LOCUS       NM_021632               2355 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 350 (ZNF350), mRNA.
ACCESSION   NM_021632
VERSION     NM_021632.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2355)
  AUTHORS   Lin,Y., Gong,H., Liu,J., Hu,Z., Gao,M., Yu,W. and Liu,J.
  TITLE     HECW1 induces NCOA4-regulated ferroptosis in glioma through the
            ubiquitination and degradation of ZNF350
  JOURNAL   Cell Death Dis 14 (12), 794 (2023)
   PUBMED   38049396
  REMARK    GeneRIF: HECW1 induces NCOA4-regulated ferroptosis in glioma
            through the ubiquitination and degradation of ZNF350.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2355)
  AUTHORS   Zhang,Y., Zhang,J., Feng,D., Zhou,H., Gui,Z., Zheng,M., Hang,Z.,
            Wang,Z., Wang,Z., Gu,M. and Tan,R.
  TITLE     IRF1/ZNF350/GPX4-mediated ferroptosis of renal tubular epithelial
            cells promote chronic renal allograft interstitial fibrosis
  JOURNAL   Free Radic Biol Med 193 (Pt 2), 579-594 (2022)
   PUBMED   36356714
  REMARK    GeneRIF: IRF1/ZNF350/GPX4-mediated ferroptosis of renal tubular
            epithelial cells promote chronic renal allograft interstitial
            fibrosis.
REFERENCE   3  (bases 1 to 2355)
  AUTHORS   Pan,H.Y. and Valapala,M.
  TITLE     Role of the Transcriptional Repressor Zinc Finger with KRAB and
            SCAN Domains 3 (ZKSCAN3) in Retinal Pigment Epithelial Cells
  JOURNAL   Cells 10 (10), 2504 (2021)
   PUBMED   34685484
  REMARK    GeneRIF: Role of the Transcriptional Repressor Zinc Finger with
            KRAB and SCAN Domains 3 (ZKSCAN3) in Retinal Pigment Epithelial
            Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2355)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2355)
  AUTHORS   Wu,J., Eni,A., Roussuri,E. and Ma,B.
  TITLE     Correlation between ZBRK1/ZNF350 gene polymorphism and breast
            cancer
  JOURNAL   BMC Med Genomics 14 (1), 7 (2021)
   PUBMED   33407485
  REMARK    GeneRIF: Correlation between ZBRK1/ZNF350 gene polymorphism and
            breast cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2355)
  AUTHORS   Tan,W., Zheng,L., Lee,W.H. and Boyer,T.G.
  TITLE     Functional dissection of transcription factor ZBRK1 reveals zinc
            fingers with dual roles in DNA-binding and BRCA1-dependent
            transcriptional repression
  JOURNAL   J Biol Chem 279 (8), 6576-6587 (2004)
   PUBMED   14660588
  REMARK    GeneRIF: ZBRK1 zinc fingers have dual roles in sequence-specific
            DNA-binding and BRCA1-dependent transcriptional repression
REFERENCE   7  (bases 1 to 2355)
  AUTHORS   Yun,J. and Lee,W.H.
  TITLE     Degradation of transcription repressor ZBRK1 through the
            ubiquitin-proteasome pathway relieves repression of Gadd45a upon
            DNA damage
  JOURNAL   Mol Cell Biol 23 (20), 7305-7314 (2003)
   PUBMED   14517299
  REMARK    GeneRIF: ZBRK1 is a novel target for DNA damage-induced degradation
REFERENCE   8  (bases 1 to 2355)
  AUTHORS   Rutter,J.L., Smith,A.M., Davila,M.R., Sigurdson,A.J., Giusti,R.M.,
            Pineda,M.A., Doody,M.M., Tucker,M.A., Greene,M.H., Zhang,J. and
            Struewing,J.P.
  TITLE     Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and
            BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from
            breast-ovarian cancer families and among early-onset breast cancer
            cases and reference individuals
  JOURNAL   Hum Mutat 22 (2), 121-128 (2003)
   PUBMED   12872252
  REMARK    GeneRIF: ZBRK1 mutation found in BRCA1 and BRCA2 mutation negative
            probands with breast or ovarian cancer.
REFERENCE   9  (bases 1 to 2355)
  AUTHORS   Ran,Q., Wadhwa,R., Bischof,O., Venable,S., Smith,J.R. and
            Pereira-Smith,O.M.
  TITLE     Characterization of a novel zinc finger gene with increased
            expression in nondividing normal human cells
  JOURNAL   Exp Cell Res 263 (1), 156-162 (2001)
   PUBMED   11161714
REFERENCE   10 (bases 1 to 2355)
  AUTHORS   Zheng,L., Pan,H., Li,S., Flesken-Nikitin,A., Chen,P.L., Boyer,T.G.
            and Lee,W.H.
  TITLE     Sequence-specific transcriptional corepressor function for BRCA1
            through a novel zinc finger protein, ZBRK1
  JOURNAL   Mol Cell 6 (4), 757-768 (2000)
   PUBMED   11090615
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011460.3, AU135269.1, BC009921.2, AF309561.1 and BM674621.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021632.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.87754.1,
                                           SRR1803614.206513.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2153347
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243644.9/ ENSP00000243644.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC011460.3         11450-11463
            15-74               AU135269.1         1-60
            75-346              BC009921.2         1-272
            347-949             AF309561.1         322-924
            950-1913            BC009921.2         876-1839
            1914-2355           BM674621.1         18-459              c
FEATURES             Location/Qualifiers
     source          1..2355
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..2355
                     /gene="ZNF350"
                     /gene_synonym="ZBRK1; ZFQR"
                     /note="zinc finger protein 350"
                     /db_xref="GeneID:59348"
                     /db_xref="HGNC:HGNC:16656"
                     /db_xref="MIM:605422"
     exon            1..71
                     /gene="ZNF350"
                     /gene_synonym="ZBRK1; ZFQR"
                     /inference="alignment:Splign:2.1.0"
     exon            72..257
                     /gene="ZNF350"
                     /gene_synonym="ZBRK1; ZFQR"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1841
                     /gene="ZNF350"
                     /gene_synonym="ZBRK1; ZFQR"
                     /note="zinc finger protein ZBRK1; KRAB zinc finger protein
                     ZFQR; zinc finger and BRCA1-interacting protein with a
                     KRAB domain 1"
                     /codon_start=1
                     /product="zinc finger protein 350"
                     /protein_id="NP_067645.3"
                     /db_xref="CCDS:CCDS12845.1"
                     /db_xref="GeneID:59348"
                     /db_xref="HGNC:HGNC:16656"
                     /db_xref="MIM:605422"
                     /translation="MIQAQESITLEDVAVDFTWEEWQLLGAAQKDLYRDVMLENYSNL
                     VAVGYQASKPDALFKLEQGEQLWTIEDGIHSGACSDIWKVDHVLERLQSESLVNRRKP
                     CHEHDAFENIVHCSKSQFLLGQNHDIFDLRGKSLKSNLTLVNQSKGYEIKNSVEFTGN
                     GDSFLHANHERLHTAIKFPASQKLISTKSQFISPKHQKTRKLEKHHVCSECGKAFIKK
                     SWLTDHQVMHTGEKPHRCSLCEKAFSRKFMLTEHQRTHTGEKPYECPECGKAFLKKSR
                     LNIHQKTHTGEKPYICSECGKGFIQKGNLIVHQRIHTGEKPYICNECGKGFIQKTCLI
                     AHQRFHTGKTPFVCSECGKSCSQKSGLIKHQRIHTGEKPFECSECGKAFSTKQKLIVH
                     QRTHTGERPYGCNECGKAFAYMSCLVKHKRIHTREKQEAAKVENPPAERHSSLHTSDV
                     MQEKNSANGATTQVPSVAPQTSLNISGLLANRNVVLVGQPVVRCAASGDNRGFAQDRN
                     LVNAVNVVVPSVINYVLFYVTENP"
     exon            258..384
                     /gene="ZNF350"
                     /gene_synonym="ZBRK1; ZFQR"
                     /inference="alignment:Splign:2.1.0"
     exon            385..480
                     /gene="ZNF350"
                     /gene_synonym="ZBRK1; ZFQR"
                     /inference="alignment:Splign:2.1.0"
     exon            481..2355
                     /gene="ZNF350"
                     /gene_synonym="ZBRK1; ZFQR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2048..2053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF350"
                     /gene_synonym="ZBRK1; ZFQR"
                     /note="hexamer: AGTAAA"
     polyA_site      2078
                     /gene="ZNF350"
                     /gene_synonym="ZBRK1; ZFQR"
     regulatory      2333..2338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF350"
                     /gene_synonym="ZBRK1; ZFQR"
                     /note="hexamer: ATTAAA"
     polyA_site      2355
                     /gene="ZNF350"
                     /gene_synonym="ZBRK1; ZFQR"
                     /note="major polyA site"
ORIGIN      
        1 actccagaag taggagcagt ttacggaagt gtaacgttga ggcccttctt gtgtatctgg
       61 agaaaataga ggttctgact cctcaggagc aaaaaacata acctgaagag ggaggaagtg
      121 gatttggggt tcaccatttc ttggggcaca cttgattgaa aactgagact tctgaagaga
      181 aggccagaag atacaaagac agaccatccc agttgaatgc tgtcttccaa gaacagaaga
      241 aaatgatcca ggcccaggaa tccataacac tggaggatgt ggctgtggac ttcacttggg
      301 aggagtggca actcctgggc gctgctcaga aggacctgta ccgggatgtg atgttggaga
      361 actacagcaa cctggtggca gtggggtatc aagccagcaa accggatgca ctcttcaagt
      421 tggaacaagg agaacaactg tggacaattg aagatggaat ccacagtgga gcctgttcag
      481 acatatggaa agttgatcat gtgctggagc gcttgcagag tgaaagcctg gtgaacagaa
      541 ggaaaccatg tcatgaacat gatgcatttg aaaatattgt tcattgcagc aaaagtcagt
      601 ttctgttagg gcaaaatcat gatatatttg acttacgtgg aaaaagtttg aaatccaatt
      661 taactttagt taaccagagc aaaggctatg aaataaagaa ctctgttgag tttactggaa
      721 atggggactc ctttcttcat gctaaccatg aacgacttca tactgcaatt aaattccctg
      781 caagtcaaaa actcatcagc actaagtccc aattcatcag tcccaagcat cagaaaacac
      841 gaaaattaga gaagcatcat gtgtgcagtg aatgtgggaa agccttcatc aagaagtctt
      901 ggctaactga tcaccaggta atgcatacag gagagaaacc ccacagatgt agtctatgtg
      961 agaaagcctt ctccagaaag ttcatgctta ctgaacatca gcgaactcat acaggagaaa
     1021 aaccttatga atgccctgaa tgtggcaaag cctttctcaa gaaatcacgg ctcaacatac
     1081 atcagaaaac acataccgga gagaaaccct atatatgcag tgaatgtgga aaaggcttca
     1141 tccagaaagg aaatctcatt gtacaccagc gaattcatac aggtgagaaa ccttatatat
     1201 gcaatgaatg tggaaaaggc ttcattcaga agacgtgtct catagcacat cagagatttc
     1261 acacaggaaa gacgcccttt gtgtgcagtg aatgtggaaa atcctgttct cagaaatcag
     1321 gtctcattaa acatcaaaga attcacacag gagagaaacc ctttgaatgt agtgaatgtg
     1381 ggaaagcctt tagcacaaag caaaagctca ttgtccatca aaggactcat acaggagaga
     1441 gaccctatgg ctgtaacgag tgtgggaaag cgtttgcgta tatgtcgtgt ctggttaagc
     1501 ataagagaat acacacaagg gagaaacaag aggcagccaa ggtggaaaat cctcctgcag
     1561 agaggcacag ctcattacac accagtgatg tcatgcagga gaaaaactct gctaacgggg
     1621 cgactacaca agtgccttct gtggcccctc agacatcatt aaacatcagc ggcctcctcg
     1681 caaacaggaa cgtagtcctt gtgggacagc cagtggtcag atgtgcagcc tcaggagata
     1741 acagaggatt tgcacaggac agaaaccttg tgaatgcagt gaatgtggtt gtgccttccg
     1801 tgatcaatta tgtcttattt tatgttacag aaaacccata ggaagaaaac tcagatctat
     1861 gtggaaaagg gttgagcaaa aatttgtagt tcattatgtg gccgaaaagc atacactgag
     1921 agaacatgta taaggctgag atagcctgat aaactcatcc tattaaaatg tatgctgtga
     1981 tacacaggca aatttgatgt taacctaagc acatacacag caattgctcg actgtgtcaa
     2041 ttaaatgagt aaaggaagcc caagtacttt taagtggagg aaatgaagta ctgtgaattt
     2101 ttaaaacaga tgagataatt ggtgtcggga gtgttgcagt gactgaaaag cttcataagg
     2161 ggcagttggt gggaaagggc taatactgta atggtggaat gtgggacaca tatgtgtcaa
     2221 ttcagtttcc ttagaccagt gccagtgtgg aggattaatt gaaaaccagg accataaact
     2281 ttcagaactt tgtattatgc agagggatct gtgaaactag tcaatttgtt tcattaaaca
     2341 aatattttaa aatta
//
