LOCUS       NM_006954               6116 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 33A (ZNF33A), transcript variant
            1, mRNA.
ACCESSION   NM_006954
VERSION     NM_006954.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6116)
  AUTHORS   Kooy,R.F.
  TITLE     ZNF711 puts a spell on DNA
  JOURNAL   Eur J Hum Genet 30 (4), 396-397 (2022)
   PUBMED   35132177
  REMARK    GeneRIF: ZNF711 puts a spell on DNA.
            Review article
REFERENCE   2  (bases 1 to 6116)
  AUTHORS   Rao,S., Shi,M., Han,X., Lam,M.H.B., Chien,W.T., Zhou,K., Liu,G.,
            Wing,Y.K., So,H.C. and Waye,M.M.Y.
  TITLE     Genome-wide copy number variation-, validation- and screening study
            implicates a new copy number polymorphism associated with suicide
            attempts in major depressive disorder
  JOURNAL   Gene 755, 144901 (2020)
   PUBMED   32554045
  REMARK    GeneRIF: Genome-wide copy number variation-, validation- and
            screening study implicates a new copy number polymorphism
            associated with suicide attempts in major depressive disorder.
REFERENCE   3  (bases 1 to 6116)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   4  (bases 1 to 6116)
  AUTHORS   Tomarev,S.I., Wistow,G., Raymond,V., Dubois,S. and Malyukova,I.
  TITLE     Gene expression profile of the human trabecular meshwork: NEIBank
            sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 44 (6), 2588-2596 (2003)
   PUBMED   12766061
REFERENCE   5  (bases 1 to 6116)
  AUTHORS   Yang,J.J.
  TITLE     A novel zinc finger protein, ZZaPK, interacts with ZAK and
            stimulates the ZAK-expressing cells re-entering the cell cycle
  JOURNAL   Biochem Biophys Res Commun 301 (1), 71-77 (2003)
   PUBMED   12535642
  REMARK    GeneRIF: Results suggest that ZAK might play a role as an upstream
            signal to suppress the ZZaPK function and decrease E2F expression.
REFERENCE   6  (bases 1 to 6116)
  AUTHORS   Tunnacliffe,A., Liu,L., Moore,J.K., Leversha,M.A., Jackson,M.S.,
            Papi,L., Ferguson-Smith,M.A., Thiesen,H.J. and Ponder,B.A.
  TITLE     Duplicated KOX zinc finger gene clusters flank the centromere of
            human chromosome 10: evidence for a pericentric inversion during
            primate evolution
  JOURNAL   Nucleic Acids Res 21 (6), 1409-1417 (1993)
   PUBMED   8464732
REFERENCE   7  (bases 1 to 6116)
  AUTHORS   Huebner,K., Druck,T., Croce,C.M. and Thiesen,H.J.
  TITLE     Twenty-seven nonoverlapping zinc finger cDNAs from human T cells
            map to nine different chromosomes with apparent clustering
  JOURNAL   Am J Hum Genet 48 (4), 726-740 (1991)
   PUBMED   2014798
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB235703.1, D31763.1, CD679489.1 and AL161931.13.
            
            On May 17, 2019 this sequence version replaced NM_006954.1.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.256390.1,
                                           SRR1660803.48971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000432900.7/ ENSP00000402467.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-537               DB235703.1         27-563
            538-6041            D31763.1           497-6000
            6042-6096           CD679489.1         279-333
            6097-6116           AL161931.13        9261-9280
FEATURES             Location/Qualifiers
     source          1..6116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.1"
     gene            1..6116
                     /gene="ZNF33A"
                     /gene_synonym="KOX2; KOX31; KOX5; NF11A; ZNF11; ZNF11A;
                     ZNF33; ZZAPK"
                     /note="zinc finger protein 33A"
                     /db_xref="GeneID:7581"
                     /db_xref="HGNC:HGNC:13096"
                     /db_xref="MIM:194521"
     exon            1..109
                     /gene="ZNF33A"
                     /gene_synonym="KOX2; KOX31; KOX5; NF11A; ZNF11; ZNF11A;
                     ZNF33; ZZAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            110..162
                     /gene="ZNF33A"
                     /gene_synonym="KOX2; KOX31; KOX5; NF11A; ZNF11; ZNF11A;
                     ZNF33; ZZAPK"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..2589
                     /gene="ZNF33A"
                     /gene_synonym="KOX2; KOX31; KOX5; NF11A; ZNF11; ZNF11A;
                     ZNF33; ZZAPK"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein 33a (KOX 31); zinc finger protein 11A;
                     brain my041 protein; zinc finger protein KOX31; zinc
                     finger and ZAK-associated protein with KRAB domain"
                     /codon_start=1
                     /product="zinc finger protein 33A isoform a"
                     /protein_id="NP_008885.1"
                     /db_xref="CCDS:CCDS44372.1"
                     /db_xref="GeneID:7581"
                     /db_xref="HGNC:HGNC:13096"
                     /db_xref="MIM:194521"
                     /translation="MNKVEQKSQESVSFKDVTVGFTQEEWQHLDPSQRALYRDVMLEN
                     YSNLVSVGYCVHKPEVIFRLQQGEEPWKQEEEFPSQSFPEVWTADHLKERSQENQSKH
                     LWEVVFINNEMLTKEQGDVIGIPFNVDVSSFPSRKMFCQCDSCGMSFNTVSELVISKI
                     NYLGKKSDEFNACGKLLLNIKHDETHTQEKNEVLKNRNTLSHHEETLQHEKIQTLEHN
                     FEYSICQETLLEKAVFNTQKRENAEENNCDYNEFGRTLCDSSSLLFHQISPSRDNHYE
                     FSDCEKFLCVKSTLSKPHGVSMKHYDCGESGNNFRRKLCLSHLQKGDKGEKHFECNEC
                     GKAFWEKSHLTRHQRVHTGQKPFQCNECEKAFWDKSNLTKHQRSHTGEKPFECNECGK
                     AFSHKSALTLHQRTHTGEKPYQCNACGKTFCQKSDLTKHQRTHTGLKPYECYECGKSF
                     RVTSHLKVHQRTHTGEKPFECLECGKSFSEKSNLTQHQRIHIGDKSYECNACGKTFYH
                     KSLLTRHQIIHTGWKPYECYECGKTFCLKSDLTVHQRTHTGQKPFACPECGKFFSHKS
                     TLSQHYRTHTGEKPYECHECGKIFYNKSYLTKHNRTHTGEKPYECNECGKAFYQKSQL
                     TQHQRIHIGEKPYKCNECGKAFCHKSALIVHQRTHTQEKPYKCNECGKSFCVKSGLIF
                     HERKHTGEKPYECNECGKFFRHKSSLTVHHRAHTGEKSCQCNECGKIFYRKSELAQHQ
                     RSHTGEKPYECNTCRKTFSQKSNLIVHQRRHIGENLMNEMDIRNFQPQVSLHNASEYS
                     HCGESPDDILNVQ"
     exon            163..307
                     /gene="ZNF33A"
                     /gene_synonym="KOX2; KOX31; KOX5; NF11A; ZNF11; ZNF11A;
                     ZNF33; ZZAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            308..403
                     /gene="ZNF33A"
                     /gene_synonym="KOX2; KOX31; KOX5; NF11A; ZNF11; ZNF11A;
                     ZNF33; ZZAPK"
                     /inference="alignment:Splign:2.1.0"
     exon            404..6116
                     /gene="ZNF33A"
                     /gene_synonym="KOX2; KOX31; KOX5; NF11A; ZNF11; ZNF11A;
                     ZNF33; ZZAPK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6064..6069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF33A"
                     /gene_synonym="KOX2; KOX31; KOX5; NF11A; ZNF11; ZNF11A;
                     ZNF33; ZZAPK"
                     /note="hexamer: AATAAA"
     polyA_site      6084
                     /gene="ZNF33A"
                     /gene_synonym="KOX2; KOX31; KOX5; NF11A; ZNF11; ZNF11A;
                     ZNF33; ZZAPK"
                     /note="major polyA site"
ORIGIN      
        1 gtttccgcct ttccttttgt ttttctcagg ttttgcgtgg gaggcggtcc cgggatttca
       61 agggtctacg cgcttttcta tggcgaatgc aacccgacga gggagtgggc tgtatcttca
      121 gagttgtctc cgtctttcca agaacagaac aaaatgaaca aggtagaaca gaagtcccag
      181 gagtcagtat catttaaaga tgtgactgtg ggcttcaccc aggaggagtg gcagcacctg
      241 gaccctagtc agagggctct gtatagagat gtgatgctgg agaactacag caaccttgtc
      301 tcagtggggt attgtgttca caaaccagag gtgatcttca ggctgcaaca aggagaagag
      361 ccatggaaac aggaggaaga attcccaagc caaagctttc cagaagtctg gacagctgat
      421 cacctgaaag agaggagcca agaaaaccaa tctaaacatt tgtgggaagt tgtattcatc
      481 aataatgaaa tgctgactaa ggaacaaggt gatgtaatag gaataccatt taatgtggat
      541 gtaagttctt ttccttccag aaaaatgttc tgtcagtgtg attcatgtgg aatgagtttc
      601 aacactgttt cagaattggt tatcagtaag ataaactatt taggaaaaaa gtctgatgaa
      661 tttaatgcct gtgggaaatt gttactcaat attaagcatg atgaaactca tactcaagag
      721 aaaaatgaag ttttgaaaaa taggaacaca ctgagtcatc atgaggagac tttgcagcat
      781 gagaagattc aaactttaga gcacaatttt gaatacagta tatgtcagga aaccctcctt
      841 gaaaaggcag tattcaatac acagaagaga gagaacgcag aagagaataa ctgtgattat
      901 aatgaatttg ggagaacttt gtgtgatagt tcatccctct tgttccatca gatatctccg
      961 tcaagggaca atcactatga atttagtgat tgtgagaagt tcttatgtgt gaagtccacc
     1021 ctttctaaac ctcatggggt atctatgaaa cactatgatt gtggtgaaag tgggaataat
     1081 ttcaggagga aattgtgtct gtcacacctt cagaaaggtg ataaaggaga gaaacacttt
     1141 gaatgtaatg aatgtgggaa agctttctgg gagaagtcac atctcactcg acatcagagg
     1201 gtgcacacag gacagaaacc ctttcaatgt aatgaatgtg aaaaagcttt ctgggataag
     1261 tcaaacctca ctaaacatca aagatcacac acaggggaga aaccttttga atgcaatgaa
     1321 tgtgggaaag cctttagcca taagtcagcc ctcacattac accagagaac acatacaggg
     1381 gagaaaccct atcaatgtaa tgcgtgtggg aaaacttttt gccagaaatc tgacctcact
     1441 aaacatcaga gaacacacac agggctgaaa ccctatgaat gttatgaatg tggaaaatcc
     1501 ttccgtgtga cttcgcacct taaagtacac cagagaactc acacaggtga gaaacctttt
     1561 gaatgtcttg agtgtgggaa atcctttagt gaaaagtcaa atcttacaca gcatcagaga
     1621 attcacatag gagataaatc ttatgaatgt aatgcatgtg ggaaaacttt ctaccacaag
     1681 tcattactca ccaggcatca gataattcat acagggtgga aaccttatga atgttatgaa
     1741 tgtgggaaaa ccttctgctt gaagtcagac ctcacagtac atcagagaac acacacaggg
     1801 cagaaaccct ttgcatgtcc cgaatgtggg aaattcttta gccataagtc aaccctctct
     1861 caacattata gaacacacac aggggagaaa ccctacgaat gtcatgaatg tggaaaaatc
     1921 ttttacaata aatcatacct aactaaacat aatagaacac atacagggga gaaaccctat
     1981 gaatgtaatg aatgtggaaa agccttctac cagaagtcac aactcactca gcatcagaga
     2041 attcacatag gggagaaacc ctataaatgt aatgagtgtg gaaaagcttt ctgccataag
     2101 tcagctctaa ttgtacatca gagaacccat acacaagaaa agccctataa atgtaatgaa
     2161 tgtggaaaat ctttctgtgt aaaatcagga cttattttcc atgagagaaa gcacacgggg
     2221 gagaaaccct atgaatgcaa tgaatgtggg aaattcttca ggcacaaatc atcactcaca
     2281 gtacatcaca gggctcacac aggagagaaa tcttgtcaat gtaatgaatg tggaaaaatc
     2341 ttttaccgta aatcggaact tgctcaacat cagagatcac atacagggga aaagccctat
     2401 gaatgtaaca catgcaggaa aactttctct caaaagtcaa atctcattgt acatcagaga
     2461 agacatatag gagaaaacct tatgaatgaa atggatatta gaaatttcca gccacaagtc
     2521 agcctccata atgcctcaga gtattcacac tgtggagaaa gccctgatga catcctgaat
     2581 gttcagtaac tatccacaaa ctcaccttat gttactccaa agtaatagta ggggataaac
     2641 ccatagacta caacaattat aggacagctt ttgttaggaa gtgatattct atgtaatatc
     2701 agatggttaa tacgggcata acaccttaca gatttttttt gaatttgtga aagtttttgg
     2761 caaaaatgca aataaggtta tgttagaatt tacactgagg agaaaattgt caatttaaga
     2821 aatctaaagt gaaaattttg cttagaaata aaatacgaca agttatgttt tgagtttgat
     2881 gccataatag tttttagggc acctaacaat aatttataga tgtatattgt ggaatgtaaa
     2941 gctttaagaa cttaaacaaa ggtaataatt aaaataacct cacaagaagt ttaatgagta
     3001 gagagaattc ccatgtacac ttcaccaaac ttcctctaag gataatgtat aatcatagta
     3061 tatggtcaag tccaagaaat cgatgttacc ttgctggtag atagagactt agtcagattt
     3121 tactatggtt tgcatgcact ctgtgtgtgt gtgtacgtgt atgtgtgtgt gtgtggttat
     3181 atcaaacttt tacgactttt acatttgagt aaccatcaac acgattagtt tacagaactg
     3241 aaaaggaatc tgagatctgt actgtatcag gattacaaag gatttagcct caagtagttc
     3301 cctttttgta ttaataacca cacgctttct gcaaccctat cccttgcatc cacttgacta
     3361 tgaagttttt ttaaagcaca gataaattga ataatcaggg caatagcatt aagcacatct
     3421 gcgaattatc cctgaagttc aaaagactta tatatgtata agtggtatgt gatataaatc
     3481 gtgtgtttca tatgcataat ggaatttaac gtaattgtga ataggaagta ggtatcctag
     3541 tttagtagtg gttacattat caggcccatc ccagatgttt gtgatgtcct gaaacaattt
     3601 aaaaggagac ccacagagct aatgtttatc catttaaaag gtataaatca aaataacaaa
     3661 ttatctaaaa aaaatctatc ctgtacatgt gaagatctag gctcgcctcc atgttactcc
     3721 ctttctcttc ctacctgtgg ctcatgccat gccatgaagt gcctagggta catatgtgaa
     3781 cattccagcc ttcagcataa gtggtagtcc aaattttctt taagcagctg ctctccaaga
     3841 cagggccctg gaaaggccca cacatacagc ccagggctgc ccagggctgt tggactgtca
     3901 tttcaaggct cattgtcccc agacagggat ctgggccctc agacttttga gaatatgaag
     3961 aggagggttg aggctggagc agaaccagaa tcaagctggt gtggggcttt tattgatagt
     4021 gtgaagattg tacactatat tacatgatca gatcatacaa ataatctaag attatacagt
     4081 ctagtgatcc tagattacac aagtaatcta agcttccact ttaggaaact agaaaaagaa
     4141 gagcaaatta aatccaaagt aacctgaaaa aacattagag taaaaatcat tgaaattgaa
     4201 aagagaaaat cgataaaacc caaaactggt tccttgaaaa ggtcagtaaa attgataaac
     4261 ctctagctag cttaagaaca aacagaagac aaatattgct aataccaaaa atgaaagagg
     4321 ccatcacagc taatcctatg gtcaccaaaa ggattagaaa gaaacatgga caactctgtc
     4381 cataaatttg ataacttagc taaaatggac caattccttg caagacgcat tctctcaaag
     4441 ctcacacaag atagacctca ataggcatat gtatctatta aataaaccaa agcagtaatt
     4501 aataaccttc caaggccagg tacagtggtt catgcctgta atcccagcac ttcactttgg
     4561 gaggctgagg cgggtggatc acaaggtcag gagttcgaga ccagcctggt caacatggtg
     4621 aaacccccta tctactaaaa atacaaaaaa ttagctgggc atggtggcat gcgtgtgtag
     4681 tcgaagctac tcaggaggct gaggcagaag aatcacttga acctgggagg tggatgttgc
     4741 agtgagctga gattgtgcca ctgtactgca gcctgggtga cagaatgaga ctgcatctca
     4801 aaaaataata atgaaacttt ccaaaacaaa gtgccaggac cagctgggtt cactgatgtg
     4861 tttttgagat acttaaggta gaaatgatac caagtctcta ccatctcttt cagaaaataa
     4921 aagcagagat aacacttccc aactcatttt gtgaggccag tattacccta atagcaaaac
     4981 caggcaaaga tattacaaga aaggaaaact acagatcaat atttccattg aacacagatg
     5041 cagaaatcct caaaatatta gcaaatcagg aatgcaaggc ttgttcaaca tttgatattc
     5101 agtgtaatcc attgcatgca ttagcagctc aaagatgaaa tacgatcata tcaataggta
     5161 cagaaaaagc atttgacaaa atccaatatc cattcatgtt aaaacctctc aacacagaag
     5221 gaatacagga gaacttactc aagttggtaa agaacatact acaaaaaacc ctacagctaa
     5281 cattatcctt gatgtttcca actagacact ttcctactaa gatcaggaac atggcaagga
     5341 acaccacacc actgcttttc agcattgtac tggaagtgct atataatgca gtgttaaaaa
     5401 aaaaagaaat aaaatgcaca tagatttgaa aggatgaaat acaactttgt tcacaagtaa
     5461 catgattgtc tttgtagaga attctaaata acaaaaaccc tgctgacatt aataagcaat
     5521 tacagcagga ttgcaggata cagtcctcag gtagatgata aaaaggaatt ggacatcaag
     5581 tcattaaaag acacggagaa accctaaatg cttattgtta agtgaaaacc aatctgaaaa
     5641 ggctttctat tttgtatgat tgcaattata tgacattttg ggagaggcaa aactattgag
     5701 ccagtgaaag gaccagtggt tgctgagagt tgaggggaaa ggagggatgg caggtagaga
     5761 ggtgattttt aaggcagtga aagtactctc tagggtactg taatttgtca aaacgcagag
     5821 aatggaaaac agtgaacgga aaacacagag taaaccctaa tgtcaactct ggacttcagt
     5881 taataataat gtatcactgt tggctcatta attgtaacaa atgaaccata atgatgcaag
     5941 atgttaatga ttggggagcc tgtggaagat gggaggggaa agggttatat gagaattctc
     6001 tatacttttt gctcaacttt ctgtaaccct aaagctactc taaaaaatga agtgtatcaa
     6061 gtaaataaat aaccaaccaa ccaaccctga ggaacatctt gtttctgtac taaggt
//
