LOCUS       NM_001385745            3407 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens zinc finger protein 384 (ZNF384), transcript variant
            10, mRNA.
ACCESSION   NM_001385745 XM_011520920
VERSION     NM_001385745.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3407)
  AUTHORS   Yamada,C., Okada,K., Odaira,K., Tokoro,M., Iwamoto,E., Sanada,M.,
            Noura,M., Okamoto,S., Yasuda,T., Tsuzuki,S., Kiyoi,H. and
            Hayakawa,F.
  TITLE     RGS1 and CREB5 are direct and common transcriptional targets of
            ZNF384-fusion proteins
  JOURNAL   Cancer Med 13 (14), e7471 (2024)
   PUBMED   39015025
  REMARK    GeneRIF: RGS1 and CREB5 are direct and common transcriptional
            targets of ZNF384-fusion proteins.
REFERENCE   2  (bases 1 to 3407)
  AUTHORS   Hou,Z., Ren,Y., Zhang,X., Huang,D., Yan,F., Sun,W., Zhang,W.,
            Zhang,Q., Fu,X., Lang,Z., Chu,C., Zou,B., Gao,B., Jin,B., Kang,Z.,
            Liu,Q. and Yan,J.
  TITLE     EP300-ZNF384 transactivates IL3RA to promote the progression of
            B-cell acute lymphoblastic leukemia
  JOURNAL   Cell Commun Signal 22 (1), 211 (2024)
   PUBMED   38566191
  REMARK    GeneRIF: EP300-ZNF384 transactivates IL3RA to promote the
            progression of B-cell acute lymphoblastic leukemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3407)
  AUTHORS   Yang,J., Yang,S., Cai,J., Chen,H., Sun,L., Wang,J., Hou,G., Gu,S.,
            Ma,J. and Ge,J.
  TITLE     A Transcription Factor ZNF384, Regulated by LINC00265, Activates
            the Expression of IFI30 to Stimulate Malignant Progression in
            Glioma
  JOURNAL   ACS Chem Neurosci 15 (2), 290-299 (2024)
   PUBMED   38141017
  REMARK    GeneRIF: A Transcription Factor ZNF384, Regulated by LINC00265,
            Activates the Expression of IFI30 to Stimulate Malignant
            Progression in Glioma.
REFERENCE   4  (bases 1 to 3407)
  AUTHORS   Shi,Z.Y., Wang,X., Chen,W.M., Li,L.D., Hao,Y., Li,J.Y., Sun,K.,
            Zhao,X.S., Jiang,H., Jiang,Q., Huang,X.J. and Qin,Y.Z.
  TITLE     ZNF384 fusion transcript levels for measurable residual disease
            monitoring in adult B-cell acute lymphoblastic leukemia
  JOURNAL   Hematol Oncol 42 (1), e3251 (2024)
   PUBMED   38287528
  REMARK    GeneRIF: ZNF384 fusion transcript levels for measurable residual
            disease monitoring in adult B-cell acute lymphoblastic leukemia.
REFERENCE   5  (bases 1 to 3407)
  AUTHORS   Zhong,C.H., Prima,V., Liang,X., Frye,C., McGavran,L., Meltesen,L.,
            Wei,Q., Boomer,T., Varella-Garcia,M., Gump,J. and Hunger,S.P.
  TITLE     E2A-ZNF384 and NOL1-E2A fusion created by a cryptic t(12;19)(p13.3;
            p13.3) in acute leukemia
  JOURNAL   Leukemia 22 (4), 723-729 (2008)
   PUBMED   18185522
REFERENCE   6  (bases 1 to 3407)
  AUTHORS   Janssen,H. and Marynen,P.
  TITLE     Interaction partners for human ZNF384/CIZ/NMP4--zyxin as a mediator
            for p130CAS signaling?
  JOURNAL   Exp Cell Res 312 (7), 1194-1204 (2006)
   PUBMED   16510139
REFERENCE   7  (bases 1 to 3407)
  AUTHORS   La Starza,R., Aventin,A., Crescenzi,B., Gorello,P., Specchia,G.,
            Cuneo,A., Angioni,A., Bilhou-Nabera,C., Boque,C., Foa,R.,
            Uyttebroeck,A., Talmant,P., Cimino,G., Martelli,M.F., Marynen,P.,
            Mecucci,C. and Hagemeijer,A.
  TITLE     CIZ gene rearrangements in acute leukemia: report of a diagnostic
            FISH assay and clinical features of nine patients
  JOURNAL   Leukemia 19 (9), 1696-1699 (2005)
   PUBMED   15990865
  REMARK    GeneRIF: The CIZ protein(also known as ZNF384)was involved and
            rearrangemented in acute leukemia.
REFERENCE   8  (bases 1 to 3407)
  AUTHORS   Martini,A., La Starza,R., Janssen,H., Bilhou-Nabera,C.,
            Corveleyn,A., Somers,R., Aventin,A., Foa,R., Hagemeijer,A.,
            Mecucci,C. and Marynen,P.
  TITLE     Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its
            homologue, TAF15, with the transcription factor CIZ/NMP4 in acute
            leukemia
  JOURNAL   Cancer Res 62 (19), 5408-5412 (2002)
   PUBMED   12359745
  REMARK    GeneRIF: The transcription factor gene CIZ/NMP4 is recurrently
            involved in acute leukemia through fusion with either EWSR1 or
            TAF15.
REFERENCE   9  (bases 1 to 3407)
  AUTHORS   Thunyakitpisal,P., Alvarez,M., Tokunaga,K., Onyia,J.E., Hock,J.,
            Ohashi,N., Feister,H., Rhodes,S.J. and Bidwell,J.P.
  TITLE     Cloning and functional analysis of a family of nuclear matrix
            transcription factors (NP/NMP4) that regulate type I collagen
            expression in osteoblasts
  JOURNAL   J Bone Miner Res 16 (1), 10-23 (2001)
   PUBMED   11149472
REFERENCE   10 (bases 1 to 3407)
  AUTHORS   Margolis,R.L., Abraham,M.R., Gatchell,S.B., Li,S.H., Kidwai,A.S.,
            Breschel,T.S., Stine,O.C., Callahan,C., McInnis,M.G. and Ross,C.A.
  TITLE     cDNAs with long CAG trinucleotide repeats from human brain
  JOURNAL   Hum Genet 100 (1), 114-122 (1997)
   PUBMED   9225980
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC125494.2.
            
            On Jul 28, 2020 this sequence version replaced XM_011520920.1.
            
            Summary: This gene encodes a C2H2-type zinc finger protein, which
            may function as a transcription factor. This gene also contains
            long CAG trinucleotide repeats that encode consecutive glutamine
            residues. The protein appears to bind and regulate the promoters of
            the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies
            in mouse suggest that nuclear matrix transcription factors
            (NP/NMP4) may be part of a general mechanical pathway that couples
            cell construction and function during extracellular matrix
            remodeling. Alternative splicing results in multiple transcript
            variants. Recurrent rearrangements of this gene with the Ewing's
            sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on
            chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have
            been observed in acute leukemia. A related pseudogene has been
            identified on chromosome 7. [provided by RefSeq, Apr 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2312263.1,
                                           SRR14038194.4196255.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683879.1/ ENSP00000507462.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               AC125494.2         109040-109317
            279-338             AC125494.2         110189-110248
            339-409             AC125494.2         118890-118960
            410-647             AC125494.2         119232-119469
            648-695             AC125494.2         119705-119752
            696-1029            AC125494.2         119955-120288
            1030-1122           AC125494.2         121156-121248
            1123-1347           AC125494.2         124975-125199
            1348-1530           AC125494.2         125883-126065
            1531-1609           AC125494.2         127577-127655
            1610-1768           AC125494.2         129226-129384
            1769-3407           AC125494.2         130300-131938
FEATURES             Location/Qualifiers
     source          1..3407
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..3407
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /note="zinc finger protein 384"
                     /db_xref="GeneID:171017"
                     /db_xref="HGNC:HGNC:11955"
                     /db_xref="MIM:609951"
     exon            1..278
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..338
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            339..409
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..2170
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /note="isoform e is encoded by transcript variant 10;
                     Cas-interacting zinc finger protein; nuclear matrix
                     transcription factor 4; expanded repeat domain, CAG/CTG 2;
                     CAG repeat protein 1; trinucleotide repeat-containing gene
                     1 protein"
                     /codon_start=1
                     /product="zinc finger protein 384 isoform e"
                     /protein_id="NP_001372674.1"
                     /db_xref="CCDS:CCDS91645.1"
                     /db_xref="GeneID:171017"
                     /db_xref="HGNC:HGNC:11955"
                     /db_xref="MIM:609951"
                     /translation="MEESHFNSNPYFWPSIPTVSGQIENTMFINKMKDQLLPEKGCGL
                     APPHYPTLLTVPASVSLPSGISMDTESKSDQLTPHSQASVTQNITVVPVPSTGLMTAG
                     VSCSQRWRREGSQSRGPGLVITSPSGSLVTTASSAQTFPISAPMIVSALPPGSQALQV
                     VPDLSKKVASTLTEEGGGGGGGGGSVAPKPPRGRKKKRMLESGLPEMNDPYVLSPEDD
                     DDHQKDGKTYRSEGNCGTGNGQSLGLMDSVPGSTTNLLCDPGCRMCSLTFYSKSEMQI
                     HSKSHTETKPHKCPHCSKTFANSSYLAQHIRIHSGAKPYSCNFCEKSFRQLSHLQQHT
                     RIHSKMHTETIKPHKCPHCSKTFANTSYLAQHLRIHSGAKPYNCSYCQKAFRQLSHLQ
                     QHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHRRQHNKDKPFKCHNCHRAYTDAASLE
                     VHLSTHTVKHAKVYTCTICSRAYTSETYLMKHMRKHNPPDLQQQVQAAAAAAAVAQAQ
                     AQAQAQAQAQAQAQAQAQASQASQQQQQQQQQQQQQQQQPPPHFQSPGAAPQGGGGGD
                     SNPNPPPQCSFDLTPYKTAEHHKDICLTVTTSTIQVEHLASS"
     exon            410..647
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..695
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..1029
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1122
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1347
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1530
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1609
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1768
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..3407
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3124..3129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /note="hexamer: TATAAA"
     polyA_site      3154
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /note="major polyA site"
     regulatory      3388..3393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /note="hexamer: AATAAA"
     polyA_site      3407
                     /gene="ZNF384"
                     /gene_synonym="CAGH1; CAGH1A; CIZ; ERDA2; NMP4; NP; TNRC1"
                     /note="major polyA site"
ORIGIN      
        1 acttccgggt gagtgcaagg ggagggcagc aaggaggggg ggccacccac tacctcgcgc
       61 ccccgccctg cgggtgtctc gcgcgcgttc cgtgcgtgtg agtgtgtggg tctgtctcgc
      121 tccagaagtg cgtgcccgcg cgctgcgcct tgcgcttttt cccctccctc gccccttcct
      181 ggtcctccca ccctcctcgg ctccctcctt tcccagcaaa cgccgcccct cccgcgccct
      241 ggctcaggct ctggcgccgc cgcagccgtc gccgcccgaa agttcaggag ccctggaaag
      301 gagaaggaat aagacggcag gaggaagaga gagagagggt agaatggaag aatctcactt
      361 caattctaac ccgtacttct ggccttctat ccccacagtc tcaggtcaga tcgagaacac
      421 aatgttcatc aacaagatga aggatcagct gttgccagag aagggctgtg gtctggcccc
      481 acctcactac cccaccttgc tgacagtgcc tgcctcagtg tccctgccct caggcatcag
      541 tatggacaca gagtccaagt cagaccagct gaccccacac agccaagcgt ccgttaccca
      601 gaatatcacg gtggtccctg tgccgtctac aggactgatg actgctggag tctcctgttc
      661 tcagaggtgg agaagagaag ggagtcaatc aaggggtccg ggtttggtaa tcacgtcccc
      721 ctcaggctct cttgtgacca cagcatcatc agctcagacc ttccccattt cggctcccat
      781 gattgtctca gctcttcccc ctggctcaca agccctgcag gttgtccctg acctctccaa
      841 gaaggtagca tcgaccctaa ccgaggaagg aggcggaggt ggtggtggag gtggcagtgt
      901 ggctcctaag ccaccccggg gccggaagaa gaagcggatg ctggaatcag ggctgcccga
      961 gatgaatgac ccttatgtcc tctcccctga ggatgatgat gaccatcaga aagacggcaa
     1021 gacctacagg agcgaaggga actgcggcac aggaaatgga cagagccttg ggctcatgga
     1081 ttcagttccc ggctccacca cgaatttgct gtgtgaccct gggtgccgga tgtgctcact
     1141 gacattctac tccaagtcgg agatgcagat ccactccaag tcacacaccg agaccaagcc
     1201 ccacaagtgc ccacattgct ccaagacctt cgccaacagc tcctacctgg cccagcacat
     1261 ccgtatacac tcaggggcta agccctacag ttgtaacttc tgtgagaaat ccttccgcca
     1321 gctctcccac cttcagcagc acacccggat ccactccaag atgcacacgg agaccatcaa
     1381 gccccacaag tgcccgcact gctccaagac cttcgccaac acctcctacc tggcccagca
     1441 cctccgtatc cactcggggg ccaagcccta caactgttcc tactgccaga aggccttccg
     1501 ccagctctcc cacctccagc agcacacacg aatccacact ggtgatagac catacaaatg
     1561 tgcacaccca ggctgtgaga aagccttcac acaactctcc aatctgcagt cccacagacg
     1621 gcaacacaac aaagataaac ccttcaagtg ccacaactgt catcgggcgt acacggatgc
     1681 agcctcacta gaggtgcacc tgtctacgca cacagtgaag catgccaagg tgtacacctg
     1741 cactatctgc agtcgggcat acacatcaga aacatacctt atgaaacata tgcgcaaaca
     1801 caacccgcct gatcttcagc aacaggtgca ggcagcagca gcagcggcag cagtggccca
     1861 ggcccaggct caagctcaag cccaggctca ggctcaggct caagcccagg cccaggccca
     1921 ggcctcccag gcatcacagc agcagcagca gcagcagcag cagcagcagc agcagcagca
     1981 acagccacca ccacacttcc agtctcctgg ggcagccccc cagggtgggg gtggtgggga
     2041 cagcaatccc aaccctccac cccagtgttc ctttgacctg accccgtata agacggcgga
     2101 gcatcataag gacatctgcc tcactgtcac caccagcacc atccaggtgg agcacctggc
     2161 cagctcttag agatccgtgc tgccacccac tgggaagagg aagaagtagt cctggtgtct
     2221 tctttctcca actcttggtg ggaaaagtcc ttttcttcct tgacaggcct tggctccatc
     2281 tccttgggcc tctgtcacgg ctttccttca caggatacca tcctttttct gaactcttct
     2341 tcaaaaggaa catcagccct cctgattgca aaggaatact gagctgatgg tgtcatccag
     2401 cagcctcccc tcccaagcaa agcttctaaa actgggggtc ggtgctcaag ggaaggattt
     2461 gctatgacct catagaacct tgtccagtgt ggccacttac cctatcctta ccctccttat
     2521 cctcaaagtt tgggctgatg taagactaga ggctggccct cccagataac agagaaaagg
     2581 gagccccaaa tgcaaccagc ctcttgttct attcttgcct gcaaaagaac agaggtttct
     2641 caaatgcctc agtccctgag agccatttct tcccctacat cgtctcactt tgcttcctat
     2701 tgactgctgg tagaaggaga tttggggtag gggctagacc tccttttatt tgaagggggc
     2761 aagggctgag atgtggtccc caaggggcca gaaattccca agttggtcac aggtggctta
     2821 gaagtgtgtg ttatggtttt acggatttcc ttgaagcctc tctccttctc tgcctacaaa
     2881 gaccctatac tctcagtctc cccaacccac ccccaaggag ctgtgggagg ctttgtgtta
     2941 tctgtgaaac tccaaaacag gggtgttgcg gagaagggag agttcaaggc aaacgcaagg
     3001 actggactta gctccctagg tgccacagtc agatgccgga cacggattta tatataaata
     3061 tatatatata aatatattat actcactcat cacggccatc tttgttgtaa ccatttctgt
     3121 gtttataaat gcattatctc tgagaatttt catatttgat gttttgttta tttttgtcct
     3181 ttttttccct ctctccaccc ctgtcctcta gccacagcat ttttcttttt gtcttttttt
     3241 ttttttttta aatcatggca gatttcagag gaaaggaaat taaaaaaaaa atcaggaaac
     3301 cagttgttat aaagtaattt aaaaatgaag aaaaaaagaa aaaaacttat gtacaaacca
     3361 aggggtgttt ttagaacatt gtatagaaat aaattcatgt aaaagga
//
