LOCUS       NM_001387601            6732 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 383 (ZNF383), transcript variant
            13, mRNA.
ACCESSION   NM_001387601 XM_005258585
VERSION     NM_001387601.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6732)
  AUTHORS   Liang,Y., Zhang,X., Geng,W., Wang,Y., Ding,Y., Song,Q., Yuan,Y.,
            Zhao,C., Tian,Z., Wang,J. and Tian,C.
  TITLE     19q13.12 KRAB zinc-finger protein ZNF383 represses p53 signaling
            pathway by interacting with p53
  JOURNAL   Cell Signal 98, 110405 (2022)
   PUBMED   35835334
  REMARK    GeneRIF: 19q13.12 KRAB zinc-finger protein ZNF383 represses p53
            signaling pathway by interacting with p53.
REFERENCE   2  (bases 1 to 6732)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6732)
  AUTHORS   Cao,L., Wang,Z., Zhu,C., Zhao,Y., Yuan,W., Li,J., Wang,Y., Ying,Z.,
            Li,Y., Yu,W., Wu,X. and Liu,M.
  TITLE     ZNF383, a novel KRAB-containing zinc finger protein, suppresses
            MAPK signaling pathway
  JOURNAL   Biochem Biophys Res Commun 333 (4), 1050-1059 (2005)
   PUBMED   15964543
  REMARK    GeneRIF: Overexpression of ZNF383 in cells inhibits the
            transcriptional activities of AP-1 and SRE, suggesting that ZNF383
            may act as a negative regulator in MAPK-mediated signaling
            pathways.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012309.8, AC016590.7 and
            KC877738.1.
            
            On Oct 9, 2020 this sequence version replaced XM_005258585.3.
            
            Summary: The protein encoded by this gene is a KRAB-related zinc
            finger protein that inhibits the transcription of some MAPK
            signaling pathway genes. The repressor activity resides in the KRAB
            domain of the encoded protein. [provided by RefSeq, Sep 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1738856.1,
                                           SRR1803616.126073.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2145313
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684119.1/ ENSP00000507972.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC012309.8         131439-131499
            62-183              AC012309.8         138043-138164
            184-237             AC012309.8         143634-143687
            238-364             AC012309.8         148774-148900
            365-460             AC012309.8         149204-149299
            461-2017            AC012309.8         155694-157250
            2018-6315           AC016590.7         113064-117361       c
            6316-6732           KC877738.1         149-565             c
FEATURES             Location/Qualifiers
     source          1..6732
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..6732
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /note="zinc finger protein 383"
                     /db_xref="GeneID:163087"
                     /db_xref="HGNC:HGNC:18609"
                     /db_xref="MIM:619499"
     exon            1..61
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /inference="alignment:Splign:2.1.0"
     exon            62..183
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /inference="alignment:Splign:2.1.0"
     exon            184..237
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1656
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /codon_start=1
                     /product="zinc finger protein 383"
                     /protein_id="NP_001374530.1"
                     /db_xref="CCDS:CCDS12501.1"
                     /db_xref="GeneID:163087"
                     /db_xref="HGNC:HGNC:18609"
                     /db_xref="MIM:619499"
                     /translation="MAEGSVMFSDVSIDFSQEEWDCLDPVQRDLYRDVMLENYGNLVS
                     MGLYTPKPQVISLLEQGKEPWMVGRELTRGLCSDLESMCETKLLSLKKEVYEIELCQR
                     EIMGLTKHGLEYSSFGDVLEYRSHLAKQLGYPNGHFSQEIFTPEYMPTFIQQTFLTLH
                     QIINNEDRPYECKKCGKAFSQNSQFIQHQRIHIGEKSYECKECGKFFSCGSHVTRHLK
                     IHTGEKPFECKECGKAFSCSSYLSQHQRIHTGKKPYECKECGKAFSYCSNLIDHQRIH
                     TGEKPYECKVCGKAFTKSSQLFQHARIHTGEKPYECKECGKAFTQSSKLVQHQRIHTG
                     EKPYECKECGKAFSSGSALTNHQRIHTGEKPYDCKECGKAFTQSSQLRQHQRIHAGEK
                     PFECLECGKAFTQNSQLFQHQRIHTDEKPYECNECGKAFNKCSNLTRHLRIHTGEKPY
                     NCKECGKAFSSGSDLIRHQGIHTNK"
     exon            238..364
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /inference="alignment:Splign:2.1.0"
     exon            365..460
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /inference="alignment:Splign:2.1.0"
     exon            461..6732
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6710..6715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /note="hexamer: AATAAA"
     polyA_site      6732
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /note="major polyA site"
ORIGIN      
        1 aagggtaggg gaagtgcgcg gtgagcggcc tgggtcttgc aggctcggct ggggcccgca
       61 gacggagtct cactctgttg cccaagctgg agtgcagtgg catgatctca gctcactgca
      121 gcctctgctt tccgggttca agcgattctc ttgcctcagc ctcctgagta gctgggatta
      181 caggagaacg gcctcaagga agactaacca tctgcaatac tagaagccat ggctgaggga
      241 tcagtgatgt tcagtgatgt gtccatagac ttctctcagg aggagtggga ctgcctggac
      301 cctgttcaga gggacttata cagagatgtg atgttggaga actacggcaa tctggtttca
      361 atgggacttt acactcctaa gcctcaagtg atctccttat tggaacaagg gaaagagccc
      421 tggatggttg gcagagagct tacaagaggc ctgtgttcag atctggaatc gatgtgtgaa
      481 accaagttat tatctctaaa gaaggaagtt tatgaaatag aattatgcca gagggagata
      541 atgggactta caaagcatgg ccttgagtac tccagttttg gagatgtttt ggaatataga
      601 agccaccttg caaaacaact gggatatcca aatgggcatt ttagtcaaga aatattcact
      661 cctgaataca tgcccacatt tattcaacag acattcctta ctctccatca aataattaat
      721 aatgaagaca gaccctatga atgtaagaaa tgtggaaagg cctttagtca gaactcacaa
      781 tttattcaac atcagagaat tcatattggt gaaaaatctt atgaatgtaa agagtgtggg
      841 aaattcttta gttgtggttc acatgttact cggcatctga aaattcatac tggcgaaaaa
      901 ccctttgaat gtaaggaatg tggaaaggcc ttcagttgta gctcatacct ttctcaacat
      961 cagagaatcc ataccggtaa gaaaccctat gaatgtaagg aatgtgggaa ggcctttagt
     1021 tattgctcaa atcttattga ccatcagcga attcacactg gtgaaaaacc ttatgaatgt
     1081 aaagtatgtg ggaaagcctt tactaagagc tcacaacttt ttcagcatgc acgaattcat
     1141 acaggtgaga aaccctatga atgtaaggaa tgtggcaaag cctttaccca gagctcaaag
     1201 cttgttcaac atcagagaat tcatactggt gagaaaccct atgagtgcaa ggaatgtggc
     1261 aaagccttta gtagtggctc agcacttact aatcatcaga gaattcacac tggtgagaaa
     1321 ccctatgatt gtaaggaatg tggaaaggct tttactcaga gctcacagct tcgtcaacat
     1381 cagagaattc acgctggtga gaaacccttt gaatgtcttg aatgtgggaa ggcctttact
     1441 cagaactcac aacttttcca gcatcagaga attcatacag atgaaaaacc atatgaatgt
     1501 aatgaatgtg gaaaggcctt taataaatgc tcaaacctta ctcgacatct gagaattcac
     1561 actggtgaaa agccctataa ctgtaaggaa tgtgggaagg cttttagtag tggctcggat
     1621 ctcattcgtc atcagggaat tcatactaat aaataataaa aattaaagcc cctgtcacct
     1681 tcctcatatt ttaaaccaaa aatcatgtct aatagttacc ctcttccgta gtttttttta
     1741 aaactttgta tttaaatttt gtatccaaat gtatttcatt ccaggttata aattcggagt
     1801 ctaaagtgac attccctctc tcccccagtc atataccgat gccagctgtt ctataattct
     1861 ttcattcatt gttttgttct actttcttgg tgacacatta tactcatgtt tatatttgct
     1921 tgtgttttta gagctatctt ttctgatctg tgtatttgtg tttgcaccag tatcacactg
     1981 tttgaattgt gtgaccttta atatttttaa attccttgtg gaggtttaac tttgtttttg
     2041 aagttagtgt tagtcttttt gttttatttt attattatta ttatatgttt tttgagacgg
     2101 agtttcactc tgttgcccag gctggagtgc agtggcgcaa tctcggctcg ctgcaacctc
     2161 cacctcccgg cttcaagcaa ttctcctgcc tcagactcct gagtagctgg gatcacaggc
     2221 gtgtgccacc acaccctgct aattttctat ttttagtaga gacagggttt ctccatgttg
     2281 gtcaggatag tcttgaactc ctgacctcag gtgatccacc tgcctcagcc tcccaaagtg
     2341 ctgggattac aggcatgagc gattgcacct ggctttattt tttgttgaga cggagtttcg
     2401 ctcttgttgc ctaggctgga gtgcaatggt gcaatctcgg ctcgtcacaa ccttcgcctc
     2461 ccaggttcaa gtggttcttc tgcctcagcc ttttgagtag ttgggattac aggcatgtgc
     2521 cacaacaccc ggctaatttt ttgtattttt agtagagacg gggtttcacc atgttagcca
     2581 ggatggtctc aatctcccga cttcaggtga tccacccgcc tcggcctccg aaagtgctgg
     2641 gattacaggc gtgagccact gcggccggtc tttttatttt acaaatgtac atttttaatt
     2701 gttaagccaa aatcacaaag caaaaaatta caaactaaaa agccaaaatt aattgtaatc
     2761 atacttatag atggctgctc tcaatttggt agagaaaatc gtgctatact ttgctttttt
     2821 aagaaagtgt aattatgata tgcatgctgt acccttaact gcttttatca tgccaaagat
     2881 ttcatgagtg ccatttcagt aaatatagat ttttattatt ttcatgacat atttaatgac
     2941 tttaaaatga ctattcccat tatggttgcc actaaatttt tgcagctata aaagctgacc
     3001 tcggctgggc acagtggctc atgcctgtaa tcccagcact ttgggaggcc gaggtgggcg
     3061 gatcacaagg tctgaagatt aaggccatcc tggctaacag tgaaaccccg tctctactta
     3121 gctgggcgtg gtggcatgta cctgtaatcc cagctactcg ggaggctgag acaggagaat
     3181 tgcttgaacc tgggaggcgg aggttgcagt gagctgagat ggtgccactg cactccagcc
     3241 tgggggacag agtgagattc cgtctcaaaa aaacacaaaa actgctgacc tcattggatg
     3301 cttattttta cttttaaaac atttatttta attgctaaaa ttatctacat tttctccttg
     3361 tgagctgttt tgttccctta catcaatcct aatcccaatg ccatactaga aagtaacact
     3421 gttatgaaag tgttatttat caatccagat attaattttt tgtttgtttg tttttttttt
     3481 tttttgagat ggagttcact ctgttgccca ggctgaagtg cagtggcaca atctcagttc
     3541 accacaactg ctgcctcccg ggttcaagcg attctcctgc ctcagccttc ctagtatctg
     3601 agactacagg cgcacgacac catgcctggc taatttttgt atttttagta gagacagggt
     3661 ttcactatgt tggccaggct ggtcttgaac tcttgacctt gtgatccacc cacctcggcc
     3721 tcccaaagtt cggggattac aggtgtgagc cactgtgccc ggtcaattat tttttcttat
     3781 agctattagt ggtgtttttg ttttttgaga cacagtctcg ctctgttgcc caggctggag
     3841 ggcagtggtg caatctcggc tcactgcaac ctctgcctcc cgagttcaag tgagtcttcc
     3901 gcctcagcct cccgagtagc tgggactaca ggcgcgcgcc accatgccta gctaattttt
     3961 gtattattag tagagatggg gtttcaccat attggccagg ctgctctcaa actcctgacc
     4021 tcgtgatcct cctgccttgg cttcccaaag tgctgggatt ataggtgtga gccaccgccc
     4081 ctggctgtta gtggtatttt aaaaaattat gtctaggcat ctataataag gctgtatgta
     4141 ttggattgct gtgaagagtc aatgaattaa taaatgcaaa gtacctcaaa ctgttatcac
     4201 ataatacagg tttagtaaaa gttttccact attatcagtg atatactcat tatcataagt
     4261 atcttcatta ggatttatgg aaaggatttt aaccatgttg tttacctttg gcaaatttgt
     4321 aattcatggt ggaaaaagag aaacacttgt aatgagtata acgaagcctt tccctatcat
     4381 tattattcag tgtggaattt taaaaggaag agaaaaagta tgtgtgcata gtctttgttc
     4441 agactttatc ttttatgcta cataaagaat accagtctga ggctgggcgc ggtggctcac
     4501 acctgtaatc ctagcacttt gggaggccaa ggtgggtgga tcacttgagg tcaggagctc
     4561 gagaccagcc tggccaacat ggtgaaaccc cgtctctact aaaaatacaa aaaaaacaaa
     4621 aacaaaaaca aatagccagg catggtgttg catgcctgta atcctagcta ctcaagaggc
     4681 tgaggtggga ggattgcttg aacctgggag ttggaggtta tagtgagctg agattgcacc
     4741 actgcacact ccagactggg tgacagagcg agactctgtc ttacaaaata aaaaataaac
     4801 ggttaccaat ctgaaaccct gaaaatatga tgagtagtag aaagcacagc tgtcaaaaaa
     4861 gcaggaagag attataaaat tttttctaat atttcccccc aaaatgcaga aaacatactg
     4921 gcaacattat ttgaccagaa gaagcagtac aataggataa ccatcaaata tctgattatt
     4981 aattcaatat tccctcttaa ttaacatggg ttaaggaata aatccctaat atatacatta
     5041 tttaaatgta catgaaaatg aaaacaattg aaaaacctgt gagtggcagt aaaagttgta
     5101 ttggaagttt tataacctaa tatttgtgca tatattgtaa tactaggaag aaaaaatata
     5161 gaacccaagg aactaaaaca agctgaaatg aattgtggga ggaaggaggt agtattattt
     5221 taaaaggcag aaataattga aagaaaaaaa ctggatctga atccaaaatt gatatttgat
     5281 ggaagagaaa aaaaatgaga caaagtttag tgattccaga ggtgaaataa ggatgacaaa
     5341 taaacaatat tgtatatgag aaattgaaat ggctatatat gtaaacttaa aagaactgtg
     5401 tcatttgggg taatgaaaat gtggcatggg taaaggttgt acaattttgt ttatatacta
     5461 caggtcactc aactatacac tttaaaaggg tgaatattat gctgtgtgaa tttgatctca
     5521 atttaaaaac ttaaggctgg ttgcagtggc tcatgcctgt aattccagca ctttgggagg
     5581 ctgaggtagg agaatggctt gaggccagga gttcaagacc agtctaggta acataatgag
     5641 atccccctcc cctcatctct acagaaaaaa aaaaaaatta aaacaacaaa cttaaaagtt
     5701 ggtattatag acatttttat aatatatctg aaaatctgga aaaagtctgt gatttttaat
     5761 aagttgacga catcagaatt aactggaggt gtaaaatctt aatagacctc cctccagaat
     5821 aaacttattt aaaaaaataa gactggccag gcatggtggc tcacgcctgt aatctcagca
     5881 ttctgtgagg ccaaggcggg tggatcacct gaggtcgggg atttgagacc agcctgacca
     5941 acatggagaa accctgtctc tactaaaaat acaaaaaatt agccgggcgt ggtggctcat
     6001 gcctgtaatc ccggctactc aggaggctga ggcaggagaa aggcttgaac ccgggaggca
     6061 gagattgcgg tgagcgggga tcatgccatt gcactccagc ctgggcaaca agagtgaaac
     6121 tctctcaaaa ataaataagt gaaataaaat ttttcttaaa atatatttta aatgtcaaat
     6181 tgctacacta aaaaagacac caaggtagag atttttatag gtgaaatcta tgaaatgtct
     6241 taggaaactc ttctaggaca tagactgaga tagcaaatta tctattttta aaatttgtca
     6301 taatcctgat gttacaacct actagaaccc aaaacaattt gtccagaatc agttatgaaa
     6361 atacagcatt ataaattagc aaatcaaatc tagtaaccca ttgaaaataa atatttgtca
     6421 cattctgaat ttaggaaaaa acaattctga taaatcaaac tttctacttt ctgaaacttg
     6481 aaaatcaaat tgatttagat aagattgtat ttcttagtgt ctgaactcag gaaccaaata
     6541 gatgtggata gcatgggatt tttggaatac aagataagat aatttacatg ggattgcaaa
     6601 agttcaaata actaaagttc tgtcaatgaa aatatatgct ctaacctcaa catcttctag
     6661 atgaaccctt ttttctagca gtatttgaca ggatgggata tattttataa ataaacttgg
     6721 actattatcc ta
//
