LOCUS       NM_001345947            6610 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 383 (ZNF383), transcript variant
            3, mRNA.
ACCESSION   NM_001345947 XM_005258587
VERSION     NM_001345947.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6610)
  AUTHORS   Liang,Y., Zhang,X., Geng,W., Wang,Y., Ding,Y., Song,Q., Yuan,Y.,
            Zhao,C., Tian,Z., Wang,J. and Tian,C.
  TITLE     19q13.12 KRAB zinc-finger protein ZNF383 represses p53 signaling
            pathway by interacting with p53
  JOURNAL   Cell Signal 98, 110405 (2022)
   PUBMED   35835334
  REMARK    GeneRIF: 19q13.12 KRAB zinc-finger protein ZNF383 represses p53
            signaling pathway by interacting with p53.
REFERENCE   2  (bases 1 to 6610)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6610)
  AUTHORS   Cao,L., Wang,Z., Zhu,C., Zhao,Y., Yuan,W., Li,J., Wang,Y., Ying,Z.,
            Li,Y., Yu,W., Wu,X. and Liu,M.
  TITLE     ZNF383, a novel KRAB-containing zinc finger protein, suppresses
            MAPK signaling pathway
  JOURNAL   Biochem Biophys Res Commun 333 (4), 1050-1059 (2005)
   PUBMED   15964543
  REMARK    GeneRIF: Overexpression of ZNF383 in cells inhibits the
            transcriptional activities of AP-1 and SRE, suggesting that ZNF383
            may act as a negative regulator in MAPK-mediated signaling
            pathways.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012309.8, AC016590.7 and
            KC877738.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001345947.1.
            
            Summary: The protein encoded by this gene is a KRAB-related zinc
            finger protein that inhibits the transcription of some MAPK
            signaling pathway genes. The repressor activity resides in the KRAB
            domain of the encoded protein. [provided by RefSeq, Sep 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.232013.1,
                                           ERR279861.2302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC012309.8         131439-131499
            62-115              AC012309.8         143634-143687
            116-242             AC012309.8         148774-148900
            243-338             AC012309.8         149204-149299
            339-1895            AC012309.8         155694-157250
            1896-6193           AC016590.7         113064-117361       c
            6194-6610           KC877738.1         149-565             c
FEATURES             Location/Qualifiers
     source          1..6610
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..6610
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /note="zinc finger protein 383"
                     /db_xref="GeneID:163087"
                     /db_xref="HGNC:HGNC:18609"
                     /db_xref="MIM:619499"
     exon            1..61
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /inference="alignment:Splign:2.1.0"
     exon            62..115
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1534
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /codon_start=1
                     /product="zinc finger protein 383"
                     /protein_id="NP_001332876.1"
                     /db_xref="CCDS:CCDS12501.1"
                     /db_xref="GeneID:163087"
                     /db_xref="HGNC:HGNC:18609"
                     /db_xref="MIM:619499"
                     /translation="MAEGSVMFSDVSIDFSQEEWDCLDPVQRDLYRDVMLENYGNLVS
                     MGLYTPKPQVISLLEQGKEPWMVGRELTRGLCSDLESMCETKLLSLKKEVYEIELCQR
                     EIMGLTKHGLEYSSFGDVLEYRSHLAKQLGYPNGHFSQEIFTPEYMPTFIQQTFLTLH
                     QIINNEDRPYECKKCGKAFSQNSQFIQHQRIHIGEKSYECKECGKFFSCGSHVTRHLK
                     IHTGEKPFECKECGKAFSCSSYLSQHQRIHTGKKPYECKECGKAFSYCSNLIDHQRIH
                     TGEKPYECKVCGKAFTKSSQLFQHARIHTGEKPYECKECGKAFTQSSKLVQHQRIHTG
                     EKPYECKECGKAFSSGSALTNHQRIHTGEKPYDCKECGKAFTQSSQLRQHQRIHAGEK
                     PFECLECGKAFTQNSQLFQHQRIHTDEKPYECNECGKAFNKCSNLTRHLRIHTGEKPY
                     NCKECGKAFSSGSDLIRHQGIHTNK"
     exon            116..242
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /inference="alignment:Splign:2.1.0"
     exon            243..338
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /inference="alignment:Splign:2.1.0"
     exon            339..6610
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6588..6593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /note="hexamer: AATAAA"
     polyA_site      6610
                     /gene="ZNF383"
                     /gene_synonym="HSD17; Zfp383"
                     /note="major polyA site"
ORIGIN      
        1 aagggtaggg gaagtgcgcg gtgagcggcc tgggtcttgc aggctcggct ggggcccgca
       61 ggagaacggc ctcaaggaag actaaccatc tgcaatacta gaagccatgg ctgagggatc
      121 agtgatgttc agtgatgtgt ccatagactt ctctcaggag gagtgggact gcctggaccc
      181 tgttcagagg gacttataca gagatgtgat gttggagaac tacggcaatc tggtttcaat
      241 gggactttac actcctaagc ctcaagtgat ctccttattg gaacaaggga aagagccctg
      301 gatggttggc agagagctta caagaggcct gtgttcagat ctggaatcga tgtgtgaaac
      361 caagttatta tctctaaaga aggaagttta tgaaatagaa ttatgccaga gggagataat
      421 gggacttaca aagcatggcc ttgagtactc cagttttgga gatgttttgg aatatagaag
      481 ccaccttgca aaacaactgg gatatccaaa tgggcatttt agtcaagaaa tattcactcc
      541 tgaatacatg cccacattta ttcaacagac attccttact ctccatcaaa taattaataa
      601 tgaagacaga ccctatgaat gtaagaaatg tggaaaggcc tttagtcaga actcacaatt
      661 tattcaacat cagagaattc atattggtga aaaatcttat gaatgtaaag agtgtgggaa
      721 attctttagt tgtggttcac atgttactcg gcatctgaaa attcatactg gcgaaaaacc
      781 ctttgaatgt aaggaatgtg gaaaggcctt cagttgtagc tcataccttt ctcaacatca
      841 gagaatccat accggtaaga aaccctatga atgtaaggaa tgtgggaagg cctttagtta
      901 ttgctcaaat cttattgacc atcagcgaat tcacactggt gaaaaacctt atgaatgtaa
      961 agtatgtggg aaagccttta ctaagagctc acaacttttt cagcatgcac gaattcatac
     1021 aggtgagaaa ccctatgaat gtaaggaatg tggcaaagcc tttacccaga gctcaaagct
     1081 tgttcaacat cagagaattc atactggtga gaaaccctat gagtgcaagg aatgtggcaa
     1141 agcctttagt agtggctcag cacttactaa tcatcagaga attcacactg gtgagaaacc
     1201 ctatgattgt aaggaatgtg gaaaggcttt tactcagagc tcacagcttc gtcaacatca
     1261 gagaattcac gctggtgaga aaccctttga atgtcttgaa tgtgggaagg cctttactca
     1321 gaactcacaa cttttccagc atcagagaat tcatacagat gaaaaaccat atgaatgtaa
     1381 tgaatgtgga aaggccttta ataaatgctc aaaccttact cgacatctga gaattcacac
     1441 tggtgaaaag ccctataact gtaaggaatg tgggaaggct tttagtagtg gctcggatct
     1501 cattcgtcat cagggaattc atactaataa ataataaaaa ttaaagcccc tgtcaccttc
     1561 ctcatatttt aaaccaaaaa tcatgtctaa tagttaccct cttccgtagt tttttttaaa
     1621 actttgtatt taaattttgt atccaaatgt atttcattcc aggttataaa ttcggagtct
     1681 aaagtgacat tccctctctc ccccagtcat ataccgatgc cagctgttct ataattcttt
     1741 cattcattgt tttgttctac tttcttggtg acacattata ctcatgttta tatttgcttg
     1801 tgtttttaga gctatctttt ctgatctgtg tatttgtgtt tgcaccagta tcacactgtt
     1861 tgaattgtgt gacctttaat atttttaaat tccttgtgga ggtttaactt tgtttttgaa
     1921 gttagtgtta gtctttttgt tttattttat tattattatt atatgttttt tgagacggag
     1981 tttcactctg ttgcccaggc tggagtgcag tggcgcaatc tcggctcgct gcaacctcca
     2041 cctcccggct tcaagcaatt ctcctgcctc agactcctga gtagctggga tcacaggcgt
     2101 gtgccaccac accctgctaa ttttctattt ttagtagaga cagggtttct ccatgttggt
     2161 caggatagtc ttgaactcct gacctcaggt gatccacctg cctcagcctc ccaaagtgct
     2221 gggattacag gcatgagcga ttgcacctgg ctttattttt tgttgagacg gagtttcgct
     2281 cttgttgcct aggctggagt gcaatggtgc aatctcggct cgtcacaacc ttcgcctccc
     2341 aggttcaagt ggttcttctg cctcagcctt ttgagtagtt gggattacag gcatgtgcca
     2401 caacacccgg ctaatttttt gtatttttag tagagacggg gtttcaccat gttagccagg
     2461 atggtctcaa tctcccgact tcaggtgatc cacccgcctc ggcctccgaa agtgctggga
     2521 ttacaggcgt gagccactgc ggccggtctt tttattttac aaatgtacat ttttaattgt
     2581 taagccaaaa tcacaaagca aaaaattaca aactaaaaag ccaaaattaa ttgtaatcat
     2641 acttatagat ggctgctctc aatttggtag agaaaatcgt gctatacttt gcttttttaa
     2701 gaaagtgtaa ttatgatatg catgctgtac ccttaactgc ttttatcatg ccaaagattt
     2761 catgagtgcc atttcagtaa atatagattt ttattatttt catgacatat ttaatgactt
     2821 taaaatgact attcccatta tggttgccac taaatttttg cagctataaa agctgacctc
     2881 ggctgggcac agtggctcat gcctgtaatc ccagcacttt gggaggccga ggtgggcgga
     2941 tcacaaggtc tgaagattaa ggccatcctg gctaacagtg aaaccccgtc tctacttagc
     3001 tgggcgtggt ggcatgtacc tgtaatccca gctactcggg aggctgagac aggagaattg
     3061 cttgaacctg ggaggcggag gttgcagtga gctgagatgg tgccactgca ctccagcctg
     3121 ggggacagag tgagattccg tctcaaaaaa acacaaaaac tgctgacctc attggatgct
     3181 tatttttact tttaaaacat ttattttaat tgctaaaatt atctacattt tctccttgtg
     3241 agctgttttg ttcccttaca tcaatcctaa tcccaatgcc atactagaaa gtaacactgt
     3301 tatgaaagtg ttatttatca atccagatat taattttttg tttgtttgtt tttttttttt
     3361 tttgagatgg agttcactct gttgcccagg ctgaagtgca gtggcacaat ctcagttcac
     3421 cacaactgct gcctcccggg ttcaagcgat tctcctgcct cagccttcct agtatctgag
     3481 actacaggcg cacgacacca tgcctggcta atttttgtat ttttagtaga gacagggttt
     3541 cactatgttg gccaggctgg tcttgaactc ttgaccttgt gatccaccca cctcggcctc
     3601 ccaaagttcg gggattacag gtgtgagcca ctgtgcccgg tcaattattt tttcttatag
     3661 ctattagtgg tgtttttgtt ttttgagaca cagtctcgct ctgttgccca ggctggaggg
     3721 cagtggtgca atctcggctc actgcaacct ctgcctcccg agttcaagtg agtcttccgc
     3781 ctcagcctcc cgagtagctg ggactacagg cgcgcgccac catgcctagc taatttttgt
     3841 attattagta gagatggggt ttcaccatat tggccaggct gctctcaaac tcctgacctc
     3901 gtgatcctcc tgccttggct tcccaaagtg ctgggattat aggtgtgagc caccgcccct
     3961 ggctgttagt ggtattttaa aaaattatgt ctaggcatct ataataaggc tgtatgtatt
     4021 ggattgctgt gaagagtcaa tgaattaata aatgcaaagt acctcaaact gttatcacat
     4081 aatacaggtt tagtaaaagt tttccactat tatcagtgat atactcatta tcataagtat
     4141 cttcattagg atttatggaa aggattttaa ccatgttgtt tacctttggc aaatttgtaa
     4201 ttcatggtgg aaaaagagaa acacttgtaa tgagtataac gaagcctttc cctatcatta
     4261 ttattcagtg tggaatttta aaaggaagag aaaaagtatg tgtgcatagt ctttgttcag
     4321 actttatctt ttatgctaca taaagaatac cagtctgagg ctgggcgcgg tggctcacac
     4381 ctgtaatcct agcactttgg gaggccaagg tgggtggatc acttgaggtc aggagctcga
     4441 gaccagcctg gccaacatgg tgaaaccccg tctctactaa aaatacaaaa aaaacaaaaa
     4501 caaaaacaaa tagccaggca tggtgttgca tgcctgtaat cctagctact caagaggctg
     4561 aggtgggagg attgcttgaa cctgggagtt ggaggttata gtgagctgag attgcaccac
     4621 tgcacactcc agactgggtg acagagcgag actctgtctt acaaaataaa aaataaacgg
     4681 ttaccaatct gaaaccctga aaatatgatg agtagtagaa agcacagctg tcaaaaaagc
     4741 aggaagagat tataaaattt tttctaatat ttccccccaa aatgcagaaa acatactggc
     4801 aacattattt gaccagaaga agcagtacaa taggataacc atcaaatatc tgattattaa
     4861 ttcaatattc cctcttaatt aacatgggtt aaggaataaa tccctaatat atacattatt
     4921 taaatgtaca tgaaaatgaa aacaattgaa aaacctgtga gtggcagtaa aagttgtatt
     4981 ggaagtttta taacctaata tttgtgcata tattgtaata ctaggaagaa aaaatataga
     5041 acccaaggaa ctaaaacaag ctgaaatgaa ttgtgggagg aaggaggtag tattatttta
     5101 aaaggcagaa ataattgaaa gaaaaaaact ggatctgaat ccaaaattga tatttgatgg
     5161 aagagaaaaa aaatgagaca aagtttagtg attccagagg tgaaataagg atgacaaata
     5221 aacaatattg tatatgagaa attgaaatgg ctatatatgt aaacttaaaa gaactgtgtc
     5281 atttggggta atgaaaatgt ggcatgggta aaggttgtac aattttgttt atatactaca
     5341 ggtcactcaa ctatacactt taaaagggtg aatattatgc tgtgtgaatt tgatctcaat
     5401 ttaaaaactt aaggctggtt gcagtggctc atgcctgtaa ttccagcact ttgggaggct
     5461 gaggtaggag aatggcttga ggccaggagt tcaagaccag tctaggtaac ataatgagat
     5521 ccccctcccc tcatctctac agaaaaaaaa aaaaattaaa acaacaaact taaaagttgg
     5581 tattatagac atttttataa tatatctgaa aatctggaaa aagtctgtga tttttaataa
     5641 gttgacgaca tcagaattaa ctggaggtgt aaaatcttaa tagacctccc tccagaataa
     5701 acttatttaa aaaaataaga ctggccaggc atggtggctc acgcctgtaa tctcagcatt
     5761 ctgtgaggcc aaggcgggtg gatcacctga ggtcggggat ttgagaccag cctgaccaac
     5821 atggagaaac cctgtctcta ctaaaaatac aaaaaattag ccgggcgtgg tggctcatgc
     5881 ctgtaatccc ggctactcag gaggctgagg caggagaaag gcttgaaccc gggaggcaga
     5941 gattgcggtg agcggggatc atgccattgc actccagcct gggcaacaag agtgaaactc
     6001 tctcaaaaat aaataagtga aataaaattt ttcttaaaat atattttaaa tgtcaaattg
     6061 ctacactaaa aaagacacca aggtagagat ttttataggt gaaatctatg aaatgtctta
     6121 ggaaactctt ctaggacata gactgagata gcaaattatc tatttttaaa atttgtcata
     6181 atcctgatgt tacaacctac tagaacccaa aacaatttgt ccagaatcag ttatgaaaat
     6241 acagcattat aaattagcaa atcaaatcta gtaacccatt gaaaataaat atttgtcaca
     6301 ttctgaattt aggaaaaaac aattctgata aatcaaactt tctactttct gaaacttgaa
     6361 aatcaaattg atttagataa gattgtattt cttagtgtct gaactcagga accaaataga
     6421 tgtggatagc atgggatttt tggaatacaa gataagataa tttacatggg attgcaaaag
     6481 ttcaaataac taaagttctg tcaatgaaaa tatatgctct aacctcaaca tcttctagat
     6541 gaaccctttt ttctagcagt atttgacagg atgggatata ttttataaat aaacttggac
     6601 tattatccta
//
