LOCUS       NM_032825               8336 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 382 (ZNF382), transcript variant
            1, mRNA.
ACCESSION   NM_032825
VERSION     NM_032825.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8336)
  AUTHORS   Ning,X.H., Qi,Y.Y., Wang,F.X., Li,S.C., Jia,Z.K. and Yang,J.J.
  TITLE     A Three Protein-Coding Gene Prognostic Model Predicts Overall
            Survival in Bladder Cancer Patients
  JOURNAL   Biomed Res Int 2020, 7272960 (2020)
   PUBMED   33150179
  REMARK    GeneRIF: A Three Protein-Coding Gene Prognostic Model Predicts
            Overall Survival in Bladder Cancer Patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8336)
  AUTHORS   Chen,S., Xiao,Z., Zhou,J., Yang,M., Feng,S., Huang,Q., Zou,J.,
            Zeng,T., Li,Y., Peng,L., Zeng,Y. and Zeng,X.
  TITLE     ZNF382: A transcription inhibitor down-regulated in multiple tumors
            due to promoter methylation
  JOURNAL   Clin Chim Acta 500, 220-225 (2020)
   PUBMED   31678273
  REMARK    GeneRIF: ZNF382 is downregulated in multiple tumors due to
            hypermethylation of its promoter
            Review article
REFERENCE   3  (bases 1 to 8336)
  AUTHORS   Dang,S., Zhou,J., Chen,Y., Chen,P., Ji,M., Shi,B., Yang,Q. and
            Hou,P.
  TITLE     Dynamic expression of ZNF382 and its tumor-suppressor role in
            hepatitis B virus-related hepatocellular carcinogenesis
  JOURNAL   Oncogene 38 (24), 4804-4819 (2019)
   PUBMED   30804458
  REMARK    GeneRIF: ZNF382 acts as a tumor suppressor, and is co-regulated by
            HBx and epigenetic mechanism in Hepatitis B virus-related
            hepatocellular carcinogenesis.
REFERENCE   4  (bases 1 to 8336)
  AUTHORS   Pei,L., He,X., Li,S., Sun,R., Xiang,Q., Ren,G. and Xiang,T.
  TITLE     KRAB zinc-finger protein 382 regulates epithelial-mesenchymal
            transition and functions as a tumor suppressor, but is silenced by
            CpG methylation in gastric cancer
  JOURNAL   Int J Oncol 53 (3), 961-972 (2018)
   PUBMED   29956735
  REMARK    GeneRIF: Study suggests that ZNF382 functions as a tumor suppressor
            in gastric cancer (GC) cells, but is frequently methylated in both
            GC cell lines and primary gastric tumors.
REFERENCE   5  (bases 1 to 8336)
  AUTHORS   Zhang,C., Xiang,T., Li,S., Ye,L., Feng,Y., Pei,L., Li,L., Wang,X.,
            Sun,R., Ren,G. and Tao,Q.
  TITLE     The novel 19q13 KRAB zinc-finger tumour suppressor ZNF382 is
            frequently methylated in oesophageal squamous cell carcinoma and
            antagonises Wnt/beta-catenin signalling
  JOURNAL   Cell Death Dis 9 (5), 573 (2018)
   PUBMED   29760376
  REMARK    GeneRIF: findings demonstrate that ZNF382 functions as a bona fide
            tumour suppressor inhibiting oesophageal squamous cell carcinoma
            pathogenesis through inhibiting the Wnt/beta-catenin signalling
            pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8336)
  AUTHORS   Liu,Z., Zhang,J., Gao,Y., Pei,L., Zhou,J., Gu,L., Zhang,L., Zhu,B.,
            Hattori,N., Ji,J., Yuasa,Y., Kim,W., Ushijima,T., Shi,H. and
            Deng,D.
  TITLE     Large-scale characterization of DNA methylation changes in human
            gastric carcinomas with and without metastasis
  JOURNAL   Clin Cancer Res 20 (17), 4598-4612 (2014)
   PUBMED   25009298
  REMARK    GeneRIF: Methylation changes of GFRA1, SRF, and ZNF382 may be a
            potential biomarker set for prediction of gastric carcinoma
            metastasis.
REFERENCE   7  (bases 1 to 8336)
  AUTHORS   Xiao,T.Z., Bhatia,N., Urrutia,R., Lomberk,G.A., Simpson,A. and
            Longley,B.J.
  TITLE     MAGE I transcription factors regulate KAP1 and KRAB domain zinc
            finger transcription factor mediated gene repression
  JOURNAL   PLoS One 6 (8), e23747 (2011)
   PUBMED   21876767
  REMARK    GeneRIF: Expression of MAGE I proteins, MAGE-A3 or MAGE-C2,
            relieved repression of a reporter gene by ZNF382 and MAGE I
            expression relieved KAP1 mediated ID1 repression.
REFERENCE   8  (bases 1 to 8336)
  AUTHORS   Cheng,Y., Geng,H., Cheng,S.H., Liang,P., Bai,Y., Li,J.,
            Srivastava,G., Ng,M.H., Fukagawa,T., Wu,X., Chan,A.T. and Tao,Q.
  TITLE     KRAB zinc finger protein ZNF382 is a proapoptotic tumor suppressor
            that represses multiple oncogenes and is commonly silenced in
            multiple carcinomas
  JOURNAL   Cancer Res 70 (16), 6516-6526 (2010)
   PUBMED   20682794
  REMARK    GeneRIF: ZNF382 is a functional tumor suppressor frequently
            methylated in multiple carcinomas.
REFERENCE   9  (bases 1 to 8336)
  AUTHORS   Urrutia,R.
  TITLE     KRAB-containing zinc-finger repressor proteins
  JOURNAL   Genome Biol 4 (10), 231 (2003)
   PUBMED   14519192
  REMARK    Review article
REFERENCE   10 (bases 1 to 8336)
  AUTHORS   Luo,K., Yuan,W., Zhu,C., Li,Y., Wang,Y., Zeng,W., Jiao,W., Liu,M.
            and Wu,X.
  TITLE     Expression of a novel Krupple-like zinc-finger gene, ZNF382, in
            human heart
  JOURNAL   Biochem Biophys Res Commun 299 (4), 606-612 (2002)
   PUBMED   12459182
  REMARK    GeneRIF: mapped to chromosome 19q13.13; transcript specific for
            ZNF382 is expressed at very early embryonic stage; at the adult
            stage, ZNF382 expression is restricted largely to heart tissue
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD690493.1, AF513816.1 and
            AC074138.5.
            
            On Nov 22, 2018 this sequence version replaced NM_032825.4.
            
            Summary: This gene encodes a KRAB domain zinc finger transcription
            factor (KZNF). KZNFs play critical roles in the regulation of many
            cellular processes including differentiation, proliferation and
            apoptosis. The encoded protein inhibits activating protein 1 (AP-1)
            and nuclear factor kappa-B (NF-kB) signaling and may function as a
            tumor suppressor in multiple carcinomas. This gene is found in a
            cluster with other zinc finger protein genes on the long arm of
            chromosome 19, and alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF513816.1, SRR1803615.134227.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292928.7/ ENSP00000292928.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-542               CD690493.1         30-571
            543-2819            AF513816.1         531-2807
            2820-8336           AC074138.5         80894-86410
FEATURES             Location/Qualifiers
     source          1..8336
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..8336
                     /gene="ZNF382"
                     /gene_synonym="KS1"
                     /note="zinc finger protein 382"
                     /db_xref="GeneID:84911"
                     /db_xref="HGNC:HGNC:17409"
                     /db_xref="MIM:609516"
     exon            1..35
                     /gene="ZNF382"
                     /gene_synonym="KS1"
                     /inference="alignment:Splign:2.1.0"
     exon            36..106
                     /gene="ZNF382"
                     /gene_synonym="KS1"
                     /inference="alignment:Splign:2.1.0"
     exon            107..258
                     /gene="ZNF382"
                     /gene_synonym="KS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1772
                     /gene="ZNF382"
                     /gene_synonym="KS1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     KRAB/zinc finger suppressor protein 1; multiple zinc
                     finger and krueppel-associated box protein KS1"
                     /codon_start=1
                     /product="zinc finger protein 382 isoform 1"
                     /protein_id="NP_116214.2"
                     /db_xref="CCDS:CCDS33004.1"
                     /db_xref="GeneID:84911"
                     /db_xref="HGNC:HGNC:17409"
                     /db_xref="MIM:609516"
                     /translation="MPLQGSVSFKDVTVDFTQEEWQQLDPAQKALYRDVMLENYCHFV
                     SVGFHMAKPDMIRKLEQGEELWTQRIFPSYSYLEEDGKTEDVLVKFKEYQDRHSRPLI
                     FINHKKLIKERSNIYGKTFTLGKNRISKTILCEYKPDGKVLKNISELVIRNISPIKEK
                     FGDSTGWEKSLLNTKHEKIHPAVNLHKQTERVLSGKQELIQHQKVQAPEQPFDHNECE
                     KSFLMKGMLFTHTRAHRGERTFEYNKDGIAFIEKSSLSVHPSNLMEKKPSAYNKYGKF
                     LCRKPVFIMPQRPQTEEKPFHCPYCGNNFRRKSYLIEHQRIHTGEKPYVCNQCGKAFR
                     QKTALTLHEKTHIEGKPFICIDCGKSFRQKATLTRHHKTHTGEKAYECPQCGSAFRKK
                     SYLIDHQRTHTGEKPYQCNECGKAFIQKTTLTVHQRTHTGEKPYICNECGKSFCQKTT
                     LTLHQRIHTGEKPYICNECGKSFRQKAILTVHHRIHTGEKSNGCPQCGKAFSRKSNLI
                     RHQKTHTGEKPYECKQCGKFFSCKSNLIVHQKTHKVETTGIQ"
     exon            259..351
                     /gene="ZNF382"
                     /gene_synonym="KS1"
                     /inference="alignment:Splign:2.1.0"
     exon            352..8336
                     /gene="ZNF382"
                     /gene_synonym="KS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2472..2477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF382"
                     /gene_synonym="KS1"
                     /note="hexamer: AATAAA"
     polyA_site      2496
                     /gene="ZNF382"
                     /gene_synonym="KS1"
     regulatory      8312..8317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF382"
                     /gene_synonym="KS1"
                     /note="hexamer: AATAAA"
     polyA_site      8336
                     /gene="ZNF382"
                     /gene_synonym="KS1"
                     /note="major polyA site"
ORIGIN      
        1 gcagacgact caccctgggc cgggggtgag gcttggactg tttctttttc caaaagagga
       61 gctcaaaaga gaaagttcat ctagaaatct caaagccatg tctcaggatg aactagagta
      121 tgcccttaca gggatcagtg tcattcaagg atgtgactgt ggacttcacc caggaggagt
      181 ggcagcaact agaccctgct cagaaggcgc tttacaggga tgtgatgttg gaaaactatt
      241 gccacttcgt atctgtgggg tttcacatgg ctaagcctga tatgatccgc aagttggaac
      301 aaggagaaga gctatggaca cagagaattt ttccaagtta cagctaccta gaagaagatg
      361 ggaaaactga agatgtctta gtgaagttca aagaatacca agacaggcat tctagacccc
      421 tcatattcat caaccacaaa aaactaatta aggagagaag taatatttat ggtaaaacat
      481 ttactctagg caagaaccgt atttcaaaaa caatactatg tgaatataaa cctgatggaa
      541 aagttttgaa aaatatttca gaactagtca ttagaaatat aagccccata aaagagaagt
      601 ttggtgacag tactggatgg gagaaatcac tcctcaatac caagcatgag aaaattcatc
      661 ctgcagtgaa tctccataaa caaacagaaa gagttctcag tggtaaacag gagcttattc
      721 agcatcagaa ggttcaagct ccagagcaac catttgacca taatgaatgt gaaaaatcct
      781 tcctgatgaa aggaatgcta tttacacata ctagagctca cagaggagaa agaacctttg
      841 aatacaataa agatggaatt gccttcatag aaaagtcaag cctcagtgtc catccaagta
      901 atcttatgga aaagaagccc tctgcctaca acaaatatgg gaaattcctc tgcagaaagc
      961 ctgtttttat tatgcctcag agacctcaaa cagaagagaa accctttcac tgtccttact
     1021 gtgggaataa ctttagaagg aagtcatacc tcattgaaca tcagcgaatt cacacaggtg
     1081 aaaaacctta tgtttgcaat caatgtggaa aggccttccg tcagaagaca gccctcaccc
     1141 ttcatgagaa aacacatata gaggggaaac cctttatttg tatcgattgt gggaagtcct
     1201 tccgccagaa ggccaccctc actagacatc acaaaacaca tacgggggag aaagcctatg
     1261 aatgtcctca gtgtggaagt gcctttagga agaagtcata cctcattgat caccagagaa
     1321 ctcacacagg agagaaaccg tatcagtgta atgagtgtgg gaaggcattt atccagaaga
     1381 caaccctcac tgttcatcag agaactcaca caggagagaa accctatatt tgcaatgaat
     1441 gtgggaagtc cttctgccaa aagacaaccc tcactctcca ccagagaatt cacacggggg
     1501 aaaaacccta tatttgtaat gaatgtggga agtccttccg ccagaaggca atcctcactg
     1561 ttcatcacag aatacataca ggagaaaaat ccaatgggtg tcctcagtgt gggaaagcct
     1621 tcagtaggaa atcaaacctc attcgccatc agaaaactca cacaggcgag aaaccatatg
     1681 aatgtaaaca gtgtgggaag ttcttcagtt gtaagtcaaa cctcattgtc catcagaaaa
     1741 ctcacaaggt agaaaccacg ggaattcagt aagtaatgtg gctttttttg taaaaaaatg
     1801 ttaagtcata gtaaaccctg tagatgatgt tgcttgcaag cgtaatatcc aacagtttaa
     1861 ggtactatac cacatggtaa cctactgttt gccagcctgt aaaacacaca cacacacaca
     1921 cacacacaca caaatattat tagacaaatt agatgacaaa aatcattaag aagtccaaac
     1981 ttttttttta ttactagctt cagcagacaa aaacttcctc tgtcaaggtg ttataaacat
     2041 ttaaaatcac attttccatt tccatacata tctttttgtt catcagtaat aactagttgg
     2101 ccaactgact gtggtccatg gactacacag tgagtagagg ttctttaaaa gaaggaggta
     2161 tgaactgtat ttctcattgc aaatacaaaa taaaaattag ttgttacctc ctcacagttg
     2221 accatgattc tgacttctaa cattacaaat tagtttttac tattataaac ctttctataa
     2281 attggattat atatcatgta ttctttcata tacagcttat taccttcatc atgtccgtga
     2341 gtctaatcat tagtacgtgt ggcagaagtt tatttatttt tatccagtat agaattcaat
     2401 tatatgatta tatcacaatt tatccattct gctgttgatg gacttttaca ttgtttacag
     2461 cttagggtca taataaatca tgcttctgag aacatacttg tcttggtgta catacatgta
     2521 tttctcttgt gtatatactt aggagtggaa tcgctgggtc ttagagcatg tgtgtattca
     2581 gtcagatact ggcagacaat tcagaacttt caccacatga gataattgac actgaaggga
     2641 aacagctata aattttatca atatggtgct ggttcaaacc agagaattca tgctgcaggg
     2701 aaactcaatc aatgttattg tgaaaactgg gaatgtgaat gtaatatatg tagaaaaaca
     2761 tttagccaca gcccaaatct tccaggcaaa tgtaataaac gtgacattgc cgttagccac
     2821 agtaaatgcc ttatttgaac tcaaaaagtc tactagagga gaggcatcca gcatttccct
     2881 tgttcaacat cagagaattc caactagaga aaagtcctgt gactgtgttg aagttagggc
     2941 gtggggagga atatagtctt tacctatggt ctgtatctac tggtcaggta caaatgatga
     3001 atatggaaaa gcttatagcc atcattcata tattatacta caccagggaa ttcacatagg
     3061 atgagaactc ttcaaatgaa atgattgtaa gaatgacttt aactgttgct catttctttt
     3121 acaccatcaa agaattaata ccaaagaaag gaagattaca aggaaacaaa tgggtcttgg
     3181 gacttttttt tttttttttt tgagacagaa tcttgctctg tcacccaggc gggagtgcag
     3241 tggcatgatc ttggctcact gcagcctctg cctcccaggt tccagtgatt ctcctgcctc
     3301 agcctcccgg gtagctgaga ttacaggcac acgccacacg cacagctaat tttcgtattt
     3361 ttagtagaga cagggtttca tcatgttggc caggctggtc tcgaactcct gacctcaggt
     3421 gatctgcctg cctcggcctc ccaaagtgct aggattacag ggacttttaa ctctggggaa
     3481 agctctcttt catgaaagaa gtctagccat accgagacca taatgctagg aagtctatgt
     3541 gtaggccccc tggtcaacag ctacagctga gctcccagcc atcagctagc atcagctgcc
     3601 aaccatgtaa gtgaggcctc ttggacatcc agtcaagcct tcagatgact gtggaccctg
     3661 ctaacaccca actggtacca caaatgagac ctcaagcaag aactgcccag ctgaggcctt
     3721 cccaaattcc tggccaacaa aatcatcagg ctttttaact acaaacagtt ttatttttta
     3781 tttaataaaa aagtttttat ttaacttgat tgttttatta aaagggaaaa gtaatttttt
     3841 agtatctgtt aatatataat aaaaataaag gtataagcct gggcttggtg gctcatttct
     3901 gtaatcccag cactttggga ggtgttggga ggatcacttg agcccaggag ttcgagacca
     3961 gcctgggaaa catgccaaaa ccccatctct acaaaaaatt agccaggaat ggtggcacat
     4021 gcctgtagtc ccagctactc gggaggctga gtgggaggat cacttgggcc cgggaggcgg
     4081 aggttgcagt gagccaggat agcaccactg cactccagcc tgggtaacag agcgagaccc
     4141 tgtctcataa ataaataaat acataaaggt gtaaatatat ggattctaga gtcaatgagc
     4201 aaaggtattg ttgttactaa taggtgattt tggcatgaag aaaaactggc cataaaatac
     4261 agttgaagat ttggctgcat ttttgcctta cgattacata ccttaataat tacaactcaa
     4321 ttgaggggtc catatatatt ctttctcatt ttctggcagt aaatcatatt catcatatac
     4381 ttcccaattt tgcacacaca aaaaatgaaa atagccccca aaagaaaggc aggataatgc
     4441 gatctatcct caaaagaccc cgtgctgtca tttctcaaca aaggcgcaga gagaaatcaa
     4501 ggtatggaat ctaatgaatg tccgtgaagg aggtactttt gaatgcttta aagaaagtct
     4561 aaataaagtt gcgttttctt ttcttttttt ttttttttga gacagagttt cacttttgtt
     4621 tcccaggctg gagtgcaatg gcgcaatttc ggctcattgc aacctctacc tcaagcaatt
     4681 ctcctgcctc agcctcccaa gtagctggga ttacaggcgc ccacctgtat ttttagtaga
     4741 gacggggttt catcatgttg gccaggctgg tctccaaagc ctgacctcag gcgatccacc
     4801 cgcctcagcc tcccaaagtg ctgagattac aggtgtgagc caccgcaccc agccgaaatt
     4861 gtgttttcta aagctattta catataagct gccgctcctt aggaaaattt ggtcctgtgg
     4921 tttatatttt ggcatgaaac agcattgggc tgtattccag aatcctgctt gaagatttct
     4981 tttgaagaaa tcagaaattt tctttgcatt ttttttattt ttttgagaca ggttctcagt
     5041 ctgtcaccta ggctggagta gagtggtgcc attatagctc actgcagact tgaattcctg
     5101 gactcaagca attctcctgc ctcagcctcc caagtagcta ggactacagg caggcgccat
     5161 tcctctcagc taatgttttt attttttata catatggggt ctcgttgtgt tgcccaggct
     5221 ggtattgaac tcctggcctc aagcaatctt ccctcttcgg cctcctaaaa tgctggggtt
     5281 acaggtgtga gccacttcac tcactttaga gattttcact ttatgaattg ataaatacag
     5341 cattgcatca cttaataggg atacattctg agaaatgcat catgaggcag tgtcatgatc
     5401 gtgcaagcat cacagagtgc tgatacaaac cgagatggta cagcctacta aacacctagg
     5461 ctatatggta gagcctgttg ctcctaggct acaaatctgt actgcatgtt actgtgctgg
     5521 atactatagg caattgtaac acaatggtaa ttatttgtat atgtaaacct atctaaacac
     5581 agaaaaggta cagtaaaaat gtggtactat aatctttttt tttttttgag acagagtctc
     5641 actctgtcgc ccaggctggt gtgcagtggt gtgatctcgg ctcattgcaa cctccgcctc
     5701 ctgggttcaa gtgattctcc tgcctcagcc tcatgagtag ctgggactac aggtgcacac
     5761 caccaaaccc ggctaatttt tgtattttta gtagagacgg ggtttcacca tgttggccag
     5821 gatggtctca atctcctgac ctcgtgatcc acccgcctcg gcctctcaaa gtgctgggat
     5881 tacaggtgtg agccaccatg cctggctggt actataatct tatgagacca ccattatata
     5941 tgcagtccat catggaccaa aatgtcatgt ggtgcatgag tatttttcat ctaacttata
     6001 tattgctcaa tgaagtttgg gcaactctaa ggagcaaaca tgtttataga atctaagtca
     6061 acttgaccta aacatatacg acaaaatagg agtgatttta caaattcata ttttgtagac
     6121 ctaactgcaa ggtcataagg catatgcaaa atgagttcat cagttcagag gactaacagg
     6181 actccacaga gcatacccag gaaatgtttt tacttagaag caaaggatgt ggctcagcaa
     6241 aagaaaggga aggtaagcat tagggctcag aatcatctag ctgcacattc ctcagtggtt
     6301 ttattcacac acagaccgca cactgtctct gaactgaagc actaagacct gtatcaaact
     6361 tgatttgggg agagctgaca gcagaacttc tctacatggg tttttttgtt gtcattgttt
     6421 tgttttttga gacagagtct tgctctgtca cccaggctgg agtgcaatgg tgcaatctca
     6481 gcccactgca acctccgcct cccaggttca agcaagtctc ctgccacagc ctccctaagt
     6541 atctgggatt acaggcatgt gccaccacaa ccagctagtt tttgtgtttt tagtagagac
     6601 agggtttctc catgttggcc aggctggtct cgaagtcctg acctcaggca atcctccgcc
     6661 cacctcggtt tcccaaagtg ctgggattat aggcatgagc caccgtgccc agccactgca
     6721 tgggtattta tgcttctctg ttcactggtt acatagtcaa gccaggctat ctaactggtt
     6781 atgtaagttt aaaaaagtta aaaagccatc ataaacaaat tggctctggg agtctcccag
     6841 ggaatatcag actttaacta gtaccttgta tagctcactg gccttatccc aaccaagagt
     6901 cagagccaga catctgggca tcgtggagat aattttagag ctttgcagtc tgactgtaaa
     6961 tcagctccat cttataaaca tggttcctat aactgctgtg tatttcctga taatgtatgt
     7021 gaacaagcat atctcctcac cctctgtgtc cccagtatca gatagtgcac agtacatctc
     7081 aaatgtgatc atttcttgtc agctaatgct tgaatttctc cactcagttt ctggtctagc
     7141 aatagagcca ggcttgccat gtcctgcttc acaagtaatg tgcaacagca aaagcacagg
     7201 ctccaacact agtctacaac atgcacctgg gatgttctag atatttatca gtttataatc
     7261 aggctttttt tttttttttg agacagtgtc tcgctctgtc gcccaggctg gaggcagtgg
     7321 ctcgatcttg gctcactgta agctccgcct cctgggttca caccattgtc ctgcctcagc
     7381 ctcctgagta gctgggacta caggcacctg ccaccatgcc cagctaattt tttgtatttt
     7441 tagtagagac ggggttttac tgtgttagcc agggtggtgt cgatctcctg acctcatgat
     7501 ccgcccacct cgacctccca aagtgctggg attacaggcg tgagccaccg cacccggcct
     7561 ataatcggac ttttcaaaac cctagatatg tgacaatacc aagtgctgac aagaatgtgg
     7621 aacaactgga actctttctt ttttaacttt tgttttagat tcaggagtac aggtgtggat
     7681 ttgttactgg aactttcata cattgctaat aggaaaggca aaatggtaaa gccggtctgg
     7741 aaaacaatat gccagtctca aaaagttaca catccaatat gacccagcaa tcccacttat
     7801 aagtacttat cctagagaaa tgaaaaatta tgtgcacaca gaaacctgta catgagtgtt
     7861 tgtaagtatt atttataatt aaaaaaaaaa ctagagacaa gcaaatgttc ttcagtgtgt
     7921 aaatggatac actgtggtac attcccaaga tggaattcta ctcaacgata acaataatga
     7981 gctactgaaa catgcagcta catagatgaa cctcaaatgc attacgctaa aggaaagaac
     8041 ccagtcccaa aaagttacat actgtatgat tccatttata tgacatgctg gaaaaggtga
     8101 aaatataaca acagaaaaca gatcaaatgt tgctgagtgt ctggggtggg gtggggtctg
     8161 aatacagagg ggttgcacga ggcaattctt tgaggtgttg gaattgtttt gtatcctgct
     8221 tgtggtcata gataaaaaat ctatgcatgt gtaaaaaata gaagtataca tacaaaaaag
     8281 tgaattgtac tgtctgtaat ttttttaaat aaataaaaat ccctagctct gcttca
//
