LOCUS       NM_014951               3988 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens zinc finger protein 365 (ZNF365), transcript variant
            A, mRNA.
ACCESSION   NM_014951
VERSION     NM_014951.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3988)
  AUTHORS   Du,X., Yu,L., Wang,L., Yan,X., Xu,B., Chai,F., Li,D., Zi,J.,
            Zhang,J. and Jiang,Y.
  TITLE     Reduced Proliferative Capacity and Defense against Staphylococcus
            aureus in Human Nasal Mucosal Epithelium Lacking ZNF365
  JOURNAL   Int Arch Allergy Immunol 185 (5), 466-479 (2024)
   PUBMED   38354721
  REMARK    GeneRIF: Reduced Proliferative Capacity and Defense against
            Staphylococcus aureus in Human Nasal Mucosal Epithelium Lacking
            ZNF365.
REFERENCE   2  (bases 1 to 3988)
  AUTHORS   Ghadamgahi,S.R., Hosseinzadeh,L., Ardalan Khales,S., Nassiri,M.,
            Alidoust,M., Etemadrezaei,S., Khorshid Shamshiri,A., Homaei
            Shandiz,F., Pasdar,A. and Afzaljavan,F.
  TITLE     Potential Role of Zinc Finger 365 rs10822013 and rs10995190 in
            Mammographic Density, Sporadic Breast Cancer Risk, and Prognosis
  JOURNAL   Iran J Med Sci 48 (6), 551-562 (2023)
   PUBMED   38094285
  REMARK    GeneRIF: Potential Role of Zinc Finger 365 rs10822013 and
            rs10995190 in Mammographic Density, Sporadic Breast Cancer Risk,
            and Prognosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3988)
  AUTHORS   Urista,J., Maldonado,M., Toscano-Marquez,F., Ramirez,R.,
            Balderas-Martinez,Y.I., Becerril,C., Romero,Y., Selman,M. and
            Pardo,A.
  TITLE     Lack of ZNF365 Drives Senescence and Exacerbates Experimental Lung
            Fibrosis
  JOURNAL   Cells 11 (18), 2848 (2022)
   PUBMED   36139424
  REMARK    GeneRIF: Lack of ZNF365 Drives Senescence and Exacerbates
            Experimental Lung Fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3988)
  AUTHORS   Du,X., Zhou,Y., Song,L., Wang,X. and Zhang,S.
  TITLE     Zinc finger protein 365 is a new maternal LPS-binding protein that
            defends zebrafish embryos against gram-negative bacterial
            infections
  JOURNAL   FASEB J 32 (2), 979-994 (2018)
   PUBMED   29042450
REFERENCE   5  (bases 1 to 3988)
  AUTHORS   Wang,Q., Du,X., Meinkoth,J., Hirohashi,Y., Zhang,H., Liu,Q.,
            Richter,M. and Greene,M.I.
  TITLE     Characterization of Su48, a centrosome protein essential for cell
            division
  JOURNAL   Proc Natl Acad Sci U S A 103 (17), 6512-6517 (2006)
   PUBMED   16617106
REFERENCE   6  (bases 1 to 3988)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3988)
  AUTHORS   Gianfrancesco,F., Esposito,T., Casu,G., Maninchedda,G., Roberto,R.
            and Pirastu,M.
  TITLE     Emergence of Talanin protein associated with human uric acid
            nephrolithiasis in the Hominidae lineage
  JOURNAL   Gene 339, 131-138 (2004)
   PUBMED   15363853
REFERENCE   8  (bases 1 to 3988)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   9  (bases 1 to 3988)
  AUTHORS   Gianfrancesco,F., Esposito,T., Ombra,M.N., Forabosco,P.,
            Maninchedda,G., Fattorini,M., Casula,S., Vaccargiu,S., Casu,G.,
            Cardia,F., Deiana,I., Melis,P., Falchi,M. and Pirastu,M.
  TITLE     Identification of a novel gene and a common variant associated with
            uric acid nephrolithiasis in a Sardinian genetic isolate
  JOURNAL   Am J Hum Genet 72 (6), 1479-1491 (2003)
   PUBMED   12740763
  REMARK    GeneRIF: A novel gene responsible for UAN was identified in an
            Italian population.
REFERENCE   10 (bases 1 to 3988)
  AUTHORS   Ombra,M.N., Forabosco,P., Casula,S., Angius,A., Maestrale,G.,
            Petretto,E., Casu,G., Colussi,G., Usai,E., Melis,P. and Pirastu,M.
  TITLE     Identification of a new candidate locus for uric acid
            nephrolithiasis
  JOURNAL   Am J Hum Genet 68 (5), 1119-1129 (2001)
   PUBMED   11309680
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC017841.1, AB020651.1,
            AC024598.7 and BC060817.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014951.2.
            
            Summary: This gene encodes a zinc finger protein that may play a
            role in the repair of DNA damage and maintenance of genome
            stability. The N-terminal C2H2 zinc finger motif is required to
            form a protein complex with PARP1 and MRE11, which are known to be
            involved in the restart of stalled DNA replication forks. A
            mutation in this gene may be associated with breast cancer
            susceptibility. [provided by RefSeq, Mar 2020].
            
            Transcript Variant: This variant (A) differs in the 3' coding
            region and UTR compared to variant C. The resulting protein
            (isoform A) is shorter and has a distinct C-terminus compared to
            isoform C.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070073.1, SRR1803616.176776.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395254.8/ ENSP00000378674.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                BC017841.1         17-106
            91-1065             AB020651.1         265-1239
            1066-3033           AC024598.7         124083-126050       c
            3034-3988           BC060817.1         2354-3308
FEATURES             Location/Qualifiers
     source          1..3988
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.2"
     gene            1..3988
                     /gene="ZNF365"
                     /gene_synonym="Su48; UAN; ZNF365D"
                     /note="zinc finger protein 365"
                     /db_xref="GeneID:22891"
                     /db_xref="HGNC:HGNC:18194"
                     /db_xref="MIM:607818"
     exon            1..90
                     /gene="ZNF365"
                     /gene_synonym="Su48; UAN; ZNF365D"
                     /inference="alignment:Splign:2.1.0"
     exon            91..846
                     /gene="ZNF365"
                     /gene_synonym="Su48; UAN; ZNF365D"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1327
                     /gene="ZNF365"
                     /gene_synonym="Su48; UAN; ZNF365D"
                     /note="isoform A is encoded by transcript variant A;
                     protein ZNF365; talanin; protein su48; DISC1-binding
                     zinc-finger protein"
                     /codon_start=1
                     /product="protein ZNF365 isoform A"
                     /protein_id="NP_055766.2"
                     /db_xref="CCDS:CCDS31209.1"
                     /db_xref="GeneID:22891"
                     /db_xref="HGNC:HGNC:18194"
                     /db_xref="MIM:607818"
                     /translation="MQQKAFEESRYPWQESFENVAVCLPLRCPRCGDHTRFRSLSSLR
                     AHLEFSHSYEERTLLTKCSLFPSLKDTDLVTSSELLKPGKLQSSGNVVKQKPSYVNLY
                     SISHEHSKDRKPFEVVAERPVSYVQTYTAMDLHADSLDGTRSGPGLPTSDTKASFEAH
                     VREKFNRMVEAVDRTIEKRIDKLTKELAQKTAELLEVRAAFVQLTQKKQEVQRRERAL
                     NRQVDVAVEMIAVLRQRLTESEEELLRKEEEVVTFNHFLEAAAEKEVQGKARLQDFIE
                     NLLQRVELAEKQLEYYQSQQASGFVRDLSGHVLTDISSNRKPKCLSRGHPHSVCNHPD
                     LKAHFHPKGRNHLKKAKDDRASMQPAKAIHEQAESSRDLCRPPKKGELLGFGRKGNIR
                     PKMAKKKPTAIVNII"
     exon            847..1027
                     /gene="ZNF365"
                     /gene_synonym="Su48; UAN; ZNF365D"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1065
                     /gene="ZNF365"
                     /gene_synonym="Su48; UAN; ZNF365D"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..3988
                     /gene="ZNF365"
                     /gene_synonym="Su48; UAN; ZNF365D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3966..3971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF365"
                     /gene_synonym="Su48; UAN; ZNF365D"
                     /note="hexamer: AATAAA"
     polyA_site      3988
                     /gene="ZNF365"
                     /gene_synonym="Su48; UAN; ZNF365D"
                     /note="major polyA site"
ORIGIN      
        1 agtctgattt acggctctgc tgaaaaccgc ttcgctcccg cagcatcagc accggaggcg
       61 gcggctgcag cagcagcagc aacaagtcgg gacttttaga gtaatgcaac agaaggcttt
      121 tgaggaaagc agatatccct ggcaggagtc ctttgagaat gttgctgtgt gcctgccatt
      181 acgctgcccg aggtgtggag accataccag atttagaagc ttgtcatcct tgagggccca
      241 tctggagttc agtcacagct acgaagaaag aaccctcttg acaaaatgca gtctctttcc
      301 atccctcaaa gacacagacc tagtcacttc ctcagaactc ctgaaaccgg gaaaattgca
      361 gagcagtggc aacgtggtaa agcagaaacc gagctatgtt aacttgtaca gcatttcaca
      421 tgaacattcc aaggacagga agccatttga ggtggtggca gagaggcctg tgtcctatgt
      481 gcagacctac actgccatgg acctccatgc agactcgctg gatgggacac ggtcgggtcc
      541 tggactgccc acctcagaca ccaaagcttc tttcgaggca catgtcagag aaaaattcaa
      601 tcgaatggtt gaggctgtgg ataggaccat tgagaagaga attgataaac tcaccaaaga
      661 gttggcccag aaaactgcgg aactgttgga agttcgggca gcttttgtgc agctgactca
      721 gaaaaagcag gaagttcaga gacgagagcg ggccttaaac agacaggtgg acgtggccgt
      781 ggaaatgata gctgtactga ggcaacgcct gacggaatct gaggaggagc ttcttaggaa
      841 agaagaagaa gttgtcacat tcaaccattt cctggaagcg gcagctgaga aggaggttca
      901 agggaaagcc cggctccagg actttattga gaatctgtta cagcgggtag aactggcgga
      961 gaagcagctt gagtactatc agagccagca ggcctctggc tttgtccgtg atctcagcgg
     1021 gcacgtgctt acagacatct cctcaaatag gaagcccaaa tgcctaagcc gagggcaccc
     1081 gcattcggta tgtaaccacc ctgatctcaa ggcccatttc cacccaaagg gaaggaacca
     1141 cctgaaaaag gccaaggatg acagagccag catgcagcct gccaaggcca ttcacgaaca
     1201 ggctgagtcc tcaagagacc tctgcagacc tccaaagaaa ggggagctcc tggggtttgg
     1261 ccgcaaaggc aacatcaggc ccaaaatggc taaaaaaaag ccaacagcca ttgtgaacat
     1321 catctaaaag ggtgggtggt gctggaccaa tcatcgctgg gctttgggga acgttgttcc
     1381 aggagccaac agtaatgtct ttctggaaac attccatagt aagacacatt ggaaaagcca
     1441 agggcataac acaggcaagc acctcaatta accagagctt agcaaatggg aatcttagtg
     1501 aaccagaatt ttattataac ccccttttag aagcttgcaa attacagaaa gaataaaaaa
     1561 attaaatcaa tcttaaagct ctaacttcta aagtaactgg cccagtctcc agtaatcttg
     1621 gcatctgggc ttctatgcag tggtcactaa ttttcaggac caaggccaca caaaatgtca
     1681 ggcctaggga gaaaattcat ctgtgcccac tgctctccaa agtgcgaggc aaggaatggc
     1741 agtgtaaagt tctgttaata gcagtaaaat gaaaatattt gtgtttgtgt ataaccttcc
     1801 cctcagctaa tttgaaagcc tccaaaataa ggattcccat tccccgagta ttctggttaa
     1861 tcaagatttc aatttctggg ttgctcaagg gactcgttca gtcagacttc agttctcatt
     1921 ccgacagggt gtctttcagt tcgtttgttt gattgaggtt ttttggtggc ctagatgcat
     1981 gtttattcag attttggtac acctctgccg tcttctttgg ctgagtattc tgcacccaca
     2041 gaccatgctg ccagcctcta tcttaatagc tgcttctgtg gatatggctg gggagcgaag
     2101 taaaatcctc ttttgattag cacccagcat gggctgggtg gctaggtggt tggaatgaca
     2161 gtggactgca cgcttggtgc atcgtgcatc gtgaccatcc tggaagcact gcgggtgtcg
     2221 ccaagccctt tcctaagacc tgcttcccgg ccagtgtcag tggccctctc tctctctgct
     2281 atgggcatga ctttctcttc gctggcttaa cttttccact gggtggttca ctttgcctcc
     2341 tgctgcttct gtgccctgtt aagggcttca ggtatctttc aaccaagtat ctggagtgtt
     2401 cactctatgt tgcattctaa agtaatttct gaaataaaca atgcatgtag gagccagaat
     2461 ctgacactgt cttcccctcc ttccctccct aaaatggctt tagtttccac aaagagctgt
     2521 taagaatttc ctgctgtatg attttcctca agaatgaatt tccatgttat tttttcctta
     2581 aatttagcaa tatcatcagg tctcttgcag agtttacaag tgctgacatt cttctgaaaa
     2641 caggaataat tttgtccaca aatatataca tatatacata tatataacac atacaaaata
     2701 tatatgttaa gtatattaat aatttatttt taaatactca tggagaaagt gtgtgtttgt
     2761 ggtgggtggt ttttaaacta tatatgtttg ttcatgtaaa ctgaattctc ttatttaaaa
     2821 aatcaaaact gtaacgtaat taacattggc agaattatga ttgttactgc aataagcatc
     2881 aaattagcag cgcattaaaa ataggaaata aagcagttgc ttaaaatgcc agtcaattga
     2941 aaagtgtaac ttatcattat acaaacattc tgaacctacc ataatgaaaa tgttcttgaa
     3001 tcttcacttt gactttcagt ttatgggggg ggtagatcat tcatgtgata tataagcagc
     3061 tatcaagtgg gcaaaaacat tgctgtgaat agcactgttt aggctaacat tgtaaaaatt
     3121 gtaatgttat aattattatt tatttggaga attaacttcc ccctctaaag ttatttatta
     3181 ttgatgctta taccatgatt gcaccttagc cttttacata ctaaaaacat gacttgttag
     3241 ttgtattgca tgctctttgt cctgtaatgt gtgtgcaatg acaacttgtt tctgttttat
     3301 ttaaagtaac tgacattttg gattttcatc taacatagag ggcatggcaa ctctctttga
     3361 cagtggtacc ccatgatctt cagaaagtac cataatgtca tcctactcta catttcacaa
     3421 gacgaattat tttgagattt gtttattata ttaaaatgtt tttttacgtt cccactaaat
     3481 tttgacccca tataaagaaa tgtgttatgt atgttgtgcc tccttagaga cataaattta
     3541 gtgtcaaaac atgggagatg gcttactcag aagcatactc cacttaacat accatggcct
     3601 gagctaagta ccatgtcctg tttgtgtctt atttttaaat attttctttg tccacatggg
     3661 ccgttgacct tagagttaag gcggttgctt ttttgaagaa atcaccaaag tttctgggaa
     3721 actatgttca aggttgaaat ggagagtaga tttaatttta tttgtcttgt agggaagaaa
     3781 tcttcctttg aaccgctttt cttgcttttt ccctttttcc caaactaggt tacaggttct
     3841 tatctgcaag gttcaagttg cttagacatt gttttccagt attctgcagg gccagtcagt
     3901 tgtacagaag ttggaatatt ctgttccaga attaaagaag tttttagatt atgaaatatt
     3961 atgataataa agctatattt ctgactaa
//
