LOCUS       NM_005649               2521 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 354A (ZNF354A), transcript variant
            1, mRNA.
ACCESSION   NM_005649
VERSION     NM_005649.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2521)
  AUTHORS   Wang,W., Cai,J., Wu,Y., Hu,L., Chen,Z., Hu,J., Chen,Z., Li,W.,
            Guo,M. and Huang,Z.
  TITLE     Novel activity of KRAB domain that functions to reinforce nuclear
            localization of KRAB-containing zinc finger proteins by interacting
            with KAP1
  JOURNAL   Cell Mol Life Sci 70 (20), 3947-3958 (2013)
   PUBMED   23665872
REFERENCE   2  (bases 1 to 2521)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 2521)
  AUTHORS   Johnatty,S.E., Beesley,J., Chen,X., Macgregor,S., Duffy,D.L.,
            Spurdle,A.B., deFazio,A., Gava,N., Webb,P.M., Rossing,M.A.,
            Doherty,J.A., Goodman,M.T., Lurie,G., Thompson,P.J., Wilkens,L.R.,
            Ness,R.B., Moysich,K.B., Chang-Claude,J., Wang-Gohrke,S.,
            Cramer,D.W., Terry,K.L., Hankinson,S.E., Tworoger,S.S.,
            Garcia-Closas,M., Yang,H., Lissowska,J., Chanock,S.J.,
            Pharoah,P.D., Song,H., Whitemore,A.S., Pearce,C.L., Stram,D.O.,
            Wu,A.H., Pike,M.C., Gayther,S.A., Ramus,S.J., Menon,U.,
            Gentry-Maharaj,A., Anton-Culver,H., Ziogas,A., Hogdall,E.,
            Kjaer,S.K., Hogdall,C., Berchuck,A., Schildkraut,J.M.,
            Iversen,E.S., Moorman,P.G., Phelan,C.M., Sellers,T.A.,
            Cunningham,J.M., Vierkant,R.A., Rider,D.N., Goode,E.L., Haviv,I.
            and Chenevix-Trench,G.
  CONSRTM   Ovarian Cancer Association Consortium; Australian Ovarian Cancer
            Study Group; Australian Cancer Study (Ovarian Cancer)
  TITLE     Evaluation of candidate stromal epithelial cross-talk genes
            identifies association between risk of serous ovarian cancer and
            TERT, a cancer susceptibility 'hot-spot'
  JOURNAL   PLoS Genet 6 (7), e1001016 (2010)
   PUBMED   20628624
  REMARK    GeneRIF: Meta-analysis of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2521)
  AUTHORS   Navarro-Lerida,I., Martinez Moreno,M., Roncal,F., Gavilanes,F.,
            Albar,J.P. and Rodriguez-Crespo,I.
  TITLE     Proteomic identification of brain proteins that interact with
            dynein light chain LC8
  JOURNAL   Proteomics 4 (2), 339-346 (2004)
   PUBMED   14760703
REFERENCE   5  (bases 1 to 2521)
  AUTHORS   Bugert,P., Pesti,T. and Kovacs,G.
  TITLE     The tcf17 gene at chromosome 5q is not involved in the development
            of conventional renal cell carcinoma
  JOURNAL   Int J Cancer 86 (6), 806-810 (2000)
   PUBMED   10842194
REFERENCE   6  (bases 1 to 2521)
  AUTHORS   Jacob,A.N., Manjunath,N.A., Bray-Ward,P. and Kandpal,R.P.
  TITLE     Molecular cloning of a zinc finger gene eZNF from a human inner ear
            cDNA library, and in situ expression pattern of its mouse homologue
            in mouse inner ear
  JOURNAL   Somat Cell Mol Genet 24 (2), 121-129 (1998)
   PUBMED   9919311
REFERENCE   7  (bases 1 to 2521)
  AUTHORS   Omori,Y., Kyushiki,H., Takeda,S., Suzuki,M., Kawai,A., Fujiwara,T.,
            Takahashi,E. and Nakamura,Y.
  TITLE     Cloning, expression and mapping of a novel human zinc-finger gene
            TCF17 homologous to rodent Kid1
  JOURNAL   Cytogenet Cell Genet 78 (3-4), 285-288 (1997)
   PUBMED   9465904
REFERENCE   8  (bases 1 to 2521)
  AUTHORS   Witzgall,R., O'Leary,E., Gessner,R., Ouellette,A.J. and
            Bonventre,J.V.
  TITLE     Kid-1, a putative renal transcription factor: regulation during
            ontogeny and in response to ischemia and toxic injury
  JOURNAL   Mol Cell Biol 13 (3), 1933-1942 (1993)
   PUBMED   8382778
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF116030.1, BC036517.1, BU685427.1 and AC113348.2.
            
            On Nov 23, 2018 this sequence version replaced NM_005649.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.65893.1, EU794664.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335815.7/ ENSP00000337122.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AF116030.1         50-67
            19-88               BC036517.1         17-86
            89-2132             AF116030.1         138-2181
            2133-2376           AF116030.1         2183-2426
            2377-2439           AF116030.1         2438-2500
            2440-2512           BU685427.1         10-82               c
            2513-2521           AC113348.2         56414-56422
FEATURES             Location/Qualifiers
     source          1..2521
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..2521
                     /gene="ZNF354A"
                     /gene_synonym="EZNF; HEL104; HKL1; KID-1; KID1; TCF17"
                     /note="zinc finger protein 354A"
                     /db_xref="GeneID:6940"
                     /db_xref="HGNC:HGNC:11628"
                     /db_xref="MIM:602444"
     exon            1..104
                     /gene="ZNF354A"
                     /gene_synonym="EZNF; HEL104; HKL1; KID-1; KID1; TCF17"
                     /inference="alignment:Splign:2.1.0"
     exon            105..188
                     /gene="ZNF354A"
                     /gene_synonym="EZNF; HEL104; HKL1; KID-1; KID1; TCF17"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1973
                     /gene="ZNF354A"
                     /gene_synonym="EZNF; HEL104; HKL1; KID-1; KID1; TCF17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor 17; zinc finger protein eZNF;
                     epididymis luminal protein 104"
                     /codon_start=1
                     /product="zinc finger protein 354A isoform 1"
                     /protein_id="NP_005640.2"
                     /db_xref="CCDS:CCDS4438.1"
                     /db_xref="GeneID:6940"
                     /db_xref="HGNC:HGNC:11628"
                     /db_xref="MIM:602444"
                     /translation="MAAGQREARPQVSLTFEDVAVLFTRDEWRKLAPSQRNLYRDVML
                     ENYRNLVSLGLPFTKPKVISLLQQGEDPWEVEKDGSGVSSLGSKSSHKTTKSTQTQDS
                     SFQGLILKRSNRNVPWDLKLEKPYIYEGRLEKKQDKKGSFQIVSATHKKIPTIERSHK
                     NTELSQNFSPKSVLIRQQILPREKTPPKCEIQGNSLKQNSQLLNQPKITADKRYKCSL
                     CEKTFINTSSLRKHEKNHSGEKLFKCKECSKAFSQSSALIQHQITHTGEKPYICKECG
                     KAFTLSTSLYKHLRTHTVEKSYRCKECGKSFSRRSGLFIHQKIHAEENPCKYNPGRKA
                     SSCSTSLSGCQRIHSRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCSECGRAFS
                     QSASLIQHERIHTGEKPYRCNECGKGFTSISRLNRHRIIHTGEKFYNCNECGKALSSH
                     STLIIHERIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSS
                     LSNHQRIHTGEKPYRCEECGISFGQSSALIQHRRIHTGEKPFKCNTCGKTFRQSSSRI
                     AHQRIHTGEKPYECNTCGKLFNHRSSLTNHYKIHIEEDP"
     exon            189..315
                     /gene="ZNF354A"
                     /gene_synonym="EZNF; HEL104; HKL1; KID-1; KID1; TCF17"
                     /inference="alignment:Splign:2.1.0"
     exon            316..411
                     /gene="ZNF354A"
                     /gene_synonym="EZNF; HEL104; HKL1; KID-1; KID1; TCF17"
                     /inference="alignment:Splign:2.1.0"
     exon            412..2521
                     /gene="ZNF354A"
                     /gene_synonym="EZNF; HEL104; HKL1; KID-1; KID1; TCF17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2424..2429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF354A"
                     /gene_synonym="EZNF; HEL104; HKL1; KID-1; KID1; TCF17"
                     /note="hexamer: AATGAA"
     polyA_site      2439
                     /gene="ZNF354A"
                     /gene_synonym="EZNF; HEL104; HKL1; KID-1; KID1; TCF17"
                     /note="major polyA site"
     regulatory      2501..2506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF354A"
                     /gene_synonym="EZNF; HEL104; HKL1; KID-1; KID1; TCF17"
                     /note="hexamer: ATTAAA"
     polyA_site      2521
                     /gene="ZNF354A"
                     /gene_synonym="EZNF; HEL104; HKL1; KID-1; KID1; TCF17"
ORIGIN      
        1 agacgccgtc ggggcggagc cgggtcgcga ggctgcatcc cggccggcgg ttccggagcc
       61 tcgcggctgg ggaggcgcgg cccgggacgc tcgagcttag ggagatctgc cttctggaga
      121 ctgcgccgtc ctcccgggag agccagaaag aggacatggc tgctgggcag cgggaagcga
      181 ggccccaggt gtcactgacg tttgaggatg tggctgtgct gtttacccga gatgagtgga
      241 gaaagctggc cccttctcag agaaacttgt accgggatgt gatgctggag aactatagga
      301 acctggtctc actggggctc ccatttacca aaccaaaagt gatctccctg ttgcagcaag
      361 gagaagatcc ctgggaggtg gagaaagacg gttctggcgt ctcctctcta ggatcgaaga
      421 gcagtcataa aaccacaaag tcaacgcaaa cacaagactc ttcatttcag ggactgatac
      481 tgaaaagatc caacaggaat gtaccttggg atttgaaatt agaaaagcct tacatatatg
      541 aaggcagatt agagaaaaag caggataaaa agggaagttt tcagatagtt tcagccaccc
      601 acaaaaaaat ccccactata gaaagaagcc ataaaaatac tgaattgagc caaaacttca
      661 gcccaaagtc agtgcttatt aggcaacaga tacttcccag agaaaaaaca ccaccaaaat
      721 gtgaaataca aggaaacagc ctcaaacaga attcacaatt acttaatcaa ccaaaaatta
      781 cagcagataa acgctataaa tgtagtctgt gtgaaaaaac cttcattaac acttcatccc
      841 ttcgtaaaca tgagaaaaac catagtggag agaaactatt taagtgtaaa gaatgttcaa
      901 aagcctttag ccaaagttca gctcttattc aacatcaaat aacgcatact ggagagaaac
      961 cctacatatg taaagaatgt gggaaagcct ttactctcag tacatccctt tataaacatc
     1021 taagaaccca tactgtggag aaatcctaca gatgtaaaga atgtggtaaa tccttcagcc
     1081 gaaggtcagg cctttttata catcaaaaaa ttcatgctga agaaaaccct tgtaagtata
     1141 atccgggtag gaaggcatct agttgcagca catccctttc tggatgtcaa agaattcatt
     1201 ctagaaagaa gtcctactta tgtaatgaat gtggcaacac ctttaagtct agctcatccc
     1261 ttcgttatca tcagagaatt cacactggag agaagccttt taaatgtagt gaatgtggga
     1321 gagccttcag ccagagtgcc tctcttattc aacatgaaag aattcacacc ggagaaaagc
     1381 cctatagatg caatgaatgt gggaaaggct ttacttctat ttcacgactt aatagacacc
     1441 gaatcattca tactggagag aagttttata attgtaatga atgtggtaaa gccttaagct
     1501 cccactcaac acttattatt cacgagcgaa ttcatactgg agaaaaacca tgtaaatgta
     1561 aagtatgtgg aaaagccttc agacagagtt cagctctcat tcaacatcag agaatgcata
     1621 ctggagaaag accctataaa tgtaacgagt gtgggaaaac attcaggtgt aactcatcac
     1681 ttagtaatca ccagagaatt catactggag agaaaccata tcgatgtgag gaatgtggga
     1741 tatcttttgg ccaaagttca gctcttattc agcatcgaag gattcataca ggagaaaaac
     1801 cctttaaatg taatacatgt ggaaaaactt ttagacaaag ctcatcacgt attgcacatc
     1861 agagaattca tactggagag aaaccctatg aatgtaatac atgtgggaaa cttttcaacc
     1921 ataggtcatc ccttactaat cattataaaa ttcatatcga agaggacccc tagaaagtag
     1981 atttgtatgt gtgaaagcct taaaccaaag ctcatcgaag aatacatcct tgagagagat
     2041 gtaataaatg taatggatgt gaaaaaaact gtaataattt agccctcatt aggtatttaa
     2101 ttccatggat aaacctcagc tatataatag atatgaggaa agtgtttgtg cctgtcagac
     2161 acttaaaaaa ataacctgag atgaagaatt tacaattgaa gacattgact ttagccattt
     2221 gtgaaatggg tttgcttttt cccttttcct acagacgtat atgctagatg tcacgtgatc
     2281 atcagaaaca gatatccgag tgggtgggga ggtgtgcttt agatttctca ttagaagacc
     2341 accaaactgg taatattttt atagcatttt aatagcttga tcaaattgta cctttttaga
     2401 gaaaaggacc aaaataaaag aaaaatgaat tatgaactac ctctcagtct ctggggtttg
     2461 tccttttcct accctgatgt caaacttatg catggatttc attaaaaaag aaaaagaaaa
     2521 a
//
