LOCUS       NM_001286769            2808 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 34 (ZNF34), transcript variant 2,
            mRNA.
ACCESSION   NM_001286769 XM_005272347
VERSION     NM_001286769.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2808)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   2  (bases 1 to 2808)
  AUTHORS   Subaran,R.L., Odgerel,Z., Swaminathan,R., Glatt,C.E. and
            Weissman,M.M.
  TITLE     Novel variants in ZNF34 and other brain-expressed transcription
            factors are shared among early-onset MDD relatives
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 171B (3), 333-341 (2016)
   PUBMED   26823146
  REMARK    GeneRIF: genes encoding transcription factors expressed in the
            brain might be an important group of major depressive disorder
            candidate genes.
REFERENCE   3  (bases 1 to 2808)
  AUTHORS   La Pillo,B., Ludecke,H.J., Thiesen,H.J. and Horsthemke,B.
  TITLE     A BanII RFLP in the ZNF34 zinc finger gene on chromosome 8
  JOURNAL   Hum Mol Genet 2 (8), 1331 (1993)
   PUBMED   8104631
REFERENCE   4  (bases 1 to 2808)
  AUTHORS   Huebner,K., Druck,T., Croce,C.M. and Thiesen,H.J.
  TITLE     Twenty-seven nonoverlapping zinc finger cDNAs from human T cells
            map to nine different chromosomes with apparent clustering
  JOURNAL   Am J Hum Genet 48 (4), 726-740 (1991)
   PUBMED   2014798
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833814.1, AF235103.5 and W43004.1.
            
            On Jan 24, 2020 this sequence version replaced NM_001286769.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR, lacks a portion of the 5' coding region, and
            initiates translation at a downstream start codon, compared to
            variant 1. The encoded isoform (2) has a shorter N-terminus
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3343434.1,
                                           SRR14038191.4213307.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429371.7/ ENSP00000396894.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1912              AL833814.1         9-1920
            1913-2462           AF235103.5         75534-76083         c
            2463-2808           W43004.1           10-355              c
FEATURES             Location/Qualifiers
     source          1..2808
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2808
                     /gene="ZNF34"
                     /gene_synonym="KOX32"
                     /note="zinc finger protein 34"
                     /db_xref="GeneID:80778"
                     /db_xref="HGNC:HGNC:13098"
                     /db_xref="MIM:194526"
     exon            1..39
                     /gene="ZNF34"
                     /gene_synonym="KOX32"
                     /inference="alignment:Splign:2.1.0"
     exon            40..92
                     /gene="ZNF34"
                     /gene_synonym="KOX32"
                     /inference="alignment:Splign:2.1.0"
     exon            93..179
                     /gene="ZNF34"
                     /gene_synonym="KOX32"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1766
                     /gene="ZNF34"
                     /gene_synonym="KOX32"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein 34 (KOX 32); zinc finger protein KOX32"
                     /codon_start=1
                     /product="zinc finger protein 34 isoform 2"
                     /protein_id="NP_001273698.1"
                     /db_xref="CCDS:CCDS69562.1"
                     /db_xref="GeneID:80778"
                     /db_xref="HGNC:HGNC:13098"
                     /db_xref="MIM:194526"
                     /translation="MAALFLSAPPQAEVTFEDVAVYLSREEWGRLGPAQRGLYRDVML
                     ETYGNLVSLGVGPAGPKPGVISQLERGDEPWVLDVQGTSGKEHLRVNSPALGTRTEYK
                     ELTSQETFGEEDPQGSEPVEACDHISKSEGSLEKLVEQRGPRAVTLTNGESSRESGGN
                     LRLLSRPVPDQRPHKCDICEQSFEQRSYLNNHKRVHRSKKTNTVRNSGEIFSANLVVK
                     EDQKIPTGKKLHYCSYCGKTFRYSANLVKHQRLHTEEKPYKCDECGKAFSQSCEFINH
                     RRMHSGEIPYRCDECGKTFTRRPNLMKHQRIHTGEKPYKCGECGKHFSAYSSLIYHQR
                     IHTGEKPYKCNDCGKAFSDGSILIRHRRTHTGEKPFECKECGKGFTQSSNLIQHQRIH
                     TGEKPYKCNECEKAFIQKTKLVEHQRSHTGEKPYECNDCGKVFSQSTHLIQHQRIHTG
                     EKPYKCSECGKAFHNSSRLIHHQRLHHGEKPYRCSDCKKAFSQSTYLIQHRRIHTGEK
                     PYKCSECGKAFRHSSNMCQHQRIHLREDFSM"
     exon            180..306
                     /gene="ZNF34"
                     /gene_synonym="KOX32"
                     /inference="alignment:Splign:2.1.0"
     exon            307..426
                     /gene="ZNF34"
                     /gene_synonym="KOX32"
                     /inference="alignment:Splign:2.1.0"
     exon            427..2808
                     /gene="ZNF34"
                     /gene_synonym="KOX32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1893..1898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF34"
                     /gene_synonym="KOX32"
                     /note="hexamer: AACAAA"
     polyA_site      1918
                     /gene="ZNF34"
                     /gene_synonym="KOX32"
                     /note="major polyA site"
     regulatory      2784..2789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF34"
                     /gene_synonym="KOX32"
                     /note="hexamer: CATAAA"
     polyA_site      2808
                     /gene="ZNF34"
                     /gene_synonym="KOX32"
ORIGIN      
        1 gggcgaggtt gggctgccgt gctgctcggc ggcgctgagg ccaaatagtt gcatcacatg
       61 tatctaatcc gagagtctca tgcttctggt agctcctcag tgaccagctc ctgctcactg
      121 ccctcagaaa gcccaaccct caggcaatgg cggccttgtt cctgtctgcc ccaccccagg
      181 ccgaggtgac cttcgaggac gtggctgtgt acctctcccg ggaggaatgg ggccgcctgg
      241 gccctgctca gaggggcctc tacagggacg tgatgctgga gacctacggg aacctagtct
      301 cactgggagt aggacctgca ggccccaagc ctggagtgat ctcgcagttg gagcgagggg
      361 atgagccctg ggtcctggat gttcagggca cctctgggaa agagcacctg agagtcaaca
      421 gcccagctct tgggaccaga actgagtaca aggagttgac ttcacaggag acatttggtg
      481 aggaagatcc ccagggatct gagccagtag aagcctgtga ccacatcagt aagtcagagg
      541 ggagcctgga aaagctagtg gagcagagag gccccagggc agtcacactg accaacgggg
      601 agagcagcag ggagtctggg ggaaacctca ggttgctgtc aagacctgtt cctgatcaga
      661 gacctcacaa atgtgatata tgtgagcaaa gttttgaaca gagatcatat ctcaacaacc
      721 ataagcgtgt acacaggtca aaaaaaacaa atacagttcg taactctggg gaaatcttca
      781 gtgcaaactt agttgttaaa gaagatcaga aaattcctac tgggaaaaaa ttgcattatt
      841 gcagttactg tgggaaaaca ttcaggtaca gtgccaacct tgtcaagcat cagcggcttc
      901 acactgaaga gaagccctac aaatgtgatg agtgtgggaa agccttcagc cagagctgcg
      961 agttcatcaa tcaccgaagg atgcactcag gagagattcc ctaccggtgt gacgagtgtg
     1021 ggaagacatt cacccggagg cccaacctca tgaagcacca gaggattcac actggggaga
     1081 aaccctacaa gtgtggggag tgtgggaagc actttagcgc ctactcttcc ctgatttatc
     1141 accagagaat ccacaccgga gagaaaccct ataaatgtaa tgactgcggg aaagccttca
     1201 gtgatggctc aatccttatc cgacatcgtc ggactcacac cggagagaag ccatttgagt
     1261 gcaaggaatg tggcaaaggc tttacacaaa gttctaacct tatccaacat cagagaattc
     1321 acactggaga gaaaccctat aaatgtaatg aatgtgagaa agctttcatt caaaaaacca
     1381 aactcgtgga acatcagaga agccacactg gagagaagcc ctatgaatgc aatgactgtg
     1441 gcaaagtttt cagccaaagc acacacctca tccagcacca gagaatccac acaggagaga
     1501 agccctacaa gtgcagcgag tgtgggaagg ccttccacaa cagttccaga ctcatccacc
     1561 accagaggct gcaccacgga gagaaaccct acagatgcag cgattgcaag aaagccttca
     1621 gccagagcac gtacttgatt cagcaccgga ggatccacac cggggagaag ccctacaagt
     1681 gcagcgagtg tgggaaggcc ttccggcaca gttccaacat gtgtcagcat cagcggattc
     1741 acctccggga ggacttctcc atgtaacagt ggcgcggtgt ccgagggcag agtccagctg
     1801 agcacttcct gcatgcgccc ccggcacctg actctgccct ttatgtatta tccacacgat
     1861 gttttcacag agtgaaagga cgtttctcat taaacaaacc tcttttctta aatcaaaagc
     1921 agtgcatgtt cattttagag aaattgagac agaaaagtgg gcaaaaaaga agcttctgtg
     1981 atctctccca cttagaaaaa aaattcattg ctgctgattt acgaatattt tcgagacata
     2041 ctggagagca ttttaaaaag aaaataccgt aatgcttgtc attgcagcac ctaggatctt
     2101 cacttttgct atttcctcaa tatcagaaaa ttcacactga agagagcacc atatatttta
     2161 acatttttac atattgtaaa tttaaaagca tcggccaggt gtggtggctc atgcctgtaa
     2221 taccagcatt ttgagaggcc aaggtgggtg gatcacttga ggtcaggagt ttgagaccag
     2281 cctggccaac atggtgaaac cccgtctcta ctaaaaatac aaaaattagc caggtgtggt
     2341 ggtgggtgcc tgtaatccca gctactcggg aggctgaggc aggagcattg cttgaacctg
     2401 ggaggcggag gttgcagtga gccaagactg tgccactgta ctccagcctg ggtgacagag
     2461 cgagacgctg tctcaaaaaa taaatgaaac aaacttaaca ttcatacttt ttatgtcaat
     2521 agagttgaag ttgcctttaa ctgtggtgaa ataacataat atgaaattta caattttaac
     2581 catttttaag tgtacaattc agtggcatta agtacattca tggtgttgtg taaccatcat
     2641 cactgtgtat ttccagaact gttttattac tccaaacaga aaccctgtac ctattaaata
     2701 ataactcttc atttccccct tctccctact gctggtaacc tcaattctat tttctgtctc
     2761 tttgaatttg cctattctag gaacataaat atgtgtggaa tcatgcaa
//
