LOCUS       NM_001242472            2959 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 345 (ZNF345), transcript variant
            2, mRNA.
ACCESSION   NM_001242472
VERSION     NM_001242472.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2959)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2959)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2959)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 2959)
  AUTHORS   Moosmann,P., Georgiev,O., Thiesen,H.J., Hagmann,M. and Schaffner,W.
  TITLE     Silencing of RNA polymerases II and III-dependent transcription by
            the KRAB protein domain of KOX1, a Kruppel-type zinc finger factor
  JOURNAL   Biol Chem 378 (7), 669-677 (1997)
   PUBMED   9278146
REFERENCE   5  (bases 1 to 2959)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK315069.1, BC032863.1 and DB289823.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001242472.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            encodes the same protein, compared to variant 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315069.1, SRR1803613.62225.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000420450.6/ ENSP00000431216.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1151              AK315069.1         1-1151
            1152-2953           BC032863.1         1317-3118
            2954-2959           DB289823.1         557-562
FEATURES             Location/Qualifiers
     source          1..2959
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..2959
                     /gene="ZNF345"
                     /gene_synonym="HZF10"
                     /note="zinc finger protein 345"
                     /db_xref="GeneID:25850"
                     /db_xref="HGNC:HGNC:16367"
     exon            1..93
                     /gene="ZNF345"
                     /gene_synonym="HZF10"
                     /inference="alignment:Splign:2.1.0"
     exon            94..168
                     /gene="ZNF345"
                     /gene_synonym="HZF10"
                     /inference="alignment:Splign:2.1.0"
     exon            169..2959
                     /gene="ZNF345"
                     /gene_synonym="HZF10"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1681
                     /gene="ZNF345"
                     /gene_synonym="HZF10"
                     /note="zinc finger protein HZF10"
                     /codon_start=1
                     /product="zinc finger protein 345"
                     /protein_id="NP_001229401.1"
                     /db_xref="CCDS:CCDS12497.1"
                     /db_xref="GeneID:25850"
                     /db_xref="HGNC:HGNC:16367"
                     /translation="MENLTKHSIECSSFRGDWECKNQFERKQGSQEGHFSEMIFTPED
                     MPTFSIQHQRIHTDEKLLECKECGKDFSFVSVLVRHQRIHTGEKPYECKECGKAFGSG
                     ANLAYHQRIHTGEKPFECKECGKAFGSGSNLTHHQRIHTGEKPYECKECGKAFSFGSG
                     LIRHQIIHSGEKPYECKECGKSFSFESALIRHHRIHTGEKPYECIDCGKAFGSGSNLT
                     QHRRIHTGEKPYECKACGMAFSSGSALTRHQRIHTGEKPYICNECGKAFSFGSALTRH
                     QRIHTGEKPYVCKECGKAFNSGSDLTQHQRIHTGEKPYECKECEKAFRSGSKLIQHQR
                     MHTGEKPYECKECGKTFSSGSDLTQHHRIHTGEKPYECKECGKAFGSGSKLIQHQLIH
                     TGERPYECKECGKSFSSGSALNRHQRIHTGEKPYECKECGKAFYSGSSLTQHQRIHTG
                     EKLYECKNCGKAYGRDSEFQQHKKSHNGKKLCELETIN"
     regulatory      2931..2936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF345"
                     /gene_synonym="HZF10"
                     /note="hexamer: ATTAAA"
     polyA_site      2959
                     /gene="ZNF345"
                     /gene_synonym="HZF10"
                     /note="major polyA site"
ORIGIN      
        1 ggatttgggc aagcggcctt ggggctttgt gagatagcta gggtcgactt gtgtggattc
       61 tagtagaacg gagctgaccc tatccgaaca ggcccctgcc ctgcttggat agaggcctcc
      121 gaacaggagt aaagaatggc tgttgaacat ccacaaggca cctgcaagac tatgaatcaa
      181 agttgagacc aagaaattat ttctgaaaaa ggatatggaa aaccttacaa aacacagcat
      241 tgagtgttca agtttcagag gtgattggga atgtaaaaac cagtttgaga gaaaacaggg
      301 atctcaggaa ggacatttca gtgaaatgat atttactcct gaagacatgc ccactttcag
      361 tatccagcat cagagaattc atactgatga gaaactcctt gaatgtaagg aatgtgggaa
      421 ggattttagt tttgtatcag tccttgttcg acatcagcga attcatactg gtgagaaacc
      481 ttatgaatgc aaagaatgtg gcaaggcctt tggtagtggt gcaaaccttg cttaccatca
      541 aagaattcat actggtgaga agccttttga atgtaaagaa tgtgggaagg cctttggtag
      601 tggctcaaac cttactcacc atcagagaat tcatactggt gagaaaccct atgagtgtaa
      661 ggaatgtggg aaagccttta gttttggatc aggccttatt cgacatcaga tcattcacag
      721 tggtgagaag ccttatgagt gtaaggaatg tgggaagtcc tttagttttg aatcagccct
      781 tattcggcat cacagaattc acacaggtga gaaaccttat gaatgtatag attgtggtaa
      841 agcctttggc agtggttcaa accttactca acatcggcgg attcatactg gtgagaaacc
      901 ttatgaatgc aaagcatgtg gaatggcctt tagcagtggt tcggctctta ctcggcatca
      961 gagaattcat accggtgaga aaccatatat atgtaatgaa tgtggtaagg cctttagttt
     1021 tggatcagcc cttactcgac atcaaagaat tcatactggt gagaaacctt atgtatgtaa
     1081 ggaatgtggg aaggctttta atagtggctc agatctcact cagcatcaga gaattcacac
     1141 tggtgagaaa ccctatgagt gtaaggagtg tgagaaagcc tttagaagtg gttcaaaact
     1201 tattcagcat caaagaatgc atactggaga gaaaccttat gaatgtaagg aatgtgggaa
     1261 gacctttagt agtggttcag accttactca acatcacaga attcatactg gtgagaaacc
     1321 ctatgaatgt aaggaatgtg ggaaggcctt tggtagtggc tcaaaactta tccaacacca
     1381 gctaatccat actggtgaaa gaccctatga atgtaaagaa tgtggaaagt cctttagtag
     1441 tggttcagct cttaatcggc accagagaat acacactggt gagaaaccct atgaatgtaa
     1501 ggagtgtggg aaggcttttt atagtggctc aagccttact cagcatcaga gaattcatac
     1561 aggtgagaaa ctttatgaat gtaagaactg tgggaaggct tatgggaggg attcagagtt
     1621 tcagcaacat aagaaaagtc ataatggtaa gaaactctgc gaattggaaa ctataaattg
     1681 aaattatgtg ctgaaggaag gactctaaac atatgactta agaaaattca tagtggtgaa
     1741 aatctctaca aatagaacta aggtacaaat gccttactta tgcttcacag gttagtcagt
     1801 ctaagaatat ttatacagga aaaaaatcac cccaaataaa ataaatattt gaagatcctt
     1861 atctatattc attccttcat tacttttgga aaattcttac ttgtgaatgt taaaaatgaa
     1921 aaaaaaatca tttattatat tttgcctcaa ctttaaacat tggaaaactc atttctgggt
     1981 taatcctact atattttttc aatggtcttt tttttttgta ttatacagaa ttactgattc
     2041 attgaaaaat tattttattt attgcaagtc taaatttatc ctttttttct ttcctgatta
     2101 tcctaacacc atttattcaa taaccttgtc cattttcata ttttttttat tgactatttg
     2161 atggtaagtt acatttttat tcacataaag cttggatatc aggtcagtgt ttttttgttt
     2221 ttgtttttgt ttttgttttt ttgagatgga gtctcactgt caccaggctg gagtgcagtg
     2281 gtgcaatctc ggttcactgc aacctccacc tcccgagttc aagtgatttt cctgcctcag
     2341 ctccccagta gctgggacta caggcgcccg ccaccacgcc cagctaattt tttgtatttt
     2401 cattagagat ggggtttcac cacgttggcc aggatggtct cgatctcttg acctcgtgat
     2461 ccatctgcct cggcctccca acgtgctgga attacaggca tgagccacca tgcctggccc
     2521 agtgtttgtt ttttaaattt atatatatgt atctatgtct catcctgttt atggtcaata
     2581 actgttactt ttaagtatcc tttaatacct gtaccttttg ttttagaaga ttgtttactt
     2641 tccttttata aaattatact ctccatttta gcaaaacagc tttccctcat cataatgtag
     2701 ataaaaagaa aaaaaggata tggttacctg taatcttacc aatcatagat aatcactgtc
     2761 aaacttttgg agcaaatcct ttaatactat ctctcattgt tttggaaaca aggtgtgatt
     2821 atgctatact ataaccagcc cttaatattt tttgtctgta aatatgttgt taccatttta
     2881 ttggctttat agtattcacc tgtctttatc aaaccccaat tttgtcaaat attaaaaatt
     2941 ttgccattat aaacactta
//
