LOCUS       NM_006955               5982 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 33B (ZNF33B), transcript variant
            2, mRNA.
ACCESSION   NM_006955
VERSION     NM_006955.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5982)
  AUTHORS   Lee,S., Prokopenko,D., Kelly,R.S., Lutz,S., Ann Lasky-Su,J.,
            Cho,M.H., Laurie,C., Celedon,J.C., Lange,C., Weiss,S.T., Hecker,J.
            and DeMeo,D.L.
  TITLE     Zinc finger protein 33B demonstrates sex interaction with
            atopy-related markers in childhood asthma
  JOURNAL   Eur Respir J 61 (1), 2200479 (2023)
   PUBMED   35953101
  REMARK    GeneRIF: Zinc finger protein 33B demonstrates sex interaction with
            atopy-related markers in childhood asthma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5982)
  AUTHORS   de los Santos,M.J., Garcia-Laez,V., Beltran-Torregrosa,D.,
            Horcajadas,J.A., Martinez-Conejero,J.A., Esteban,F.J., Pellicer,A.
            and Labarta,E.
  TITLE     Hormonal and molecular characterization of follicular fluid,
            cumulus cells and oocytes from pre-ovulatory follicles in
            stimulated and unstimulated cycles
  JOURNAL   Hum Reprod 27 (6), 1596-1605 (2012)
   PUBMED   22451503
REFERENCE   3  (bases 1 to 5982)
  AUTHORS   Tunnacliffe,A., Liu,L., Moore,J.K., Leversha,M.A., Jackson,M.S.,
            Papi,L., Ferguson-Smith,M.A., Thiesen,H.J. and Ponder,B.A.
  TITLE     Duplicated KOX zinc finger gene clusters flank the centromere of
            human chromosome 10: evidence for a pericentric inversion during
            primate evolution
  JOURNAL   Nucleic Acids Res 21 (6), 1409-1417 (1993)
   PUBMED   8464732
REFERENCE   4  (bases 1 to 5982)
  AUTHORS   Rousseau-Merck,M.F., Tunnacliffe,A., Berger,R., Ponder,B.A. and
            Thiesen,H.J.
  TITLE     A cluster of expressed zinc finger protein genes in the
            pericentromeric region of human chromosome 10
  JOURNAL   Genomics 13 (3), 845-848 (1992)
   PUBMED   1639412
REFERENCE   5  (bases 1 to 5982)
  AUTHORS   Huebner,K., Druck,T., Croce,C.M. and Thiesen,H.J.
  TITLE     Twenty-seven nonoverlapping zinc finger cDNAs from human T cells
            map to nine different chromosomes with apparent clustering
  JOURNAL   Am J Hum Genet 48 (4), 726-740 (1991)
   PUBMED   2014798
REFERENCE   6  (bases 1 to 5982)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK310073.1 and AJ491697.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006955.2.
            
            Summary: This gene encodes a member of the zinc finger family of
            proteins. This gene shows decreased expression in cumulus cells
            derived from patients undergoing controlled ovarian stimulation.
            This gene is present in a gene cluster with several related zinc
            finger genes in the pericentromeric region of chromosome 10.
            Pseudogenes have been identified on chromosomes 7 and 10.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            contains an alternate exon in the 5' coding region and initiates
            translation at an alternate start codon, compared to variant 1. The
            encoded isoform (2) has a distinct N-terminus and is shorter
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA540683.1, AJ491697.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359467.8/ ENSP00000352444.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AK310073.1         268-293
            27-5982             AJ491697.1         1-5956
FEATURES             Location/Qualifiers
     source          1..5982
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.21"
     gene            1..5982
                     /gene="ZNF33B"
                     /gene_synonym="KOX2; KOX31; ZNF11B"
                     /note="zinc finger protein 33B"
                     /db_xref="GeneID:7582"
                     /db_xref="HGNC:HGNC:13097"
                     /db_xref="MIM:194522"
     exon            1..97
                     /gene="ZNF33B"
                     /gene_synonym="KOX2; KOX31; ZNF11B"
                     /inference="alignment:Splign:2.1.0"
     exon            98..150
                     /gene="ZNF33B"
                     /gene_synonym="KOX2; KOX31; ZNF11B"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..2478
                     /gene="ZNF33B"
                     /gene_synonym="KOX2; KOX31; ZNF11B"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein 33b (KOX 31); zinc finger protein 11b (KOX
                     2)"
                     /codon_start=1
                     /product="zinc finger protein 33B isoform 2"
                     /protein_id="NP_008886.1"
                     /db_xref="CCDS:CCDS7198.1"
                     /db_xref="GeneID:7582"
                     /db_xref="HGNC:HGNC:13097"
                     /db_xref="MIM:194522"
                     /translation="MNKVDQKFQGSVSFKDVTVGFTQEEWQHLDPSQRALYRDVMLEN
                     YSNLVSVGYCAHKPEVIFRLEQGEEPWRLEEEFPSQSFPEVWTADHLKERSQENQSKH
                     LWEVVFINNEMLTKEQGNVIGIPFNMDVSSFPSRKMFCQYDSRGMSFNTVSELVISKI
                     NYLGKKSDEFNACGKLLLNIKHDETHTREKNEVLKNRNTLSHRENTLQHEKIQTLDHN
                     FEYSICQETLLEKAVFNTRKRENAEENNCDYNEFGRTFCDSSSLLFHQIPPSKDSHYE
                     FSDCEKFLCVKSTLSKHDGVPVKHYDCGESGNNFRRKLCLSQLQKGDKGEKHFECNEC
                     GKAFWEKSHLTRHQRVHTGEKHFQCNQCGKTFWEKSNLTKHQRSHTGEKPFECNECGK
                     AFSHKSALTLHQRTHTGEKPYQCNACGKTFYQKSDLTKHQRTHTGQKPYECYECGKSF
                     CMNSHLTVHQRTHTGEKPFECLECGKSFCQKSHLTQHQRTHIGDKPYECNACGKTFYH
                     KSVLTRHQIIHTGLKPYECYECGKTFCLKSDLTIHQRTHTGEKPFACPECGKFFSHKS
                     TLSQHYRTHTGEKPYECHECGKIFYNKSYLTKHNRTHTGEKPYECNECGKTFCQKSQL
                     TQHQRIHIGEKPYECNECGKAFCHKSALIVHQRTHTQEKPYKCNECGKSFCVKSGLIL
                     HERKHTGEKPYECNECGKSFSHKSSLTVHHRAHTGEKSCQCNECGKIFYRKSDLAKHQ
                     RSHTGEKPYECNTCRKTFSQKSNLIVHQRTHIGEKPYE"
     exon            151..295
                     /gene="ZNF33B"
                     /gene_synonym="KOX2; KOX31; ZNF11B"
                     /inference="alignment:Splign:2.1.0"
     exon            296..391
                     /gene="ZNF33B"
                     /gene_synonym="KOX2; KOX31; ZNF11B"
                     /inference="alignment:Splign:2.1.0"
     exon            392..5982
                     /gene="ZNF33B"
                     /gene_synonym="KOX2; KOX31; ZNF11B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5962..5967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF33B"
                     /gene_synonym="KOX2; KOX31; ZNF11B"
                     /note="hexamer: AATAAG"
     regulatory      5966..5971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF33B"
                     /gene_synonym="KOX2; KOX31; ZNF11B"
                     /note="hexamer: AGTAAA"
     polyA_site      5978
                     /gene="ZNF33B"
                     /gene_synonym="KOX2; KOX31; ZNF11B"
     polyA_site      5982
                     /gene="ZNF33B"
                     /gene_synonym="KOX2; KOX31; ZNF11B"
                     /note="major polyA site"
ORIGIN      
        1 ccttttgttt gtctcacgtt ttgcgtggga ggcggtcccg ggatttcagg ggtctaccgg
       61 ctctcttatg gcgaatgcaa cccgaagaga gagtgagctg tatcttcaga gttgtctccg
      121 tctttccaag aacagaacaa aatgaacaag gtagatcaga agttccaggg gtcagtatca
      181 tttaaagatg tgactgtggg cttcacccag gaggagtggc agcacctgga ccctagtcag
      241 agggctctgt atagagatgt gatgctggag aactacagca accttgtctc agtggggtat
      301 tgtgctcaca aaccagaggt gatcttcagg ctggaacaag gagaagaacc atggagactg
      361 gaggaagaat tcccaagcca gagctttcca gaagtctgga cagctgatca cctgaaagag
      421 aggagccaag aaaatcaatc taaacatttg tgggaagttg tattcatcaa taatgaaatg
      481 ctgactaagg aacaaggtaa tgtaatagga ataccattta acatggacgt aagttctttt
      541 ccttccagaa aaatgttctg tcagtatgac tcacgtggaa tgagtttcaa cactgtttca
      601 gaattggtta tcagtaagat aaactattta ggaaaaaagt ctgacgaatt taatgcatgt
      661 gggaaattgt tactcaatat taagcatgat gaaactcata ctcgagagaa aaatgaagtt
      721 ttgaaaaata ggaacactct gagtcatcgt gagaacactt tgcagcatga gaagattcaa
      781 actttagacc acaattttga atacagtata tgtcaggaaa ccctccttga aaaggcagta
      841 ttcaatacac ggaagagaga gaatgcagaa gagaataact gtgactataa tgaatttggg
      901 agaactttct gtgatagttc atccctcttg ttccatcaga tacctccatc aaaggacagt
      961 cactatgaat ttagtgattg tgagaagttc ttatgtgtga agtccaccct ttctaaacat
     1021 gatggggtac ctgtgaaaca ctatgattgt ggtgaaagtg ggaataattt caggaggaaa
     1081 ttgtgtctgt cacagcttca gaaaggtgat aaaggagaga aacactttga atgtaatgaa
     1141 tgtgggaaag ctttctggga gaagtcacat ctcactcgac atcagagggt gcacacagga
     1201 gagaaacact ttcaatgtaa tcaatgtgga aaaactttct gggagaagtc aaacctcact
     1261 aaacatcaga gatcacacac aggggagaaa ccttttgaat gcaatgaatg tgggaaagcc
     1321 tttagccata agtcagccct cacattacac cagagaacac atacagggga gaaaccctat
     1381 cagtgtaatg catgtgggaa aactttttac cagaaatctg acctcactaa acatcagaga
     1441 acacacacag ggcagaaacc ctatgaatgt tatgaatgtg gaaaatcctt ctgtatgaat
     1501 tcacacctta cagtacacca gagaactcac acaggtgaga aaccttttga atgtcttgag
     1561 tgtgggaaat ccttttgtca aaagtcacat cttacacagc atcagagaac tcacatagga
     1621 gataaacctt atgaatgtaa tgcatgtggg aaaactttct accacaagtc agtactcacc
     1681 aggcatcaga taattcatac agggttgaaa ccttatgaat gttatgaatg tgggaaaacc
     1741 ttctgcttga agtcagacct cacaatacat cagagaacgc acacagggga gaaacccttt
     1801 gcatgtcctg aatgtgggaa attctttagc cataagtcaa ccctctctca acattataga
     1861 acacacacgg gggagaaacc ctatgaatgt catgaatgtg gaaaaatctt ttacaataaa
     1921 tcatacctaa caaaacataa tagaacacat acaggggaga aaccctatga atgtaatgaa
     1981 tgtggaaaaa ccttctgcca gaagtcacaa ctcactcagc atcagagaat tcacataggg
     2041 gagaaaccct atgaatgtaa tgagtgtgga aaagctttct gccataagtc agctctaatt
     2101 gtacatcaga gaacccatac acaagaaaag ccttataaat gtaacgaatg tggaaaatct
     2161 ttctgtgtga agtcaggact tattttacat gagagaaagc acacggggga gaaaccctat
     2221 gaatgcaatg aatgtgggaa atccttcagt cacaaatcat cactcacagt acatcacagg
     2281 gctcacacag gagagaaatc ttgtcagtgt aatgaatgtg gaaaaatctt ttaccgtaaa
     2341 tcagaccttg ctaaacatca gagatcacat acaggggaaa agccctatga atgtaacaca
     2401 tgcaggaaaa ccttctctca aaagtcaaat ctcattgtac atcagagaac acacatagga
     2461 gaaaaacctt atgaatgaat tggatattag aaatttccag ccacaagtca gcctccataa
     2521 tgcctcagag tcttcacact gtggagaagg gcctgttgac atcctgaatg ttcaataact
     2581 atccacaaac tcgccttatg ttactccaaa gtaacagtag gggataaacc catagactac
     2641 aacaactata ggatggcttt tgttaggaag tgatattctg ttgaatatca gatggttaat
     2701 actggcataa aacctcacag atttttttga atttgtgaaa gtttttggca aaactacaaa
     2761 taggattatg ttagcattta cactgaggag aaaattgtca atttaagaaa tctaaagtga
     2821 aaattttgct tagaaataaa atatgacaag ttctgttttg agtttgatgc cataatagtt
     2881 tttaaggtat ctaacaataa tttatagatg tacattgtgg aatgtaaagc tttaagaatt
     2941 ttttaagaag taataattaa aataacctca caagaagttg taatgagtac agagaattcc
     3001 cgtgtaccct tcaccaagct tcctctaagg ataatatata atcatagtat atggtcaagt
     3061 ccaagaaatc gatgttacct tgctagtaga tgcagactta ctcagatttt gctatggttt
     3121 gcgtgcactc tgtgtgtgta cgtgtatgtg tgtgtgtgtg gttataacaa actggtactt
     3181 ttacatttga gtaaccatca acacaattag tttacagaat ggaaaaggag tctgagatct
     3241 gtactgtttc aggattacaa aggaatcagg atttagcctc aagtagttcc cttgttgtat
     3301 taataaccac accctttctg catccctgtc cctggcatcc acttgactat gaagcttttt
     3361 gtaaagcata gataaattga ataatcaggg caacagcatt aagcacatct gtgaattatc
     3421 cctgaagttc ataggactta catatgtaca agtggtatgt gatataaatc gtgtgtttca
     3481 tatgcataat ggtatttaac gtaattgtga ataggaagta ggtatcctaa tttagtagtg
     3541 gttacttcat caggcccatc ccaggtgttt gtcgtgtcct gaaacaattt aaatagagac
     3601 ccacagagct aatgtttatc catttaaaag ttataaatca aaataacaga ttatctgaaa
     3661 aaaaatctat cctgtacgtg tgaagatcta ggcctgcctc catgttactc cctttctctt
     3721 actacctgtg gctcatccca tgccatgaac tgcctggggt acatatgtga acactccagc
     3781 cttcagcgta agtgatagtc caaattttct ttaagcagct gctctccaag acagggccct
     3841 ggaaagaggc ccacacatac agcccagttg ctgcccaggg ctgttggact gtcatttcat
     3901 tgctcattgt acccagacag ggatctgggc cttcagagac ttttgagaat atgaagagga
     3961 gggttgaggc tggagaagag ccagaatcaa gctggcatgg ggcttttatt gacagtgtga
     4021 agattgtaca ctacattaca tgatcagatc atacaaataa tctaagattt tacagtctgg
     4081 tgaccctaga ttacacaagt aatctaagct tccactttgg aaaactagaa aaagaagagc
     4141 aaattaaatc caaagtaacc tggaaaaaaa ttagagtaaa aatcagtgaa attgaaaaga
     4201 gaaaatcaat aaaacccaaa actgttcttt gaaaaggtgg gtaaaattga taaacctcta
     4261 gctagattaa gaaaaaacag aagacaaata ctgctaatac caaaagtgaa agaggccatc
     4321 atagctgatc ctatggtcac caaaaggatt agaaagaaat atggacaact ctgtccataa
     4381 atttgataac ttagctaaaa tggatcaatt ccttgcaaga tgcattctct caaagctcat
     4441 aaaaggtaga tctcagtagg catatatatc tattaaataa attgaagcag taattaataa
     4501 ccttccaaga ccaggcgcgg tggctaaaaa tacaaaaagt tagccgggcg tggtggcatg
     4561 cgtgtatagt ccaagctact caggaggctg aggcagaaga atcacttgaa cctgggaggt
     4621 ggaggttgca gtgagccaag attgtgccac tgtactccag cctgggtgac agagtgagac
     4681 tccatctcaa taaaattaat aataataaaa ccttccaaaa aaagtgccgg gaccaaatgg
     4741 attcactgat gtgcattttt cgagatactt aaggtagaaa tgataccaag tctgtactgt
     4801 ctctttcaga aaataaaagc agggataaca cttcccaaat cattttgtga ggccaggatt
     4861 accctaatac caaagccagg caaaaacatt acaagaaagg aaaactacag atcaatattt
     4921 ccagtgaaca cagatgcaga aatccttaaa atgttagcaa atcaggaatg caagccttgt
     4981 tcaacatttg atattcagtg caatccattg catgcattag cagttcaaag attaaatatg
     5041 atcatatcaa taggtacaga aaaagcattt gacaaaatcc aatatccatt catgataaaa
     5101 cctctcaaca cagaaggaat acaggagaac ttactcaatt tgataaagaa ctactacaaa
     5161 aaaccctaca tctagcatca tccttgatgt ttccaactaa atgctttcct actaagatca
     5221 ggaacatggc aaggaacacc actgcttttc agcattgtac tggaagtgct atctaatgca
     5281 gtgataccaa aaaaaaagga aataaaatgc acataaattt ggaaggagga aatacaactg
     5341 tctttgttct caaataacat gattgtcttt gtagaaaatt ctaaataaca aaaacctgct
     5401 gacattaata agcaattata gcagggttgt agaatgtagt cctcaggtat atgataaaaa
     5461 agaattagac atcaagtcat taaaagacat ataggaaccc taaatgctta ttgttaagtg
     5521 aaaaccaatc tgaaaaggct ttctatgttg tatgattgca attatatgac attctgggag
     5581 aggcaaaact atcgagcgag tcaaaggacc agtggttgct gagagttgag gggaaaggag
     5641 ggatggcagg taggtgattt ttaggacagt gaaagtactc tgtagggtac tgtaatttgt
     5701 caaaatgcag agaatggaaa acagtgaacg gaaaacacag agtaaaccct agtgtcaact
     5761 ctggacttca gttaataaca gtgtaccact attggctcat caattgtaac aaatgaacca
     5821 taatgatgca agatgttaat aattggggag cctgtggagg atgggagggt taaaggttta
     5881 tatgagaatt ctctgtactt tttgctcaat ttttctgtaa ccctaaagct gctctaaaaa
     5941 atgaagtgta ttaagtaaat aaataagtaa ataaccaacc aa
//
