LOCUS       NM_022095               4454 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 335 (ZNF335), mRNA.
ACCESSION   NM_022095
VERSION     NM_022095.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4454)
  AUTHORS   Hubacek,J.A., Philipp,T., Adamkova,V., Majek,O., Dlouha,D. and
            Dusek,L.
  TITLE     Possible effect of OAS1 and TMPRSS6 but not DPP4 and ZNF335
            polymorphisms on COVID-19 severity in the Czech population
  JOURNAL   Cent Eur J Public Health 31 (4), 235-239 (2023)
   PUBMED   38309700
  REMARK    GeneRIF: Possible effect of OAS1 and TMPRSS6 but not DPP4 and
            ZNF335 polymorphisms on COVID-19 severity in the Czech population.
REFERENCE   2  (bases 1 to 4454)
  AUTHORS   Stouffs,K., Stergachis,A.B., Vanderhasselt,T., Dica,A.,
            Janssens,S., Vandervore,L., Gheldof,A., Bodamer,O., Keymolen,K.,
            Seneca,S., Liebaers,I., Jayaraman,D., Hill,H.E., Partlow,J.N.,
            Walsh,C.A. and Jansen,A.C.
  TITLE     Expanding the clinical spectrum of biallelic ZNF335 variants
  JOURNAL   Clin Genet 94 (2), 246-251 (2018)
   PUBMED   29652087
  REMARK    GeneRIF: We describe, herein, 2 additional affected individuals
            with biallelic ZNF335 variants, 1 individual with a homozygous
            c.1399 T > C, p.(Cys467Arg) variant, and a second individual with
            compound heterozygous c.2171_2173delTCT, p.(Phe724del) and c.3998A
            > G, p.(Glu1333Gly) variants with the latter variant predicted to
            affect splicing..Our findings expand the clinical spectrum of
            ZNF335-associated microcephaly
REFERENCE   3  (bases 1 to 4454)
  AUTHORS   Sato,R., Takanashi,J., Tsuyusaki,Y., Kato,M., Saitsu,H.,
            Matsumoto,N. and Takahashi,T.
  TITLE     Association Between Invisible Basal Ganglia and ZNF335 Mutations: A
            Case Report
  JOURNAL   Pediatrics 138 (3) (2016)
   PUBMED   27540107
  REMARK    GeneRIF: In this article, we describe another family harboring
            ZNF335 mutations.  The mutations were individually transmitted by
            her parents, indicating that the proband was compound heterozygous
            for the mutations. We speculate that invisible basal ganglia may be
            the key feature of ZNF335 mutations.
REFERENCE   4  (bases 1 to 4454)
  AUTHORS   Nishida,T., Mihara,T., Horiki,T. and Ka,K.
  TITLE     Anaesthesia and orphan disease: primary autosomal recessive
            microcephaly-10 caused by a mutation in the ZNF335 gene
  JOURNAL   Eur J Anaesthesiol 33 (7), 543-545 (2016)
   PUBMED   26479514
  REMARK    GeneRIF: ZNF335 gene mutation is associated with extreme
            microcephaly with a severely simplified gyral pattern, decreased
            brain size, increased extra-axial space, enlarged ventricles,
            absence of the corpus callosum and delayed myelination
REFERENCE   5  (bases 1 to 4454)
  AUTHORS   Coleman,C., Quinn,E.M., Ryan,A.W., Conroy,J., Trimble,V.,
            Mahmud,N., Kennedy,N., Corvin,A.P., Morris,D.W., Donohoe,G.,
            O'Morain,C., MacMathuna,P., Byrnes,V., Kiat,C., Trynka,G.,
            Wijmenga,C., Kelleher,D., Ennis,S., Anney,R.J. and McManus,R.
  TITLE     Common polygenic variation in coeliac disease and confirmation of
            ZNF335 and NIFA as disease susceptibility loci
  JOURNAL   Eur J Hum Genet 24 (2), 291-297 (2016)
   PUBMED   25920553
  REMARK    GeneRIF: we performed a meta-analysis of our data with the previous
            reports, identifying two further loci harbouring the ZNF335 and
            NIFA genes which now exceed genome-wide significance, taking the
            total number of CD susceptibility loci to 42.
REFERENCE   6  (bases 1 to 4454)
  AUTHORS   Garapaty,S., Xu,C.F., Trojer,P., Mahajan,M.A., Neubert,T.A. and
            Samuels,H.H.
  TITLE     Identification and characterization of a novel nuclear protein
            complex involved in nuclear hormone receptor-mediated gene
            regulation
  JOURNAL   J Biol Chem 284 (12), 7542-7552 (2009)
   PUBMED   19131338
REFERENCE   7  (bases 1 to 4454)
  AUTHORS   Garapaty,S., Mahajan,M.A. and Samuels,H.H.
  TITLE     Components of the CCR4-NOT complex function as nuclear hormone
            receptor coactivators via association with the NRC-interacting
            Factor NIF-1
  JOURNAL   J Biol Chem 283 (11), 6806-6816 (2008)
   PUBMED   18180299
  REMARK    GeneRIF: CCR4 plays a role in the regulation of certain endogenous
            RARalpha target genes and RCD1 and CCR4 might mediate their
            function through their interaction with NIF-1
REFERENCE   8  (bases 1 to 4454)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 4454)
  AUTHORS   Mahajan,M.A., Murray,A. and Samuels,H.H.
  TITLE     NRC-interacting factor 1 is a novel cotransducer that interacts
            with and regulates the activity of the nuclear hormone receptor
            coactivator NRC
  JOURNAL   Mol Cell Biol 22 (19), 6883-6894 (2002)
   PUBMED   12215545
  REMARK    GeneRIF: NRC-interacting factor 1 is a novel cotransducer that
            interacts with and regulates the activity of the nuclear hormone
            receptor coactivator NRC
REFERENCE   10 (bases 1 to 4454)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162458.10, BC041331.2,
            AF395833.1 and BF755826.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022095.3.
            
            Summary: The protein encoded by this gene enhances transcriptional
            activation by ligand-bound nuclear hormone receptors. However, it
            does this not by direct interaction with the receptor, but by
            direct interaction with the nuclear hormone receptor
            transcriptional coactivator NRC. The encoded protein may function
            by altering local chromatin structure. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF395833.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322927.3/ ENSP00000325326.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL162458.10        58611-58619         c
            10-32               BC041331.2         4-26
            33-1901             AF395833.1         1-1869
            1902-2005           BF755826.1         310-413             c
            2006-4454           AF395833.1         1974-4422
FEATURES             Location/Qualifiers
     source          1..4454
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..4454
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /note="zinc finger protein 335"
                     /db_xref="GeneID:63925"
                     /db_xref="HGNC:HGNC:15807"
                     /db_xref="MIM:610827"
     exon            1..82
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            83..333
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..4161
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /note="NRC-interacting factor 1;
                     zinc-finger/leucine-zipper co-transducer NIF1"
                     /codon_start=1
                     /product="zinc finger protein 335"
                     /protein_id="NP_071378.1"
                     /db_xref="CCDS:CCDS13389.1"
                     /db_xref="GeneID:63925"
                     /db_xref="HGNC:HGNC:15807"
                     /db_xref="MIM:610827"
                     /translation="MEENEVESSSDAAPGPGRPEEPSESGLGVGTSEAVSADSSDAAA
                     APGQAEADDSGVGQSSDRGSRSQEEVSESSSSADPLPNSYLPDSSSVSHGPVAGVTGG
                     PPALVHSSALPDPNMLVSDCTASSSDLGSAIDKIIESTIGPDLIQNCITVTSAEDGGA
                     ETTRYLILQGPDDGAPMTSPMSSSTLAHSLAAIEALADGPTSTSTCLEAQGGPSSPVQ
                     LPPASGAEEPDLQSLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPVAAAA
                     AAAGKKGRLRKWSTSTKSQEEEGPEEEDDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQ
                     LRLQRPTPSTPRPRRRPGRPRKLPRLEISDLPDGVEGEPLVSSQSGQSPPEPQDPEAP
                     SSSGPGHLVAMGKVSRTPVEAGVSQSDAENAAPSCPDEHDTLPRRRGRPSRRFLGKKY
                     RKYYYKSPKPLLRPFLCRICGSRFLSHEDLRFHVNSHEAGDPQLFKCLQCSYRSRRWS
                     SLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSRDRKKRPDPTPKLSSFPCPV
                     CGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCE
                     FCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEY
                     CHFSTRHKKNLRLHVRCRHASSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSAAP
                     GPPPSSPGPPEIPPEATTFQSSEAPSLLCSDTLGGATIIYQQGAEESTAMATQTALDL
                     LLNMSAQRELGGTALQVAVVKSEDVEAGLASPGGQPSPEGATPQVVTLHVAEPGGGAA
                     AESQLGPPDLPQITLAPGPFGGTGYSVITAPPMEEGTSAPGTPYSEEPAGEAAQAVVV
                     SDTLKEAGTHYIMATDGTQLHHIELTADGSISFPSPDALASGAKWPLLQCGGLPRDGP
                     EPPSPAKTHCVGDSQSSASSPPATSKALGLAVPPSPPSAATAASKKFSCKICAEAFPG
                     RAEMESHKRAHAGPGAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCSQCSFASKNKK
                     DLRRHMLTHTKEKPFACHLCGQRFNRNGHLKFHIQRLHSPDGRKSGTPTARAPTQTPT
                     QTIILNSDDETLATLHTALQSSHGVLGPERLQQALSQEHIIVAQEQTVTNQEEAAYIQ
                     EITTADGQTVQHLVTSDNQVQYIISQDGVQHLLPQEYVVVPEGHHIQVQEGQITHIQY
                     EQGAPFLQESQIQYVPVSPGQQLVTQAQLEAAAHSAVTAVADAAMAQAQGLFGTDETV
                     PEHIQQLQHQGIEYDVITLADD"
     exon            334..574
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..652
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            653..946
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1087
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1234
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1487
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1665
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1778
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1797
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1914
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..1991
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2152
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2385
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2479
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2574
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2834
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2946
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3321
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3464
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3465..3619
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..3723
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3724..3801
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3802..3885
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3886..3951
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3952..4033
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4034..4454
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4427..4432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /note="hexamer: AATAAA"
     polyA_site      4454
                     /gene="ZNF335"
                     /gene_synonym="MCPH10; NIF-1; NIF1; NIF2"
                     /note="major polyA site"
ORIGIN      
        1 gggttcctcc gcagcggagg aaagaggatg gcgacctcgt cgatgccgga gtcagagagg
       61 aacgtggcta cgaaagcctc ggagtgaagt tcccagaccc tacgccccgc tgtcaggcag
      121 cccgccgatc agatggagga gaacgaggtg gagagcagca gcgacgcggc ccctgggcct
      181 ggccggcccg aggagccctc tgagagcggc ctgggtgtgg gcacctcaga agccgtgtcc
      241 gccgacagca gcgacgccgc ggccgccccg gggcaggcag aggccgatga ctctggcgtg
      301 gggcaaagct cggaccgcgg cagccgttct caggaggagg tatctgagag cagctcgagc
      361 gcagaccccc tgcctaatag ctacctccct gattcatcgt ctgtgtctca tgggccagtg
      421 gcaggggtga caggcggtcc cccagcactt gtgcactcta gtgcactccc agaccccaac
      481 atgctggtgt ccgactgcac agcttcctcc tcggacctgg gctcggccat cgacaagatc
      541 atcgagtcca ccatcgggcc cgacctcatc cagaactgca tcactgtgac cagtgctgag
      601 gatggcgggg ccgagaccac acggtacctg atcctacagg gcccagatga tggagccccc
      661 atgacatcac caatgtccag ttccaccttg gcccacagcc tagcagccat tgaggccctg
      721 gcagatggcc ccacatccac atccacatgc ctggaggcac agggtgggcc cagctccccg
      781 gtgcagctgc ccccagcctc cggtgccgaa gagccggacc tgcagagcct ggaggccatg
      841 atggaggtgg tggtggtgca gcagttcaaa tgcaagatgt gccagtaccg gagcagcacc
      901 aaggccacac tgctgcgcca catgcgggaa cgccacttcc gtccagtagc agcagccgca
      961 gcagcagctg gtaaaaaagg acgtctacgg aagtggagca cctccaccaa gagccaagag
     1021 gaagagggac cagaggagga ggacgatgat gacattgtag acgctggagc cattgatgac
     1081 ctggaggagg atagcgacta taatccagct gaggatgagc cccgaggccg gcagcttcgg
     1141 ctccagcgcc ccacccccag taccccaagg ccccgaagga gacctggccg gccccggaag
     1201 ctgccccgcc tggagatctc agacctccca gatggtgtgg aaggagagcc tctagtgagt
     1261 tcccagagtg gacagagccc tccagagcca caggatcccg aggctcccag ctcctcaggc
     1321 ccaggacacc tggtggccat gggcaaggtg agcaggaccc ctgtggaagc tggtgtgagc
     1381 cagtcagatg cagagaacgc agccccctcc tgcccggatg agcatgacac tctgccccgg
     1441 cgccgaggtc gaccttccag gcgcttccta ggcaagaaat accgcaagta ctattacaag
     1501 tcgcccaaac cacttttgag gcccttcctg tgccgcatct gtggttctcg ctttctgtcc
     1561 cacgaggacc tgcgcttcca cgtcaactcc catgaggctg gcgatcccca gctcttcaag
     1621 tgcctgcagt gcagctatcg ttcccgccgc tggtcctcgc tcaaggagca catgttcaac
     1681 cacgtgggca gcaagcccta caagtgtgac gagtgcagct acaccagtgt ctaccggaag
     1741 gacgtcattc ggcacgccgc tgtgcacagc cgggaccgga agaagaggcc agatccgact
     1801 ccaaagctga gctctttccc ctgccctgtg tgtggccgtg tgtaccccat gcagaaaaga
     1861 ctcacgcagc acatgaagac gcacagcact gagaagcccc acatgtgtga caagtgtgga
     1921 aagtccttta agaagcgcta caccttcaaa atgcacctgc tcacgcacat ccaggctgtt
     1981 gccaaccgca ggttcaagtg tgagttctgt gagtttgttt gtgaagacaa gaaggcactg
     2041 ctgaaccacc agttgtccca cgtcagtgac aagcccttca aatgcagctt ttgtccctac
     2101 cgcaccttcc gagaggactt cttgctgtcc catgtggctg tcaagcacac aggggccaag
     2161 cccttcgcct gtgagtactg ccacttcagc acacggcaca agaagaacct gcgcctgcac
     2221 gtacggtgcc gacacgcaag cagcttcgag gaatggggga ggcgccaccc tgaggagccc
     2281 ccctcccgcc gtcgcccctt cttctctctg cagcagattg aggagctgaa gcagcagcac
     2341 agtgcggccc ctggaccacc tcccagttcc ccaggacctc ctgagatacc cccagaggcg
     2401 acaactttcc agtcatctga ggctccctca ttgctctgtt ctgacaccct gggcggcgcc
     2461 accatcatct accagcaagg agctgaggag tcgacagcga tggccacgca gacagccttg
     2521 gatcttctgc tgaacatgag tgctcagcgg gaactggggg gcacagccct gcaggtggct
     2581 gtggtgaagt cggaagatgt ggaagcaggg ttagcatccc ctggtgggca gccctcccct
     2641 gaaggtgcca ctccacaggt ggtcaccctc cacgtggcag agccaggggg cggtgcagca
     2701 gccgagagcc agctaggccc tcctgaccta ccgcagatca ccctggcacc tggtccattt
     2761 ggtgggactg gctacagtgt catcacagca ccccctatgg aggagggaac atcagctcct
     2821 ggcacacctt acagcgagga gcccgcagga gaggcagccc aggctgtggt tgtgagtgac
     2881 accctaaaag aagctggcac ccactacatc atggctactg atggtaccca gttgcaccac
     2941 attgagctca ccgcagatgg ctccatctcc ttcccaagtc cagatgctct ggcctctggt
     3001 gccaaatggc ccctgctgca gtgtggggga ctgcccagag acggccctga gcccccatct
     3061 ccagccaaga cccactgcgt aggggactcc cagagctctg cctcctcacc tcctgcaacc
     3121 agcaaagccc tgggcctggc agtgcccccg tcaccgccat ctgcagccac tgctgcatca
     3181 aagaagtttt cctgcaagat ctgtgccgag gccttccctg gccgagctga gatggagagt
     3241 cacaagcggg cccacgctgg gcctggtgcc ttcaagtgcc ccgactgccc cttcagtgcc
     3301 cgccagtggc ccgaggtccg ggcgcacatg gcacagcact caagcctacg gccccaccag
     3361 tgtagccagt gcagctttgc ctccaagaac aagaaggacc tgcgtcggca catgctgact
     3421 cacacaaagg agaagccttt tgcatgccac ctctgcgggc agcgtttcaa ccgtaacggg
     3481 cacctcaagt tccacatcca gcggctgcac agtcctgatg ggaggaagtc aggaacccct
     3541 acagcccggg cccctaccca gaccccaacc cagaccatca tcctgaacag tgatgacgaa
     3601 acactggcca ccctgcacac tgcactccag tccagtcacg gggtcctggg cccagagcgg
     3661 ctacagcagg cactgagcca ggaacacatc atcgttgccc aggaacagac agtgaccaat
     3721 caggaggaag ccgcctacat ccaagagatc accacggcag atggccagac cgtacagcac
     3781 ctggtgacct ccgacaacca ggtgcagtat atcatctccc aggatggtgt ccagcacctg
     3841 ctcccccagg aatatgttgt ggtccctgaa ggccatcaca tccaggtaca ggagggccag
     3901 atcacacaca tccagtatga acaaggagcc ccgttccttc aggagtccca gatccagtat
     3961 gtgcctgtgt ccccaggcca gcagcttgtc acacaggctc aacttgaggc tgcagcacac
     4021 tcagctgtca cagcagtggc tgatgctgcc atggcccaag cccagggcct gtttggtaca
     4081 gacgagacag tgcccgaaca cattcaacag ctgcagcacc agggcatcga gtacgacgtc
     4141 atcaccctgg ccgatgactg agccccgagg gcccaacaca gatcatggat ttgcggccag
     4201 ctctcctggg ggtagggggc caccaggact cacctccctc ttcatttagg atctccagat
     4261 actggatagc cagcatcctc tcattcccag ggagccagac ctgtgctgtt ggggttaggg
     4321 gcagccatgg gccccagcca ggacatgctg ggtgccccag cctgcaggca ggctttggga
     4381 gagaaattta tttttgtttg ggtggaccca ctggcctgtc agtctcaata aagggaccgg
     4441 agtccagtcc tgaa
//
