LOCUS       NM_001282933            3343 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 341 (ZNF341), transcript variant
            1, mRNA.
ACCESSION   NM_001282933
VERSION     NM_001282933.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3343)
  AUTHORS   Beziat,V., Fieschi,C., Momenilandi,M., Migaud,M., Belaid,B.,
            Djidjik,R. and Puel,A.
  TITLE     Inherited human ZNF341 deficiency
  JOURNAL   Curr Opin Immunol 82, 102326 (2023)
   PUBMED   37080116
  REMARK    GeneRIF: Inherited human ZNF341 deficiency.
            Review article
REFERENCE   2  (bases 1 to 3343)
  AUTHORS   Cekic,S., Huriyet,H., Hortoglu,M., Kasap,N., Ozen,A.,
            Karakoc-Aydiner,E., Metin,A., Ocakoglu,G., Demiroz Abakay,C.,
            Temel,S.G., Ozemri Sag,S., Baris,S., Cavas,T. and Sebnem Kilic,S.
  TITLE     Increased radiosensitivity and impaired DNA repair in patients with
            STAT3-LOF and ZNF341 deficiency, potentially contributing to
            malignant transformations
  JOURNAL   Clin Exp Immunol 209 (1), 83-89 (2022)
   PUBMED   35511492
  REMARK    GeneRIF: Increased radiosensitivity and impaired DNA repair in
            patients with STAT3-LOF and ZNF341 deficiency, potentially
            contributing to malignant transformations.
REFERENCE   3  (bases 1 to 3343)
  AUTHORS   Lachover-Roth,I., Lagovsky,I., Shtorch-Asor,A., Confino-Cohen,R.,
            Reinstein,E. and Garty,B.Z.
  TITLE     Hyper IgE Syndrome in an Isolated Population in Israel
  JOURNAL   Front Immunol 13, 829239 (2022)
   PUBMED   35185921
  REMARK    GeneRIF: Hyper IgE Syndrome in an Isolated Population in Israel.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3343)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3343)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3343)
  AUTHORS   Beziat,V., Li,J., Lin,J.X., Ma,C.S., Li,P., Bousfiha,A.,
            Pellier,I., Zoghi,S., Baris,S., Keles,S., Gray,P., Du,N., Wang,Y.,
            Zerbib,Y., Levy,R., Leclercq,T., About,F., Lim,A.I., Rao,G.,
            Payne,K., Pelham,S.J., Avery,D.T., Deenick,E.K., Pillay,B.,
            Chou,J., Guery,R., Belkadi,A., Guerin,A., Migaud,M., Rattina,V.,
            Ailal,F., Benhsaien,I., Bouaziz,M., Habib,T., Chaussabel,D.,
            Marr,N., El-Benna,J., Grimbacher,B., Wargon,O., Bustamante,J.,
            Boisson,B., Muller-Fleckenstein,I., Fleckenstein,B.,
            Chandesris,M.O., Titeux,M., Fraitag,S., Alyanakian,M.A.,
            Leruez-Ville,M., Picard,C., Meyts,I., Di Santo,J.P., Hovnanian,A.,
            Somer,A., Ozen,A., Rezaei,N., Chatila,T.A., Abel,L., Leonard,W.J.,
            Tangye,S.G., Puel,A. and Casanova,J.L.
  TITLE     A recessive form of hyper-IgE syndrome by disruption of
            ZNF341-dependent STAT3 transcription and activity
  JOURNAL   Sci Immunol 3 (24) (2018)
   PUBMED   29907691
  REMARK    GeneRIF: Human ZNF341 is essential for the STAT3
            transcription-dependent autoinduction and sustained activity of
            STAT3.
REFERENCE   7  (bases 1 to 3343)
  AUTHORS   Frey-Jakobs,S., Hartberger,J.M., Fliegauf,M., Bossen,C.,
            Wehmeyer,M.L., Neubauer,J.C., Bulashevska,A., Proietti,M.,
            Frobel,P., Noltner,C., Yang,L., Rojas-Restrepo,J., Langer,N.,
            Winzer,S., Engelhardt,K.R., Glocker,C., Pfeifer,D., Klein,A.,
            Schaffer,A.A., Lagovsky,I., Lachover-Roth,I., Beziat,V., Puel,A.,
            Casanova,J.L., Fleckenstein,B., Weidinger,S., Kilic,S.S.,
            Garty,B.Z., Etzioni,A. and Grimbacher,B.
  TITLE     ZNF341 controls STAT3 expression and thereby immunocompetence
  JOURNAL   Sci Immunol 3 (24) (2018)
   PUBMED   29907690
  REMARK    GeneRIF: Study reports two distinct homozygous nonsense mutations
            in exons 6 and 8 of ZNF341 in four consanguineous families with
            recurrent bacterial and fungal infections. ZNF341 mutations
            segregate with a phenotype resembling hyper-immunoglobulin E
            syndrome. Authors describe ZNF341 as a positive regulator of STAT3
            expression and report the clinical and laboratory phenotype of
            individuals lacking ZNF341.
REFERENCE   8  (bases 1 to 3343)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC132873.1, BC094738.1 and AK027550.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001282933.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146811.1, SRR1660803.184316.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375200.6/ ENSP00000364346.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2530              BC132873.1         37-2566
            2531-2614           BC094738.1         2329-2412
            2615-3337           AK027550.1         1626-2348
            3338-3343           BC094738.1         3136-3141
FEATURES             Location/Qualifiers
     source          1..3343
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..3343
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /note="zinc finger protein 341"
                     /db_xref="GeneID:84905"
                     /db_xref="HGNC:HGNC:15992"
                     /db_xref="MIM:618269"
     exon            1..57
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2591
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 341 isoform 1"
                     /protein_id="NP_001269862.1"
                     /db_xref="CCDS:CCDS74719.1"
                     /db_xref="GeneID:84905"
                     /db_xref="HGNC:HGNC:15992"
                     /db_xref="MIM:618269"
                     /translation="MAQAIFEALEGMDNQTVLAVQSLLDGQGAVPDPTGQSVNAPPAI
                     QPLDDEDVFLCGKCKKQFNSLPAFMTHKREQCQGNAPALATVSLATNSIYPPSAAPTA
                     VQQAPTPANRQISTYITVPPSPLIQTLVQGNILVSDDVLMSAMSAFTSLDQPMPQGPP
                     PVQSSLNMHSVPSYLTQPPPPPPPPPPLPPPPPPQPPPPPPQSLGPPGRPNPGGNGVV
                     EVYSAAAPLAGSGTVEIQALGMQPYPPLEVPNQCVEPPVYPTPTVYSPGKQGFKPKGP
                     NPAAPMTSATGGTVATFDSPATLKTRRAKGARGLPEAAGKPKAQKLKCSYCDKSFTKN
                     FDLQQHIRSHTGEKPFQCIACGRAFAQKSNVKKHMQTHKVWPPGHSGGTVSRNSVTVQ
                     VMALNPSRQEDEESTGLGQPLPGAPQPQALSTAGEEEGDKPESKQVVLIDSSYLCQFC
                     PSKFSTYFQLKSHMTQHKNEQVYKCVVKSCAQTFPKLDTFLEHIKSHQEELSYRCHLC
                     GKDFPSLYDLGVHQYSHSLLPQHSPKKDNAVYKCVKCVNKYSTPEALEHHLQTATHNF
                     PCPHCQKVFPCERYLRRHLPTHGSGGRFKCQVCKKFFRREHYLKLHAHIHSGEKPYKC
                     SVCESAFNRKDKLKRHMLIHEPFKKYKCPFSTHTGCSKEFNRPDKLKAHILSHSGMKL
                     HKCALCSKSFSRRAHLAEHQRAHTGNYKFRCAGCAKGFSRHKYLKDHRCRLGPQKDKD
                     LQTRRPPQRRAAPRSCGSGGRKVLTPLPDPLGLEELKDTGAGLVPEAVPGKPPFAEPD
                     AVLSIVVGGAVGAETELVVPGHAEGLGSNLALAELQAGAEGPCAMLAVPVYIQASE"
     exon            58..168
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /inference="alignment:Splign:2.1.0"
     exon            169..365
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /inference="alignment:Splign:2.1.0"
     exon            366..515
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /inference="alignment:Splign:2.1.0"
     exon            516..767
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /inference="alignment:Splign:2.1.0"
     exon            768..963
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1054
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1248
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1439
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1648
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1745
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1878
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1990
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2061
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..3343
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3320..3325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /note="hexamer: AATAAA"
     polyA_site      3343
                     /gene="ZNF341"
                     /gene_synonym="HIES3"
                     /note="major polyA site"
ORIGIN      
        1 gtggcggcga cggcggcggc tccaagatgg cgcaggcgat ctttgaggcc ctggagggaa
       61 tggacaatca gaccgttctg gctgtccagt cattattgga tggccaagga gcagtccctg
      121 atccgacagg ccagagtgtc aatgcgcccc ctgctatcca gccattggat gacgaggatg
      181 tatttctctg cgggaagtgt aagaagcaat tcaactcgct gccagcgttt atgacccaca
      241 agcgggaaca gtgccagggg aatgcccccg ccctggccac agtctcactg gccaccaaca
      301 gcatctaccc accttcggca gcacccacag cggtccagca ggccccaact cctgccaatc
      361 gccagatctc cacatacatc acagtgcccc cgtccccact gatccagacc ctggtgcagg
      421 ggaacatctt ggtgagcgat gatgtgctca tgtctgccat gtcagccttc acatccctgg
      481 accagcccat gccccagggc cccccacctg tgcagagcag cctgaacatg cattccgtgc
      541 ccagctacct cacccagcct ccacctcctc ctccacctcc tccaccactg cccccaccgc
      601 caccacctca gcctccacca cctccacccc agagcctggg cccccctggg cgtcccaacc
      661 ctggtgggaa cggtgtggtg gaggtgtaca gtgctgctgc gcccctggct gggagtggaa
      721 cggtggagat ccaggcactg gggatgcagc cctacccacc cctagaggtg ccaaaccagt
      781 gtgtggagcc tccagtatat cccaccccca cagtgtacag ccctggcaaa cagggattca
      841 aacccaaagg accaaacccc gccgccccca tgaccagcgc caccgggggc acggtggcca
      901 cctttgactc tccagcaacg ctgaagaccc gacgagctaa aggtgccagg ggactcccgg
      961 aagctgcagg gaagccaaag gctcagaaac tcaagtgctc atactgtgac aagtcattca
     1021 ccaaaaactt tgacctgcag cagcacatcc gaagccacac cggtgagaag cccttccagt
     1081 gcattgcatg tggccgtgcc tttgcccaga agtctaatgt taagaaacac atgcagaccc
     1141 acaaggtgtg gcctccagga cacagtggtg gcaccgtgtc tcgaaactct gtgaccgtac
     1201 aggtcatggc cctgaacccc agcaggcagg aggacgagga aagcacaggg ttgggccagc
     1261 ccctgccggg tgcgccacag ccccaggcct tgtccacagc tggtgaggaa gagggggaca
     1321 agccggagtc caagcaggtg gtcctcatcg acagctccta cctgtgccaa ttctgcccca
     1381 gcaaattcag cacctacttc cagctcaagt ctcacatgac ccagcataag aatgagcagg
     1441 tgtacaagtg tgtggtcaaa agctgtgccc agacgttccc aaagctcgac acatttctgg
     1501 agcacatcaa gagccaccag gaggagctga gctaccgctg ccacctctgc ggcaaggact
     1561 tcccctcgct gtacgacctg ggcgtgcacc agtactccca cagcctcctg ccacagcaca
     1621 gccccaagaa ggacaatgcc gtctacaagt gtgtcaaatg tgtcaacaaa tactccaccc
     1681 ctgaggccct ggagcaccac ctgcagaccg ccactcacaa cttcccctgc ccacactgcc
     1741 agaaggtgtt tccttgtgaa cgctacctgc ggcgtcatct gcccacccac ggcagcgggg
     1801 gcaggttcaa gtgccaagtg tgcaagaagt tcttccggcg ggagcattat ctcaaactgc
     1861 atgctcacat ccactcgggt gagaagccct acaaatgctc agtgtgcgag tctgcgttca
     1921 accgcaagga caaactgaag agacacatgt tgatccacga gcccttcaag aaatacaaat
     1981 gccctttctc gacgcacaca ggctgcagta aggagttcaa ccggccggac aagctgaagg
     2041 cccacatcct ctcccactct ggcatgaagc tccacaaatg cgccctgtgc agcaagtcct
     2101 tcagccgccg tgcccacctc gccgagcatc agcgcgccca cacgggcaac tacaagttcc
     2161 gctgtgctgg ctgcgccaag ggcttttccc gccacaaata cctcaaagat caccgctgtc
     2221 gtctcggccc ccaaaaggac aaggacctgc aaacccggcg gcccccccag aggagggcag
     2281 ccccccgcag ttgcggcagt ggtgggcgca aggtgctgac ccccttgcct gacccgctgg
     2341 ggctggagga gctgaaggac acaggggctg ggctggtgcc cgaggctgtc cccggcaagc
     2401 cgcccttcgc agagccggac gcggtgctgt ccatcgttgt gggtggtgcg gtgggcgcgg
     2461 aaactgagct ggtggtacct ggacacgctg aggggctggg ctccaacctg gctctggcgg
     2521 agctgcaggc tggggccgag ggcccatgtg ccatgctcgc tgtgcccgtc tacatccagg
     2581 cctccgagtg acggacctga ggtgtctgtt tcctgggcag gcctgatgct cctgtttggg
     2641 tccagggccc ctgggggcag accggtgatc cttaccagtg gaagcgagcc atcgagccat
     2701 tggcagaaat cctgctgaat gtcattcaga aacctcagcc catggtcgcc ctcctgtgcc
     2761 cctctcctgc cggaaagccc tgcaacattc tagggttggg ggcagggcca tccacggttt
     2821 ctgggcagag ccatggtggc aggagagaga tggctgaagc ctgagcagcc cagagtcccg
     2881 ctggtctagg ctggtggtcg gggcccctgg gagaggagac agggcattcc tccccactct
     2941 gtctccaggc tgcctctggg tagcctctag tctgctgttc ttcaggaggc ctgccataaa
     3001 ctcttcggag tttacgtgtt gcaccttttc acagacggtt ccccacagca tcctcagaca
     3061 gctctgtgat gtagctttta ggaggcactc aggtgtcacg gctagactgc agctatgaga
     3121 cagatctggc ttcaaatcca agagttgcca tgcacttgct gtgtgacctt gggcaagtca
     3181 cttcacttct ctgagccccg tgttcctcat ctgtacaatg gggcttacga tactactacc
     3241 tcatagggtt gtcctgggga tccagtatga tgaagtgcgc caggggcttg gcatggtgcc
     3301 cggcacgcag aaagtgctca ataaatgttt ttgtcataac gtg
//
