                     /note="major polyA site"
ORIGIN      
        1 actgtgctcc attgctctgg agccagcagg ggaagtgtgt acactatgtg cactgagggt
       61 gacacttctg agtgtggggg ccctggctag ggagtgggac tggcaggctt gggtggggtt
      121 cccaagcttt aatcttccta ccccacagaa tgttttctct gcccttcagg cagcctgagc
      181 cgggcagggc ccctgcctct gctacggcag cccccgatca tgcagccccc actggacctc
      241 aagcagatcc tgcccttccc actcgagcca gcccctaccc ttggcctctt cagcaactac
      301 agcaccatgg accctgtgca gaaggctgtg ctctcccaca cttttggggg acccttgctc
      361 aagaccaagc ggcccgtcat ttcctgtaat atctgtcaaa tccgcttcaa ttctcagagc
      421 caggctgagg cgcactacaa aggtaatcgc cacgcccgac gagtcaaagg cattgaggct
      481 gccaagacca gaggcaggga gcctggcgtc cgagaacctg gagacccagc tcccccaggc
      541 agcaccccaa caaatgggga tggtgtagca ccccgtccag tttccatgga gaatggactg
      601 gggccagccc caggatcccc agagaaacag cctggctccc catcccctcc cagcattccg
      661 gagactggtc agggtgtaac caagggtgaa ggggggactc cagccccggc ttccttgcct
      721 gggggtagca aggaagagga ggagaaagcc aagcggctgc tctactgtgc tctgtgcaag
      781 gtggctgtga actccctgtc ccagcttgag gcacataaca aaggtactaa gcacaagaca
      841 attctggagg cccgaagtgg gctcgggccc atcaaagctt accctcggct ggggcctccc
      901 accccggggg aaccagaggc tcctgcccag gaccgaactt tccactgtga gatctgcaat
      961 gtcaaggtca actcggaggt ccaactgaaa cagcacatct ccagccggcg gcaccgagac
     1021 ggcgtggccg ggaagcccaa cccactactg agccgtcaca agaagtctag gggcgccggg
     1081 gagctggcgg gcacgctgac tttctccaag gagctgccca agtccctggc gggcggcctg
     1141 ctccccagcc ccctggcggt ggctgcagtg atggcagcgg cagcaggctc gccgctgtcc
     1201 ctgcgcccgg ctccagccgc acctcttctc cagggaccgc cgatcactca ccctctgctt
     1261 cacccggccc ccggacccat ccgaactgcg cacggaccca tcctcttctc cccgtactga
     1321 cctcaaccct gaacccctcc cattcaactc cccacctcca gccgggaccc aggcgtccgg
     1381 gctcccagcc cgcccctcct cccggcactc cctaaatgat ctctccttcc ccccccccac
     1441 cccgagatac ggggttccag gaaaggggag gggtagcggg ggaggggggc ttcagaaggg
     1501 ggggaacacc ccagatctca gggaaccccg ccccctgcct ttccctctcc cctagaaaag
     1561 ggggggccgt ctcacccccg agcccccttg gagacacccc ccctcccaaa agccatgtcc
     1621 atccagccct tccccccaaa cctagcacaa aacggggttc acaagccatg gtcggggtcc
     1681 gggggggaca gaaatggatt ttcttggcaa taagcggact ctgggactcc ggctccctac
     1741 cccaaactga agcgcttccg tgaacacccc cgtcctccgt agggggaggg gagcaggcgg
     1801 gatcctgggt ccctcataag cactttggtt ttaccgcctg caacctcact gtgcccgccc
     1861 cgcaccatgc cctagcccca ggtctagccg ggcccattgc agggggcagc acttgggggc
     1921 atctccggca cttgggtggg accaaggaga tgccaccata gacctttccc tcgccttctt
     1981 cctccctagt ccgggttcca ttcttttcac cagcacccat cgcccaaggg gtaccgaggg
     2041 gggcaagggg tgtccagtcc aagcccaccc ccgcctcgcc ttccgcaaaa ctgtgagcaa
     2101 aaagcaatag aagcctcgcc cccgcccttc cccttcgcag gattcgccga gtctgtagcc
     2161 tccccgatcc aagttcctag acctcatggc tgtcccctcc caccagtcac ctccactgca
     2221 caactcgggc gggggtgtga cacctctccc ccacccccga ctccgtggtt tccgtatcgt
     2281 caacccttca gccgccgacc cgggaggggt ctggcctaca ctggtcttcc ccttcccatc
     2341 aactctttct gcttgacaat gtagcaaccc aggcccccca cccacggtcc tccccttttt
     2401 cctctccctg acaataaagt ctgaatttgt tctgccctcc
//
