LOCUS       NM_014594               5893 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 354C (ZNF354C), mRNA.
ACCESSION   NM_014594
VERSION     NM_014594.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5893)
  AUTHORS   Oo,J.A., Irmer,B., Gunther,S., Warwick,T., Palfi,K., Izquierdo
            Ponce,J., Teichmann,T., Pfluger-Muller,B., Gilsbach,R.,
            Brandes,R.P. and Leisegang,M.S.
  TITLE     ZNF354C is a transcriptional repressor that inhibits endothelial
            angiogenic sprouting
  JOURNAL   Sci Rep 10 (1), 19079 (2020)
   PUBMED   33154469
  REMARK    GeneRIF: ZNF354C is a transcriptional repressor that inhibits
            endothelial angiogenic sprouting.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5893)
  AUTHORS   Matsunami,K., Nishida,N., Kaneko,N., Ikeo,K., Toyo-Oka,L.,
            Takeuchi,H., Matsuura,K., Tamori,A., Nomura,H., Yoshiji,H.,
            Imamura,M., Masaki,N., Hayakawa,T., Ide,T., Shimada,N., Ikeda,F.,
            Hino,K., Nishiguchi,S., Okuse,C., Nojiri,S., Sawamoto,K.,
            Tokunaga,K., Joh,T. and Tanaka,Y.
  TITLE     Genome-Wide Association Study Identifies ZNF354C Variants
            Associated with Depression from Interferon-Based Therapy for
            Chronic Hepatitis C
  JOURNAL   PLoS One 11 (10), e0164418 (2016)
   PUBMED   27723809
  REMARK    GeneRIF: The SNP rs1863918 in strong linkage disequilibrium with
            SNPs located around the Zinc finger 354C (ZNF354C) gene on
            chromosome 5 showed a significant association when the results of
            GWAS and replication were combined (odds ratio = 2.55, P =
            7.89x10-8 in the allele frequency model), suggesting that the
            rs1863918 T allele was associated with IFN-induced depression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5893)
  AUTHORS   Gao,L., Sun,C., Qiu,H.L., Liu,H., Shao,H.J., Wang,J. and Li,W.X.
  TITLE     Cloning and characterization of a novel human zinc finger gene,
            hKid3, from a C2H2-ZNF enriched human embryonic cDNA library
  JOURNAL   Biochem Biophys Res Commun 325 (4), 1145-1152 (2004)
   PUBMED   15555547
  REMARK    GeneRIF: cloning and characterization; results indicate that hKid3
            may function as a transcription repressor with regulated expression
            pattern during human development of brain and kidney
REFERENCE   4  (bases 1 to 5893)
  AUTHORS   Watson,R.P., Tekki-Kessaris,N. and Boulter,C.A.
  TITLE     Characterisation, chromosomal localisation and expression of the
            mouse Kid3 gene
  JOURNAL   Biochim Biophys Acta 1490 (1-2), 153-158 (2000)
   PUBMED   10786630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104117.2, BC063312.1, CN482682.1, AF525463.1, DA548517.1,
            AK124385.1, DA527405.1 and DA393183.1.
            
            On May 17, 2019 this sequence version replaced NM_014594.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.10075.1,
                                           SRR1803615.267199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315475.7/ ENSP00000324064.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC104117.2         176382-176423
            43-216              BC063312.1         1-174
            217-233             CN482682.1         153-169
            234-262             AF525463.1         1-29
            263-263             CN482682.1         199-199
            264-2610            AF525463.1         31-2377
            2611-2611           AC104117.2         196704-196704
            2612-2664           DA548517.1         1-53
            2665-2953           AC104117.2         196758-197046
            2954-3179           DA548517.1         340-565
            3180-4479           AK124385.1         66-1365
            4480-4480           AC104117.2         198573-198573
            4481-4962           BC063312.1         4438-4919
            4963-4963           DA527405.1         131-131
            4964-5186           BC063312.1         4921-5143
            5187-5445           AK124385.1         2073-2331
            5446-5829           DA393183.1         195-578
            5830-5893           AC104117.2         199923-199986
FEATURES             Location/Qualifiers
     source          1..5893
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..5893
                     /gene="ZNF354C"
                     /gene_synonym="KID3"
                     /note="zinc finger protein 354C"
                     /db_xref="GeneID:30832"
                     /db_xref="HGNC:HGNC:16736"
                     /db_xref="MIM:619511"
     exon            1..294
                     /gene="ZNF354C"
                     /gene_synonym="KID3"
                     /inference="alignment:Splign:2.1.0"
     exon            295..375
                     /gene="ZNF354C"
                     /gene_synonym="KID3"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..2013
                     /gene="ZNF354C"
                     /gene_synonym="KID3"
                     /note="KRAB-zinc finger protein synten; kidney, ischemia,
                     and developmentally-regulated protein 3"
                     /codon_start=1
                     /product="zinc finger protein 354C"
                     /protein_id="NP_055409.1"
                     /db_xref="CCDS:CCDS4443.1"
                     /db_xref="GeneID:30832"
                     /db_xref="HGNC:HGNC:16736"
                     /db_xref="MIM:619511"
                     /translation="MAVDLLSAQEPVTFRDVAVFFSQDEWLHLDSAQRALYREVMLEN
                     YSSLVSLGIPFSMPKLIHQLQQGEDPCMVEREVPSDTRLGFKTWLETEALPHRQDIFI
                     EETSQGMVKKESIKDGHWDINFEEAVEFESEIEEEQEKKPLRQMIDSHEKTISEDGNH
                     TSLELGKSLFTNTALVTQQSVPIERIPNMYYTFGKDFKQNFDLMKCFQIYPGGKPHIC
                     NECGKSFKQNLHLIEHQRIHTGEKPYKCNECEKTFSHRSSLLSHQRIHTGEKPYKCNE
                     CEKAFSNSSTLIKHLRVHTGEKPYRCRECGKAFSQCSTLTVHQRIHTGEKLYKCGECE
                     KAFNCRAKLHRHQRIHTGEKPYKCSECGKGYSQFTSLAEHQRFHTGEQLYTCLECGRT
                     FTRIVTLIEHQRIHTGQKPYQCNECEKAFNQYSSFNEHRKIHTGEKLYTCEECGKAFG
                     CKSNLYRHQRIHTGEKPYQCNQCGKAFSQYSFLTEHERIHTGEKLYKCMECGKAYSYR
                     SNLCRHKKVHTKEKLYKWKEYGKPFICSSSLTQYQRFFKGDKAYEV"
     exon            376..502
                     /gene="ZNF354C"
                     /gene_synonym="KID3"
                     /inference="alignment:Splign:2.1.0"
     exon            503..598
                     /gene="ZNF354C"
                     /gene_synonym="KID3"
                     /inference="alignment:Splign:2.1.0"
     exon            599..5893
                     /gene="ZNF354C"
                     /gene_synonym="KID3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5320..5325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF354C"
                     /gene_synonym="KID3"
                     /note="hexamer: AATAAA"
     polyA_site      5339
                     /gene="ZNF354C"
                     /gene_synonym="KID3"
                     /note="major polyA site"
     regulatory      5422..5427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF354C"
                     /gene_synonym="KID3"
                     /note="hexamer: AATAAA"
     polyA_site      5446
                     /gene="ZNF354C"
                     /gene_synonym="KID3"
ORIGIN      
        1 agttctcccg cggttggcgg ggtttcgggg acagctcgcg gcctttcggg ggttctcctg
       61 gcttgggcca tccaggcttg gctaggattg ccggcctggg gttgaggcgc tcgcagtggt
      121 ctcttccggg ccggggtgga tccgggcctc tccagcgagt gggcggcgtg cagcctcgtc
      181 tgggcttctg ggaccagccc tacgcggctc gggccccttg gccactgggt cccggggcgc
      241 cgtccgcgag cggcctggac tgccggagac ccgcgggagg gagcgcctcg ccagacccac
      301 cgtgtccaca ctctgctctc cctgggcagg aagactgagg aggaagggat ggctgtggat
      361 ctgctgtctg ctcaggagcc tgtgacattc agggatgtgg ccgtgttctt cagccaggac
      421 gagtggttgc acctggactc tgcccagagg gccttgtacc gggaggtgat gctggagaac
      481 tacagcagcc tggtctcact ggggattcca ttttcaatgc caaagttgat tcatcagttg
      541 cagcaaggag aagatccctg catggtggaa agagaagtcc cttcagatac ccgtctaggt
      601 ttcaagactt ggcttgaaac agaagcattg cctcatagac aggacatttt tatagaagaa
      661 acatctcagg gaatggtaaa gaaagaatcc attaaggatg gtcactggga cattaacttt
      721 gaagaagctg tggaatttga gagcgagata gaagaagagc aagagaagaa acctcttaga
      781 caaatgatag attcgcatga gaaaaccatc agtgaagatg gaaaccatac aagtcttgaa
      841 ttggggaaaa gcttatttac aaatacagct cttgtcacac aacagagtgt tcctatagaa
      901 aggataccca atatgtatta tacatttggg aaagatttta aacagaattt tgatctcatg
      961 aaatgcttcc agatttaccc aggaggaaaa cctcacatct gtaatgaatg tgggaagagc
     1021 ttcaagcaga atctgcatct tattgaacat cagagaattc atacaggtga gaaaccctac
     1081 aaatgtaatg agtgtgaaaa aaccttcagc cacagatcat cccttctttc tcatcagaga
     1141 attcatactg gagagaaacc ttacaagtgt aatgaatgtg agaaggcatt tagcaacagt
     1201 tcaaccctta tcaaacatct gagagtgcat actggagaga aaccgtatcg atgtagggaa
     1261 tgtggtaaag cctttagcca gtgttcaacc ctcactgtac atcagagaat tcatactgga
     1321 gagaaactct ataaatgcgg cgaatgtgag aaggccttca actgtagagc aaaacttcac
     1381 aggcatcaaa gaatccatac aggtgagaaa ccctataaat gtagtgagtg tgggaaggga
     1441 tacagccagt ttacatctct agctgaacat cagaggtttc atactggaga acaactgtat
     1501 acatgcttgg aatgtgggag aaccttcaca cgtattgtaa cccttatcga acatcagcga
     1561 attcacactg gacaaaaacc ttatcagtgc aacgaatgtg agaaagcctt caaccagtat
     1621 tcatccttta atgaacatcg gaaaattcat actggggaaa aactttatac atgtgaggaa
     1681 tgtgggaaag cctttggttg caaatctaac ctttataggc atcagagaat tcatactgga
     1741 gagaaaccgt atcagtgtaa tcagtgtgga aaggccttca gccagtattc atttttaacc
     1801 gaacatgaga ggatccacac tggagagaaa ctgtataaat gtatggaatg tgggaaagcc
     1861 tacagttaca gatcaaacct ttgtagacac aaaaaagttc acacgaaaga gaaactctat
     1921 aagtggaagg aatatgggaa acctttcatc tgcagctcct cacttaccca gtatcagaga
     1981 ttttttaaag gagataaagc ctatgaggtt tagttcatct ctcaaataat ccaagacttc
     2041 tcactgggga ataagggaat aataaatagg gtacaaactc ctaatagatt tgtctttttt
     2101 acttctcctg aaggaaatat gttagttgcc actaagtcat gataaaattg atcagtgaga
     2161 ctatgaagag cactgacttg ttaaatttta aaagaaccat aaattctaag gtatctaaaa
     2221 acctatgagt atttaattca tagaaaaaat gtaaaaggtc tttttaaaaa tcatgaaaaa
     2281 tagttgaata tacattttgt ttctctcata agaccatatt ccctttaaaa gagtaagctt
     2341 caatatgtga attttctttt aaaaacagtc actgagttaa taatgtaaat aagtgtgtgg
     2401 ccttctttaa aatagctggc taacatagga ggcacttctt ttcataaaga gaagctaaac
     2461 ataaaaagga attttaaatt taactcttca catggaaata ataaagctct ttatatgagc
     2521 tgtcccacca gcaacttata tatgtaaaca tacatatata cacatatgca tgtgtgtgtg
     2581 taaacataaa agtcctttat tattaaaaaa tgtagtttta ttgatttaga atttagttct
     2641 taaaatcttg cccaaaggta gactctcttt cttttacttt cttccattat ttcttaaatt
     2701 gatgtggttt tatataactg aacagagtac tattacagta ccgtagaagg cggattaact
     2761 gaagcagctg gaaagactgt caagcacata ctttgttatc tgttgcagaa gggatgtatt
     2821 tggcagaatc tcaggctgca tgtctggtag ctcattagag ccaggagaga ttttagttta
     2881 attatagcct ttcattgtac taacgaagga tttgaactta gtgaacagag tcaagactag
     2941 aatctaggtc tttggttctg gtgttttgtg atcattatag gctcgtttcc aacctgaggt
     3001 cccaagagta ctatttgttt tgtagcctgg ttagacatag ttgcagtaat ttaaagttac
     3061 tgtgttatct ttaagggctt cctctcacct taatcttaat aattgactca caactatatt
     3121 cttttttctt atgagtccct aattatgcct gcttttgtta taattgtact taaatcctta
     3181 aagctagctg aggtccagat agtgtaattg cttttggagg cttcacatat aaggttgcct
     3241 tcttattaca catattttag gaattaatta ttttatggaa agttatatat gaagagttta
     3301 ttattaagca ttcctttcat cagtttaaat gtttaattcc tcccaggcgt ttttcctcca
     3361 attttatatt tgatttttca ttcaattcac agttggtatc attaaaaaaa attctaatac
     3421 aattagctag accttctgag aaaaatgtta gaattaaact caagcagtca gtatagtata
     3481 tttcttaacc gactggtttt agcttatcag aaagtaatta ttttatgtat ttaaatacat
     3541 ttacaaagaa aatgaggctt ttaaacagac ctcactattt aacattgtac ccagtagtgg
     3601 tgagcatgct tagtacccaa attttggttt ctaaatgcca ttccccacta aaaggaacca
     3661 gggttccttg gagaaatggc tgattccatg tttggagcag gggaagtggg tggtgtggct
     3721 aaaatacttt ttattaagaa aataaaataa aaagcaagat agtatttgaa gactaatggg
     3781 gtaatgtcag aagggaacag gcgccaagtt gaaggtattc tcactggcca aatttaggac
     3841 aacttagaat aatcactctt actggtgata atactaagaa ggaaaagaag ttcataatga
     3901 tgaaagtaga gaaaaaagaa aactctatac aattatttga agaatgtctt cttttaaatg
     3961 tacatggaat gatagatttg gaaaaattac cattttacaa cccttaatgt aattaaatct
     4021 ggcaaaaatc gatggtaaaa cccattaagt ggaaaaaatt ttaaggaact ttgtttacaa
     4081 ggtgtcagaa catcacagat atctattgca aaagaattgc ctttacagtg agatttggct
     4141 atcaaactgc atttcactac ttctggaata agccagcatt atgtggctct tgatgggatg
     4201 cggtatgaag catgtgtgat catccttgat gtactgccga aaatgtttac ctcaaattta
     4261 attaaatctt ttgtctagac ttatcttcct gtttaaagaa atacaggaat agaggaacaa
     4321 gttgaattac acagtatgga aataaataga caagtccaga gttggtatag gacaactgga
     4381 ctttttttta tatatttatt ttaaaatggt tttcttaaat ttattttttt aaacataaca
     4441 cgaggaagct gttaaaactg gtgtaatagc tcaaaagaac taagtattcc agatttcggg
     4501 agggatgaag agggagatat tcagaaacct tcaccagatt cctcccaact tgatcatagt
     4561 ggattaatga cgtgctttgt ggatgtggtt agtcaatgac accagcttga cggatctttc
     4621 tttctgcacc aaaccccatt gagttatctg gtccccttgg ctgacgaaga gccattaggc
     4681 gaggatcact ggcatcatcc agggtgatgt tcttcaagcg actgaccaac cgatcaggtc
     4741 gaggagctgc aacagccttg gggccctcac agactcgcca aacattccag gcactgcact
     4801 tgccagtgcg ctgatgaaga atcacggaga actccacctc atctcctgcc tggagctcaa
     4861 ggccatcctc aacttctttc atatggaaaa agagcttctt gctatcccct acttcatagt
     4921 taatgaagcc aaactgatct tgcacacatt ccactggccc tacgcagggg tgtgatgttg
     4981 taagccatag tttgtgcatt ttggccctgg tctggacttt tcaaaaagca aatgtagtaa
     5041 aacaaaaagt ggtctctgct agattaagac aagagacata accaaatgga aagtgtgatc
     5101 ctttattagc ttctgattca taaaaaaacc tataagagac atttgggggg atatttgggg
     5161 aaataggaag atggaatggg tagtagataa tgtggtatat ttgatttttc tagaagtgat
     5221 aattgagtta cgtaggataa tgttctaatt cttaggagat gcatgcagaa gttttttttt
     5281 taagttttga aaagtcatga tgttgacagc atattttcaa ataaatatgt acaaaatcag
     5341 tcaattgttt tttgtggtgg atctatatgt ggtggatgtt cattggtcat ttaaaacatt
     5401 tttctatgtg tgtcaatttt taataaaaat gcaaaaagtg attggataaa gaagtgatga
     5461 atattaatct ttcaatcaga attctccatt tatattctta ggaagttcct gtttgagagt
     5521 ttatcctcca gggatgtaat cattggcaat aaagtaacta ggtggtacca gttctccttt
     5581 aaatggaatg agcatgttcc actttatctc tcatgctaaa tgtaactaag gcatggagca
     5641 gctgtctggg gaccctcaaa agtaatgatt gataacaaca ggcagatttg ggaaggaaac
     5701 tagaatttga aacaagatca ttgtggcgct cctgggcatt cctgtggtga ggacagagat
     5761 ggctgagcag gcatctaaac ctcagagtta ggaacccttc actctgggca gaggatttgt
     5821 gagccaaaaa gggttaggag actccccatt gcttttcttc cctatctatc ttcctgctac
     5881 ttggacctgg agg
//
