LOCUS       NM_024325               3415 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 343 (ZNF343), transcript variant
            1, mRNA.
ACCESSION   NM_024325 NM_052881
VERSION     NM_024325.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3415)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3415)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3415)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 3415)
  AUTHORS   Dong,C., Beecham,A., Wang,L., Slifer,S., Wright,C.B., Blanton,S.H.,
            Rundek,T. and Sacco,R.L.
  TITLE     Genetic loci for blood lipid levels identified by linkage and
            association analyses in Caribbean Hispanics
  JOURNAL   J Lipid Res 52 (7), 1411-1419 (2011)
   PUBMED   21558551
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL133339.13 and AL049650.8.
            
            On May 17, 2019 this sequence version replaced NM_024325.5.
            
            Transcript Variant: This variant (1) encodes isoform (1). Variants
            1-3 and 7 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.30356.1,
                                           SRR1660805.213772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267755 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278772.9/ ENSP00000278772.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL133339.13        14162-14196         c
            36-122              AL133339.13        5937-6023           c
            123-389             AL049650.8         780-1046
            390-448             AL049650.8         1247-1305
            449-575             AL049650.8         1999-2125
            576-3415            AL049650.8         10168-13007
FEATURES             Location/Qualifiers
     source          1..3415
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..3415
                     /gene="ZNF343"
                     /gene_synonym="dJ734P14.5"
                     /note="zinc finger protein 343"
                     /db_xref="GeneID:79175"
                     /db_xref="HGNC:HGNC:16017"
     exon            1..35
                     /gene="ZNF343"
                     /gene_synonym="dJ734P14.5"
                     /inference="alignment:Splign:2.1.0"
     exon            36..122
                     /gene="ZNF343"
                     /gene_synonym="dJ734P14.5"
                     /inference="alignment:Splign:2.1.0"
     exon            123..389
                     /gene="ZNF343"
                     /gene_synonym="dJ734P14.5"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..2071
                     /gene="ZNF343"
                     /gene_synonym="dJ734P14.5"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 343 isoform 1"
                     /protein_id="NP_077301.4"
                     /db_xref="CCDS:CCDS13028.1"
                     /db_xref="GeneID:79175"
                     /db_xref="HGNC:HGNC:16017"
                     /translation="MMLPYPSALGDQYWEEILLPKNGENVETMKKLTQNHKAKGLPSN
                     DTDCPQKKEGKAQIVVPVTFRDVTVIFTEAEWKRLSPEQRNLYKEVMLENYRNLLSLA
                     EPKPEIYTCSSCLLAFSCQQFLSQHVLQIFLGLCAENHFHPGNSSPGHWKQQGQQYSH
                     VSCWFENAEGQERGGGSKPWSARTEERETSRAFPSPLQRQSASPRKGNMVVETEPSSA
                     QRPNPVQLDKGLKELETLRFGAINCREYEPDHNLESNFITNPRTLLGKKPYICSDCGR
                     SFKDRSTLIRHHRIHSMEKPYVCSECGRGFSQKSNLSRHQRTHSEEKPYLCRECGQSF
                     RSKSILNRHQWTHSEEKPYVCSECGRGFSEKSSFIRHQRTHSGEKPYVCLECGRSFCD
                     KSTLRKHQRIHSGEKPYVCRECGRGFSQNSDLIKHQRTHLDEKPYVCRECGRGFCDKS
                     TLIIHERTHSGEKPYVCGECGRGFSRKSLLLVHQRTHSGEKHYVCRECRRGFSQKSNL
                     IRHQRTHSNEKPYICRECGRGFCDKSTLIVHERTHSGEKPYVCSECGRGFSRKSLLLV
                     HQRTHSGEKHYVCRECGRGFSHKSNLIRHQRTH"
     exon            390..448
                     /gene="ZNF343"
                     /gene_synonym="dJ734P14.5"
                     /inference="alignment:Splign:2.1.0"
     exon            449..575
                     /gene="ZNF343"
                     /gene_synonym="dJ734P14.5"
                     /inference="alignment:Splign:2.1.0"
     exon            576..3415
                     /gene="ZNF343"
                     /gene_synonym="dJ734P14.5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3380..3385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF343"
                     /gene_synonym="dJ734P14.5"
                     /note="hexamer: AATAAA"
     polyA_site      3415
                     /gene="ZNF343"
                     /gene_synonym="dJ734P14.5"
                     /note="major polyA site"
ORIGIN      
        1 ggtcggtggc cgagatcccg ggcacgctgg ctctggtcca ccttctccaa tccctgcctg
       61 ctgggagagg acgatctctt gagaaaggaa agacttctgt gctcccgaga acttcctatc
      121 aggtcctggc tgcagggaaa caagctgggc tttttataat taaggttgga agaagtcacc
      181 acaggcagca gaactccatc ttgagatgaa ataacatcta cctggacctc tggcagaatt
      241 tcaaggcaca cactgggctg actctggcgc catgatgttg ccttatcctt cagcactggg
      301 agatcaatac tgggaagaga ttttgcttcc aaagaatggg gaaaatgtag agactatgaa
      361 gaaattgacc caaaatcata aagcgaaagg cttgccttct aatgatactg actgccccca
      421 gaaaaaggag ggaaaggccc aaatagtggt accagttaca ttcagggatg tgactgtgat
      481 cttcacagaa gcagaatgga agagactgag tccagagcag aggaatctat acaaagaagt
      541 gatgctggag aattacagga atcttctctc attggcagaa ccaaagccag aaatctacac
      601 ttgttcctcc tgccttctgg ccttctcctg tcagcagttc ctcagtcaac atgtacttca
      661 gatcttcctg ggcttatgtg cagaaaatca cttccatcca gggaattcta gcccagggca
      721 ttggaaacag caggggcagc agtattccca tgtaagctgt tggtttgaaa atgcagaagg
      781 tcaggagaga ggaggtggct ccaaaccctg gtctgcaagg acagaggaga gagaaacctc
      841 aagggcattc cccagcccac tccaaagaca gtcagcaagt cctagaaaag gcaacatggt
      901 ggtagaaaca gagcccagct cagcccaaag accaaaccct gtgcagctag acaaaggctt
      961 gaaggaatta gaaaccttga gatttggagc aatcaactgt agagagtatg aaccggacca
     1021 taacctggaa tcaaacttta ttacaaaccc gaggaccctc ttagggaaga agccctacat
     1081 ttgcagtgat tgtgggcgaa gctttaaaga tagatcaacc ctcatcagac accatcgtat
     1141 acactcgatg gagaagcctt atgtgtgcag tgagtgcggg cgaggtttta gccagaagtc
     1201 caacctcagc agacaccaga gaacacattc agaagagaag ccttatttgt gcagggagtg
     1261 tgggcaaagc tttagaagta agtccatcct caatagacat cagtggactc actcagagga
     1321 gaagccctat gtttgcagcg agtgtgggcg aggctttagc gagaagtcat ccttcatcag
     1381 acaccagagg acacactccg gtgagaaacc ctatgtgtgc ctggagtgtg gacgaagctt
     1441 ttgtgataag tcaaccctca gaaaacacca gaggatacac tcaggggaga agccttatgt
     1501 ttgcagggag tgtgggcgag gctttagcca gaactcagat ctcatcaaac accagaggac
     1561 acacttggat gagaagcctt atgtttgcag ggagtgtggg cgaggctttt gtgacaagtc
     1621 aaccctcatc atacacgagc ggacgcactc tggagagaag ccttatgtgt gtggtgagtg
     1681 tggccgaggc tttagtcgga aatcactcct ccttgtccac cagaggacac actcagggga
     1741 gaagcattat gtctgcaggg agtgtaggcg aggttttagc cagaagtcaa atctcatcag
     1801 acaccagagg acgcactcaa atgagaagcc ttatatttgc agggaatgtg ggcgaggctt
     1861 ttgtgacaag tcaaccctca ttgtacatga gaggacacac tcaggagaga agccttacgt
     1921 gtgcagtgag tgtggccgag gctttagccg gaaatcactc ctccttgtcc accagaggac
     1981 acactcaggg gagaagcatt atgtttgtag ggagtgtggg cgaggcttta gtcataagtc
     2041 aaatctcatc agacaccaga ggacacactg acgggagaaa cctgtgtatg caggggtcat
     2101 gaacaagacc tgagtgacca gtcaagcctc atgttacccc agagagacac atggggagta
     2161 gaccctgtgt acacagattg tgagtgaagt tccagagatg tgtcagccct tatcaggcat
     2221 gggagggaca cgttcaggag aggagcctta tgagtataga gtacgggcaa ctgtagccat
     2281 cagtcagcct tgagcatgca caaaaggaca cacttaggag agaagtttat gtgtagggac
     2341 tgtgggaagg ctttagcaat aatcaacatt taccagacat ccaatgacag cctcagggga
     2401 aagcaccctt gtctggggag tgttggggag catcagtaaa agaatggaca ctcaggcaca
     2461 gagtggccct caggaaggag gtctttgttt gtaggatgta tgggcaaagc ttttgtgatc
     2521 acacaccaca gggagaatct gcatgtgggg acactgtgga gctctgccca gatgaccttt
     2581 tcaggggtaa caccccagct gcttgagaga acagtgttgc tgctggcaga gatgcattcc
     2641 agagatgcac tccgctctgg aactcactct cagccacagg gagctgcatg caccacaggg
     2701 gcaatgcacc tttgcagggg taccttctgg ccccaaccct tgactcaacg gggacaactc
     2761 cagaaggtca ttccagatcc agagatcccc atcgaactga aggatcactg ggttgcagac
     2821 acattgcagg tcagcttctt cctctgccca gtcctgccct cactccccag tgaatcctca
     2881 attttctgtc tcgttgtctg tccagataat tgattctaag acatgttagg tatataagga
     2941 gtgtagataa ggcttcagcc atgagtcacc ccgcagtaag ccccagagta tattgaatag
     3001 aaattctgca tgtgtgggga gaatggacaa ggacttagga aaaagtcctc atcaaagaac
     3061 agcttttttg ggacaagctt tacatgggtg gggagggaaa atgtgaaaca cattagcaat
     3121 aagttaaacc tcatcttgta ctaaaggagg acacactcag ggagaagacc tctgtgggca
     3181 gggcttgtgg gtggagcttc atcccgatgt cactcctcaa ctgacttagg aggacagtct
     3241 tgctacccca agtcactacc tcactcacct ctgagggatt ttcaggaaat gtcttgactc
     3301 ccccatgtac tctgtatgtg agcgaagatg gcagtaactg ttaaataagc attcttttct
     3361 acttcttgga atcagatgaa ataaaaaagc aggctttatt taagtaatca aaaaa
//
