LOCUS       NM_152625               6262 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 366 (ZNF366), mRNA.
ACCESSION   NM_152625
VERSION     NM_152625.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6262)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 6262)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6262)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6262)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 6262)
  AUTHORS   Sondergaard,J.N., Poghosyan,S., Hontelez,S., Louche,P.,
            Looman,M.W., Ansems,M. and Adema,G.J.
  TITLE     DC-SCRIPT Regulates IL-10 Production in Human Dendritic Cells by
            Modulating NF-kappaBp65 Activation
  JOURNAL   J Immunol 195 (4), 1498-1505 (2015)
   PUBMED   26170389
  REMARK    GeneRIF: These data demonstrate that besides nuclear receptor
            regulation, DC-SCRIPT also modulates activation of NF-kappaBp65
            after TLR activation in human DCs.
REFERENCE   6  (bases 1 to 6262)
  AUTHORS   Ansems,M., Hontelez,S., Karthaus,N., Span,P.N. and Adema,G.J.
  TITLE     Crosstalk and DC-SCRIPT: expanding nuclear receptor modulation
  JOURNAL   Biochim Biophys Acta 1806 (2), 193-199 (2010)
   PUBMED   20478364
  REMARK    GeneRIF: DC-SCRIPT can act as a tumor suppressor in breast cancer
            development.[review]
            Review article
REFERENCE   7  (bases 1 to 6262)
  AUTHORS   Malarstig,A., Buil,A., Souto,J.C., Clarke,R., Blanco-Vaca,F.,
            Fontcuberta,J., Peden,J., Andersen,M., Silveira,A., Barlera,S.,
            Seedorf,U., Watkins,H., Almasy,L., Hamsten,A. and Soria,J.M.
  CONSRTM   Genetic Analysis of Idiopathic Thrombophilia (GAIT) and Precocious
            Coronary Artery Disease (PROCARDIS) consortia
  TITLE     Identification of ZNF366 and PTPRD as novel determinants of plasma
            homocysteine in a family-based genome-wide association study
  JOURNAL   Blood 114 (7), 1417-1422 (2009)
   PUBMED   19525478
  REMARK    GeneRIF: Identification of ZNF366 and PTPRD as novel determinants
            of plasma homocysteine in a family-based genome-wide association
            study
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 6262)
  AUTHORS   Triantis,V., Trancikova,D.E., Looman,M.W., Hartgers,F.C.,
            Janssen,R.A. and Adema,G.J.
  TITLE     Identification and characterization of DC-SCRIPT, a novel dendritic
            cell-expressed member of the zinc finger family of transcriptional
            regulators
  JOURNAL   J Immunol 176 (2), 1081-1089 (2006)
   PUBMED   16393996
  REMARK    GeneRIF: DC-SCRIPT consists of a proline-rich region, 11 C2H2-type
            zinc fingers, and an acidic region. Localization studies reveal
            that DC-SCRIPT resides in the nucleus and that nuclear localization
            is critically dependent on the zinc fingers. (DC-SCRIPT)
REFERENCE   9  (bases 1 to 6262)
  AUTHORS   Lopez-Garcia,J., Periyasamy,M., Thomas,R.S., Christian,M., Leao,M.,
            Jat,P., Kindle,K.B., Heery,D.M., Parker,M.G., Buluwela,L.,
            Kamalati,T. and Ali,S.
  TITLE     ZNF366 is an estrogen receptor corepressor that acts through CtBP
            and histone deacetylases
  JOURNAL   Nucleic Acids Res 34 (21), 6126-6136 (2006)
   PUBMED   17085477
  REMARK    GeneRIF: Results indicate that ZNF366 may play an important role in
            regulating the expression of genes in response to estrogen.
REFERENCE   10 (bases 1 to 6262)
  AUTHORS   Gilligan,P., Brenner,S. and Venkatesh,B.
  TITLE     Fugu and human sequence comparison identifies novel human genes and
            conserved non-coding sequences
  JOURNAL   Gene 294 (1-2), 35-44 (2002)
   PUBMED   12234665
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK097115.1, BK000210.1 and AC093278.2.
            
            On Nov 22, 2018 this sequence version replaced NM_152625.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.50275.1, BX647592.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318442.6/ ENSP00000313158.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AK097115.1         13-27
            16-2481             BK000210.1         1-2466
            2482-6262           AC093278.2         119892-123672       c
FEATURES             Location/Qualifiers
     source          1..6262
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..6262
                     /gene="ZNF366"
                     /gene_synonym="DC-SCRIPT; DCSCRIPT"
                     /note="zinc finger protein 366"
                     /db_xref="GeneID:167465"
                     /db_xref="HGNC:HGNC:18316"
                     /db_xref="MIM:610159"
     exon            1..160
                     /gene="ZNF366"
                     /gene_synonym="DC-SCRIPT; DCSCRIPT"
                     /inference="alignment:Splign:2.1.0"
     exon            161..1506
                     /gene="ZNF366"
                     /gene_synonym="DC-SCRIPT; DCSCRIPT"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..2409
                     /gene="ZNF366"
                     /gene_synonym="DC-SCRIPT; DCSCRIPT"
                     /note="dendritic cell-specific transcript protein"
                     /codon_start=1
                     /product="zinc finger protein 366"
                     /protein_id="NP_689838.1"
                     /db_xref="CCDS:CCDS4015.1"
                     /db_xref="GeneID:167465"
                     /db_xref="HGNC:HGNC:18316"
                     /db_xref="MIM:610159"
                     /translation="MQKEMKMIKDEDVHFDLAVKKTPSFPHCLQPVASRGKAPQRHPF
                     PEALRGPFSQFRYEPPPGDLDGFPGVFEGAGSRKRKSMPTKMPYNHPAEEVTLALHSE
                     ENKNHGLPNLPLLFPQPPRPKYDSQMIDLCNVGFQFYRSLEHFGGKPVKQEPIKPSAV
                     WPQPTPTPFLPTPYPYYPKVHPGLMFPFFVPSSSPFPFSRHTFLPKQPPEPLLPRKAE
                     PQESEETKQKVERVDVNVQIDDSYYVDVGGSQKRWQCPTCEKSYTSKYNLVTHILGHS
                     GIKPHACTHCGKLFKQLSHLHTHMLTHQGTRPHKCQVCHKAFTQTSHLKRHMMQHSEV
                     KPHNCRVCGRGFAYPSELKAHEAKHASGRENICVECGLDFPTLAQLKRHLTTHRGPIQ
                     YNCSECDKTFQYPSQLQNHMMKHKDIRPYICSECGMEFVQPHHLKQHSLTHKGVKEHK
                     CGICGREFTLLANMKRHVLIHTNIRAYQCHLCYKSFVQKQTLKAHMIVHSDVKPFKCK
                     LCGKEFNRMHNLMGHMHLHSDSKPFKCLYCPSKFTLKGNLTRHMKVKHGVMERGLHSQ
                     GLGRGRIALAQTAGVLRSLEQEEPFDLSQKRRAKVPVFQSDGESAQGSHCHEEEEEDN
                     CYEVEPYSPGLAPQSQQLCTPEDLSTKSEHAPEVLEEACKEEKEDASKGEWEKRSKGD
                     LGAEGGQERDCAGRDECLSLRAFQSTRRGPSFSDYLYFKHRDESLKELLERKMEKQAV
                     LLGI"
     exon            1507..1698
                     /gene="ZNF366"
                     /gene_synonym="DC-SCRIPT; DCSCRIPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1873
                     /gene="ZNF366"
                     /gene_synonym="DC-SCRIPT; DCSCRIPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..6262
                     /gene="ZNF366"
                     /gene_synonym="DC-SCRIPT; DCSCRIPT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6243..6248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF366"
                     /gene_synonym="DC-SCRIPT; DCSCRIPT"
                     /note="hexamer: AATAAA"
     polyA_site      6262
                     /gene="ZNF366"
                     /gene_synonym="DC-SCRIPT; DCSCRIPT"
                     /note="major polyA site"
ORIGIN      
        1 ctctttctta agtcattcga aacactgtcc ctgcgagttc tttaagttcc ctgcaatctg
       61 tacacaagag aaagagggag agagagaggg agagagacag agagagcagg gatcaggtaa
      121 aggagtgggg ctgctgcagc cattcagacc tcaggagctg gaaaattgcc aaggatgcag
      181 aaggaaatga agatgatcaa agacgaggat gtgcatttcg acttggctgt gaagaagacc
      241 ccctcctttc cccactgcct gcagccagtg gcttctcggg gaaaggctcc ccaaagacac
      301 cccttcccgg aagctctccg agggccattt tcccagtttc ggtatgaacc tcccccagga
      361 gacctagatg ggttccccgg ggtcttcgaa ggagcagggt ctaggaaacg gaagagcatg
      421 cccacaaaga tgccctataa ccaccctgca gaagaagtca ccctcgccct ccactcagag
      481 gagaacaaaa accacggcct tcccaacctc cctttgctgt tcccgcagcc cccgcgcccc
      541 aagtatgact ctcagatgat cgacctgtgc aacgtgggct tccaattcta ccgcagcctg
      601 gaacactttg ggggcaagcc cgtcaagcag gaacccatta agcccagcgc cgtgtggccc
      661 cagccaacgc ccactccatt cctgcccacg ccctacccct actaccccaa agtccacccg
      721 ggcctcatgt tccccttctt cgtgccctcg tcctcgccct tccccttcag ccggcacacc
      781 ttcctgccca agcagccccc ggaacctctg ctgccccgga aagccgagcc ccaggagagc
      841 gaggagacca agcagaaggt ggagagggtg gacgtgaacg tgcagatcga tgacagctac
      901 tacgtggacg tgggcggctc gcagaagcgc tggcagtgcc ccacctgcga gaagtcctac
      961 acctccaagt acaacctggt cacccacatc ctgggccaca gtgggatcaa gccgcacgcg
     1021 tgcacgcact gcgggaagct cttcaagcag ctcagccacc tgcataccca catgctgacc
     1081 caccagggca cgcggcccca caagtgccag gtgtgccaca aggccttcac ccagaccagc
     1141 cacctgaagc gccacatgat gcagcacagc gaggtgaagc cgcacaactg ccgcgtgtgc
     1201 ggccgcggct ttgcctaccc cagcgagctc aaggcccacg aagccaagca cgccagtggg
     1261 cgcgagaaca tctgtgtgga gtgcggcctc gacttcccca ccttggccca gctgaagaga
     1321 cacctcacca cgcaccgggg ccccatccag tacaactgct ccgagtgcga caagaccttc
     1381 cagtacccga gccagctgca gaaccacatg atgaagcaca aggacatccg gccctacatc
     1441 tgctcagagt gtggcatgga gtttgtgcag ccgcaccacc tcaagcagca ctccctcacc
     1501 cacaagggtg tgaaggagca taagtgtggg atttgtgggc gggagttcac cctgctggcc
     1561 aacatgaagc gacacgtgct gatccacacc aacatccgcg cctaccagtg tcacctctgc
     1621 tacaagagct tcgtgcagaa gcagaccctc aaggcacaca tgatcgtcca ctctgacgtg
     1681 aagcctttca aatgcaagct ttgtgggaag gaattcaacc ggatgcacaa cctgatgggc
     1741 cacatgcacc tgcactcaga cagcaaaccc ttcaagtgcc tctattgccc aagcaaattc
     1801 accctgaagg ggaacctgac acgccacatg aaagtcaagc atggagtcat ggagcggggc
     1861 cttcattccc aaggtctggg aagggggaga atcgccctgg cacagacagc cggtgtcctg
     1921 aggagtctgg agcaggagga gccctttgac ctctctcaga agcgccgggc caaggtgccg
     1981 gtgttccagt cagacgggga gagtgcccag ggcagccact gccacgagga ggaagaggag
     2041 gataactgct acgaggtgga gccctacagc cctggcctgg ccccccagag ccagcagctc
     2101 tgcacacccg aggatctgtc caccaagtcg gagcacgccc ccgaggtgct ggaggaagcc
     2161 tgcaaggagg agaaggagga tgcatccaag ggagaatggg agaagaggag caagggtgac
     2221 cttggggcag agggcggcca ggagagagac tgtgccggca gagatgagtg tctcagtctc
     2281 agggcttttc agagtacccg gcggggcccc tctttttctg attacttata cttcaagcac
     2341 agagatgaga gtttgaaaga attactggag aggaaaatgg aaaaacaagc agtgctttta
     2401 ggtatctaag tggacagttt taaaattaca tttggaaaat gagaaggagg cagttcaaat
     2461 atagctttct gcatgaactg tcattttctg gagactggcg aatagtacca atctctacaa
     2521 atggcttaga ctaaatgagc agggatgtag gtaatggaaa gccttctcag gtcattcacg
     2581 gggcccttga tacccttcac acatgtgcag ggtcttcatc agtggcgttt tatgcattgc
     2641 cagtataata aactgtgagt attcttccag atatctaatt gtaagctgat gctgaggtgc
     2701 ttttagaaat tctactttcc tttgattcat atgcaataca tggtaaattt ctaattgcaa
     2761 aaatatggtg cttgaggtgt caccttatta ataactattt aggtgaattt gtgaaggtta
     2821 taatattttc catatagatg aaaatattag tcgtcatata tataaaaata gcctttattc
     2881 tataaccaaa aatgtcagaa atggcacagg aggatgagct attgaagaga atgctctcca
     2941 gtagttgctg cagatataag gtaaaatttc aggagaagaa taattttgac taagggaaac
     3001 tggtgaccta gaatacttag attctcttgt tctgtgtcgg ctgtcttcat cagattgagc
     3061 atttggagca ttatttttca gatgatatga tgatgtttgg ggccctggct cctcagacaa
     3121 accctcactt ctcgagcacg gctccctcct ggagaccatt gctgtcttgc tctgaggcct
     3181 catgccccat aagacagatg caggggccgg gcgcagaggc tcacgcctgt aatcccagca
     3241 ctttgggagg ccgaggcagg cagatcactt gaggtcagga gtttgagacc aacctggcca
     3301 acgtggcaaa accccttctc tactaaaaat acaaaaatta gccaggcatg atggcaggag
     3361 cctgtagttc cagctactcg ggaggctgaa gcaggagaat cgtttgaacc caggcagtgg
     3421 agattgcagt gagctgagct gagatcacgc tactgcacta cagcctgggt gacagagtga
     3481 gactctgcct caaaaaaaaa aaaaaaaaaa aaaggacaga tgcaggaaga cttgtcacca
     3541 gtgaccaggg ggctttctcc tcagagctag agctgggggg gtgacctcag agaattctcc
     3601 cagaaatcta agctctgact tatttggggt actagaatag ttgacagcaa atcattagta
     3661 aagaagactc tggactgtgt tttcagtgct ggctgtacat tagaagcatc tggggtgacc
     3721 tttaaaaaaa aaccaccaaa ccaaggcctt acccattaag attctgattt aattgatctg
     3781 gagtggagcc ctaggactga aattttccaa attgctcctg gcaattctta tgtgcagcca
     3841 agattgagaa gattgagggg actaaaatag aactcaccat ttctgtggct tccaggacac
     3901 ttcccagaga cttcataagt atttctgttc ctagcctcag actctttaag gttgagaata
     3961 ggagacctca caatcatact gctgacttag gctttcttac ctgtctgtaa gagccttatg
     4021 agcggacaca cacagtctat atatagatac acacttttta cattatacta gaagatgatg
     4081 cctgtgatgt ttatggtcac ttactatgtt taaaaaatgc atgactggcc tatggtgact
     4141 cattatttct tcccagatgc ttgaaccatg atgccagtga gtggaaatga ctctattggg
     4201 tgggatgggc ccagcaggtc agacttactt aggcactggc actgagaaaa gcaatactga
     4261 ctgggtgtcg tgtacgtgtg actgcccata gcaataaccc tctggtactg tgtctgttta
     4321 tgtaaaaact tcttgtttgg tagttttgac tcgtatttgt agagctaggt actggttatt
     4381 attgtgcttc atcctatccc agatttccca gtacattcct ttagaagaca tgtccatctc
     4441 caactgctgg gggctggcct tttctgtagg ccaaggtgct gccccattag ccccacctgg
     4501 ttgtcatcac tcacccatgt gttgtgtcca tctctgaccc atttcccctg ccaccttgcc
     4561 taaagcttct cctgtcagcc tccccaccac catgaagtgc taagagtact atgtcctgag
     4621 gtaagggcac ctgcaacgga gattgtgaag agaagactgt gggtttctgt ggttacaagc
     4681 acaactctgg gtcaaaaacc cattccaagt cctcagaggg gcaagtccct tccattcagt
     4741 attaatatag ctcatcagtg cctctgatga aattgcccag gatgctggca gtgtggcctg
     4801 ggaggcttcc agctcttggg gtctggttac acatttattc acactgcggc catgtgttga
     4861 ggacctacta tgtgctgtgt ttgaccacac gtcctgtaga atgccgtttg gttctgagta
     4921 tgcctggctg gaatggaaac caggaaattc tagagtaaca ggctctagtc ctttccaacc
     4981 aaaacaaacc tcatgggaat gtttgaggga ccagttaatg ttgagacaga gagagtatgg
     5041 tctagaatgg tggttttcag attgtgtttt gagaagccag aggtcatctt taggcctctg
     5101 aagagtggta aggggaggag aagctctcaa ctcccacacc cacctcactc caagcagctc
     5161 aagttccatc tgatttatac attagcattc taagtaaaat tttatttgga ggcagtaaaa
     5221 aggtctagga gaaataaaaa caatttgtta tggagtgtat tccagggcct gtttttagtt
     5281 gttgactctg ggcataagac acttaattag atctaacctg atggttaata cagcattaac
     5341 ctgagcacca atgctaaaac attggttttg tatgctgttg agtgaccaac atcctggttt
     5401 gcctgggatg atcgtggttt agacctgttg tcccaggata attattcaag tgtcacctta
     5461 attctcaaaa gtattccagt ttgggtgaga aattacatgg acactttatg caagagcaca
     5521 gagttaaggg aagggttggc cagccttgcc taatgagctg atgaaccaga aggcaagcct
     5581 tgaaggagag tccatgtggg ccatctcaga gaactaaggg atgaagcctt ccaagattac
     5641 cagcattcca aaaccagaat atcatattgt gagactctga aaataggtca ctaccaaatg
     5701 ctttccagcc ttttgaccac tgtcactttg aacaaatcaa tggaccagca aagtggcata
     5761 tttttctttt attcttttta ttctttccta tgattactcc tcatgttacc tttcaattcc
     5821 tctttctgtc tctcttttta aaaatttgac tccccaccgg ccatgagact aaggctgacc
     5881 tttcataaac ccacaagagt aactggtata tttgtatatg agtagttgca tgagaaagct
     5941 caatgtgcat actgtattta ttaagccctg aacgcattta ataaaatatt aacatggtgt
     6001 tttgaattat gatctttgtc tgctttgctg gaacaaaata taacagagct aacgtttgaa
     6061 atccttcgca tatttggaca acattacacc aaatgttgat tttgtacaga actctggctt
     6121 gctatttaaa aactaaaact ctaagtatat agcagcccaa gttgtgaata ttgctttctg
     6181 cttcactgaa aaagcagttt acctgaaaag agcatgtaac ctatattttg ttaatttaag
     6241 caaataaaga catgttgaaa aa
//
