LOCUS       NM_012279               4314 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 346 (ZNF346), transcript variant
            1, mRNA.
ACCESSION   NM_012279
VERSION     NM_012279.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4314)
  AUTHORS   Peng,Q., Li,J., Wu,Q., Wang,P., Kang,Z., Deng,Y., Xiao,Y.,
            Zheng,P., Ge,F. and Chen,Y.
  TITLE     ZNF385A and ZNF346 Serve as Prognostic Biomarkers Associated with
            an Inflamed Immunosuppressive Tumor Microenvironment in
            Hepatocellular Carcinoma
  JOURNAL   Int J Mol Sci 24 (4), 3155 (2023)
   PUBMED   36834567
  REMARK    GeneRIF: ZNF385A and ZNF346 Serve as Prognostic Biomarkers
            Associated with an Inflamed Immunosuppressive Tumor
            Microenvironment in Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4314)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4314)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4314)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4314)
  AUTHORS   Mallick,S. and D'Mello,S.R.
  TITLE     JAZ (Znf346), a SIRT1-interacting protein, protects neurons by
            stimulating p21 (WAF/CIP1) protein expression
  JOURNAL   J Biol Chem 289 (51), 35409-35420 (2014)
   PUBMED   25331946
REFERENCE   6  (bases 1 to 4314)
  AUTHORS   Schmitt,J., Heisel,S., Keller,A., Leidinger,P., Ludwig,N.,
            Habel,N., Furtwangler,R., Nourkami-Tutdibi,N., Wegert,J.,
            Grundy,P., Gessler,M., Graf,N., Lenhof,H.P. and Meese,E.
  TITLE     Multicenter study identified molecular blood-born protein
            signatures for Wilms Tumor
  JOURNAL   Int J Cancer 131 (3), 673-682 (2012)
   PUBMED   21913182
REFERENCE   7  (bases 1 to 4314)
  AUTHORS   Yang,M., Wu,S., Jia,J. and May,W.S.
  TITLE     JAZ mediates G1 cell cycle arrest by interacting with and
            inhibiting E2F1
  JOURNAL   Cell Cycle 10 (14), 2390-2399 (2011)
   PUBMED   21715977
  REMARK    GeneRIF: JAZ directly binds E2F1 in vitro in a dsRNA-independent
            manner, and JAZ's dsRNA binding ZF domains, which are necessary for
            localizing JAZ to the nucleus, are required for repression of
            transcriptional activity in vivo.
REFERENCE   8  (bases 1 to 4314)
  AUTHORS   Kijanka,G., Hector,S., Kay,E.W., Murray,F., Cummins,R., Murphy,D.,
            MacCraith,B.D., Prehn,J.H. and Kenny,D.
  TITLE     Human IgG antibody profiles differentiate between symptomatic
            patients with and without colorectal cancer
  JOURNAL   Gut 59 (1), 69-78 (2010)
   PUBMED   19828471
REFERENCE   9  (bases 1 to 4314)
  AUTHORS   Chen,T., Brownawell,A.M. and Macara,I.G.
  TITLE     Nucleocytoplasmic shuttling of JAZ, a new cargo protein for
            exportin-5
  JOURNAL   Mol Cell Biol 24 (15), 6608-6619 (2004)
   PUBMED   15254228
  REMARK    GeneRIF: JAZ is exported by exportin-5 but translocates back into
            nuclei by a facilitated diffusion mechanism
REFERENCE   10 (bases 1 to 4314)
  AUTHORS   Yang,M., May,W.S. and Ito,T.
  TITLE     JAZ requires the double-stranded RNA-binding zinc finger motifs for
            nuclear localization
  JOURNAL   J Biol Chem 274 (39), 27399-27406 (1999)
   PUBMED   10488071
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA789054.1, AF083340.1,
            AL359576.1, AC027317.6 and DB548047.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012279.3.
            
            Summary: The protein encoded by this gene is a nucleolar, zinc
            finger protein that preferentially binds to double-stranded (ds)
            RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies
            indicate that the zinc finger domains are not only essential for
            dsRNA binding, but are also required for its nucleolar
            localization. The encoded protein may be involved in cell growth
            and survival. It plays a role in protecting neurons by inhibiting
            cell cycle re-entry via stimulation of p21 gene expression.
            Alternative splicing of this gene results in multiple transcript
            variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.19267.1,
                                           SRR1803611.172243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358149.8/ ENSP00000350869.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA789054.1         19-29
            12-955              AF083340.1         1-944
            956-2299            AL359576.1         920-2263
            2300-3870           AC027317.6         7464-9034           c
            3871-4311           DB548047.1         33-473
            4312-4314           AC027317.6         7020-7022           c
FEATURES             Location/Qualifiers
     source          1..4314
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..4314
                     /gene="ZNF346"
                     /gene_synonym="JAZ; Zfp346"
                     /note="zinc finger protein 346"
                     /db_xref="GeneID:23567"
                     /db_xref="HGNC:HGNC:16403"
                     /db_xref="MIM:605308"
     exon            1..218
                     /gene="ZNF346"
                     /gene_synonym="JAZ; Zfp346"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..928
                     /gene="ZNF346"
                     /gene_synonym="JAZ; Zfp346"
                     /note="isoform a is encoded by transcript variant 1;
                     double-stranded RNA-binding zinc finger protein JAZ; just
                     another zinc finger protein"
                     /codon_start=1
                     /product="zinc finger protein 346 isoform a"
                     /protein_id="NP_036411.1"
                     /db_xref="CCDS:CCDS4409.1"
                     /db_xref="GeneID:23567"
                     /db_xref="HGNC:HGNC:16403"
                     /db_xref="MIM:605308"
                     /translation="MEYPAPATVQAADGGAAGPYSSSELLEGQEPDGVRFDRERARRL
                     WEAVSGAQPVGREEVEHMIQKNQCLFTNTQCKVCCALLISESQKLAHYQSKKHANKVK
                     RYLAIHGMETLKGETKKLDSDQKSSRSKDKNQCCPICNMTFSSPVVAQSHYLGKTHAK
                     NLKLKQQSTKVEALHQNREMIDPDKFCSLCHATFNDPVMAQQHYVGKKHRKQETKLKL
                     MARYGRLADPAVTDFPAGKGYPCKTCKIVLNSIEQYQAHVSGFKHKNQSPKTVASSLG
                     QIPMQRQPIQKDSTTLED"
     exon            219..322
                     /gene="ZNF346"
                     /gene_synonym="JAZ; Zfp346"
                     /inference="alignment:Splign:2.1.0"
     exon            323..415
                     /gene="ZNF346"
                     /gene_synonym="JAZ; Zfp346"
                     /inference="alignment:Splign:2.1.0"
     exon            416..560
                     /gene="ZNF346"
                     /gene_synonym="JAZ; Zfp346"
                     /inference="alignment:Splign:2.1.0"
     exon            561..746
                     /gene="ZNF346"
                     /gene_synonym="JAZ; Zfp346"
                     /inference="alignment:Splign:2.1.0"
     exon            747..840
                     /gene="ZNF346"
                     /gene_synonym="JAZ; Zfp346"
                     /inference="alignment:Splign:2.1.0"
     exon            841..4314
                     /gene="ZNF346"
                     /gene_synonym="JAZ; Zfp346"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2275..2280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF346"
                     /gene_synonym="JAZ; Zfp346"
                     /note="hexamer: AATAAA"
     polyA_site      2312
                     /gene="ZNF346"
                     /gene_synonym="JAZ; Zfp346"
                     /note="major polyA site"
     polyA_site      2335
                     /gene="ZNF346"
                     /gene_synonym="JAZ; Zfp346"
     regulatory      4291..4296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF346"
                     /gene_synonym="JAZ; Zfp346"
                     /note="hexamer: AATAAA"
     polyA_site      4314
                     /gene="ZNF346"
                     /gene_synonym="JAZ; Zfp346"
ORIGIN      
        1 aggcgcctga gaggctctct accggtgagg gtttgcgggg aagatggagt atcccgcgcc
       61 ggccacggtg caggccgcgg acggcggagc ggccgggcct tacagcagct cggagttgct
      121 ggagggccag gagccggacg gggtgcgctt tgaccgcgag agggcgcgcc gcctgtggga
      181 agccgtgtcc ggtgcccagc cggtgggtag agaggaagtg gagcacatga tccagaagaa
      241 ccaatgtctc ttcaccaaca cccagtgtaa ggtttgctgc gccttgctta tttctgagtc
      301 ccagaagctg gcacattacc agagcaaaaa acatgccaac aaagtgaaga gatacctagc
      361 aatccatgga atggagacat taaaggggga aacgaagaag ctagactcag atcagaagag
      421 cagcagaagc aaagacaaga accagtgctg ccccatctgt aacatgacct tttcctcccc
      481 tgtcgtggcc cagtcgcact acctggggaa gacccacgca aagaacttaa agctgaagca
      541 gcagtccact aaggtggaag ccttgcacca gaatagagag atgatagacc cagacaagtt
      601 ctgcagcctc tgccatgcaa ctttcaacga ccctgtcatg gctcaacaac attatgtggg
      661 caagaaacac agaaaacagg agaccaagct caaactaatg gcacgctatg ggcggctggc
      721 ggaccctgct gtcactgact ttccagctgg aaagggctac ccctgcaaaa catgtaagat
      781 agtgctgaac tccatagaac agtaccaagc tcatgtcagc ggcttcaaac acaagaacca
      841 gtcaccaaaa acagtggcat catccctggg ccagattcca atgcaaaggc aacccattca
      901 gaaagactca accaccttgg aagactagag gtgattctgc ccagcatccc atattgggcc
      961 agccatgagc cagcttcccg tgactgctca gcccttggct ccctcttgct cgttgttctc
     1021 accaggaaag tacacgggcc tgaggcagga ttgggccaca gacagcctct cattggtccg
     1081 ggctaattca ctcctgctgc tcccctttgg caggggtcct gtaggtcatg acaggggagg
     1141 caagggtatt gagagactcg gggtctcgcg gggtggtagt ttggagggtg gctttcccca
     1201 tttcccaacc cctctgggcc ttaggtgctg aggcccctgc cacctgtctt tcctctaaag
     1261 gtcagttttg ggccagttct tgcaactaaa gagcagagat ctctctgggc cctagacatt
     1321 tccagcaaaa cctggaactt tcatgccaaa cctggggcag ggcaggaaac agaggaaatg
     1381 gctgcaacat gggagcttgg agctaatacg acactctgcc ttcccccaga aggtgcaggc
     1441 tttcctgagt cttagaccag atatggccag ttgcgcaggt ttctgccaac tgtgaagtat
     1501 cctcctggag cagtgacaca atcttggcgg agcattgcta cccccgctgc cccctccaca
     1561 gttcctgaat ggtgctaagg atctgcagca gttggcaacg agctggggct gggggcggcc
     1621 tccatgtcca ctgagatcat aggacactcc aatggggatg ggacctttcc cctcctccat
     1681 cagaggtgct ctgaccctag gttacacggg aaagtgcccc acatgcaagt ctccctgagg
     1741 gttctgcccc taaaggcaga ctgcctcatg cccgctagct gtgaggttca ttgctaccct
     1801 cggccctact agccctctct tcccccttgt gcagcggacc acttgcccag tttgctgtgg
     1861 tgctagcctt ccccatcatc caccgggtga tttctgggtc ccagggaaag aaagagagag
     1921 ctgatgcagg tttctacagt gaggaacagg cgtttcccag gccccacacc cagatttctc
     1981 tatctttgct gtgttttatg gcctgggact gagtccacac ggatagattt ttccttgtaa
     2041 ccttgagacg agaattccaa ggagtgtcac catcagaggc ttctcttcat tgtgtcaaag
     2101 aagcccctag ctgctctcgt ggcctccttc ccccactccc tatcccttca cctgtgaaat
     2161 gcctttgctt tgcatattgt gtgtggatgt gtgtgtgtgt gtgtgtgtgt ttgtgtgtat
     2221 gtgtgtgctt ctgtgtgtgc ctaatgctct gtctcttggt cactgaagca tccaaataaa
     2281 gaatttccct catgggccag actacaactt aacagaccta gggttttgag ccatattgcc
     2341 attggatcta gtatgtctgt cttgacccct cacccccacc ccattcagac ctcagtagtc
     2401 cccagtagtc actttaggag ttgggacaga gtcgagcacc ctgtgaaagt ctcccttgag
     2461 ttcaggtgcc ctgaactcag tacagcctca tcttctcatc caccaccttc tcctgcttct
     2521 cctgtcacat agggcctcat gaaggtcttt aaagggttta agctggggat ctgctttatg
     2581 tttgagagaa ctgttctggc tgttatgtaa aggagtgcag ggaggggcag gaaaggagac
     2641 aaggaggcca gtatggacac tgtgtccagt atggctttcc aggctaatca cttagggcag
     2701 agacccagcc ttattcatct ctacttcctg atgtccatag tggtgtgtca tgaattttta
     2761 ttgaatgaac aaatgaggtg tatgaggaga gatggttttc tcctgctcag ctcttacaca
     2821 gtgataggtt tgttccatgg gacttatcat aggcctggtg attcttgaaa gagcattttt
     2881 catgactcaa aaatgagctg agaaggagtg ttatggccag gtgcggcgtc atgcacctat
     2941 agtcccagct gctcaggagg ctaaggcaga aagaccattc aagcccagga gttccagcct
     3001 gaagtatgct gtgatcatgc ctgtgaataa ccactgcact ccagccaggg caacataaca
     3061 agactctatc taaaaaaaaa aaaaaattat aaaaataaat ttgaaggctg ggcgccgtgg
     3121 ctcacgcctg taatccaagc actttgagag gccaaggcag gtggataacc tgaggtcaga
     3181 agttcgagac cagcctggcc aacatgatgg caaaaccccg tccctataaa aaatacgaaa
     3241 atcagctgcg cctggtggca cacatctgta gtcccagcta cttgggaggc tgaggcaaga
     3301 gaattgcttg aacccgggag gcggagggtc gcattgagcc aagatcgtgc cactgcactc
     3361 cagcctaggt gacagagtga gactcctgtc tcaaaataaa taaataataa attttaaaag
     3421 aaggtagcca ggtgtggtgg tgcattcctg tagtcctggc tacctggaag ggtgaggcag
     3481 gaggatcgct ttaaccatga gttcaaggca gcagtgagct atgattatgc cactgtactc
     3541 cagcctggac aacagagcaa gaccctgtct ctaaaaataa taatttttaa aatttaaaaa
     3601 aagaaaggaa tgttatggcc tcaagagctc tttgtccatc ctttactgta gacagccaga
     3661 tttgaggaag gggcccaggc agcctcagct cccattcagt gccactcagc ccctgctcct
     3721 ggtcagctgt gaaaggctct acacagcccc aagggaggtt ctcagcttcc catgatcaga
     3781 ctgcctcagc aattccccag agtccttcta agccacctag tatgtcagat tcagccccat
     3841 ctaccaagca aggaaatgaa gggcaggggg tgagtgggct atcataccgt gagcctccgg
     3901 cctgcaagac cactttgtag tccctaccag ctgtgtggcc agccctgttg gtaaagggac
     3961 ctagagatga acactttctt gcccttaggg gttcacacac agtcaaagat catgatgaca
     4021 atgataagaa tgcccaggat gcaggagctg actcagccaa gggcatgaaa aagctggaga
     4081 ggttggaaag ctagcatttc atctgcataa caacctttga gctaagagtt aatattccat
     4141 atagagaagg aggccaggca gggtggctca catctgtaat cccagcactt tgggaggcca
     4201 aggcgggtgt atcacttgcg gccgggagtt taagaccatc ctggccaacg tggtgaaatc
     4261 ccatctctac aaaaaataaa aaataaaata aataaaaacc atggagagaa ggaa
//
